Bioanalysis of drug in tissue: Current status and challenges

Bioanalysis

Volumn 4, Issue 21, 2012, Pages 2637-2653

  Xue, Y J ^a   Gao, Hong ^b   Ji, Qin C ^c   Lam, Zamas ^d   Fang, Xinping ^e   Lin, Zhongping ^f   Hoffman, Matthew ^a   Schulz Jander, Daniel ^g   Weng, Naidong ^h  

^a CELGENE CORPORATION   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d QPS LLC   (United States)

^e XENOBIOTIC LABORATORIES INC   (United States)

^f Frontage Laboratories Inc   (United States)

^g MEDTRONIC INC   (United States)

^h JANSSEN RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; DRUG; DRUG METABOLITE; FLUCONAZOLE;

ANALYTIC METHOD; BEADS BEATING ANALYSIS; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; CARDIOTOXICITY; CHEMICAL DIGESTION; CRYOGENIC PULVERIZING; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EXPOSURE; DRUG MECHANISM; DRUG PENETRATION; DRUG RETENTION; DRUG STABILITY; DRUG TISSUE LEVEL; ENZYME METABOLISM; EXTRACTION; GRINDING; HUMAN; IMAGE ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION SPECTROMETRY; MYOCARDITIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOLOGICAL PARAMETERS; PHYSICAL CHEMISTRY; PLASMA PROTEIN BINDING; PROCESS DEVELOPMENT; REVIEW; ROTATING BLADE ANALYSIS; SAMPLING; SOLVENT EXTRACTION; SYSTEMIC CIRCULATION; TISSUE BIOANALYSIS; TISSUE HOMOGENATE; TISSUE PREPARATION; TISSUE SAMPLING; TOXICITY TESTING; ULTRASOUND; VALIDATION PROCESS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; SPECIMEN HANDLING; TISSUE FIXATION;

EID: 84870170181     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.252     Document Type: Review

References (139)

1. Solon EG, Lee F. Methods determining phosphor imaging limits of quantitation in whole-body autoradiography rodent tissue distribution studies affect predictions of 14C human dosimetry. J. Pharmacol. Toxicol. Methods 46(2), 83-91 (2001). (Pubitemid 34680997)
2. Shani J, Young D, Schlesinger T et al. Dosimetry and preliminary human studies of 18F-5-fuorouracil. Int. J. Nucl. Med. Biol. 9 (1), 25-31 (1982).
3. Yu C, Cohen LH. Tissue sample preparation-not the same old grind. LCGC Europe 17(2), 96 (2004).
4. Smith KM, Xu Y. Tissue sample preparation in bioanalytical assays. Bioanalysis 4, 741-749 (2012).
5. US Department of Health and Human Services, US FDA, Center for Drug Evaluation and Research. Guidance for Industry: exposure-response relationships-study design, data ana lysis, and regulatory applications. Rockville, MD, USA (2003).
6. Maurer TS, DeBartolo DB, Tess DA et al. Relationship between exposure and nonspecifc binding of thirty-three central nervous systemic drugs in mice. Drug Metabol. Dispos. 33, 175-181 (2005). (Pubitemid 40023529)
7. Reddy JA, Dorton R, Westrick E et al. Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate. Cancer Res. 67, 4434-4442 (2007). (Pubitemid 46815093)
8. Verrijk, R, Smolders IJ, Bosnie N et al. Reduction of systemic exposure and toxicity of cisplatin by encapsulation in poly-lactide-co-glycolide. Cancer Res. 52, 6653-6656 (1992).
9. Sakurada K, Ohta H. Liquid chromatography-tandem mass spectrometry method for determination of the pyridinium aldoxime 4-PAO in brain, liver, lung, and kidney. J. Chromatogr. B 878(17-18), 1414-1419 (2010).
10. Zhou Q, Gallo JM. Quantifcation of sunitinib in mouse plasma, brain tumor and normal brain using liquid chromatography-electrospray ionization-tandem mass spectrometry and pharmacokinetic application. J. Pharm. Biomed. Anal. 51(4), 958-964 (2010).
11. Walsh TJ, Foulds G, Pizzo PA. Pharmacokinetics and tissue penetration of fuconazole in rabbits. Antimicrob. Agents Chemother. 33(4), 467-469 (1989). (Pubitemid 19094274)
12. Gaudin PB, Hruban RH, Beschorner WE et al. Myocarditis associated with doxorubicin cardiotoxicity. Am. J. Clin. Pathol. 100(2), 158-63 (1993). (Pubitemid 23251886)
13. van Asperen J, van Tellingen O, Tijssen F et al. Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein. Br. J. Cancer. 79(1), 108-13 (1999). (Pubitemid 28566934)
14. Wiemer M, Seth A, Chandra P et al. Systemic exposure of everolimus after stent implantation: a pharmacokinetic study. Am. Heart J. 156, 751. e1-e7 (2008).
