메뉴 건너뛰기




Volumn 18, Issue 6, 2010, Pages 735-741

Bone Morphogenetic Proteins and articular cartilage. To serve and protect or a wolf in sheep clothing's?

Author keywords

BMPs; Chondrocyte differentiation; MMP 13; Osteoarthritis

Indexed keywords

BONE MORPHOGENETIC PROTEIN; COLLAGENASE 3;

EID: 77952878627     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2010.03.001     Document Type: Review
Times cited : (98)

References (86)
  • 1
    • 34250019537 scopus 로고
    • Bone: formation by autoinduction
    • Urist M.R. Bone: formation by autoinduction. Science 1965, 150(698):893-899.
    • (1965) Science , vol.150 , Issue.698 , pp. 893-899
    • Urist, M.R.1
  • 2
    • 0032979875 scopus 로고    scopus 로고
    • Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers
    • Newfeld S.J., Wisotzkey R.G., Kumar S. Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers. Genetics 1999, 152(2):783-795.
    • (1999) Genetics , vol.152 , Issue.2 , pp. 783-795
    • Newfeld, S.J.1    Wisotzkey, R.G.2    Kumar, S.3
  • 3
    • 0036904895 scopus 로고    scopus 로고
    • Genetic analysis of the mammalian transforming growth factor-beta superfamily
    • Chang H., Brown C.W., Matzuk M.M. Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 2002, 23(6):787-823.
    • (2002) Endocr Rev , vol.23 , Issue.6 , pp. 787-823
    • Chang, H.1    Brown, C.W.2    Matzuk, M.M.3
  • 4
    • 48449097540 scopus 로고    scopus 로고
    • A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7
    • Sengle G., Ono R.N., Lyons K.M., Bachinger H.P., Sakai L.Y. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol 2008, 381(4):1025-1039.
    • (2008) J Mol Biol , vol.381 , Issue.4 , pp. 1025-1039
    • Sengle, G.1    Ono, R.N.2    Lyons, K.M.3    Bachinger, H.P.4    Sakai, L.Y.5
  • 5
    • 64949097323 scopus 로고    scopus 로고
    • Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing
    • Yano K., Hoshino M., Ohta Y., Manaka T., Naka Y., Imai Y., et al. Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing. J Bone Miner Metab 2009, 27(3):355-363.
    • (2009) J Bone Miner Metab , vol.27 , Issue.3 , pp. 355-363
    • Yano, K.1    Hoshino, M.2    Ohta, Y.3    Manaka, T.4    Naka, Y.5    Imai, Y.6
  • 6
    • 27644509933 scopus 로고    scopus 로고
    • The effects of heat on the biological activity of recombinant human bone morphogenetic protein-2
    • Ohta H., Wakitani S., Tensho K., Horiuchi H., Wakabayashi S., Saito N., et al. The effects of heat on the biological activity of recombinant human bone morphogenetic protein-2. J Bone Miner Metab 2005, 23(6):420-425.
    • (2005) J Bone Miner Metab , vol.23 , Issue.6 , pp. 420-425
    • Ohta, H.1    Wakitani, S.2    Tensho, K.3    Horiuchi, H.4    Wakabayashi, S.5    Saito, N.6
  • 7
    • 51049098368 scopus 로고    scopus 로고
    • BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells
    • Lavery K., Swain P., Falb D., Aoui-Ismaili M.H. BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem 2008, 283(30):20948-20958.
    • (2008) J Biol Chem , vol.283 , Issue.30 , pp. 20948-20958
    • Lavery, K.1    Swain, P.2    Falb, D.3    Aoui-Ismaili, M.H.4
  • 9
    • 42049120300 scopus 로고    scopus 로고
    • TGFbeta signaling in Tribolium: vertebrate-like components in a beetle
    • van der Zee M., da Fonseca R.N., Roth S. TGFbeta signaling in Tribolium: vertebrate-like components in a beetle. Dev Genes Evol 2008, 218(3-4):203-213.
    • (2008) Dev Genes Evol , vol.218 , Issue.3-4 , pp. 203-213
    • van der Zee, M.1    da Fonseca, R.N.2    Roth, S.3
  • 10
    • 33646567450 scopus 로고    scopus 로고
    • Developmental roles of the BMP1/TLD metalloproteinases
    • Ge G., Greenspan D.S. Developmental roles of the BMP1/TLD metalloproteinases. Birth Defects Res C Embryo Today 2006, 78(1):47-68.
    • (2006) Birth Defects Res C Embryo Today , vol.78 , Issue.1 , pp. 47-68
    • Ge, G.1    Greenspan, D.S.2
  • 11
    • 35348923714 scopus 로고    scopus 로고
    • The bone morphogenetic protein 1/Tolloid-like metalloproteinases
    • Hopkins D.R., Keles S., Greenspan D.S. The bone morphogenetic protein 1/Tolloid-like metalloproteinases. Matrix Biol 2007, 26(7):508-523.
