메뉴 건너뛰기




Volumn 90, Issue 11, 2012, Pages 1434-1445

PGE2 and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways

Author keywords

Bone morphogenetic proteins; Cellular signaling; Osteoblasts; Osteoclasts; Prostaglandins

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; PROSTAGLANDIN E2;

EID: 84870171076     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/y2012-123     Document Type: Article
Times cited : (35)

References (72)
  • 1
    • 0034103380 scopus 로고    scopus 로고
    • Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: Antagonism by noggin
    • doi:10.1359/jbmr.2000.15.4.663. PMID:10780858
    • Abe, E., Yamamoto, M., Taguchi, Y., Lecka-Czernik, B., O'Brien, C.A., Economides, A.N., et al. 2000. Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J. Bone Miner. Res. 15(4): 663-673. doi:10.1359/jbmr.2000.15.4.663. PMID:10780858.
    • (2000) J. Bone Miner. Res , vol.15 , Issue.4 , pp. 663-673
    • Abe, E.1    Yamamoto, M.2    Taguchi, Y.3    Lecka-Czernik, B.4    O'Brien, C.A.5    Economides, A.N.6
  • 2
    • 20044370085 scopus 로고    scopus 로고
    • PGE2 signal through EP2 promotes the growth of articular chondrocytes
    • doi:10.1359/JBMR.041122. PMID:15746982
    • Aoyama, T., Liang, B., Okamoto, T., Matsusaki, T., Nishijo, K., Ishibe, T., et al. 2005. PGE2 signal through EP2 promotes the growth of articular chondrocytes. J. Bone Miner. Res. 20(3): 377-389. doi:10.1359/JBMR.041122. PMID:15746982.
    • (2005) J. Bone Miner. Res , vol.20 , Issue.3 , pp. 377-389
    • Aoyama, T.1    Liang, B.2    Okamoto, T.3    Matsusaki, T.4    Nishijo, K.5    Ishibe, T.6
  • 3
    • 57349169432 scopus 로고    scopus 로고
    • Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: Evidence for signaling via the EP4 receptor
    • PMID:18802112
    • Attur, M., Al-Mussawir, H.E., Patel, J., Kitay, A., Dave, M., Palmer, G., et al. 2008. Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor. J. Immunol. 181(7): 5082-5088. PMID:18802112.
    • (2008) J. Immunol , vol.181 , Issue.7 , pp. 5082-5088
    • Attur, M.1    Al-Mussawir, H.E.2    Patel, J.3    Kitay, A.4    Dave, M.5    Palmer, G.6
  • 4
    • 32844461217 scopus 로고    scopus 로고
    • Early changes in prostaglandins precede bone formation in a rabbit model of heterotopic ossification
    • doi:10.1016/j.bone.2005.08.016. PMID:16226065
    • Bartlett, C.S., Rapuano, B.E., Lorich, D.G., Wu, T., Anderson, R.C., Tomin, E., et al. 2006. Early changes in prostaglandins precede bone formation in a rabbit model of heterotopic ossification. Bone, 38(3): 322-332. doi:10.1016/j.bone.2005.08.016. PMID:16226065.
    • (2006) Bone , vol.38 , Issue.3 , pp. 322-332
    • Bartlett, C.S.1    Rapuano, B.E.2    Lorich, D.G.3    Wu, T.4    Anderson, R.C.5    Tomin, E.6
  • 5
    • 0027830638 scopus 로고
    • Changes in bone inducing activity of bone morphogenetic protein with aging
    • PMID:8154837
    • Bessho, K., and Iizuka, T. 1993. Changes in bone inducing activity of bone morphogenetic protein with aging. Ann. Chir. Gynaecol. Suppl. 207: 49-53. PMID:8154837.
    • (1993) Ann. Chir. Gynaecol. Suppl , vol.207 , pp. 49-53
    • Bessho, K.1    Iizuka, T.2
  • 6
    • 71549169272 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 enhances PGE(2)-stimulated osteoclast formation in murine bone marrow cultures
    • doi:10.1016/j.prostaglandins.2009.08.005. PMID: 19744575
    • Blackwell, K.A., Hortschansky, P., Sanovic, S., Choudhary, S., Raisz, L.G., and Pilbeam, C.C. 2009. Bone morphogenetic protein 2 enhances PGE(2)-stimulated osteoclast formation in murine bone marrow cultures. Prostaglandins Other Lipid Mediat. 90 (3-4): 76-80. doi:10.1016/j.prostaglandins.2009.08.005. PMID: 19744575.
    • (2009) Prostaglandins Other Lipid Mediat , vol.90 , Issue.3-4 , pp. 76-80
    • Blackwell, K.A.1    Hortschansky, P.2    Sanovic, S.3    Choudhary, S.4    Raisz, L.G.5    Pilbeam, C.C.6
  • 7
    • 77952495406 scopus 로고    scopus 로고
    • Prostaglandins in bone: Bad cop, good cop?
    • doi:10.1016/j.tem.2009.12.004. PMID:20079660
    • Blackwell, K.A., Raisz, L.G., and Pilbeam, C.C. 2010. Prostaglandins in bone: bad cop, good cop? Trends Endocrinol. Metab. 21(5): 294-301. doi:10.1016/j.tem.2009.12.004. PMID:20079660.
    • (2010) Trends Endocrinol. Metab , vol.21 , Issue.5 , pp. 294-301
    • Blackwell, K.A.1    Raisz, L.G.2    Pilbeam, C.C.3
  • 8
    • 36348932149 scopus 로고    scopus 로고
    • Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
    • doi:10.1186/ar2305. PMID:17922907
    • Blaney Davidson, E.N., Vitters, E.L., van Lent, P.L., van de Loo, F.A., van den Berg, W.B., and van der Kraan, P.M. 2007. Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling. Arthritis Res. Ther. 9(5): R102. doi:10.1186/ar2305. PMID:17922907.