15. Ikeno F, Bailey L, Willard C Kopia GA, Tio F, Dooley J. Sirolimus-eluting stents: pharmacokinetics in blood, vessel, and myocardium in a porcine coronary model. JACC 43(5s1), A83-A83 (2004).
16. Ostojic M, Sagic D, Jung R et al. The Pharmacokinetics of biolimus A9 after elution from the nobori stent in patients with coronary artery disease: the NOBORI PK study. Catheter. Cardiovas.c Interv. 72(7), 901-908 (2008).
17. Udipi K, Melder B, Chen M et al. The next generation endeavor resolute stent: role of the BioLinxTM. Polymer. System EuroInterv. 3, 137-139 (2007).
18. Ji QC, Zhang J, Reimer MT, Watson P, El-Shourbagy T. Method development for the quantitation of ABT-578 in rabbit artery tissue by 96-well liquid-liquid extraction and liquid chromatography-tandem mass spectrometric detection. Rapid Commun. Mass Spectrom. 18, 2293-2298 (2004). (Pubitemid 39297366)
19. Zhang J, Reimer MT, Alexander NE, Ji QC, El-Shourbagy TA, Burke S, Schwartz L. Method development and validation for zotarolimus concentration determination in stented swine arteries by liquid chromatography-tandem mass spectrometry detection. Rapid Commun. Mass Spectrom. 20, 3427-3434 (2006). (Pubitemid 44763943)
20. Zhang J, Reimer MT, Ji QC et al. Accurate determination of an immunosuppressant in stented swine tissues with LC-MS/MS. Anal. Bioanal. Chem. 387, 2745-2756 (2007). (Pubitemid 46479937)
21. Filigenzi MS, Tor ER, Poppenga RH, Aston LA, Puschner B. The determination of melamine in muscle tissue by liquid chromatography-tandem mass spectrometry. Rapid Commun. Mass Spectrom. 21(24), 4027-4032 (2007).
22. Ramagiri S, Ma F, Kosanam H et al. Fast and sensitive liquid chromatography-electrospray mass spectrometry method to study ocular penetration of EDL-155, a novel antitumor agent for retinoblastoma in rats. J. Mass Spectrom. 44, 786-93 (2009).
23. Jiang S, Chappa AK, Proksch JW. A rapid and sensitive LC-MS/MS assay for the quantitation of brimonidine in ocular fuids and tissues. J. Chromatogr. B 877, 107-114 (2009).
24. Earla R, Boddu SHS, Cholkar K, Hariharan S, Jwala J, Mitra AK. Development and validation of a fast and sensitive bioanalytical method for the quantitative determination of glucocorticoidsquantitative measurement of dexamethasone in rabbit ocular matrices by liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 52, 525-533 (2010).
25. Ji AJ, Saunders JP, Amorusi P et al. Determination of tigecycline in human skin using a novel validated LC-MS/MS method. Bioanalysis 2(1), 81-94 (2010).
26. Peng SX, King SL, Bornes DM, Foltz DJ, Baker TR, Natchus MG. Automated 96-well SPE and LC-MS-MS for determination of protease inhibitors in plasma and cartilage tissues. Anal. Chem. 72, 1913-1917 (2000). (Pubitemid 30220189)
27. Gupta A, Jansson B, Chatelain P, Massingham R, Hammarlund-Udenaes M. Quantitative determination of cetirizine enantiomers in guinea pig plasma, brain tissue and microdialysis samples using liquid chromato-graphy-tandem mass spectrometry. Rapid Commun. Mass Spectrom. 19, 1749-1757 (2005). (Pubitemid 40831958)
28. Roy B, Das A, Bhaumik U et al. Determination of gemifoxacin in different tissues of rat after oral dosing of gemifoxacin mesylate by LC-MS/MS and its application in drug tissue distribution study. J. Pharm. Biomed. Anal. 52, 216-226 (2010).
29. Boström, E, Jansson B, Hammarlund-Udenaes M, Simonsson USH. The use of liquid chromatography-mass spectrometry for quantitative ana lysis of oxycodone, oxymorphone and noroxycodone in Ringer solution, rat plasma and rat brain tissue. Rapid Commun. Mass Spectrom. 18, 2565-2576 (2004). (Pubitemid 39481712)
30. Xu S, Zheng S, Shen X, Yao Z, Pivnichny J, Tong X. Automated sample preparation and purifcation of homogenized brain tissues. J. Pharm. Biomed. Anal. 44, 581-585 (2007). (Pubitemid 46880098)
31. Turnpenny P, Fraier D. Sensitive quantitation of reboxetine enantiomers in rat plasma and brain, using an optimized reverse phase chiral LC-MS/MS method. J. Pharm. Biomed. Anal. 49, 133-139 (2009).
