Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas

Journal of Clinical Investigation

Volumn 116, Issue 6, 2006, Pages 1484-1493

  Fukuda, Akihisa ^a,b   Kawaguchi, Yoshiya ^a,c   Furuyama, Kenichiro ^a   Kodama, Sota ^a   Horiguchi, Masashi ^a   Kuhara, Takeshi ^a   Koizumi, Masayuki ^a   Boyer, Daniel F ^d   Fujimoto, Koji ^a   Doi, Ryuichiro ^a   Kageyama, Ryoichiro ^a   Wright, Christopher V E ^d   Chiba, Tsutomu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR HES 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; ECTOPIC PANCREAS; EMBRYO; ENDOCRINE CELL; HEPATIC DUCT; HEREDITY; INTESTINE EPITHELIUM; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BILE DUCTS; CELL LINEAGE; CHORISTOMA; DUODENAL DISEASES; EMBRYO; ENDODERM; GASTROINTESTINAL TRACT; GENES, REPORTER; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; MORPHOGENESIS; NERVE TISSUE PROTEINS; PANCREAS; PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 33745214464     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI27704     Document Type: Article

References (43)

1. Rosai, J., and Ackerman, L.V. 2004. Rosai and Ackerman's surgical pathology. 9th edition. Mosby. Edinburgh, United Kingdom/New York, New York, USA. 3080 pp.
2. Yamada, T. 1995. Textbook of gastroenterology. Volume 2. Lippincott. Philadelphia, Pennsylvania, USA. 151 pp.
3. Chen, C.H., Yang, C.C., Yeh, Y.H., Chou, D.A., and Kuo, C.L. 2001. Ectopic pancreas located in the major duodenal papilla: case report and review. Gastrointest. Endosc. 53:121-123.
4. Jarriault, S., et al. 1995. Signalling downstream of activated mammalian Notch. Nature. 377:355-358.
5. Artavanis-Tsakonas, S., Rand, M.D., and Lake, R.J. 1999. Notch signaling: cell fate control and signal integration in development. Science. 284:770-776.
6. Kageyama, R., Ohtsuka, T., and Tomita, K. 2000. The bHLH gene Hes1 regulates differentiation of multiple cell types. Mol. Cells. 10:1-7.
7. Lee, J.C., et al. 2001. Regulation of the pancreatic proendocrine gene neurogenin3. Diabetes. 50:928-936.
8. Kuroda, K., et al. 1999. Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis. J. Biol. Chem. 274:7238-7244.
9. Offield, M.F., et al. 1996. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 122:983-995.
10. Fukuda, A., et al. 2006. Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice. Gastroenterology. 130:855-867.
11. Jonsson, J., Carlsson, L., Edlund, T., and Edlund, H. 1994. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature. 371:606-609.
12. Krapp, A., et al. 1998. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 12:3752-3763.
13. Kawaguchi, Y., et al. 2002. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genet. 32:128-134.
14. Apelqvist, A., et al. 1999. Notch signalling controls pancreatic cell differentiation. Nature. 400:877-881.
15. Jensen, J., et al. 2000. Control of endodermal endocrine development by Hes-1. Nat. Genet. 24:36-44.
16. Murtaugh, L.C., Stanger, B.Z., Kwan, K.M., and Melton, D.A. 2003. Notch signaling controls multiple steps of pancreatic differentiation. Proc. Natl. Acad. Sci. U. S. A. 100:14920-14925.
17. Hald, J., et al. 2003. Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev. Biol. 260:426-437.
18. Esni, F., et al. 2004. Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development. 131:4213-4224.
19. Sumazaki, R., et al. 2004. Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat. Genet. 36:83-87.
20. Gu, G., Dubauskaite, J., and Melton, D.A. 2002. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 129:2447-2457.
21. Gradwohl, G., Dierich, A., LeMeur, M., and Guillemot, F. 2000. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. U. S. A. 97:1607-1611.
22. Ishibashi, M., et al. 1995. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 9:3136-3148.
23. Soriano, P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21:70-71.
24. Silberg, D.G., Swain, G.P., Suh, E.R., and Traber, P.G. 2000. Cdx1 and cdx2 expression during intestinal development. Gastroenterology. 119:961-971.
25. Shiojiri, N., and Katayama, H. 1988. Development of Dolichos biflorus agglutinin (DBA) binding sites in the bile duct of the embryonic mouse liver. Anat. Embryol. (Berl.). 178:15-20.
26. Kobayashi, H., et al. 2002. Lectin as a marker for staining and purification of embryonic pancreatic epithelium. Biochem. Biophys. Res. Commun. 293:691-697.
27. Kodama, Y., Hijikata, M., Kageyama, R., Shimotohno, K., and Chiba, T. 2004. The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology. 127:1775-1786.
28. Grapin-Botton, A., Majithia, A.R., and Melton, D.A. 2001. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev. 15:444-454.
29. Haumaitre, C., et al. 2005. Lack of TCF2/vHNF1 in mice leads to pancreas agenesis. Proc. Natl. Acad. Sci. U. S. A. 102:1490-1495.
30. Coffinier, C., Barra, J., Babinet, C., and Yaniv, M. 1999. Expression of the vHNF1/HNF1beta homeoprotein gene during mouse organogenesis. Mech. Dev. 89:211-213.
31. Lammert, E., Cleaver, O., and Melton, D. 2001. Induction of pancreatic differentiation by signals from blood vessels. Science. 294:564-567.
32. Yoshitomi, H., and Zaret, K.S. 2004. Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development. 131:807-817.
33. Edsbagge, J., et al. 2005. Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development. 132:1085-1092.
34. Schroder, N., and Gossler, A. 2002. Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expr. Patterns. 2:247-250.
35. Kim, S.K., and Melton, D.A. 1998. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. U. S. A. 95:13036-13041.
36. Heller, R.S., Stoffers, D.A., Hussain, M.A., Miller, C.P., and Habener, J.F. 1998. Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum. Gastroenterology. 115:381-387.
37. Horb, M.E., Shen, C.N., Tosh, D., and Slack, J.M. 2003. Experimental conversion of liver to pancreas. Curr. Biol. 13:105-115.
38. Ferber, S., et al. 2000. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat. Med. 6:568-572.
39. Ber, I., et al. 2003. Functional, persistent, and extended liver to pancreas transdifferentiation. J. Biol. Chem. 278:31950-31957.
40. Sapir, T., et al. 2005. Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells. Proc. Natl. Acad. Sci. U. S. A. 102:7964-7969.
41. Elliott, W.M., and Youson, J.H. 1993. Development of the adult endocrine pancreas during metamorphosis in the sea lamprey, Petromyzon marinus L. I. Light microscopy and autoradiography. Anat. Rec. 237:259-270.
42. Hoshino, M., et al. 2005. Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron. 47:201-213.
43. Glasgow, S.M., Henke, R.M., Macdonald, R.J., Wright, C.V., and Johnson, J.E. 2005. Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn. Development. 132:5461-5469.