    • (2007) Arthritis Res. Ther , vol.9 , Issue.5
    • Blaney, D.E.N.1    Vitters, E.L.2    van Lent, P.L.3    van de Loo, F.A.4    van den Berg, W.B.5    van der Kraan, P.M.6
  • 9
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • doi: 10.1038/nature01658. PMID:12748652
    • Boyle, W.J., Simonet, W.S., and Lacey, D.L. 2003. Osteoclast differentiation and activation. Nature, 423(6937): 337-342. doi: 10.1038/nature01658. PMID:12748652.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 10
    • 9144245578 scopus 로고    scopus 로고
    • PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway
    • doi: 10.1016/S0736-0266(03)00153-0. PMID:14656653
    • Bukata, S.V., Gelinas, J., Wei, X., Rosier, R.N., Puzas, J.E., Zhang, X., et al. 2004. PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. J. Orthop. Res. 22(1): 6-12. doi: 10.1016/S0736-0266(03)00153-0. PMID:14656653.
    • (2004) J. Orthop. Res , vol.22 , Issue.1 , pp. 6-12
    • Bukata, S.V.1    Gelinas, J.2    Wei, X.3    Rosier, R.N.4    Puzas, J.E.5    Zhang, X.6
  • 11
    • 2542479890 scopus 로고    scopus 로고
    • Signal transduction and biological functions of bone morphogenetic proteins
    • doi:10.2741/1090. PMID:14766372
    • Chen, D., Zhao, M., Harris, S.E., and Mi, Z. 2004. Signal transduction and biological functions of bone morphogenetic proteins. Front. Biosci. 9(1-3): 349-358. doi:10.2741/1090. PMID:14766372.
    • (2004) Front. Biosci , vol.9 , Issue.1-3 , pp. 349-358
    • Chen, D.1    Zhao, M.2    Harris, S.E.3    Mi, Z.4
  • 12
    • 0035992648 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: Role in effects of bone morphogenetic protein 2 in vitro and in vivo
    • doi:10.1359/jbmr.2002. 17.8.1430. PMID:12162497
    • Chikazu, D., Li, X., Kawaguchi, H., Sakuma, Y., Voznesensky, O.S., Adams, D.J., et al. 2002. Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. J. Bone Miner. Res. 17(8): 1430-1440. doi:10.1359/jbmr.2002. 17.8.1430. PMID:12162497.
    • (2002) J. Bone Miner. Res , vol.17 , Issue.8 , pp. 1430-1440
    • Chikazu, D.1    Li, X.2    Kawaguchi, H.3    Sakuma, Y.4    Voznesensky, O.S.5    Adams, D.J.6
  • 13
    • 43049173756 scopus 로고    scopus 로고
    • Effect of deletion of the prostaglandin EP2 receptor on the anabolic response to prostaglandin E2 and a selective EP2 receptor agonist
    • doi: 10.1016/j.prostaglandins.2008.02.001. PMID:18406186
    • Choudhary, S., Alander, C., Zhan, P., Gao, Q., Pilbeam, C., and Raisz, L. 2008. Effect of deletion of the prostaglandin EP2 receptor on the anabolic response to prostaglandin E2 and a selective EP2 receptor agonist. Prostaglandins Other Lipid Mediat. 86(1-4): 35-40. doi: 10.1016/j.prostaglandins.2008.02.001. PMID:18406186.
    • (2008) Prostaglandins Other Lipid Mediat , vol.86 , Issue.1-4 , pp. 35-40
    • Choudhary, S.1    Alander, C.2    Zhan, P.3    Gao, Q.4    Pilbeam, C.5    Raisz, L.6
  • 14
    • 66049159060 scopus 로고    scopus 로고
    • Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production
    • doi:10.1002/art.24489. PMID:19404930
    • Couchourel, D., Aubry, I., Delalandre, A., Lavigne, M., Martel- Pelletier, J., Pelletier, J.P., and Lajeunesse, D. 2009. Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production. Arthritis Rheum. 60(5): 1438-1450. doi:10.1002/art.24489. PMID:19404930.
    • (2009) Arthritis Rheum , vol.60 , Issue.5 , pp. 1438-1450
    • Couchourel, D.1    Aubry, I.2    Delalandre, A.3    Lavigne, M.4    Martel-Pelletier, J.5    Pelletier, J.P.6    Lajeunesse, D.7
  • 15
    • 0029852463 scopus 로고    scopus 로고
    • The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2
    • doi:10.1210/en.137.11.4605. PMID:8895323
    • Fleet, J.C., Cashman, K., Cox, K., and Rosen, V. 1996. The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Endocrinology, 137(11): 4605-4610. doi:10.1210/en.137.11.4605. PMID:8895323.
    • (1996) Endocrinology , vol.137 , Issue.11 , pp. 4605-4610
    • Fleet, J.C.1    Cashman, K.2    Cox, K.3    Rosen, V.4
  • 17
    • 77954215265 scopus 로고    scopus 로고
    • Low innate pro- duction of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age
    • PMID:20417290
    • Goekoop, R.J., Kloppenburg, M., Kroon, H.M., Frolich, M., Huizinga, T.W., Westendorp, R.G., et al. 2010. Low innate pro- duction of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age. Osteoarthritis Cartilage, 18(7): 942-947. PMID:20417290.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.7 , pp. 942-947
    • Goekoop, R.J.1    Kloppenburg, M.2    Kroon, H.M.3    Frolich, M.4    Huizinga, T.W.5    Westendorp, R.G.6
  • 18
    • 0036899744 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients
    • BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group, PMID: 12473698
    • Govender, S., Csimma, C., Genant, H.K., Valentin-Opran, A., Amit, Y., Arbel, R., et al. BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. 2002. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J. Bone Joint Surg. Am. 84-A(12): 2123-2134. PMID: 12473698.
    • (2002) J. Bone Joint Surg. Am , vol.84 A , Issue.12 , pp. 2123-2134
    • Govender, S.1    Csimma, C.2    Genant, H.K.3    Valentin-Opran, A.4    Amit, Y.5    Arbel, R.6
  • 19
    • 67649616236 scopus 로고    scopus 로고
    • Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence
    • doi: 10.1517/13543780902893051. PMID:19426119
    • Graham, S., Gamie, Z., Polyzois, I., Narvani, A.A., Tzafetta, K., Tsiridis, E., et al. 2009. Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence. Expert Opin. Investig. Drugs, 18(6): 746-766. doi: 10.1517/13543780902893051. PMID:19426119.