32. Chng HT, New LS, Neo AH, Goh CW, Browne ER, Chan ECY. A sensitive LC-MS/MS bioana lysis assay of orally administered lipoic acid in rat blood and brain tissue. J. Pharm. Biomed. Anal. 51, 754-757 (2010).
33. Poli D, Caglieri A, Goldoni M, Coccini T, Roda E, Vitalone A. Single step determination of PCB 126 and 153 in rat tissues by using solid phase microextraction/gas chromatography-mass spectrometry: Comparison with solid phase extraction and liquid/liquid extraction. J. Chromatogr. B 877, 773-783 (2009).
34. Xu N, Qiu C, Wang W et al. HPLC-MS/MS for quantifcation of two types of neurotransmitters in rat brain and application: Myocardial ischemia and protection of Sheng-Mai-San. J. Pharm. Biomed. Anal. 55 (1), 101-108 (2011).
35. Wong YC, Wo SK, Zuo Z. Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC-MS/MS. J. Pharm. Biomed. Anal. 58, 83-93 (2012).
36. Yu C, Penn LD, Hollembaek J, Li W, Cohen LH. Enzymatic tissue digestion as an alternative sample preparation approach for quantitative ana lysis using liquid chromatography-tandem mass spectrometry. Anal. Chem. 76, 1761-1767 (2004). (Pubitemid 38338426)
37. Safarpour H, Connolly P, Tong X, Bielawski M, Wilcox E. Overcoming extractability hurdles of a 14C labeled taxane analogue milataxel and its metabolite from xenograft mouse tumor and brain tissues. J. Pharm. Biomed. Anal. 49, 774-779 (2009).
38. Jiang H, Zeng J, Zheng N et al. A Convenient strategy for quantitative determination of drug concentrations in tissue homogenates using a liquid chromatography-tandem mass spectrometry assay for plasma samples. Anal. Chem. 83, 6237-6244 (2011).
39. Hansen RJ, Samber BJ, Gustafson DL. Rapid and sensitive LC-MS/MS method for determination of felbamate in mouse plasma and tissues and human plasma. J. Chromatogr. B 878, 3432-3436 (2010).
40. Tamvakopoulos CT, Colwell LF, Barakat K, Fenyk-Melody J, Griffn PR, Nargund R et al., Determination of brain and plasma drug concentrations by liquid chromatography-tandem mass spectrometry. Rapid Commun. Mass Spectrom. 14, 1729-1735 (2000).
41. Zagol-Ikapitte I, Amarnath V, Jadhav S, Oatesa JA, Boutaud S. Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies. J. Chromatogr. B 879, 1098-1104 (2011).
42. Pisano R, Breda M, Grassi S, James CA. Hydrophilic interaction liquid chromatography-APCI-mass spectrometry determination of 5-fuorouracil in plasma and tissues. J. Pharm. Biomed. Anal. 38, 738-745 (2005). (Pubitemid 40835574)
43. Sun F, Ong JC-L, Yu Q, Chan E. Quantifcation of 3-deazaneplanocin A, a novel epigenetic anticancer agent, in rat biosamples by hydrophilic interaction liquid chromatography-tandem mass spectrometric detection. J. Chromatogr. B 879(3-4), 285-290 (2011).
44. Bi H, Law FCP, Zhong G et al. Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method. Biomed. Chrom. 21, 473-479 (2007). (Pubitemid 46744732)
45. Zhao Y, Yu Z, Zhang L et al. Simultaneous determination of homoeriodictyol-7-O-b-D-glccopyranosideand its metabolite homoeriodictyol in rat tissues and urine byliquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 44, 293-300 (2007). (Pubitemid 46551598)
46. Tong X, Zhou J, Tan Y. Liquid chromatography-tandem triple-quadrupole mass spectrometry for determination of paclitaxel in rat tissues. Rapid Commun. Mass Spectrom. 20, 1905-1912 (2006). (Pubitemid 43893344)
47. Garimella TS, Ross DD, Bauer KS. Liquid chromatography method for the quantitation of the breast cancer resistance protein ABCG2 inhibitor fumitremorgin C and its chemical analogues in mouse plasma and tissues. J. Chromatogr. B 807(2), 203-208 (2004). (Pubitemid 38759983)
48. Jia Y, Xie H, Wang G et al. Quantitative determination of helicid in rat biosamples by liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. B 878(9-10), 791-797 (2010).
49. Wang C, Wang S, Chen Q, He L. A capillary gas chromatography-selected ion monitoring mass spectrometry method for the ana lysis of atractylenolide I in rat plasma and tissues, and application in a pharmacokinetic study. J. Chromatogr. B 863(2), 215-222 (2008).
