PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes

Journal of Cellular Biochemistry

Volumn 109, Issue 2, 2010, Pages 425-433

  Nishitani, Kohei ^a   Ito, Hiromu ^a   Hiramitsu, Teruko ^a   Tsutsumi, Ryosuke ^a   Tanida, Shimei ^a   Kitaori, Toshiyuki ^a   Yoshitomi, Hiroyuki ^a   Kobayashi, Masahiko ^a   Nakamura, Takashi ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Articular chondrocyte; EP4; JNK; MMP; Osteoarthritis; PGE2

Indexed keywords

COLLAGENASE 3; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; RECOMBINANT INTERLEUKIN 1BETA; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DINOPROSTONE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MAP KINASE KINASE 7; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; OSTEOARTHRITIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, PROSTAGLANDIN E; SIGNAL TRANSDUCTION;

EID: 74949085350     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22421     Document Type: Article

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