    • (2009) Expert Opin. Investig. Drugs , vol.18 , Issue.6 , pp. 746-766
    • Graham, S.1    Gamie, Z.2    Polyzois, I.3    Narvani, A.A.4    Tzafetta, K.5    Tsiridis, E.6
  • 20
    • 0022556316 scopus 로고
    • Prostaglandin E2 stimulates DNA synthesis by a cyclic AMP-independent pathway in osteoblastic clone MC3T3-E1 cells
    • doi:10.1002/ jcp.1041280204. PMID:2426284
    • Hakeda, Y., Yoshino, T., Natakani, Y., Kurihara, N., Maeda, N., and Kumegawa, M. 1986. Prostaglandin E2 stimulates DNA synthesis by a cyclic AMP-independent pathway in osteoblastic clone MC3T3-E1 cells. J. Cell. Physiol. 128(2): 155-161. doi:10.1002/ jcp.1041280204. PMID:2426284.
    • (1986) J. Cell. Physiol , vol.128 , Issue.2 , pp. 155-161
    • Hakeda, Y.1    Yoshino, T.2    Natakani, Y.3    Kurihara, N.4    Maeda, N.5    Kumegawa, M.6
  • 21
    • 0035089788 scopus 로고    scopus 로고
    • The role of osteoprotegerin and receptor activator of nuclear factor kappaB ligand in the pathogenesis and treatment of rheumatoid arthritis
    • doi:10.1002/1529-0131(200102)44:2<253::AIDANR41 <3.0.CO;2-S. PMID:11229454
    • Hofbauer, L.C., and Heufelder, A.E. 2001. The role of osteoprotegerin and receptor activator of nuclear factor kappaB ligand in the pathogenesis and treatment of rheumatoid arthritis. Arthritis Rheum. 44(2): 253-259. doi:10.1002/1529-0131(200102)44:2<253::AIDANR41 <3.0.CO;2-S. PMID:11229454.
    • (2001) Arthritis Rheum , vol.44 , Issue.2 , pp. 253-259
    • Hofbauer, L.C.1    Heufelder, A.E.2
  • 22
    • 17844398732 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand
    • doi:10.1210/en.142.8.3656. PMID:11459815
    • Itoh, K., Udagawa, N., Katagiri, T., Iemura, S., Ueno, N., Yasuda, H., et al. 2001. Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand. Endocrinology, 142(8): 3656-3662. doi:10.1210/en.142.8.3656. PMID:11459815.
    • (2001) Endocrinology , vol.142 , Issue.8 , pp. 3656-3662
    • Itoh, K.1    Udagawa, N.2    Katagiri, T.3    Iemura, S.4    Ueno, N.5    Yasuda, H.6
  • 23
    • 77749309997 scopus 로고    scopus 로고
    • Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors
    • PMID:20039313
    • Jensen, E.D., Pham, L., Billington, C.J., Jr, Espe, K., Carlson, A.E., Westendorf, J.J., et al. 2010. Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors. J. Cell. Biochem. 109(4): 672-682. PMID:20039313.
    • (2010) J. Cell. Biochem , vol.109 , Issue.4 , pp. 672-682
    • Jensen, E.D.1    Pham, L.2    Billington Jr., C.J.3    Espe, K.4    Carlson, A.E.5    Westendorf, J.J.6
  • 24
    • 77952070589 scopus 로고    scopus 로고
    • Effect of IL-1beta, PGE(2), and TGF-beta1 on the expression of OPG and RANKL in normal and osteoporotic primary human osteoblasts
    • PMID:20225238
    • Jurado, S., Garcia-Giralt, N., Diez-Perez, A., Esbrit, P., Yoskovitz, G., Agueda, L., et al. 2010. Effect of IL-1beta, PGE(2), and TGF-beta1 on the expression of OPG and RANKL in normal and osteoporotic primary human osteoblasts. J. Cell. Biochem. 110(2): 304-310. PMID:20225238.
    • (2010) J. Cell. Biochem , vol.110 , Issue.2 , pp. 304-310
    • Jurado, S.1    Garcia-Giralt, N.2    Diez-Perez, A.3    Esbrit, P.4    Yoskovitz, G.5    Agueda, L.6
  • 25
    • 84861726292 scopus 로고    scopus 로고
    • The role of BMPs in bone anabolism and their potential targets SOST and DKK1
    • PMID:21787290
    • Kamiya, N. 2011. The role of BMPs in bone anabolism and their potential targets SOST and DKK1. Curr Mol Pharmacol. 5(2): 153-163. PMID:21787290.
    • (2011) Curr Mol Pharmacol , vol.5 , Issue.2 , pp. 153-163
    • Kamiya, N.1
  • 26
    • 79953692404 scopus 로고    scopus 로고
    • Nanogel-based scaffold delivery of prostaglandin E(2) receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice
    • doi:10.1002/ art.30151. PMID:21190246
    • Kamolratanakul, P., Hayata, T., Ezura, Y., Kawamata, A., Hayashi, C., Yamamoto, Y., et al. 2011. Nanogel-based scaffold delivery of prostaglandin E(2) receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice. Arthritis Rheum. 63(4): 1021-1033. doi:10.1002/ art.30151. PMID:21190246.
    • (2011) Arthritis Rheum , vol.63 , Issue.4 , pp. 1021-1033
    • Kamolratanakul, P.1    Hayata, T.2    Ezura, Y.3    Kawamata, A.4    Hayashi, C.5    Yamamoto, Y.6
  • 27
    • 0033800431 scopus 로고    scopus 로고
    • Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts
    • doi:10.1016/S8756-3282(00)00358-6. PMID:11033442
    • Kaneko, H., Arakawa, T., Mano, H., Kaneda, T., Ogasawara, A., Nakagawa, M., et al. 2000. Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts. Bone, 27(4): 479-486. doi:10.1016/S8756-3282(00)00358-6. PMID:11033442.
    • (2000) Bone , vol.27 , Issue.4 , pp. 479-486
    • Kaneko, H.1    Arakawa, T.2    Mano, H.3    Kaneda, T.4    Ogasawara, A.5    Nakagawa, M.6
  • 28
    • 0031595958 scopus 로고    scopus 로고
    • Prostaglandin E2 increases bone strength in intact rats and in ovariectomized rats with established osteopenia
    • doi:10.1016/S8756-3282(98)00102-1. PMID:9737347
    • Ke, H.Z., Shen, V.W., Qi, H., Crawford, D.T., Wu, D.D., Liang, X.G., et al. 1998. Prostaglandin E2 increases bone strength in intact rats and in ovariectomized rats with established osteopenia. Bone, 23(3): 249-255. doi:10.1016/S8756-3282(98)00102-1. PMID:9737347.
