메뉴 건너뛰기




Volumn 223, Issue 3, 2010, Pages 810-818

Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; HYPOXIA INDUCIBLE FACTOR 1; INTEGRIN LINKED KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RAPAMYCIN; BMP2 PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTEGRIN-LINKED KINASE; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

EID: 77951242575     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22104     Document Type: Article
Times cited : (87)

References (43)
  • 1
    • 0036211764 scopus 로고    scopus 로고
    • Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain
    • Bernaudin M, Nedelec AS, Divoux D, MacKenzie ET, Petit E, Schumann-Bard P. 2002. Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in associationwith an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain. J Cereb Blood Flow Metab 22:393-403. (Pubitemid 34273595)
    • (2002) Journal of Cerebral Blood Flow and Metabolism , vol.22 , Issue.4 , pp. 393-403
    • Bernaudin, M.1    Nedelec, A.-S.2    Divoux, D.3    MacKenzie, E.T.4    Petit, E.5    Schumann-Bard, P.6
  • 2
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn HF, Poyton RO. 1996. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76:839-885. (Pubitemid 26286080)
    • (1996) Physiological Reviews , vol.76 , Issue.3 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 3
    • 0028230389 scopus 로고
    • 65Zn in rat muscles
    • DOI 10.1016/0031-9384(94)90093-0
    • Cordova A, Anghileri L, Saunier C. 1994. Effect of hypoxia and exercise on the distribution of 65Zn in rat muscles. Physiol Behav 55:413-416. (Pubitemid 24088005)
    • (1994) Physiology and Behavior , vol.55 , Issue.3 , pp. 413-416
    • Cordova, A.1    Anghileri, L.2    Saunier, C.3
  • 4
    • 0032852497 scopus 로고    scopus 로고
    • Osteocyte hypoxia: A novel mechanotransduction pathway
    • Dodd JS, Raleigh JA, Gross TS. 1999. Osteocyte hypoxia: A novel mechanotransduction pathway. Am J Physiol 277:C598-C602.
    • (1999) Am J Physiol , vol.277
    • Dodd, J.S.1    Raleigh, J.A.2    Gross, T.S.3
  • 5
    • 50949109494 scopus 로고    scopus 로고
    • Pressure, oxygen tension and temperature in the periosteal callus during bone healing-An in vivo study in sheep
    • Epari DR, Lienau J, Schell H, Witt F, Duda GN. 2008. Pressure, oxygen tension and temperature in the periosteal callus during bone healing-An in vivo study in sheep. Bone 43:734-739.
    • (2008) Bone , vol.43 , pp. 734-739
    • Epari, D.R.1    Lienau, J.2    Schell, H.3    Witt, F.4    Duda, G.N.5
  • 6
    • 0029852463 scopus 로고    scopus 로고
    • The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2
    • DOI 10.1210/en.137.11.4605
    • Fleet JC, Cashman K, Cox K, Rosen V. 1996. The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Endocrinology 137:4605-4610. (Pubitemid 26403295)
    • (1996) Endocrinology , vol.137 , Issue.11 , pp. 4605-4610
    • Fleet, J.C.1    Cashman, K.2    Cox, K.3    Rosen, V.4
  • 7
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • DOI 10.1074/jbc.M203781200
    • Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. 2002. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277:38205-38211. (Pubitemid 35154674)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.41 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 9
    • 0029665283 scopus 로고    scopus 로고
    • 31P magnetic resonance spectroscopy of the Sherpa heart: A phosphocreatine/adenosine triphosphate signature of metabolic defense against hypobaric hypoxia
    • Hochachka PW, Clark CM, Holden JE, Stanley C, Ugurbil K, Menon RS. 1996. 31P magnetic resonance spectroscopy of the Sherpa heart: A phosphocreatine/ adenosine triphosphate signature of metabolic defense against hypobaric hypoxia. Proc Natl Acad Sci USA 93:1215-1220.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1215-1220
    • Hochachka, P.W.1    Clark, C.M.2    Holden, J.E.3    Stanley, C.4    Ugurbil, K.5    Menon, R.S.6
  • 11
    • 0029859510 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
    • Jiang BH, Semenza GL, Bauer C, Marti HH. 1996. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. AmJ Physiol 271:C1172-C1180.
    • (1996) AmJ Physiol , vol.271
    • Jiang, B.H.1    Semenza, G.L.2    Bauer, C.3    Marti, H.H.4
  • 12
    • 0034925041 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
    • Jiang BH, Jiang G, Zheng JZ, Lu Z, Hunter T, Vogt PK. 2001. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 12: 363-369.
    • (2001) Cell Growth Differ , vol.12 , pp. 363-369
    • Jiang, B.H.1    Jiang, G.2    Zheng, J.Z.3    Lu, Z.4    Hunter, T.5    Vogt, P.K.6
  • 13
    • 0033525830 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
    • Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L. 1999. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J Biol Chem 274:6519-6525.