50. Zimmer D, Muschalek V, Muller C. Determination of metrifonate enantiomers in blood and brain samples using liquid chromatography on a chiral stationary phase coupled to tandem mass spectrometry. Rapid Commun. Mass Spectrom. 14, 1425-1432 (2000). (Pubitemid 30621971)
51. Serrano E, Pozo OJ, Beltrán J, Hernández F, Font L, Miquel M, Aragon CMG. Liquid chromatography-tandem mass spectrometry determination of (4S, 2RS)-2, 5, 5-trimethylthiazolidine-4-carboxylic acid, a stable adduct formed between D-(-)-penicillamine and acetaldehyde (main biological metabolite of ethanol), in plasma, liver and brain rat tissues. Rapid Commun. Mass Spectrom. 21, 1221-1229 (2007). (Pubitemid 46506576)
52. Scheidweiler KB, Barnes AJ, Huestis MA. A validated gas chromatographic electron impact ionization mass spectrometric method for methamphetamine, methylenedioxy-methamphetamine (MDMA), and metabolites in mouse plasma and brain. J. Chromatogr. B 876(2), 266-276 (2008).
53. Rodriguez-Gutierrez G, Wood S, Guzman JFB, Duthie GG, De Roos B. Determination of 3, 4-dihydroxyphenylglycol, hydroxytyrosol and tyrosol purifed from olive oil by-products with HPLC in animal plasma and tissues. Food Chemistry 12 6 (4), 1948-1952 (2011).
54. Lehtonen M, Storvik M, Malinen H et al. Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry. J. Chromatogr. B 879, 677-694 (2011).
55. Yue H, Jansen SA, Kenneth I et al. A liquid chromatography/mass spectrometric method for simultaneous ana lysis of arachidonic acid and its endogenous eicosanoid metabolites prostaglandins, dihydroxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and epoxyeicosatrienoic acids in rat brain tissue. J. Pharm. Biomed. Anal. 43, 1122-1134 (2007). (Pubitemid 46185820)
56. Yamaguchi J, Matsuno Y, Hachiuma K, Ogawa N, Higuchi S. A strategy for quantitative bioana lysis of non-polar neutral compounds by liquid chromatography-electrospray ionization tandem mass spectrometry: determination of TS-962, a novel acyl-CoA: cholesterol acyltransferase inhibitor, in rabbit aorta and liver tissues. Rapid Commun. Mass Spectrom. 15, 629-636 (2001). (Pubitemid 32391099)
57. Teshima K, Kondo T. Analytical method for determination of allylic isoprenols in rat tissues by liquid chromatography-tandem mass spectrometry following chemical derivatization with 3-nitrophtalic anhydride. J. Pharm. Biomed. Anal. 47, 560-566 (2008).
58. Wang P, Qi M, Jin X. Determination of roxithromycin in rat lung tissue by liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 39, 618-623 (2005). (Pubitemid 41196072)
59. Maestri L, Negri S, Ferrari M et al. Determination of perfuorooctanoic acid and perfuorooctanesulfonate in human tissues by liquid chromatography- single quadrupole mass spectrometry. Rapid Commun. Mass Spectrom. 20, 2728-2734 (2006). (Pubitemid 44497402)
60. Wang L, Liu Z, Liu D, Liu C, Juan Z, Zhang N. Docetaxel-loaded-lipid- based-nanosuspensions (DTX-LNS): Preparation, pharmacokinetics, tissue distribution and antitumor activity. Int. J. Pharm. 413, 194-201 (2011).
61. Croubels S, Maes A, Baert K, De Backer P. Quantitative determination of salicylic acid and metabolites in animal tissues by liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta 529, 179-1870 (2005).
62. Cherlet M, De Baere S, De Backer P. Quantitative ana lysis of oxytetracycline and its 4-epimer in calf tissues by highperformance liquid chromatography combined with positive electrospray ionization mass spectrometry. Analyst 128, 871-878 (2003a). (Pubitemid 36897876)
63. Shao B, Jia X, Wu Y, Hu J, Tu X, Zhang J. Multi-class confrmatory method for analyzing trace levels of tetracyline and quinolone antibiotics in pig tissues by ultra-performance liquid chromatography coupled with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 21, 3487-3496 (2007). (Pubitemid 350033329)
64. Cherlet M, Schelkens M, Croubels S, De Backeret P. Quantitative multi-residue ana lysis of tetracyclines and their 4-epimers in pig tissues by high-performance liquid chromatography combined with positive-ion electrospray ionization mass spectrometry. Anal. Chim. Acta 492, 199-213 (2003). (Pubitemid 37101399)
65. Cherlet M, De Backer P, Croubels S. Control of the keto-enol tautomerism of chlortetracycline for its straightforward quantitation in pig tissues by liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. A 1133, 135-141 (2006). (Pubitemid 44573163)
66. Takach EJ, Zhu Q, Yu S et al. New technology in tissue homogenization: using focused acoustic energy to improve extraction effciency of drug compounds prior to LC-MS/MS ana lysis. Presented at: 52nd ASMS Conference on Mass Spectrometry. TN, USA, 23-27 May 2004.