    • (1998) Bone , vol.23 , Issue.3 , pp. 249-255
    • Ke, H.Z.1    Shen, V.W.2    Qi, H.3    Crawford, D.T.4    Wu, D.D.5    Liang, X.G.6
  • 29
    • 21244458496 scopus 로고    scopus 로고
    • Prostaglandin E2 receptors EP2 and EP4 are down-regulated during differentiation of mouse osteoclasts from their precursors
    • doi: 10.1074/jbc.M500926200. PMID:15834134
    • Kobayashi, Y., Take, I., Yamashita, T., Mizoguchi, T., Ninomiya, T., Hattori, T., et al. 2005. Prostaglandin E2 receptors EP2 and EP4 are down-regulated during differentiation of mouse osteoclasts from their precursors. J. Biol. Chem. 280(25): 24035-24042. doi: 10.1074/jbc.M500926200. PMID:15834134.
    • (2005) J. Biol. Chem , vol.280 , Issue.25 , pp. 24035-24042
    • Kobayashi, Y.1    Take, I.2    Yamashita, T.3    Mizoguchi, T.4    Ninomiya, T.5    Hattori, T.6
  • 30
    • 76949084049 scopus 로고    scopus 로고
    • Prostaglandin expression profile in hypoxic osteoblastic cells
    • doi:10.1007/s00774-009-0096-0. PMID: 19471853
    • Lee, C.M., Genetos, D.C., Wong, A., and Yellowley, C.E. 2010. Prostaglandin expression profile in hypoxic osteoblastic cells. J. Bone Miner. Metab. 28(1): 8-16. doi:10.1007/s00774-009-0096-0. PMID: 19471853.
    • (2010) J. Bone Miner. Metab , vol.28 , Issue.1 , pp. 8-16
    • Lee, C.M.1    Genetos, D.C.2    Wong, A.3    Yellowley, C.E.4
  • 31
    • 0028987285 scopus 로고
    • Prostaglandin E2 administration prevents bone loss induced by orchidectomy in rats
    • doi:10.1002/jbmr.5650100111. PMID:7747632
    • Li, M., Jee, W.S., Ke, H.Z., Tang, L.Y., Ma, Y.F., Liang, X.G., and Setterberg, R.B. 1995. Prostaglandin E2 administration prevents bone loss induced by orchidectomy in rats. J. Bone Miner. Res. 10(1): 66-73. doi:10.1002/jbmr.5650100111. PMID:7747632.
    • (1995) J. Bone Miner. Res , vol.10 , Issue.1 , pp. 66-73
    • Li, M.1    Jee, W.S.2    Ke, H.Z.3    Tang, L.Y.4    Ma, Y.F.5    Liang, X.G.6    Setterberg, R.B.7
  • 32
    • 29644432280 scopus 로고    scopus 로고
    • Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation
    • doi:10.1359/JBMR.050911. PMID: 16355269
    • Li, T.F., Darowish, M., Zuscik, M.J., Chen, D., Schwarz, E.M., Rosier, R.N., et al. 2006. Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J. Bone Miner. Res. 21(1): 4-16. doi:10.1359/JBMR.050911. PMID: 16355269.
    • (2006) J. Bone Miner. Res , vol.21 , Issue.1 , pp. 4-16
    • Li, T.F.1    Darowish, M.2    Zuscik, M.J.3    Chen, D.4    Schwarz, E.M.5    Rosier, R.N.6
  • 33
    • 59649098933 scopus 로고    scopus 로고
    • Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis
    • doi:10.1002/art.24258. PMID:19180509
    • Li, X., Ellman, M., Muddasani, P., Wang, J.H., Cs-Szabo, G., van Wijnen, A.J., and Im, H.-J. 2009. Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis. Arthritis Rheum. 60(2): 513-523. doi:10.1002/art.24258. PMID:19180509.
    • (2009) Arthritis Rheum , vol.60 , Issue.2 , pp. 513-523
    • Li, X.1    Ellman, M.2    Muddasani, P.3    Wang, J.H.4    Cs-Szabo, G.5    van Wijnen, A.J.6    Im, H.-J.7
  • 34
    • 59749083169 scopus 로고    scopus 로고
    • BMP-2 vs. BMP-4 expression and activity in glucocorticoidarrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization
    • doi:10.1080/08977190802277880. PMID:19021035
    • Luppen, C.A., Chandler, R.L., Noh, T., Mortlock, D.P., and Frenkel, B. 2008. BMP-2 vs. BMP-4 expression and activity in glucocorticoidarrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization. Growth Factors, 26(4): 226-237. doi:10.1080/08977190802277880. PMID:19021035.
    • (2008) Growth Factors , vol.26 , Issue.4 , pp. 226-237
    • Luppen, C.A.1    Chandler, R.L.2    Noh, T.3    Mortlock, D.P.4    Frenkel, B.5
  • 35
    • 79958202199 scopus 로고    scopus 로고
    • BMP-9 induced osteogenic differentiation of mesenchymal stem cells: Molecular mechanism and therapeutic potential
    • doi:10.2174/156652311795684777. PMID:21453282
    • Luther, G., Wagner, E.R., Zhu, G., Kang, Q., Luo, Q., Lamplot, J., et al. 2011. BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential. Curr. Gene Ther. 11(3): 229-240. doi:10.2174/156652311795684777. PMID:21453282.
    • (2011) Curr. Gene Ther , vol.11 , Issue.3 , pp. 229-240
    • Luther, G.1    Wagner, E.R.2    Zhu, G.3    Kang, Q.4    Luo, Q.5    Lamplot, J.6
  • 36
    • 79960015095 scopus 로고    scopus 로고
    • Biomimetic calcium phosphate coatings as bone morphogenetic protein delivery systems in spinal fusion
    • PMID:20097616
    • Majid, K., Tseng, M.D., Baker, K.C., Reyes-Trocchia, A., and Herkowitz, H.N. 2010. Biomimetic calcium phosphate coatings as bone morphogenetic protein delivery systems in spinal fusion. Spine J. 11(6): 560-567. PMID:20097616.
