Bone Morphogenetic Protein 2 Induces Cyclo-oxygenase 2 in Osteoblasts via a Cbfa1 Binding Site: Role in Effects of Bone Morphogenetic Protein 2 In Vitro and In Vivo

Journal of Bone and Mineral Research

Volumn 17, Issue 8, 2002, Pages 1430-1440

  Chikazu, Daichi ^a   Li, Xiaodong ^a   Kawaguchi, Hiroshi ^b   Sakuma, Yoko ^a   Voznesensky, Olga S ^a   Adams, Douglas J ^a   Xu, Manshan ^a   Hoshi, Kazuto ^b   Katavic, Vedran ^a   Herschman, Harvey R ^c   Raisz, Lawrence G ^a   Pilbeam, Carol C ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

COX 2 knockout; MC3T3 E1 cells; Promoter regulation; Prostaglandin E2; Prostaglandin G H synthase

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CORE BINDING FACTOR; CYCLOOXYGENASE 2; LUCIFERASE; OSTEOCALCIN; PROSTAGLANDIN G; PROSTAGLANDIN H; BMP2 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN; ISOENZYME; MESSENGER RNA; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN 3T3; ENZYME INDUCTION; GENE DELETION; GENETIC REGULATION; MINERALIZATION; MOUSE; NONHUMAN; OSTEOBLAST; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; BONE MINERALIZATION; ENZYMOLOGY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

3T3 CELLS; ANIMAL; BONE MORPHOGENETIC PROTEINS; CALCIFICATION, PHYSIOLOGIC; DINOPROSTONE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IN VITRO; ISOENZYMES; LUCIFERASE; MICE; MUTAGENESIS, SITE-DIRECTED; OSTEOBLASTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS; ANIMALS; CORE BINDING FACTORS; CYCLOOXYGENASE 2; LUCIFERASES; NEOPLASM PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035992648     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.8.1430     Document Type: Article

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