Safety and efficacy of adeno-associated viral vector-mediated insulin gene transfer via portal vein to the livers of streptozotocin-induced diabetic Sprague-Dawley rats

Journal of Gene Medicine

Volumn 7, Issue 5, 2005, Pages 621-629

  Park, Young Mi ^a   Woo, Seonock ^a   Lee, Geun Taek ^a   Ko, Ji Yun ^a   Lee, Yongho ^a   Zhao, Zheng Shan ^a   Kim, Hye Joo ^a   Ahn, Chul Woo ^a   Cha, Bong Soo ^a   Kim, Kyung Sup ^a   Park, Cheol Won ^a   Lee, Hyun Chul ^a  

^a Yonsei University   (South Korea)

Author keywords

Basal insulin; Diabetes mellitus; Gene therapy; Recombinant viral vectors

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; HUMAN INSULIN; INSULIN; MESSENGER RNA; PARVOVIRUS VECTOR; RECOMBINANT HUMAN INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GLUCOSE MONITORING; CONTROLLED STUDY; DIABETES CONTROL; DIABETES MELLITUS; DIET RESTRICTION; DRUG EFFICACY; DRUG SAFETY; GENE EXPRESSION; GENE TRANSFER; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN BLOOD LEVEL; LONG TERM CARE; MALE; NONHUMAN; NORTHERN BLOTTING; PORTAL VEIN; PRIORITY JOURNAL; PROMOTER REGION; RAT; RAT STRAIN; STREPTOZOCIN DIABETES; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS RECOMBINANT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD GLUCOSE; CYTOSKELETAL PROTEINS; DEPENDOVIRUS; DIABETES MELLITUS, EXPERIMENTAL; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; INSULIN; LIVER; MALE; PORTAL VEIN; PROINSULIN; RATS; RATS, SPRAGUE-DAWLEY; SAFETY; TREATMENT OUTCOME;

ANIMALIA; CYTOMEGALOVIRUS;

EID: 21144484250     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.708     Document Type: Article

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