67. Bobeldijk I, Hekman M, derWeij J de V et al. Quantitative profling of bile acids in biofuids and tissues based on accurate mass high resolution LC-FT-MS: compound class targeting in a metabolomics workfow. J. Chromatogr. B 871, 306-313 (2008).
68. Oliveira LT, Garcia GM, Kano EK, Tedesco AC, Mosqueira VCF. HPLC-FLD methods to quantify chloroaluminum phthalocyanine in nanoparticles, plasma and tissue: application in pharmacokinetic and biodistribution studies. J. Pharm. Biomed. Anal. 56 (1), 70-77 (2011).
69. Ebling WF, Milis-Williams L, Harapat SR, Stanski DR. High-performance liquid chromatographic method for determining thiopental concentrations in twelve rat tissues: application to physiologic modeling of disposition of barbiturate. J. Chromatogr. 490, 339-353 (1989). (Pubitemid 19147233)
70. Estella-Hermoso de Mendoza A, Imbuluzqueta I, Campanero MA. et al. Development and validation of ultra high performance liquid chromatography-mass spectrometry method for LBH589 in mouse plasma and tissues. J. Chromatogr. B 879 3490-3496 (2011).
71. Otaegui D, Rodrguez-Gascon A, Zubia A, Cosslo F P, Pedraz JL. Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of Kendine 91, a novel histone deacetylase inhibitor, in mice plasma and tissues: Application to a pharmacokinetic study. J. Chromatogr. B 870, 109-116 (2008).
72. Van Eeckhout N, Perez JC, Van Peteghem C. Determination of eight sulfonamides in bovine kidney by liquid chromatography-tandem mass spectrometry with on-line extraction and sample clean-up. Rapid Commun. Mass Spectrom. 14, 2331-2338 (2000). (Pubitemid 32001085)
73. Van Eeckhout N, Perez JC, Van Peteghem C et al. Determination of tetracyclines in bovine kidney by liquid chromatography-tandem mass spectrometry with on-line extraction and cleanup. Rapid Commun. Mass Spectrom. 14, 280-285 (2000b). (Pubitemid 30097639)
74. Van den hauwea O, Dumoulina F, Elliottb C, Van Peteghem C. Detection of synthetic glucocorticoid residues in cattle tissue and hair samples after a single dose administration using LC-MS/MS. J. Chromatogr. B 817, 215-223 (2005). (Pubitemid 40430986)
75. Fagerquist CK, Lightfeld AR. Confrmatory ana lysis of b-lactam antibiotics in kidney tissue by liquid chromatography/electrospray ionization selective reaction monitoring ion trap tandem mass spectrometry. Rapid Commun. Mass Spectrom. 17, 660-671 (2003). (Pubitemid 36373165)
76. Heller DN, Michelle L, Smith O, Chiesa A. LC-MS/MS measurement of penicillin G in bovine plasma, urine, and biopsy samples taken from kidneys of standing animals. J. Chromatogr. B 830, 91-96 (2006).
77. Heller DN, Peggins JO, Cristina B et al. LC-MS/MS measurement of gentamicin in bovine plasma, urine, milk, and biopsy samples taken from kidneys of standing animals. J. Chromatogr. B 821, 22-30 (2005). (Pubitemid 40779581)
78. Barattè S, Sarati S, Frigerio E, James CA, Yeb C, Zhang Q. Quantitation of SU11248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatography with tandem mass spectrometry following semi-automated liquid-liquid extraction. J. Chromatogr. A 1024, 87-94 (2004). (Pubitemid 37532538)
79. Khan S, Ahmad A, Wei Guo et al. A simple and sensitive LC-MS/MS assay for 7-ethyl-10-hydroxycamptothecin (SN-38) in mouse plasma and tissues: application to pharmacokinetic study of liposome entrapped SN-38 (LE-SN38). J. Pharm. Biomed. Anal. 37, 135-142 (2005). (Pubitemid 40138726)
80. Delinsky AD, Delinsky DC, Muralidhara S et al. Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry. Rapid Commun. Mass Spectrom 19, 1075-1083 (2005). (Pubitemid 40589029)
81. Spoto B, Fezza F, Parlongo G et al. Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. Biochimie 88(12), 1889-1897 (2006). (Pubitemid 44881190)
82. Kadam RS, Kompella UB. Cassette ana lysis of eight beta-blockers in bovine eye sclera, choroid-RPE, retina, and vitreous by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 877, 253-260 (2009).