    • (2010) Spine J , vol.11 , Issue.6 , pp. 560-567
    • Majid, K.1    Tseng, M.D.2    Baker, K.C.3    Reyes-Trocchia, A.4    Herkowitz, H.N.5
  • 37
    • 70350332198 scopus 로고    scopus 로고
    • Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation
    • doi:10.1210/en.2009-0026. PMID:19819979
    • Mandal, C.C., Ghosh Choudhury, G., and Ghosh-Choudhury, N. 2009. Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation. Endocrinology, 150(11): 4989-4998. doi:10.1210/en.2009-0026. PMID:19819979.
    • (2009) Endocrinology , vol.150 , Issue.11 , pp. 4989-4998
    • Mandal, C.C.1    Ghosh, C.G.2    Ghosh-Choudhury, N.3
  • 38
    • 0033624336 scopus 로고    scopus 로고
    • Prostaglandin E2 directly inhibits boneresorbing activity of isolated mature osteoclasts mainly through the EP4 receptor
    • doi:10.1007/ s00223001102. PMID:10908419
    • Mano, M., Arakawa, T., Mano, H., Nakagawa, M., Kaneda, T., Kaneko, H., et al. 2000. Prostaglandin E2 directly inhibits boneresorbing activity of isolated mature osteoclasts mainly through the EP4 receptor. Calcif. Tissue Int. 67(1): 85-92. doi:10.1007/ s00223001102. PMID:10908419.
    • (2000) Calcif. Tissue Int , vol.67 , Issue.1 , pp. 85-92
    • Mano, M.1    Arakawa, T.2    Mano, H.3    Nakagawa, M.4    Kaneda, T.5    Kaneko, H.6
  • 39
    • 33644585606 scopus 로고    scopus 로고
    • Prostaglandin E2 EP4 receptor-selective agonist facilitates sternal healing after harvesting bilateral internal thoracic arteries in diabetic rats
    • doi:10.1016/j.jtcvs.2005.10.026. PMID:16515909
    • Marui, A., Hirose, K., Maruyama, T., Arai, Y., Huang, Y., Doi, K., et al. 2006. Prostaglandin E2 EP4 receptor-selective agonist facilitates sternal healing after harvesting bilateral internal thoracic arteries in diabetic rats. J. Thorac. Cardiovasc. Surg. 131(3): 587-593. doi:10.1016/j.jtcvs.2005.10.026. PMID:16515909.
    • (2006) J. Thorac. Cardiovasc. Surg , vol.131 , Issue.3 , pp. 587-593
    • Marui, A.1    Hirose, K.2    Maruyama, T.3    Arai, Y.4    Huang, Y.5    Doi, K.6
  • 40
    • 65449165333 scopus 로고    scopus 로고
    • EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures
    • doi:10.1016/j.bone.2009.02.010. PMID:19233324
    • Minamizaki, T., Yoshiko, Y., Kozai, K., Aubin, J.E., and Maeda, N. 2009. EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures. Bone, 44(6): 1177-1185. doi:10.1016/j.bone.2009.02.010. PMID:19233324.
    • (2009) Bone , vol.44 , Issue.6 , pp. 1177-1185
    • Minamizaki, T.1    Yoshiko, Y.2    Kozai, K.3    Aubin, J.E.4    Maeda, N.5
  • 41
    • 58649121014 scopus 로고    scopus 로고
    • Reduced COX-2 expression in aged mice is associated with impaired fracture healing
    • doi:10.1359/jbmr.081002. PMID:18847332
    • Naik, A.A., Xie, C., Zuscik, M.J., Kingsley, P., Schwarz, E.M., Awad, H., et al. 2009. Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J. Bone Miner. Res. 24(2): 251-264. doi:10.1359/jbmr.081002. PMID:18847332.
    • (2009) J. Bone Miner. Res , vol.24 , Issue.2 , pp. 251-264
    • Naik, A.A.1    Xie, C.2    Zuscik, M.J.3    Kingsley, P.4    Schwarz, E.M.5    Awad, H.6
  • 42
    • 34548532872 scopus 로고    scopus 로고
    • Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation
    • doi:10.1016/ j.bone.2007.06.013. PMID:17681894
    • Nakagawa, K., Imai, Y., Ohta, Y., and Takaoka, K. 2007. Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation. Bone, 41(4): 543-548. doi:10.1016/ j.bone.2007.06.013. PMID:17681894.
    • (2007) Bone , vol.41 , Issue.4 , pp. 543-548
    • Nakagawa, K.1    Imai, Y.2    Ohta, Y.3    Takaoka, K.4
  • 43
    • 0032823306 scopus 로고    scopus 로고
    • Prostanoid receptors: Structures, properties, and functions
    • PMID:10508233
    • Narumiya, S., Sugimoto, Y., and Ushikubi, F. 1999. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79(4): 1193-1226. PMID:10508233.
    • (1999) Physiol. Rev , vol.79 , Issue.4 , pp. 1193-1226
    • Narumiya, S.1    Sugimoto, Y.2    Ushikubi, F.3
  • 44
    • 74949085350 scopus 로고    scopus 로고
    • PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes
    • PMID: 19998410
    • Nishitani, K., Ito, H., Hiramitsu, T., Tsutsumi, R., Tanida, S., Kitaori, T., et al. 2010. PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes. J. Cell. Biochem. 109(2): 425-433. PMID: 19998410.
    • (2010) J. Cell. Biochem , vol.109 , Issue.2 , pp. 425-433
    • Nishitani, K.1    Ito, H.2    Hiramitsu, T.3    Tsutsumi, R.4    Tanida, S.5    Kitaori, T.6
  • 45
    • 33744719718 scopus 로고    scopus 로고
    • COX-2 has a critical role during incorporation of structural bone allografts
    • doi:10.1196/annals.1346.012. PMID:16831949
    • O'Keefe, R.J., Tiyapatanaputi, P., Xie, C., Li, T.F., Clark, C., Zuscik, M.J., et al. 2006. COX-2 has a critical role during incorporation of structural bone allografts. Ann. N. Y. Acad. Sci. 1068(1): 532-542. doi:10.1196/annals.1346.012. PMID:16831949.