    • (2007) Matrix Biol , vol.26 , Issue.7 , pp. 508-523
    • Hopkins, D.R.1    Keles, S.2    Greenspan, D.S.3
  • 12
    • 0035858884 scopus 로고    scopus 로고
    • Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation
    • Monzen K., Hiroi Y., Kudoh S., Akazawa H., Oka T., Takimoto E., et al. Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation. J Cell Biol 2001, 153(4):687-698.
    • (2001) J Cell Biol , vol.153 , Issue.4 , pp. 687-698
    • Monzen, K.1    Hiroi, Y.2    Kudoh, S.3    Akazawa, H.4    Oka, T.5    Takimoto, E.6
  • 13
    • 0032481312 scopus 로고    scopus 로고
    • Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
    • Shibuya H., Iwata H., Masuyama N., Gotoh Y., Yamaguchi K., Irie K., et al. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J 1998, 17(4):1019-1028.
    • (1998) EMBO J , vol.17 , Issue.4 , pp. 1019-1028
    • Shibuya, H.1    Iwata, H.2    Masuyama, N.3    Gotoh, Y.4    Yamaguchi, K.5    Irie, K.6
  • 14
    • 0029153741 scopus 로고
    • Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors
    • Nohno T., Ishikawa T., Saito T., Hosokawa K., Noji S., Wolsing D.H., et al. Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. J Biol Chem 1995, 270(38):22522-22526.
    • (1995) J Biol Chem , vol.270 , Issue.38 , pp. 22522-22526
    • Nohno, T.1    Ishikawa, T.2    Saito, T.3    Hosokawa, K.4    Noji, S.5    Wolsing, D.H.6
  • 15
    • 0029008597 scopus 로고
    • Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs
    • Liu F., Ventura F., Doody J., Massague J. Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol 1995, 15(7):3479-3486.
    • (1995) Mol Cell Biol , vol.15 , Issue.7 , pp. 3479-3486
    • Liu, F.1    Ventura, F.2    Doody, J.3    Massague, J.4
  • 16
    • 34247331476 scopus 로고    scopus 로고
    • BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
    • Scharpfenecker M., van D.M., Liu Z., van Bezooijen R.L., Zhao Q., Pukac L., et al. BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. J Cell Sci 2007, 120(Pt 6):964-972.
    • (2007) J Cell Sci , vol.120 , Issue.PART 6 , pp. 964-972
    • Scharpfenecker, M.1    van, D.M.2    Liu, Z.3    van Bezooijen, R.L.4    Zhao, Q.5    Pukac, L.6
  • 17
    • 33847369980 scopus 로고    scopus 로고
    • Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
    • David L., Mallet C., Mazerbourg S., Feige J.J., Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood 2007, 109(5):1953-1961.
    • (2007) Blood , vol.109 , Issue.5 , pp. 1953-1961
    • David, L.1    Mallet, C.2    Mazerbourg, S.3    Feige, J.J.4    Bailly, S.5
  • 18
    • 3543127068 scopus 로고    scopus 로고
    • BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo
    • de Sousa Lopes S.M., Roelen B.A., Monteiro R.M., Emmens R., Lin H.Y., Li E., et al. BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev 2004, 18(15):1838-1849.
    • (2004) Genes Dev , vol.18 , Issue.15 , pp. 1838-1849
    • de Sousa Lopes, S.M.1    Roelen, B.A.2    Monteiro, R.M.3    Emmens, R.4    Lin, H.Y.5    Li, E.6
  • 19
    • 0042978771 scopus 로고    scopus 로고
    • ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development
    • Zhang D., Schwarz E.M., Rosier R.N., Zuscik M.J., Puzas J.E., O'Keefe R.J. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res 2003, 18(9):1593-1604.
    • (2003) J Bone Miner Res , vol.18 , Issue.9 , pp. 1593-1604
    • Zhang, D.1    Schwarz, E.M.2    Rosier, R.N.3    Zuscik, M.J.4    Puzas, J.E.5    O'Keefe, R.J.6
  • 20
    • 0041885046 scopus 로고    scopus 로고
    • Effect of the distribution and clustering of the type I A BMP receptor (ALK3) with the type II BMP receptor on the activation of signalling pathways
    • Nohe A., Keating E., Underhill T.M., Knaus P., Petersen N.O. Effect of the distribution and clustering of the type I A BMP receptor (ALK3) with the type II BMP receptor on the activation of signalling pathways. J Cell Sci 2003, 116(Pt 16):3277-3284.
    • (2003) J Cell Sci , vol.116 , Issue.PART 16 , pp. 3277-3284
    • Nohe, A.1    Keating, E.2    Underhill, T.M.3    Knaus, P.4    Petersen, N.O.5
  • 21
    • 0033968046 scopus 로고    scopus 로고
    • BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis
    • Gupta I.R., Macias-Silva M., Kim S., Zhou X., Piscione T.D., Whiteside C., et al. BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis. J Cell Sci 2000, 113(Pt 2):269-278.