83. Kadam RS, Kompella UB. Infuence of lipophilicity on drug partitioning into sclera, choroid-retinal pigment epithelium, retina, trabecular meshwork, and optic nerve. J. Pharmacol. Exp. Ther. 332 (3), 1107-1120 (2010).
84. Johnson RD, Lewis RJ. Quantitation of atenolol, metoprolol, and propranolol in postmortem human fuid and tissue specimens via LC-APCI-MS. Forensic Sci. Int. 156, 106-117 (2006). (Pubitemid 43061251)
85. Bardin S, Guo W, Johnson JL et al. Liquid chromatographic-tandem mass spectrometric assay for the simultaneous quantifcation of Camptosar® and its metabolite SN-38 in mouse plasma and tissues. J. Chromatogr. A 1073, 249-255 (2005). (Pubitemid 40544495)
86. Vinci F, Guadagnuolo G, Danese V, Salini M, Serpe L, Gallo P. In-house validation of a liquid chromatography/electrospray tandem mass pectrometry method for confrmation of chloramphenicol residues in muscle according to Decision 2002/657/EC. Rapid Commun. Mass Spectrom. 19, 3349-3355 (2005). (Pubitemid 41682065)
87. Hermo MP, Barrón D, Barbosa J. Development of analytical methods for multiresidue determination of quinolones in pig muscle samples by liquid chromatography with ultraviolet detection, liquid chromatography-mass spectrometry and liquid chromagraphy-tandem mass spectrometry. J. Chromatogr. A 1104, 132-139 (2006). (Pubitemid 43099884)
88. Jimenez-Diaz I, Vela-Soria F, Zafra-Gomez A et al. A new liquid chromatography-tandem mass spectrometry method for determination of parabens in human placental tissue samples. Talanta 84(3), 702-709 (2011).
89. Jimenez-Diaz I, Zafra-Gomez A, Ballesteros O et al. Determination of bisphenol A and its chlorinated derivatives in placental tissue samples by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 878(32), 3363-3369 (2010).
90. Priyanthi RMA, Dassanayake S, Wei H, Chen RC, Li A. Optimization of the matrix solid phase dispersion extraction procedure for the Analysis of polybrominated diphenyl ethers in human placenta. Anal. Chem. 81, 9795-9801 (2009).
91. Getie M, Neubert RHH. LC-MS determination of desmopressin acetate in human skin samples. J. Pharm. Biomed. Anal. 35, 921-927 (2004). (Pubitemid 38757683)
92. Ji AJ, Saunders J P, Amorusi P et al. A sensitive human bone assay for quantitation of tigecycline using LC-MS/MS. J. Pharm. Biomed. Anal. 48(3), 866-875 (2008).
93. Favretto D, Frison G, Vogliardi S, Ferrara SD. Potentials of ion trap collisional spectrometry for liquid chromatography-electrospray ionization tandem mass spectrometry determination of buprenorphine and nor-buprenorphine in urine, blood and hair samples. Rapid Commun. Mass Spectrom. 20, 1257-1265 (2006).
94. Jemal M, Ouyang Z, Xia YQ. Systematic LC-MS/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well throught-out chromatography. Biomed. Chrom. 24, 2-19 (2010).
95. Liu G, Snapp HM, Ji QC, Arnold ME. Strategy of accelerated method development for high-throughput bioanalytical assays using ultra high-performance liquid chromatography coupled with mass spectrometry. Anal. Chem. 81, 9225-9232 (2009).
96. Xue YJ, Melo B, Vallejo M, Zhao Y, Tang L, Chen YS et al. An integrated bioanalytical method development and validation approach: case studies. Biomed. Chrom. doi:10.10 02/bmc.2682 (2012) (Epub ahead of print).
97. Woods AS, Jackson SN, Brian tissue lipidomics: direct probing using matrix-assisted laser desorption/ionization mass spectrometry. AAPS J. 8(2), E391-E395 (2006). (Pubitemid 43884214)
98. Cunanan CM, Cabilinget CM, Dinh TT et al. Tissue characterization and calcifcation potential of commercial bioprodthetic heart valves. Ann. Thorac. Surg. 71, S417-421 (2001).
99. Patel BA, Arundell M, Parker KH, Yeoman MS, O'hare D. Simple and rapid determination of serotonin and catecholamines in biological tissue using high performance liquid chromatography with electrochemical detection. J. Chromatogr. B 818(2), 269-276 (2005). (Pubitemid 40340121)
100. Shen Y, Yin C, Su M, Tu J. Rapid, sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantifcation of topically applied azithromycin in rabbit conjunctiva tissues. J. Pharm. Biomed. Anal. 52, 99-104 (2010).