    • (2006) Ann. N. Y. Acad. Sci , vol.1068 , Issue.1 , pp. 532-542
    • O'Keefe, R.J.1    Tiyapatanaputi, P.2    Xie, C.3    Li, T.F.4    Clark, C.5    Zuscik, M.J.6
  • 46
    • 0038651097 scopus 로고    scopus 로고
    • An EP2 receptor-selective prostaglandin E2 agonist induces bone healing
    • doi:10.1073/pnas.1037343100. PMID:12748385
    • Paralkar, V.M., Borovecki, F., Ke, H.Z., Cameron, K.O., Lefker, B., Grasser, W.A., et al. 2003. An EP2 receptor-selective prostaglandin E2 agonist induces bone healing. Proc. Natl. Acad. Sci. U.S.A. 100(11): 6736-6740. doi:10.1073/pnas.1037343100. PMID:12748385.
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , Issue.11 , pp. 6736-6740
    • Paralkar, V.M.1    Borovecki, F.2    Ke, H.Z.3    Cameron, K.O.4    Lefker, B.5    Grasser, W.A.6
  • 47
    • 67649607270 scopus 로고    scopus 로고
    • Cobalt ions induce chemokine secretion in primary human osteoblasts
    • doi:10.1002/jor.20837. PMID:19132727
    • Queally, J.M., Devitt, B.M., Butler, J.S., Malizia, A.P., Murray, D., Doran, P.P., and O'Byrne, J.M. 2009. Cobalt ions induce chemokine secretion in primary human osteoblasts. J. Orthop. Res. 27(7): 855-864. doi:10.1002/jor.20837. PMID:19132727.
    • (2009) J. Orthop. Res , vol.27 , Issue.7 , pp. 855-864
    • Queally, J.M.1    Devitt, B.M.2    Butler, J.S.3    Malizia, A.P.4    Murray, D.5    Doran, P.P.6    O'Byrne, J.M.7
  • 48
    • 39149129082 scopus 로고    scopus 로고
    • The effects of COX-1 and COX-2 inhibitors on prostaglandin synthesis and the formation of heterotopic bone in a rat model
    • doi:10.1007/s00402-007-0436-2. PMID:18034350
    • Rapuano, B.E., Boursiquot, R., Tomin, E., Macdonald, D.E., Maddula, S., Raghavan, D., et al. 2008. The effects of COX-1 and COX-2 inhibitors on prostaglandin synthesis and the formation of heterotopic bone in a rat model. Arch. Orthop. Trauma Surg. 128(3): 333-344. doi:10.1007/s00402-007-0436-2. PMID:18034350.
    • (2008) Arch. Orthop. Trauma Surg , vol.128 , Issue.3 , pp. 333-344
    • Rapuano, B.E.1    Boursiquot, R.2    Tomin, E.3    Macdonald, D.E.4    Maddula, S.5    Raghavan, D.6
  • 49
    • 67651083430 scopus 로고    scopus 로고
    • Complications associated with single-level transforaminal lumbar interbody fusion
    • doi: 10.1016/j.spinee.2009.04.004. PMID:19482519
    • Rihn, J.A., Patel, R., Makda, J., Hong, J., Anderson, D.G., Vaccaro, A.R., et al. 2009. Complications associated with single-level transforaminal lumbar interbody fusion. Spine J. 9(8): 623-629. doi: 10.1016/j.spinee.2009.04.004. PMID:19482519.
    • (2009) Spine J , vol.9 , Issue.8 , pp. 623-629
    • Rihn, J.A.1    Patel, R.2    Makda, J.3    Hong, J.4    Anderson, D.G.5    Vaccaro, A.R.6
  • 50
    • 32044447008 scopus 로고    scopus 로고
    • Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells
    • doi:10.1016/j.gene. 2005.10.011. PMID:16314053
    • Ryoo, H.M., Lee, M.H., and Kim, Y.J. 2006. Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells. Gene, 366(1): 51-57. doi:10.1016/j.gene. 2005.10.011. PMID:16314053.
    • (2006) Gene , vol.366 , Issue.1 , pp. 51-57
    • Ryoo, H.M.1    Lee, M.H.2    Kim, Y.J.3
  • 51
    • 2342539801 scopus 로고    scopus 로고
    • Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells
    • doi:10.1016/j.bone.2003.12.007. PMID:15121014
    • Sakuma, Y., Li, Z., Pilbeam, C.C., Alander, C.B., Chikazu, D., Kawaguchi, H., and Raisz, L.G. 2004. Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells. Bone, 34(5): 827-834. doi:10.1016/j.bone.2003.12.007. PMID:15121014.
    • (2004) Bone , vol.34 , Issue.5 , pp. 827-834
    • Sakuma, Y.1    Li, Z.2    Pilbeam, C.C.3    Alander, C.B.4    Chikazu, D.5    Kawaguchi, H.6    Raisz, L.G.7
  • 52
    • 0025323376 scopus 로고
    • Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily
    • PMID:2376592
    • Sampath, T.K., Coughlin, J.E., Whetstone, R.M., Banach, D., Corbett, C., Ridge, R.J., et al. 1990. Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. J. Biol. Chem. 265(22): 13198-13205. PMID:2376592.
    • (1990) J. Biol. Chem , vol.265 , Issue.22 , pp. 13198-13205
    • Sampath, T.K.1    Coughlin, J.E.2    Whetstone, R.M.3    Banach, D.4    Corbett, C.5    Ridge, R.J.6
  • 53
    • 0346496061 scopus 로고    scopus 로고
    • BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
    • doi:10.1111/j.1432-0436.2003.07109003.x. PMID:14686954
    • Schmitt, B., Ringe, J., Haupl, T., Notter, M., Manz, R., Burmester, G.R., et al. 2003. BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture. Differentiation, 71(9 -10): 567-577. doi:10.1111/j.1432-0436.2003.07109003.x. PMID:14686954.
    • (2003) Differentiation , vol.71 , Issue.9-10 , pp. 567-577
    • Schmitt, B.1    Ringe, J.2    Haupl, T.3    Notter, M.4    Manz, R.5    Burmester, G.R.6
  • 54
    • 70349667528 scopus 로고    scopus 로고
    • Regulation of prostaglandin E(2) synthesis in cells derived from chondrocytes of patients with osteoarthritis
    • doi:10.1007/s00776-009-1370-7. PMID:19802674
    • Shimpo, H., Sakai, T., Kondo, S., Mishima, S., Yoda, M., Hiraiwa, H., and Ishiguro, N. 2009. Regulation of prostaglandin E(2) synthesis in cells derived from chondrocytes of patients with osteoarthritis. J. Orthop. Sci. 14(5): 611-617. doi:10.1007/s00776-009-1370-7. PMID:19802674.