    • (2000) J Cell Sci , vol.113 , Issue.PART 2 , pp. 269-278
    • Gupta, I.R.1    Macias-Silva, M.2    Kim, S.3    Zhou, X.4    Piscione, T.D.5    Whiteside, C.6
  • 22
    • 46749158788 scopus 로고    scopus 로고
    • Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
    • Xia Y., Babitt J.L., Sidis Y., Chung R.T., Lin H.Y. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 2008, 111(10):5195-5204.
    • (2008) Blood , vol.111 , Issue.10 , pp. 5195-5204
    • Xia, Y.1    Babitt, J.L.2    Sidis, Y.3    Chung, R.T.4    Lin, H.Y.5
  • 23
    • 33745272290 scopus 로고    scopus 로고
    • Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands
    • Mazerbourg S., Hsueh A.J. Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands. Hum Reprod Update 2006, 12(4):373-383.
    • (2006) Hum Reprod Update , vol.12 , Issue.4 , pp. 373-383
    • Mazerbourg, S.1    Hsueh, A.J.2
  • 25
    • 0037447890 scopus 로고    scopus 로고
    • Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling
    • Chimal-Monroy J., Rodriguez-Leon J., Montero J.A., Ganan Y., Macias D., Merino R., et al. Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: Sox genes and BMP signaling. Dev Biol 2003, 257(2):292-301.
    • (2003) Dev Biol , vol.257 , Issue.2 , pp. 292-301
    • Chimal-Monroy, J.1    Rodriguez-Leon, J.2    Montero, J.A.3    Ganan, Y.4    Macias, D.5    Merino, R.6
  • 26
    • 49649109581 scopus 로고    scopus 로고
    • Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter
    • Pan Q., Yu Y., Chen Q., Li C., Wu H., Wan Y., et al. Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter. J Cell Physiol 2008, 217(1):228-241.
    • (2008) J Cell Physiol , vol.217 , Issue.1 , pp. 228-241
    • Pan, Q.1    Yu, Y.2    Chen, Q.3    Li, C.4    Wu, H.5    Wan, Y.6
  • 27
    • 58149494122 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 induces chromatin remodeling and modification at the proximal promoter of Sox9 gene
    • Pan Q., Wu Y., Lin T., Yao H., Yang Z., Gao G., et al. Bone morphogenetic protein-2 induces chromatin remodeling and modification at the proximal promoter of Sox9 gene. Biochem Biophys Res Commun 2009, 379(2):356-361.
    • (2009) Biochem Biophys Res Commun , vol.379 , Issue.2 , pp. 356-361
    • Pan, Q.1    Wu, Y.2    Lin, T.3    Yao, H.4    Yang, Z.5    Gao, G.6
  • 28
    • 0034643084 scopus 로고    scopus 로고
    • BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes
    • Pizette S., Niswander L. BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes. Dev Biol 2000, 219(2):237-249.
    • (2000) Dev Biol , vol.219 , Issue.2 , pp. 237-249
    • Pizette, S.1    Niswander, L.2
  • 29
    • 0036836664 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 modulation of chondrogenic differentiation in vitro involves gap junction-mediated intercellular communication
    • Zhang W., Green C., Stott N.S. Bone morphogenetic protein-2 modulation of chondrogenic differentiation in vitro involves gap junction-mediated intercellular communication. J Cell Physiol 2002, 193(2):233-243.
    • (2002) J Cell Physiol , vol.193 , Issue.2 , pp. 233-243
    • Zhang, W.1    Green, C.2    Stott, N.S.3
  • 30
    • 12344291865 scopus 로고    scopus 로고
    • Bone morphogenetic proteins
    • Chen D., Zhao M., Mundy G.R. Bone morphogenetic proteins. Growth Factors 2004, 22(4):233-241.
    • (2004) Growth Factors , vol.22 , Issue.4 , pp. 233-241
    • Chen, D.1    Zhao, M.2    Mundy, G.R.3
  • 31
    • 0031147795 scopus 로고    scopus 로고
    • Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner
    • Erickson D.M., Harris S.E., Dean D.D., Harris M.A., Wozney J.M., Boyan B.D., et al. Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner. J Orthop Res 1997, 15(3):371-380.
    • (1997) J Orthop Res , vol.15 , Issue.3 , pp. 371-380
    • Erickson, D.M.1    Harris, S.E.2    Dean, D.D.3    Harris, M.A.4    Wozney, J.M.5    Boyan, B.D.6
  • 32
    • 36849048808 scopus 로고    scopus 로고
    • BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures
    • Mailhot G., Yang M., Mason-Savas A., Mackay C.A., Leav I., Odgren P.R. BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures. J Cell Physiol 2008, 214(1):56-64.
