Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: Evidence for signaling via the EP4 receptor

Journal of Immunology

Volumn 181, Issue 7, 2008, Pages 5082-5088

  Attur, Mukundan ^a   Al Mussawir, Hayf E ^a   Patel, Jyoti ^a   Kitay, Alison ^a   Dave, Mandar ^a   Palmer, Glyn ^a   Pillinger, Michael H ^a   Abramson, Steven B ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 [5 (4 BIPHENYLYLMETHOXY) 2 MORPHOLINO 3 OXOCYCLOPENTYL] 4 HEPTENOIC ACID; AGGRECANASE; AGGRECANASE 5; CELECOXIB; COLLAGEN; COLLAGENASE 3; ILOMASTAT; INTERLEUKIN 1; INTERSTITIAL COLLAGENASE; METALLOPROTEASE ADAMTS 4; METALLOPROTEASE ADAMTS 5; METALLOPROTEINASE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E RECEPTOR EP4; PROSTAGLANDIN E2; PROTEOGLYCAN; UNCLASSIFIED DRUG; EP4 RECEPTOR;

ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CATABOLISM; COLLAGEN DEGRADATION; CONTROLLED STUDY; DRUG INHIBITION; EXPLANT; HUMAN; HUMAN CELL; KNEE; KNEE ARTHROPLASTY; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN SECRETION; PROTEOGLYCAN SYNTHESIS; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SURGICAL TECHNIQUE; AGED; BIOSYNTHESIS; CELL CULTURE; CELL LINE; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SECRETION; TISSUE CULTURE TECHNIQUE;

AGED; CARTILAGE, ARTICULAR; CELL LINE; CELLS, CULTURED; CHONDROCYTES; DINOPROSTONE; ENZYME ACTIVATION; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MIDDLE AGED; OSTEOARTHRITIS; RECEPTORS, PROSTAGLANDIN E; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES;

EID: 57349169432     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.7.5082     Document Type: Article

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