Prostaglandin E2 (PGE2) autoamplifies its production through EP1 subtype of PGE receptor in mouse osteoblastic MC3T3-E1 cells

Calcified Tissue International

Volumn 62, Issue 4, 1998, Pages 327-331

  Suda, M ^a   Tanaka, K ^a   Yasoda, A ^a   Natsui, K ^a   Sakuma, Y ^a   Tanaka, I ^a   Ushikubi, F ^a   Narumiya, S ^a   Nakao, K ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

MC3T3 E1 cells; Osteoblast; Prostaglandin E receptor; Prostaglandin E2; Prostaglandin G H synthase 2

Indexed keywords

PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; RECEPTOR SUBTYPE; ABORTIVE AGENT; BUTAPROST; CYCLOOXYGENASE 2; DRUG DERIVATIVE; FIBRINOLYTIC AGENT; INOSITOL 1,4,5 TRISPHOSPHATE; ISOENZYME; MESSENGER RNA; OXYTOCIC AGENT; PROSTAGLANDIN E; PROSTAGLANDIN E1; SULPROSTONE;

ANIMAL CELL; ARTICLE; BONE ATROPHY; BONE DEVELOPMENT; BONE METABOLISM; FRACTURE HEALING; HORMONAL REGULATION; HORMONE RECEPTOR INTERACTION; MECHANICAL STRESS; MOUSE; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RECEPTOR UPREGULATION; WEIGHT BEARING; ANIMAL; CELL STRAIN 3T3; CLASSIFICATION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; OSTEOBLAST;

3T3 CELLS; ABORTIFACIENT AGENTS, NONSTEROIDAL; ALPROSTADIL; ANIMALS; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOLYTIC AGENTS; INOSITOL 1,4,5-TRISPHOSPHATE; ISOENZYMES; MICE; OSTEOBLASTS; OXYTOCICS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS E, SYNTHETIC; RECEPTORS, PROSTAGLANDIN E; RNA, MESSENGER;

EID: 0031594125     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900440     Document Type: Article

References (16)

1. Pilbeam CC, Harrison JR, Raisz LG (1996) Prostaglandins and bone metabolism. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. Academic Press, San Diego, p 715
2. Raisz LG (1995) Physiologic and pathologic roles of prostaglandins and other eicosanoids in bone metabolism. J Nutr 125: 2024S-2027S
3. Mitchell JA, Larkin S, Williams TJ (1995) Cyclooxygenase-2: regulation and relevance in inflammation. Biochem Pharmacol 50: 1535-1542
4. Pilbeam CC, Kawaguchi H, Hakeda Y, Voznesensky O. Alander CB, Raisz LG (1993) Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-K1 cells. J Biol Chem 268: 25643-25649
5. Takahashi T, Taketani Y, Endo T, Yamamoto S, Kumegawa M (1994) Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways. Biochim Biophys Acta 1212: 217-224
6. Pilbeam CC, Raisz LG, Voznesensky O, Alander CB, Delman BN, Kawaguchi K (1994) Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. J Bone Miner Res 10: 406-414
7. Coleman RA, Smith WL, Narumiya S (1994) Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46: 205-229
8. Suda M, Tanaka K, Natsui K, Usui T, Tanaka I, Fukushima M, Shigeno C, Konishi J, Nakao K (1996) Prostaglandin E receptor subtypes in mouse osteoblastic cells line. Endocrinology 137: 1698-1705
9. Ohshima T, Yoshimolo T, Yamamoto S, Kumegawa M, Yokoyama C, Tanabe T (1991) cAMP-dependent induction of fatty acid cyclooxygenasc mRNA in mouse osteoblastic cells (MC3T3-E1). J Biol Chem 266: 13621-13626
10. 2α stimulate dif- ferentiation and proliferation, respectively, of clonal osteoblastic MC3T3-E1 cells by different second messengers in vitro. Endocrinology 121: 1966-1974
11. Ushikubi F, Hirata M, Narumiya S (1995) Molecular biology of prostanoid receptors; an overview. J Lipid Mediators 12: 343-359
12. 2α receptor mRNA in rodent osteoblastic cells. Prostaglandins 50: 349-358
13. Yokota K, Kusaka M, Ohshima T, Yamamoto S, Kurihara N, Yoshino T, Kumegawa M (1986) Stimulation of prostaglandin E2 synthesis in cloned osteoblastic cells of mouse (MC3T3- E1) by epidermal growth factor. J Biol Chem 261: 15410-15415
14. 2 release: a new experimental method. Calcif Tissue Int 47: 35-39
15. Klein-Nulend J, Burger EH, Semeins CM, Raisz LG, Pilbeam CC (1995) Pulsating fluid flow stimulates prostaglandin E2 release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells. J Bone Miner Res 10: 5405
16. Pead MJ, Lanyon LE (1989) Indomethacin modulation of load-related stimulation of new hone formation in vitro. Calcif Tissue Int 45: 34-40