    • (2008) J Cell Physiol , vol.214 , Issue.1 , pp. 56-64
    • Mailhot, G.1    Yang, M.2    Mason-Savas, A.3    Mackay, C.A.4    Leav, I.5    Odgren, P.R.6
  • 33
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina E., Wenzel H.M., Kreschel C., Karp S., Gaffield W., McMahon A.P., et al. BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 2001, 128(22):4523-4534.
    • (2001) Development , vol.128 , Issue.22 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6
  • 34
    • 0030726411 scopus 로고    scopus 로고
    • OP-1 (BMP-7) affects mRNA expression of type I, II, X collagen, and matrix Gla protein in ossifying long bones in vitro
    • Haaijman A., D'Souza R.N., Bronckers A.L., Goei S.W., Burger E.H. OP-1 (BMP-7) affects mRNA expression of type I, II, X collagen, and matrix Gla protein in ossifying long bones in vitro. J Bone Miner Res 1997, 12(11):1815-1823.
    • (1997) J Bone Miner Res , vol.12 , Issue.11 , pp. 1815-1823
    • Haaijman, A.1    D'Souza, R.N.2    Bronckers, A.L.3    Goei, S.W.4    Burger, E.H.5
  • 35
    • 52649083250 scopus 로고    scopus 로고
    • Effects induced by BMPS in cultures of human articular chondrocytes: comparative studies
    • Chubinskaya S., Segalite D., Pikovsky D., Hakimiyan A.A., Rueger D.C. Effects induced by BMPS in cultures of human articular chondrocytes: comparative studies. Growth Factors 2008, 26(5):275-283.
    • (2008) Growth Factors , vol.26 , Issue.5 , pp. 275-283
    • Chubinskaya, S.1    Segalite, D.2    Pikovsky, D.3    Hakimiyan, A.A.4    Rueger, D.C.5
  • 36
    • 65949089831 scopus 로고    scopus 로고
    • SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation
    • Zhao L., Li G., Zhou G.Q. SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation. J Bone Miner Res 2009, 24(5):826-836.
    • (2009) J Bone Miner Res , vol.24 , Issue.5 , pp. 826-836
    • Zhao, L.1    Li, G.2    Zhou, G.Q.3
  • 37
    • 0034807637 scopus 로고    scopus 로고
    • Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing
    • Uusitalo H., Hiltunen A., Ahonen M., Gao T.J., Lefebvre V., Harley V., et al. Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing. J Bone Miner Res 2001, 16(10):1837-1845.
    • (2001) J Bone Miner Res , vol.16 , Issue.10 , pp. 1837-1845
    • Uusitalo, H.1    Hiltunen, A.2    Ahonen, M.3    Gao, T.J.4    Lefebvre, V.5    Harley, V.6
  • 38
    • 66349117431 scopus 로고    scopus 로고
    • BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation
    • Retting K.N., Song B., Yoon B.S., Lyons K.M. BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development 2009, 136(7):1093-1104.
    • (2009) Development , vol.136 , Issue.7 , pp. 1093-1104
    • Retting, K.N.1    Song, B.2    Yoon, B.S.3    Lyons, K.M.4
  • 39
    • 33750822719 scopus 로고    scopus 로고
    • Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model
    • Hecht J., Seitz V., Urban M., Wagner F., Robinson P.N., Stiege A., et al. Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model. Gene Expr Patterns 2007, 7(1-2):102-112.
    • (2007) Gene Expr Patterns , vol.7 , Issue.1-2 , pp. 102-112
    • Hecht, J.1    Seitz, V.2    Urban, M.3    Wagner, F.4    Robinson, P.N.5    Stiege, A.6
  • 40
    • 2942574380 scopus 로고    scopus 로고
    • Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins
    • Miyazono K., Maeda S., Imamura T. Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins. Oncogene 2004, 23(24):4232-4237.
    • (2004) Oncogene , vol.23 , Issue.24 , pp. 4232-4237
    • Miyazono, K.1    Maeda, S.2    Imamura, T.3
  • 41
    • 12244313406 scopus 로고    scopus 로고
    • Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions
    • Lian J.B., Stein J.L., Stein G.S., van Wijnen A.J., Montecino M., Javed A., et al. Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions. Connect Tissue Res 2003, 44(Suppl 1):141-148.
    • (2003) Connect Tissue Res , vol.44 , Issue.1 SUPPL. , pp. 141-148
    • Lian, J.B.1    Stein, J.L.2    Stein, G.S.3    van Wijnen, A.J.4    Montecino, M.5    Javed, A.6
  • 43
    • 33744745896 scopus 로고    scopus 로고
    • Regulating bone growth and development with bone morphogenetic proteins
    • Leboy P.S. Regulating bone growth and development with bone morphogenetic proteins. Ann N Y Acad Sci 2006, 1068:14-18.
    • (2006) Ann N Y Acad Sci , vol.1068 , pp. 14-18
    • Leboy, P.S.1
  • 44
    • 43749091299 scopus 로고    scopus 로고
    • Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal
    • Javed A., Bae J.S., Afzal F., Gutierrez S., Pratap J., Zaidi S.K., et al. Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J Biol Chem 2008, 283(13):8412-8422.