    • (1999) J Biol Chem , vol.274 , pp. 6519-6525
    • Kallio, P.J.1    Wilson, W.J.2    O'Brien, S.3    Makino, Y.4    Poellinger, L.5
  • 14
    • 1642333512 scopus 로고    scopus 로고
    • Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair
    • Komatsu DE, Hadjiargyrou M. 2004. Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair. Bone 34:680-688.
    • (2004) Bone , vol.34 , pp. 680-688
    • Komatsu, D.E.1    Hadjiargyrou, M.2
  • 15
    • 0036837864 scopus 로고    scopus 로고
    • Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha
    • Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG. 2002. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol 22:7405-7416.
    • (2002) Mol Cell Biol , vol.22 , pp. 7405-7416
    • Koumenis, C.1    Naczki, C.2    Koritzinsky, M.3    Rastani, S.4    Diehl, A.5    Sonenberg, N.6    Koromilas, A.7    Wouters, B.G.8
  • 17
    • 33748562106 scopus 로고    scopus 로고
    • Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha
    • Lu DY, Liou HC, Tang CH, Fu WM. 2006. Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha. Biochem Pharmacol 72:992-1000.
    • (2006) Biochem Pharmacol , vol.72 , pp. 992-1000
    • Lu, D.Y.1    Liou, H.C.2    Tang, C.H.3    Fu, W.M.4
  • 18
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J. 1998. TGF-beta signal transduction. Annu Rev Biochem 67:753-791.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 19
    • 0035375351 scopus 로고    scopus 로고
    • Effect of aging on bone formation induced by recombinant human bone morphogenetic protein-2 combined with fibrous collagen membranes at subperiosteal sites
    • Matsumoto A, Yamaji K, Kawanami M, Kato H. 2001. Effect of aging on bone formation induced by recombinant human bone morphogenetic protein-2 combined with fibrous collagen membranes at subperiosteal sites. J Periodontal Res 36:175-182.
    • (2001) J Periodontal Res , vol.36 , pp. 175-182
    • Matsumoto, A.1    Yamaji, K.2    Kawanami, M.3    Kato, H.4
  • 21
    • 34249660052 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes
    • Mojsilovic-Petrovic J, Callaghan D, Cui H, Dean C, Stanimirovic DB, Zhang W. 2007. Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes. J Neuroinflammation 4:12.
    • (2007) J Neuroinflammation , vol.4 , pp. 12
    • Mojsilovic-Petrovic, J.1    Callaghan, D.2    Cui, H.3    Dean, C.4    Stanimirovic, D.B.5    Zhang, W.6
  • 22
    • 0035920145 scopus 로고    scopus 로고
    • Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343
    • Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S. 2001. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem 276:27462-27469.
    • (2001) J Biol Chem , vol.276 , pp. 27462-27469
    • Persad, S.1    Attwell, S.2    Gray, V.3    Mawji, N.4    Deng, J.T.5    Leung, D.6    Yan, J.7    Sanghera, J.8    Walsh, M.P.9    Dedhar, S.10
  • 23
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone diseases
    • Rodan GA, Martin TJ. 2000. Therapeutic approaches to bone diseases. Science 289:1508-1514.
    • (2000) Science , vol.289 , pp. 1508-1514
    • Rodan, G.A.1    Martin, T.J.2
  • 24
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S, Caro J. 1997. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642-22647.
    • (1997) J Biol Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 25
    • 4544304745 scopus 로고    scopus 로고
    • Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts
    • Salim A, Nacamuli RP, Morgan EF, Giaccia AJ, Longaker MT. 2004. Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. J Biol Chem 279:40007-40016.
    • (2004) J Biol Chem , vol.279 , pp. 40007-40016
    • Salim, A.1    Nacamuli, R.P.2    Morgan, E.F.3    Giaccia, A.J.4    Longaker, M.T.5
  • 26
    • 33744764250 scopus 로고    scopus 로고
    • Hypoxia and HIF-1alpha in chondrogenesis
    • Schipani E. 2006. Hypoxia and HIF-1alpha in chondrogenesis. Ann NY Acad Sci 1068:66-73.
    • (2006) Ann NY Acad Sci , vol.1068 , pp. 66-73
    • Schipani, E.1
  • 27
    • 55849109650 scopus 로고    scopus 로고
    • Hypoxia-induced energy stress inhibits themTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma
    • Schneider A, Younis RH, Gutkind JS. 2008. Hypoxia-induced energy stress inhibits themTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. Neoplasia 10:1295-1302.
    • (2008) Neoplasia , vol.10 , pp. 1295-1302
    • Schneider, A.1    Younis, R.H.2    Gutkind, J.S.3
  • 28
    • 0033991530 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1:Mechanisms and consequences
    • Semenza GL. 2000. Expression of hypoxia-inducible factor 1:Mechanisms and consequences. Biochem Pharmacol 59:47-53.
    • (2000) Biochem Pharmacol , vol.59 , pp. 47-53
    • Semenza, G.L.1
  • 29
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A. 1996. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271:32529-32537.
    • (1996) J Biol Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6    Giallongo, A.7
  • 30
    • 2642555563 scopus 로고    scopus 로고
    • HIF1 and oxygen sensing in the brain
    • Sharp FR, Bernaudin M. 2004. HIF1 and oxygen sensing in the brain. Nat Rev Neurosci 5:437-448.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 437-448
    • Sharp, F.R.1    Bernaudin, M.2
  • 31
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • Sofer A, Lei K, Johannessen CM, Ellisen LW. 2005. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 25:5834-5845.