101. Gao H, Thompson S, Verollet R, Duval A. New tool refnes tissue homogenization. Genet. Engin. Biotechnol. 27(19), 28 (2007).
102. Zhao M, Hartke C, Jimeno A et al. Specifc method for determination of geftinib in human plasma, mouse plasma and tissues using high performance liquid chromatography coupled to tandem mass spectrometry. J. Chromatogr. B 819, 73-80 (2005). (Pubitemid 41583164)
103. Wang H, Manicke NE, Yang Q et al. Direct ana lysis of biological tissue by paper spray mass spectrometry. Anal. Chem. 83 (4), 1197-1201 (2011).
104. Alnouti Y, Lewis SR, White CA, Bartlett MG. Simultaneous determination of zidovudine and lamivudine from rat tissues by liquid chromatography-tandem mass spectrometry. Rapid Commun. Mass Spectrom. 19, 503-508 (2005). (Pubitemid 40269535)
105. Mendoza FJ, Martinez-Moreno J, Almaden Y et al. Effect of calcium and the calcimimetic AMG 641 on Matrix-Gla protein in vascular smooth muscle cells. Calcifed Tissue Int. 88 (3), 169-178 (2011).
106. Annola K, Keski-Rahkonen P, Vähäkangas K, Lehtonen M. Simultaneous determination of acrylamide, its metabolite glycidamide and antipyrine in human placental perfusion fuid and placental tissue by liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. B, 876, 191-198 (2008).
107. Blum M, Dolnikowski G, Seyoum E et al. Vitamin D-3 in fat tissue. Endocrine 33(1), 90-94 (2008).
108. Xiong H, Bi H, Wen Y et al. Determination of SYUIQ-F5, a Novel telomerase inhibitor and anti-tumor lead-compound, in tissues and plasma samples by LC-MS/MS: Application to a tissue distribution study in rat. Chromatographia 73(11-12), 1073-1080 (2011).
109. Nguyen L, Zhong WZ, Painter CL, Zhang C, Rahavendran SV, Shen ZZ. Quantitative analysis of PD 0332991 in xenograft mouse tumor tissue by a 96-well supported liquid extraction format and liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 53(3), 228-234 (2010).
110. Keller JH, Karas M, Muller WE et al. Determination of hyperforin in mouse brain by high-performance liquid chromatography-tandem mass spectrometry. Anal. Chem. 75, 6084-6088 (2003). (Pubitemid 37420598)
111. Zirrolli JA, Bradshaw EL, Long ME, Gustafson DL. Rapid and sensitive LC-MS/MS ana lysis of the novel tyrosine kinase inhibitor ZD6474 in mouse plasma and tissues. J. Pharm. Biomed. Anal. 39, 705-711 (2005). (Pubitemid 41196086)
112. Ahmadkhaniha R, Shafee A, Rastkari N, Kobarfard F. Accurate quantifcation of endogenous androgenic steroids in cattle's meat by gas chromatography-mass spectrometry using a surrogate analyte approach. Anal. Chim. Acta 631(1), 80-86 (2009).
113. Korecka M, Clark CM, Lee VMY, Trojanowski JQ, Shaw LM. Simultaneous HPLCMS-MS quantifcation of 8-iso-PGF(2 a) and 8, 12-iso-iPF(2 a) in CSF and brain tissue samples with on-line cleanup. J. Chromatogr. B 878(24), 2209-2216 (2010).
114. Solon EG, Balani SK, Luo G et al. Interaction of ritonavir on tissue distribution of a [14C] L-valinamide, a potent human immunodefciency virus-1 protease inhibitor, in rats using quantitative whole-body autoradiography. Drug Metab. Dispos. 30, 1164-1169 (2002). (Pubitemid 35265821)
115. Potchoiba MJ, Nocerini MR. Utility of whole-body autoradioluminography in drug discovery for the quantifcation of tritiumlabeled drug candidates. Drug Metab. Dispos. 32, 1190-1198 (2004). (Pubitemid 39287595)
116. Skotland T, Hustvedt SO, Oulie I et al. NC100668, a new tracer for imaging of venous thromboembolism: disposition and metabolism in rats. Drug Metab. Dispos. 34, 111-120 (2006). (Pubitemid 43042652)
117. Yu RZ, Kim T-W, An HA, Watanabe TA, Gaus HJ, Geary RS. Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100. Drug Metab. Dispos. 35, 460-468 (2007). (Pubitemid 46333910)
118. Hopfgartner GEV, Markus S. Matrix-assisted laser desorption/ionization mass spectrometric imaging of complete rat sections using a triple quadrupole linear ion trap. Rapid Commun. Mass Spectrom. 23, 733-736 (2009).