    • (2008) J Biol Chem , vol.283 , Issue.13 , pp. 8412-8422
    • Javed, A.1    Bae, J.S.2    Afzal, F.3    Gutierrez, S.4    Pratap, J.5    Zaidi, S.K.6
  • 45
    • 57449098472 scopus 로고    scopus 로고
    • Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation
    • Javed A., Afzal F., Bae J.S., Gutierrez S., Zaidi K., Pratap J., et al. Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation. Cells Tissues Organs 2009, 189(1-4):133-137.
    • (2009) Cells Tissues Organs , vol.189 , Issue.1-4 , pp. 133-137
    • Javed, A.1    Afzal, F.2    Bae, J.S.3    Gutierrez, S.4    Zaidi, K.5    Pratap, J.6
  • 46
    • 43949090746 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)
    • Bessa P.C., Casal M., Reis R.L. Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts). J Tissue Eng Regen Med 2008, 2(1):1-13.
    • (2008) J Tissue Eng Regen Med , vol.2 , Issue.1 , pp. 1-13
    • Bessa, P.C.1    Casal, M.2    Reis, R.L.3
  • 48
  • 49
    • 0142187329 scopus 로고    scopus 로고
    • Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration
    • Reddi A.H. Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration. Ann Rheum Dis 2003, 62(Suppl 2):ii73-ii78.
    • (2003) Ann Rheum Dis , vol.62 , Issue.2 SUPPL.
    • Reddi, A.H.1
  • 50
    • 4944265564 scopus 로고    scopus 로고
    • Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage
    • Chen A.L., Fang C., Liu C., Leslie M.P., Chang E., Di Cesare P.E. Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage. J Orthop Res 2004, 22(6):1188-1192.
    • (2004) J Orthop Res , vol.22 , Issue.6 , pp. 1188-1192
    • Chen, A.L.1    Fang, C.2    Liu, C.3    Leslie, M.P.4    Chang, E.5    Di Cesare, P.E.6
  • 51
    • 0141453478 scopus 로고    scopus 로고
    • Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro
    • Bobacz K., Gruber R., Soleiman A., Erlacher L., Smolen J.S., Graninger W.B. Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro. Arthritis Rheum 2003, 48(9):2501-2508.
    • (2003) Arthritis Rheum , vol.48 , Issue.9 , pp. 2501-2508
    • Bobacz, K.1    Gruber, R.2    Soleiman, A.3    Erlacher, L.4    Smolen, J.S.5    Graninger, W.B.6
  • 52
    • 0037383836 scopus 로고    scopus 로고
    • Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte
    • Nakase T., Miyaji T., Tomita T., Kaneko M., Kuriyama K., Myoui A., et al. Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte. Osteoarthritis Cartilage 2003, 11(4):278-284.
    • (2003) Osteoarthritis Cartilage , vol.11 , Issue.4 , pp. 278-284
    • Nakase, T.1    Miyaji, T.2    Tomita, T.3    Kaneko, M.4    Kuriyama, K.5    Myoui, A.6
  • 53
    • 0043136513 scopus 로고    scopus 로고
    • Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes
    • Fukui N., Zhu Y., Maloney W.J., Clohisy J., Sandell L.J. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes. J Bone Joint Surg Am 2003, 85-A(Suppl 3):59-66.
    • (2003) J Bone Joint Surg Am , Issue.3 SUPPL. , pp. 59-66
    • Fukui, N.1    Zhu, Y.2    Maloney, W.J.3    Clohisy, J.4    Sandell, L.J.5
  • 54
    • 35548944211 scopus 로고    scopus 로고
    • Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury
    • Dell'Accio F., De B.C., El Tawil N.M., Barone F., Mitsiadis T.A., O'Dowd J., et al. Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. Arthritis Res Ther 2006, 8(5):R139.
    • (2006) Arthritis Res Ther , vol.8 , Issue.5
    • Dell'Accio, F.1    De, B.C.2    El Tawil, N.M.3    Barone, F.4    Mitsiadis, T.A.5    O'Dowd, J.6
  • 55
    • 0035100974 scopus 로고    scopus 로고
    • Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN
    • Reddi A.H. Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN. Arthritis Res 2001, 3(1):1-5.
    • (2001) Arthritis Res , vol.3 , Issue.1 , pp. 1-5
    • Reddi, A.H.1
  • 56
    • 33745013841 scopus 로고    scopus 로고
    • Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis
    • Lories R.J., Daans M., Derese I., Matthys P., Kasran A., Tylzanowski P., et al. Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis. Arthritis Rheum 2006, 54(6):1736-1746.