    • (2005) Mol Cell Biol , vol.25 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4
  • 32
    • 34547107359 scopus 로고    scopus 로고
    • Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol
    • Su JL, Yang CY, Zhao M, Kuo ML, Yen ML. 2007. Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. J Biol Chem 282:19385-19398.
    • (2007) J Biol Chem , vol.282 , pp. 19385-19398
    • Su, J.L.1    Yang, C.Y.2    Zhao, M.3    Kuo, M.L.4    Yen, M.L.5
  • 34
    • 60149091505 scopus 로고    scopus 로고
    • Cyr61 increasesmigration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells
    • Tan TW, Yang WH, Lin YT, Hsu SF, Li TM, Kao ST, Chen WC, Fong YC, Tang CH. 2009. Cyr61 increasesmigration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells. Carcinogenesis 30:258-268.
    • (2009) Carcinogenesis , vol.30 , pp. 258-268
    • Tan, T.W.1    Yang, W.H.2    Lin, Y.T.3    Hsu, S.F.4    Li, T.M.5    Kao, S.T.6    Chen, W.C.7    Fong, Y.C.8    Tang, C.H.9
  • 35
    • 34548492472 scopus 로고    scopus 로고
    • Ultrasound induces hypoxia-inducible factor-1 activation and inducible nitric-oxide synthase expression through the integrin/integrin-linked kinase/Akt/mammalian target of rapamycin pathway in osteoblasts
    • Tang CH, Lu DY, Tan TW, Fu WM, Yang RS. 2007. Ultrasound induces hypoxia-inducible factor-1 activation and inducible nitric-oxide synthase expression through the integrin/integrin-linked kinase/Akt/mammalian target of rapamycin pathway in osteoblasts. J Biol Chem 282:25406-25415.
    • (2007) J Biol Chem , vol.282 , pp. 25406-25415
    • Tang, C.H.1    Lu, D.Y.2    Tan, T.W.3    Fu, W.M.4    Yang, R.S.5
  • 36
    • 0037666792 scopus 로고    scopus 로고
    • Conditional knockout of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
    • Troussard AA, Mawji NM, Ong C, Mui A, St-Arnaud R, Dedhar S. 2003. Conditional knockout of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 278:22374-22378.
    • (2003) J Biol Chem , vol.278 , pp. 22374-22378
    • Troussard, A.A.1    Mawji, N.M.2    Ong, C.3    Mui, A.4    St-Arnaud, R.5    Dedhar, S.6
  • 37
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helixloop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL. 1995. Hypoxia-inducible factor 1 is a basic-helixloop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92:5510-5514.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 39
    • 0035969233 scopus 로고    scopus 로고
    • Integrin-linked kinase (ILK) and its interactors: A new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
    • Wu C, Dedhar S. 2001. Integrin-linked kinase (ILK) and its interactors: A new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J Cell Biol 155:505-510.
    • (2001) J Cell Biol , vol.155 , pp. 505-510
    • Wu, C.1    Dedhar, S.2
  • 40
    • 44649083061 scopus 로고    scopus 로고
    • Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts
    • Wu JB, Fong YC, Tsai HY, Chen YF, Tsuzuki M, Tang CH. 2008. Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. Eur J Pharmacol 588:333-341.
    • (2008) Eur J Pharmacol , vol.588 , pp. 333-341
    • Wu, J.B.1    Fong, Y.C.2    Tsai, H.Y.3    Chen, Y.F.4    Tsuzuki, M.5    Tang, C.H.6
  • 41
    • 13944256944 scopus 로고    scopus 로고
    • Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHRpathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts
    • Yau CY, Wheeler JJ, Sutton KL, Hedley DW. 2005. Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHRpathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer Res 65:1497-1504.
    • (2005) Cancer Res , vol.65 , pp. 1497-1504
    • Yau, C.Y.1    Wheeler, J.J.2    Sutton, K.L.3    Hedley, D.W.4
  • 42
    • 44949095154 scopus 로고    scopus 로고
    • Oxygen tension regulates preosteocyte maturation and mineralization
    • Zahm AM, Bucaro MA, Srinivas V, Shapiro IM, Adams CS. 2008. Oxygen tension regulates preosteocyte maturation and mineralization. Bone 43:25-31.
    • (2008) Bone , vol.43 , pp. 25-31
    • Zahm, A.M.1    Bucaro, M.A.2    Srinivas, V.3    Shapiro, I.M.4    Adams, C.S.5
  • 43
    • 0037054548 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
    • Zhao M, Harris SE, Horn D, Geng Z, Nishimura R, Mundy GR, Chen D. 2002. Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. J Cell Biol 157:1049-1060.
    • (2002) J Cell Biol , vol.157 , pp. 1049-1060
    • Zhao, M.1    Harris, S.E.2    Horn, D.3    Geng, Z.4    Nishimura, R.5    Mundy, G.R.6    Chen, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.