PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis

Journal of Bone and Mineral Research

Volumn 24, Issue 10, 2009, Pages 1753-1762

  Tsutsumi, Ryosuke ^a   Xie, Chao ^a   Wei, Xiaochao ^a   Zhang, Minjie ^a   Zhang, Xinping ^a   Flick, Lisa M ^a   Schwarz, Edward M ^a   O'Keefe, Regis J ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

EP4; Fibroblast; Inflammatory bone loss; Prostaglandin; RANKL

Indexed keywords

CYCLOOXYGENASE 2; OSTEOCLAST DIFFERENTIATION FACTOR; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2;

ARTHROPLASTY; ARTICLE; C57BL 6 MOUSE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PATHOGENESIS; PROSTHESIS LOOSENING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CALCIUM-BINDING PROTEINS; DINOPROSTONE; FEMALE; FIBROBLASTS; INFLAMMATION; INTEGRASES; MALE; MICE; OSTEOLYSIS; PARTICULATE MATTER; POLYETHYLENE; RANK LIGAND; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; S100 PROTEINS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 70349924967     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.090412     Document Type: Article

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