    • (2006) Arthritis Rheum , vol.54 , Issue.6 , pp. 1736-1746
    • Lories, R.J.1    Daans, M.2    Derese, I.3    Matthys, P.4    Kasran, A.5    Tylzanowski, P.6
  • 57
    • 36348932149 scopus 로고    scopus 로고
    • Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
    • Blaney Davidson E.N., Vitters E.L., van Lent P.L., van de Loo F.A., van den Berg W.B., van der Kraan P.M. Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling. Arthritis Res Ther 2007, 9(5):R102.
    • (2007) Arthritis Res Ther , vol.9 , Issue.5
    • Blaney Davidson, E.N.1    Vitters, E.L.2    van Lent, P.L.3    van de Loo, F.A.4    van den Berg, W.B.5    van der Kraan, P.M.6
  • 58
    • 4043100538 scopus 로고    scopus 로고
    • Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts
    • Tardif G., Hum D., Pelletier J.P., Boileau C., Ranger P., Martel-Pelletier J. Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum 2004, 50(8):2521-2530.
    • (2004) Arthritis Rheum , vol.50 , Issue.8 , pp. 2521-2530
    • Tardif, G.1    Hum, D.2    Pelletier, J.P.3    Boileau, C.4    Ranger, P.5    Martel-Pelletier, J.6
  • 59
    • 59249092231 scopus 로고    scopus 로고
    • The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study
    • Tardif G., Pelletier J.P., Boileau C., Martel-Pelletier J. The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study. Osteoarthritis Cartilage 2009, 17(2):263-270.
    • (2009) Osteoarthritis Cartilage , vol.17 , Issue.2 , pp. 263-270
    • Tardif, G.1    Pelletier, J.P.2    Boileau, C.3    Martel-Pelletier, J.4
  • 60
    • 8444228925 scopus 로고    scopus 로고
    • Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta
    • Kaiser M., Haag J., Soder S., Bau B., Aigner T. Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta. Arthritis Rheum 2004, 50(11):3535-3540.
    • (2004) Arthritis Rheum , vol.50 , Issue.11 , pp. 3535-3540
    • Kaiser, M.1    Haag, J.2    Soder, S.3    Bau, B.4    Aigner, T.5
  • 61
    • 0034524755 scopus 로고    scopus 로고
    • Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus
    • Uusitalo H., Hiltunen A., Soderstrom M., Aro H.T., Vuorio E. Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus. Calcif Tissue Int 2000, 67(5):382-390.
    • (2000) Calcif Tissue Int , vol.67 , Issue.5 , pp. 382-390
    • Uusitalo, H.1    Hiltunen, A.2    Soderstrom, M.3    Aro, H.T.4    Vuorio, E.5
  • 62
    • 13844315153 scopus 로고    scopus 로고
    • Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways
    • Wang Y., Middleton F., Horton J.A., Reichel L., Farnum C.E., Damron T.A. Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways. Bone 2004, 35(6):1273-1293.
    • (2004) Bone , vol.35 , Issue.6 , pp. 1273-1293
    • Wang, Y.1    Middleton, F.2    Horton, J.A.3    Reichel, L.4    Farnum, C.E.5    Damron, T.A.6
  • 63
    • 10344245561 scopus 로고    scopus 로고
    • Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
    • Inada M., Wang Y., Byrne M.H., Rahman M.U., Miyaura C., Lopez-Otin C., et al. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A 2004, 101(49):17192-17197.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.49 , pp. 17192-17197
    • Inada, M.1    Wang, Y.2    Byrne, M.H.3    Rahman, M.U.4    Miyaura, C.5    Lopez-Otin, C.6
  • 64
    • 0036674028 scopus 로고    scopus 로고
    • Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13
    • Wu W., Billinghurst R.C., Pidoux I., Antoniou J., Zukor D., Tanzer M., et al. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum 2002, 46(8):2087-2094.
    • (2002) Arthritis Rheum , vol.46 , Issue.8 , pp. 2087-2094
    • Wu, W.1    Billinghurst, R.C.2    Pidoux, I.3    Antoniou, J.4    Zukor, D.5    Tanzer, M.6
  • 65
    • 18744385527 scopus 로고    scopus 로고
    • Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions
    • Tchetina E.V., Squires G., Poole A.R. Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. J Rheumatol 2005, 32(5):876-886.
    • (2005) J Rheumatol , vol.32 , Issue.5 , pp. 876-886
    • Tchetina, E.V.1    Squires, G.2    Poole, A.R.3
  • 66
    • 66249121386 scopus 로고    scopus 로고
    • BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture
    • Shen B., Wei A., Tao H., Diwan A.D., Ma D.D. BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture. Tissue Eng Part A 2009, 15(6):1311-1320.
    • (2009) Tissue Eng Part A , vol.15 , Issue.6 , pp. 1311-1320
    • Shen, B.1    Wei, A.2    Tao, H.3    Diwan, A.D.4    Ma, D.D.5
  • 67
    • 37249015430 scopus 로고    scopus 로고
    • Multiplicity of BMP signaling in skeletal development
    • Wu X., Shi W., Cao X. Multiplicity of BMP signaling in skeletal development. Ann N Y Acad Sci 2007, 1116:29-49.