    • (2009) J. Orthop. Sci , vol.14 , Issue.5 , pp. 611-617
    • Shimpo, H.1    Sakai, T.2    Kondo, S.3    Mishima, S.4    Yoda, M.5    Hiraiwa, H.6    Ishiguro, N.7
  • 55
    • 0031594125 scopus 로고    scopus 로고
    • Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells
    • doi:10.1007/ s002239900440. PMID:9504958
    • Suda, M., Tanaka, K., Yasoda, A., Natsui, K., Sakuma, Y., Tanaka, I., et al. 1998. Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells. Calcif. Tissue Int. 62(4): 327-331. doi:10.1007/ s002239900440. PMID:9504958.
    • (1998) Calcif. Tissue Int , vol.62 , Issue.4 , pp. 327-331
    • Suda, M.1    Tanaka, K.2    Yasoda, A.3    Natsui, K.4    Sakuma, Y.5    Tanaka, I.6
  • 56
    • 65549116404 scopus 로고    scopus 로고
    • Short-term osteoclastic activity induced by locally high concentrations of recombinant human bone morphogenetic protein-2 in a cancellous bone environment
    • doi:10.1097/BRS.0b013e3181952695. PMID: 19240666
    • Toth, J.M., Boden, S.D., Burkus, J.K., Badura, J.M., Peckham, S.M., and McKay, W.F. 2009. Short-term osteoclastic activity induced by locally high concentrations of recombinant human bone morphogenetic protein-2 in a cancellous bone environment. Spine, 34(6): 539-550. doi:10.1097/BRS.0b013e3181952695. PMID: 19240666.
    • (2009) Spine , vol.34 , Issue.6 , pp. 539-550
    • Toth, J.M.1    Boden, S.D.2    Burkus, J.K.3    Badura, J.M.4    Peckham, S.M.5    McKay, W.F.6
  • 57
    • 24944446761 scopus 로고    scopus 로고
    • Augmentation of bone morphogenetic protein-induced bone mass by local delivery of a prostaglandin
    • doi:10.1016/j.bone.2005.04.042. PMID:16027058
    • Toyoda, H., Terai, H., Sasaoka, R., Oda, K., and Takaoka, K. 2005. Augmentation of bone morphogenetic protein-induced bone mass by local delivery of a prostaglandin E EP4 receptor agonist. Bone, 37(4): 555-562. doi:10.1016/j.bone.2005.04.042. PMID:16027058.
    • (2005) E EP4 Receptor Agonist. Bone , vol.37 , Issue.4 , pp. 555-562
    • Toyoda, H.1    Terai, H.2    Sasaoka, R.3    Oda, K.4    Takaoka, K.5
  • 58
    • 77951242575 scopus 로고    scopus 로고
    • Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts
    • PMID: 20232298
    • Tseng, W.P., Yang, S.N., Lai, C.H., and Tang, C.H. 2010. Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts. J. Cell. Physiol. 223(3): 810-818. PMID: 20232298.
    • (2010) J. Cell. Physiol , vol.223 , Issue.3 , pp. 810-818
    • Tseng, W.P.1    Yang, S.N.2    Lai, C.H.3    Tang, C.H.4
  • 59
    • 33751506452 scopus 로고    scopus 로고
    • BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
    • doi:10.1038/ng1916. PMID:17099713
    • Tsuji, K., Bandyopadhyay, A., Harfe, B.D., Cox, K., Kakar, S., Gerstenfeld, L., et al. 2006. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat. Genet. 38(12): 1424-1429. doi:10.1038/ng1916. PMID:17099713.
    • (2006) Nat. Genet , vol.38 , Issue.12 , pp. 1424-1429
    • Tsuji, K.1    Bandyopadhyay, A.2    Harfe, B.D.3    Cox, K.4    Kakar, S.5    Gerstenfeld, L.6
  • 60
    • 70349924967 scopus 로고    scopus 로고
    • PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis
    • doi:10.1359/jbmr.090412. PMID: 19419302
    • Tsutsumi, R., Xie, C., Wei, X., Zhang, M., Zhang, X., Flick, L.M., et al. 2009. PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis. J. Bone Miner. Res. 24(10): 1753-1762. doi:10.1359/jbmr.090412. PMID: 19419302.
    • (2009) J. Bone Miner. Res , vol.24 , Issue.10 , pp. 1753-1762
    • Tsutsumi, R.1    Xie, C.2    Wei, X.3    Zhang, M.4    Zhang, X.5    Flick, L.M.6
  • 61
    • 0036944302 scopus 로고    scopus 로고
    • Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice
    • doi:10.1002/ jcb.10231. PMID:12210753
    • Turgeman, G., Zilberman, Y., Zhou, S., Kelly, P., Moutsatsos, I.K., Kharode, Y.P., et al. 2002. Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice. J. Cell. Biochem. 86(3): 461-474. doi:10.1002/ jcb.10231. PMID:12210753.
    • (2002) J. Cell. Biochem , vol.86 , Issue.3 , pp. 461-474
    • Turgeman, G.1    Zilberman, Y.2    Zhou, S.3    Kelly, P.4    Moutsatsos, I.K.5    Kharode, Y.P.6
  • 62
    • 34250019537 scopus 로고
    • Bone: Formation by autoinduction
    • doi:10.1126/science.150.3698.893. PMID: 5319761
    • Urist, M.R. 1965. Bone: formation by autoinduction. Science, 150(3698): 893-899. doi:10.1126/science.150.3698.893. PMID: 5319761.
    • (1965) Science , vol.150 , Issue.3698 , pp. 893-899
    • Urist, M.R.1
  • 63
    • 77952878627 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's?
