Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation

Journal of Bone and Mineral Research

Volumn 21, Issue 1, 2006, Pages 4-16

  Li, Tian Fang ^a   Darowish, Michael ^a   Zuscik, Michael J ^a   Chen, Di ^a   Schwarz, Edward M ^a   Rosier, Randy N ^a   Drissi, Hicham ^a   O'Keefe, Regis J ^b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

BMP; Chondrocyte maturation; Smad3; TGF

Indexed keywords

ALKALINE PHOSPHATASE; BIOCHEMICAL MARKER; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 6; GENE PRODUCT; LUCIFERASE; NOGGIN; PROTEIN COLX; PROTEIN INHIBITOR; PROTEIN SMURF2; PROTEIN SNO; RECOMBINANT PROTEIN; RETROVIRUS VECTOR; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ACCELERATION; ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL MATURATION; CHONDROPATHY; CONTROLLED STUDY; DWARFISM; ENZYME ACTIVITY; GENE DISRUPTION; GENE EXPRESSION; GENE OVEREXPRESSION; IN VITRO STUDY; MOUSE; NEWBORN; NONHUMAN; OSTEOARTHRITIS; PROTEIN DEFICIENCY; REPORTER GENE; SIGNAL TRANSDUCTION; STERNUM; WILD TYPE;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CARTILAGE DISEASES; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; GENE EXPRESSION REGULATION; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 29644432280     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.050911     Document Type: Article

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