    • (2007) Ann N Y Acad Sci , vol.1116 , pp. 29-49
    • Wu, X.1    Shi, W.2    Cao, X.3
  • 68
    • 29144529005 scopus 로고    scopus 로고
    • BMP signaling stimulates cellular differentiation at multiple steps during cartilage development
    • Kobayashi T., Lyons K.M., McMahon A.P., Kronenberg H.M. BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A 2005, 102(50):18023-18027.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.50 , pp. 18023-18027
    • Kobayashi, T.1    Lyons, K.M.2    McMahon, A.P.3    Kronenberg, H.M.4
  • 69
    • 0027279791 scopus 로고
    • Collagen and alkaline phosphatase gene expression during bone morphogenetic protein (BMP)-induced cartilage and bone differentiation
    • Sakano S., Murata Y., Miura T., Iwata H., Sato K., Matsui N., et al. Collagen and alkaline phosphatase gene expression during bone morphogenetic protein (BMP)-induced cartilage and bone differentiation. Clin Orthop Relat Res 1993, 292:337-344.
    • (1993) Clin Orthop Relat Res , vol.292 , pp. 337-344
    • Sakano, S.1    Murata, Y.2    Miura, T.3    Iwata, H.4    Sato, K.5    Matsui, N.6
  • 70
    • 0025789151 scopus 로고
    • Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor beta 1 and beta 2
    • Chen P., Carrington J.L., Hammonds R.G., Reddi A.H. Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor beta 1 and beta 2. Exp Cell Res 1991, 195(2):509-515.
    • (1991) Exp Cell Res , vol.195 , Issue.2 , pp. 509-515
    • Chen, P.1    Carrington, J.L.2    Hammonds, R.G.3    Reddi, A.H.4
  • 71
    • 2442459812 scopus 로고    scopus 로고
    • Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia
    • Horiki M., Imamura T., Okamoto M., Hayashi M., Murai J., Myoui A., et al. Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia. J Cell Biol 2004, 165(3):433-445.
    • (2004) J Cell Biol , vol.165 , Issue.3 , pp. 433-445
    • Horiki, M.1    Imamura, T.2    Okamoto, M.3    Hayashi, M.4    Murai, J.5    Myoui, A.6
  • 72
    • 0042889063 scopus 로고    scopus 로고
    • Smad6 is induced by BMP-2 and modulates chondrocyte differentiation
    • Li X., Ionescu A.M., Schwarz E.M., Zhang X., Drissi H., Puzas J.E., et al. Smad6 is induced by BMP-2 and modulates chondrocyte differentiation. J Orthop Res 2003, 21(5):908-913.
    • (2003) J Orthop Res , vol.21 , Issue.5 , pp. 908-913
    • Li, X.1    Ionescu, A.M.2    Schwarz, E.M.3    Zhang, X.4    Drissi, H.5    Puzas, J.E.6
  • 73
    • 1242331351 scopus 로고    scopus 로고
    • Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1
    • Fan Z., Chubinskaya S., Rueger D.C., Bau B., Haag J., Aigner T. Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1. Clin Exp Rheumatol 2004, 22(1):103-106.
    • (2004) Clin Exp Rheumatol , vol.22 , Issue.1 , pp. 103-106
    • Fan, Z.1    Chubinskaya, S.2    Rueger, D.C.3    Bau, B.4    Haag, J.5    Aigner, T.6
  • 74
    • 39149123550 scopus 로고    scopus 로고
    • Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1
    • Majumdar M.K., Chockalingam P.S., Bhat R.A., Sheldon R., Keohan C., Blanchet T., et al. Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1. J Cell Physiol 2008, 215(1):68-76.
    • (2008) J Cell Physiol , vol.215 , Issue.1 , pp. 68-76
    • Majumdar, M.K.1    Chockalingam, P.S.2    Bhat, R.A.3    Sheldon, R.4    Keohan, C.5    Blanchet, T.6
  • 75
    • 58249098395 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 enhances the motility of chondrosarcoma cells via activation of matrix metalloproteinase-13
    • Hou C.H., Hsiao Y.C., Fong Y.C., Tang C.H. Bone morphogenetic protein-2 enhances the motility of chondrosarcoma cells via activation of matrix metalloproteinase-13. Bone 2009, 44(2):233-242.
    • (2009) Bone , vol.44 , Issue.2 , pp. 233-242
    • Hou, C.H.1    Hsiao, Y.C.2    Fong, Y.C.3    Tang, C.H.4
  • 76
    • 11144326370 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through a runt domain factor 2 binding site
    • Varghese S., Rydziel S., Canalis E. Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through a runt domain factor 2 binding site. J Cell Physiol 2005, 202(2):391-399.