    • doi:10.1016/j.joca.2010.03.001. PMID:20211748
    • van der Kraan, P.M., Davidson, E.N., and van den Berg, W.B. 2010. Bone morphogenetic proteins and articular cartilage: to serve and protect or a wolf in sheep clothing's? Osteoarthritis Cartilage, 18(6): 735-741. doi:10.1016/j.joca.2010.03.001. PMID:20211748.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.6 , pp. 735-741
    • van der Kraan, P.M.1    Davidson, E.N.2    van den Berg, W.B.3
  • 64
    • 0025216220 scopus 로고
    • Recombinant human bone morphogenetic protein induces bone formation
    • doi:10.1073/pnas.87.6.2220. PMID:2315314
    • Wang, E.A., Rosen, V., D'Alessandro, J.S., Bauduy, M., Cordes, P., Harada, T., et al. 1990. Recombinant human bone morphogenetic protein induces bone formation. Proc. Natl. Acad. Sci. U.S.A. 87(6): 2220-2224. doi:10.1073/pnas.87.6.2220. PMID:2315314.
    • (1990) Proc. Natl. Acad. Sci. U.S.A , vol.87 , Issue.6 , pp. 2220-2224
    • Wang, E.A.1    Rosen, V.2    D'Alessandro, J.S.3    Bauduy, M.4    Cordes, P.5    Harada, T.6
  • 65
    • 68449103187 scopus 로고    scopus 로고
    • -/- mice via activation of prostaglandin E2 receptor subtype 4
    • doi:10.2353/ajpath.2009.081099. PMID: 19628768
    • -/- mice via activation of prostaglandin E2 receptor subtype 4. Am. J. Pathol. 175(2): 772-785. doi:10.2353/ajpath.2009.081099. PMID: 19628768.
    • (2009) Am. J. Pathol , vol.175 , Issue.2 , pp. 772-785
    • Xie, C.1    Liang, B.2    Xue, M.3    Lin, A.S.4    Loiselle, A.5    Schwarz, E.M.6
  • 66
    • 70349214840 scopus 로고    scopus 로고
    • Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute
    • doi:10.1002/jor.20890. PMID:19350632
    • Xu, J., Li, X., Lian, J.B., Ayers, D.C., and Song, J. 2009. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J. Orthop. Res. 27(10): 1306-1311. doi:10.1002/jor.20890. PMID:19350632.
    • (2009) J. Orthop. Res , vol.27 , Issue.10 , pp. 1306-1311
    • Xu, J.1    Li, X.2    Lian, J.B.3    Ayers, D.C.4    Song, J.5
  • 67
    • 73849091390 scopus 로고    scopus 로고
    • Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healing
    • doi:10.1359/jbmr.090603. PMID:19558315
    • Yamaguchi, T., Takada, Y., Maruyama, K., Shimoda, K., Arai, Y., Nango, N., et al. 2009. Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healing. J. Bone Miner. Res. 24(12): 2056-2065. doi:10.1359/jbmr.090603. PMID:19558315.
    • (2009) J. Bone Miner. Res , vol.24 , Issue.12 , pp. 2056-2065
    • Yamaguchi, T.1    Takada, Y.2    Maruyama, K.3    Shimoda, K.4    Arai, Y.5    Nango, N.6
  • 68
    • 0037007077 scopus 로고    scopus 로고
    • Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation
    • doi: 10.1073/pnas.062053399. PMID:11917107
    • Yoshida, K., Oida, H., Kobayashi, T., Maruyama, T., Tanaka, M., Katayama, T., et al. 2002. Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. Proc. Natl. Acad. Sci. U.S.A. 99(7): 4580-4585. doi: 10.1073/pnas.062053399. PMID:11917107.
    • (2002) Proc. Natl. Acad. Sci. U.S.A , vol.99 , Issue.7 , pp. 4580-4585
    • Yoshida, K.1    Oida, H.2    Kobayashi, T.3    Maruyama, T.4    Tanaka, M.5    Katayama, T.6
  • 69
    • 0037007098 scopus 로고    scopus 로고
    • Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice
    • doi: 10.1073/pnas.052523599. PMID:11930008
    • Yumoto, K., Ishijima, M., Rittling, S.R., Tsuji, K., Tsuchiya, Y., Kon, S., et al. 2002. Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. Proc. Natl. Acad. Sci. U.S.A. 99(7): 4556-4561. doi: 10.1073/pnas.052523599. PMID:11930008.
    • (2002) Proc. Natl. Acad. Sci. U.S.A , vol.99 , Issue.7 , pp. 4556-4561
    • Yumoto, K.1    Ishijima, M.2    Rittling, S.R.3    Tsuji, K.4    Tsuchiya, Y.5    Kon, S.6
  • 70
    • 0036259278 scopus 로고    scopus 로고
    • Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    • PMID:12045254
    • Zhang, X., Schwarz, E.M., Young, D.A., Puzas, J.E., Rosier, R.N., and O'Keefe, R.J. 2002. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J. Clin. Invest. 109(11): 1405-1415. PMID:12045254.
    • (2002) J. Clin. Invest , vol.109 , Issue.11 , pp. 1405-1415
    • Zhang, X.1    Schwarz, E.M.2    Young, D.A.3    Puzas, J.E.4    Rosier, R.N.5    O'Keefe, R.J.6
  • 71
    • 79953056654 scopus 로고    scopus 로고
    • EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair
    • doi:10.1002/jbmr.272. PMID:20939055
    • Zhang, M., Ho, H.C., Sheu, T.J., Breyer, M.D., Flick, L.M., Jonason, J.H., et al. 2011. EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair. J. Bone Miner. Res. 26(4): 792-802. doi:10.1002/jbmr.272. PMID:20939055.
    • (2011) J. Bone Miner. Res , vol.26 , Issue.4 , pp. 792-802
    • Zhang, M.1    Ho, H.C.2    Sheu, T.J.3    Breyer, M.D.4    Flick, L.M.5    Jonason, J.H.6
  • 72
    • 0037249209 scopus 로고    scopus 로고
    • Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells
    • doi:10.1210/me.2002- 0210. PMID:12511606
    • Zhou, S., Turgeman, G., Harris, S.E., Leitman, D.C., Komm, B.S., Bodine, P.V., and Gazit, D. 2003. Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells. Mol. Endocrinol. 17(1): 56-66. doi:10.1210/me.2002- 0210. PMID:12511606.
    • (2003) Mol. Endocrinol , vol.17 , Issue.1 , pp. 56-66
    • Zhou, S.1    Turgeman, G.2    Harris, S.E.3    Leitman, D.C.4    Komm, B.S.5    Bodine, P.V.6    Gazit, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.