119. Fehniger TE, Vegvari A, Rezeli M et al. Direct demonstration of tissue uptake of an inhaled drug: proof-of-principle study using matrix-assisted laser desorption ionization mass spectrometry imaging. Anal. Chem. 83(21), 8329-8336 (2011).
120. Takai N, Tanaka Y, Inazawa K, Saji H. Quantitative ana lysis of pharmaceutical drug distribution in multiple organs by imaging mass spectrometry. Rapid Commun. Mass Spectrom. 26, 1549-1556 (2012).
121. Castellino S, Groseclose MR, Wagner D. MALDI imaging mass spectrometry: bridging biology and chemistry in drug development. Bioanalysis 3(21), 2427-2441 (2011).
122. Ye H, Greer T, Li L. From pixel to voxel: a deeper view of biological tissue by 3D mass spectral imaging. Bioanalysis 3(3), 313-332 (2011).
123. Liu J, Cooks RG, Ouyang Z. Biological tissue diagnostics using needle biopsy and spray ionization mass spectrometry. Anal. Chem. 83 (24), 9221-9225 (2011).
124. Serkova NJ, Brown MS. Quantitative ana lysis in magnetic resonance spectroscopy: from metabolic profling to in vivo biomarkers. Bioanalysis 4(3), 321-341 (2012).
125. Lucas LH, Wilson SF, Lunte CE et al. Concentration profling in rat tissue by high-resolution magic-angle spinning NMR spectroscopy: investigation of a model drug. Anal. Chem. 77(9), 2978-2984 (2005). (Pubitemid 40617349)
126. James CA, Breda M, Baratte S et al. Analysis of drugs and metabolites in tissues and other solid matrices. Chromatographia 59(Suppl. 2), S149-S156 (2004).
127. Tamvakopoulos CS, Colwell L F, Barakat K et al. Determination of brain and plasma drug concentrations by liquid chromatography-tandem mass spectrometry. Rapid Commun. Mass Spectrom. 14, 1729-1735 (2000).
128. Chen QH, Zeng Y, Kuang JC et al. Quantifcation of aesculin in rabbit plasma and ocular tissues by high performance liquid chromatography using fuorescent detection: Application to a pharmacokinetic study. J. Pharm. Biomed. Anal. 55, 161-167 (2011).
129. Josefsson M, Kronstrand R, Andersson J, Roman M. Evaluation of electrospray ionisation liquid chromatography-tandem mass spectrometry for rational determination of a number of neuroleptics and their major metabolites in human body fuids and tissues. J. Chromatogr. B 789, 151-167 (2003). (Pubitemid 36513796)
130. Savage RE, Hall T, Bresciano K, Bailey J, Starace M, Chan TCK. Development and validation of a liquid chromatography-tandem mass spectrometry
131. US Department of Health and Human Services, US FDA, Center for Drug Evaluation and Research. Guidance for industry: Bioanalytical Method Validation. Rockville, MD, USA (2001).
132. Viswanathan CT, Bansal S, Booth B et al. Workshop/conference report-quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays. AAPS J. 9 (1), E30-E42 (2007). (Pubitemid 46296546)
133. DeMuth JE, Hayes MJ, Amaravadi L et al. Summary of the eleventh annual University of Wisconsin Land O'Lakes bioanalytical conference. Bioanalysis 2(10), 1677-1681 (2010).
134. Savoie N, Garofolo F, van Amsterdam P et al. Recent issues in regulated bioana lysis and global harmonization of bioanalytical guidance. Bioanalysis 2 (12), 1945-1960 (2010).
135. Garofolo F, Rocci ML Jr, Dumont I et al. Recent issues in bioana lysis and regulatory fndings from audits and inspections. Bioanalysis 3(18), 2081-2096 (2011).
136. Breda M, Garofolo F, Caturla MC et al. The 3rd Global CRO Council for Bioana lysis at the International Rid bioanalytical forum. Bioanalysis 3(24), 2721-2727 (2011).
137. Tudan C, Rogenthien S, Jones A. SQA opinion paper on global harmonization of the Bioanalytical Method Validation guidances. Bioanalysis 2 (12), 1921-1925 (2010).
138. Lee J W, Weiner RS, Sailstad JM et al. Fit-for-Purpose method development and validation for successful biomarker measurement. Pharm. Res. 23(2), 312-328 (2006). (Pubitemid 43237862)
139. Timmerman P, Anders KM, Gordon B, Laakso S, Freisleben A, Hucker R. Best practices in a tiered approach to metabolite quantifcation: views and recommendations of the European Bioanalysis Forum. Bioanalysis 2 (7), 1185-1194 (2010).