    • (2005) J Cell Physiol , vol.202 , Issue.2 , pp. 391-399
    • Varghese, S.1    Rydziel, S.2    Canalis, E.3
  • 77
    • 0031046770 scopus 로고    scopus 로고
    • Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures
    • Varghese S., Canalis E. Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures. Endocrinology 1997, 138(3):1035-1040.
    • (1997) Endocrinology , vol.138 , Issue.3 , pp. 1035-1040
    • Varghese, S.1    Canalis, E.2
  • 78
    • 32844455093 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1 gene expression by WNT3A and bone morphogenetic protein-2 in osteoblastic differentiation
    • Nakashima A., Tamura M. Regulation of matrix metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1 gene expression by WNT3A and bone morphogenetic protein-2 in osteoblastic differentiation. Front Biosci 2006, 11:1667-1678.
    • (2006) Front Biosci , vol.11 , pp. 1667-1678
    • Nakashima, A.1    Tamura, M.2
  • 79
    • 66249091571 scopus 로고    scopus 로고
    • Influence of bone morphogenetic protein-2 on the extracellular matrix, material properties, and gene expression of long-term articular chondrocyte cultures: loss of chondrocyte stability
    • Krawczak D.A., Westendorf J.J., Carlson C.S., Lewis J.L. Influence of bone morphogenetic protein-2 on the extracellular matrix, material properties, and gene expression of long-term articular chondrocyte cultures: loss of chondrocyte stability. Tissue Eng Part A 2009, 15(6):1247-1255.
    • (2009) Tissue Eng Part A , vol.15 , Issue.6 , pp. 1247-1255
    • Krawczak, D.A.1    Westendorf, J.J.2    Carlson, C.S.3    Lewis, J.L.4
  • 80
    • 33750032729 scopus 로고    scopus 로고
    • Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
    • Aigner T., Fundel K., Saas J., Gebhard P.M., Haag J., Weiss T., et al. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 2006, 54(11):3533-3544.
    • (2006) Arthritis Rheum , vol.54 , Issue.11 , pp. 3533-3544
    • Aigner, T.1    Fundel, K.2    Saas, J.3    Gebhard, P.M.4    Haag, J.5    Weiss, T.6
  • 81
    • 0035677833 scopus 로고    scopus 로고
    • Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology
    • Aigner T., Zien A., Gehrsitz A., Gebhard P.M., McKenna L. Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum 2001, 44(12):2777-2789.
    • (2001) Arthritis Rheum , vol.44 , Issue.12 , pp. 2777-2789
    • Aigner, T.1    Zien, A.2    Gehrsitz, A.3    Gebhard, P.M.4    McKenna, L.5
  • 82
    • 6344270259 scopus 로고    scopus 로고
    • Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes
    • Hermansson M., Sawaji Y., Bolton M., Alexander S., Wallace A., Begum S., et al. Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes. J Biol Chem 2004, 279(42):43514-43521.
    • (2004) J Biol Chem , vol.279 , Issue.42 , pp. 43514-43521
    • Hermansson, M.1    Sawaji, Y.2    Bolton, M.3    Alexander, S.4    Wallace, A.5    Begum, S.6
  • 83
    • 44949166539 scopus 로고    scopus 로고
    • Expression and function of BMP3 during chick limb development
    • Gamer L.W., Ho V., Cox K., Rosen V. Expression and function of BMP3 during chick limb development. Dev Dyn 2008, 237(6):1691-1698.
    • (2008) Dev Dyn , vol.237 , Issue.6 , pp. 1691-1698
    • Gamer, L.W.1    Ho, V.2    Cox, K.3    Rosen, V.4
  • 84
    • 35648944164 scopus 로고    scopus 로고
    • BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors
    • Allendorph G.P., Isaacs M.J., Kawakami Y., Belmonte J.C., Choe S. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Biochemistry 2007, 46(43):12238-12247.
    • (2007) Biochemistry , vol.46 , Issue.43 , pp. 12238-12247
    • Allendorph, G.P.1    Isaacs, M.J.2    Kawakami, Y.3    Belmonte, J.C.4    Choe, S.5
  • 85
    • 33748659352 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation
    • Blaney Davidson E.N., Vitters E.L., van der Kraan P.M., van den Berg W.B. Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation. Ann Rheum Dis 2006, 65(11):1414-1421.
    • (2006) Ann Rheum Dis , vol.65 , Issue.11 , pp. 1414-1421
    • Blaney Davidson, E.N.1    Vitters, E.L.2    van der Kraan, P.M.3    van den Berg, W.B.4
  • 86
    • 67649216115 scopus 로고    scopus 로고
    • Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice
    • Blaney Davidson E.N., Remst D.F., Vitters E.L., van Beuningen H.M., Blom A.B., Goumans M.J., et al. Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J Immunol 2009, 182(12):7937-7945.
    • (2009) J Immunol , vol.182 , Issue.12 , pp. 7937-7945
    • Blaney Davidson, E.N.1    Remst, D.F.2    Vitters, E.L.3    van Beuningen, H.M.4    Blom, A.B.5    Goumans, M.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.