Quantification of 3-deazaneplanocin A, a novel epigenetic anticancer agent, in rat biosamples by hydrophilic interaction liquid chromatography-tandem mass spectrometric detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 3-4, 2011, Pages 285-290

  Sun, Feng ^a   Ong, Jasmine Chiat Ling ^a   Yu, Qiang ^b   Chan, Eli ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

3 Deazaneplanocin A; Excretion studies; LC MS MS; Pharmacokinetics; Rat biosamples; Tissue distribution

Indexed keywords

3-DEAZANEPLANOCIN A; AGILENT; ANALYTES; ANTI-CANCER AGENTS; ANTITUMOR DRUGS; BIO-SAMPLES; BIOANALYTICAL METHODS; EXCRETION STUDIES; EXTRACTION RECOVERY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; INTERNAL STANDARDS; LC-MS/MS; LIMIT OF QUANTIFICATIONS; MATRIX EFFECTS; MULTIPLE REACTION MONITORING; PHARMACOKINETIC STUDIES; PHENYLBORONIC ACIDS; POSITIVE ION MODE; RELATIVE STANDARD DEVIATIONS; SOLID-PHASE EXTRACTION; TANDEM MASS SPECTROMETRIC DETECTION; TISSUE DISTRIBUTION; TISSUE SAMPLES;

COLUMN CHROMATOGRAPHY; HYDROPHILICITY; IONIC LIQUIDS; LIQUID CHROMATOGRAPHY; ORGANIC ACIDS; PHARMACOKINETICS; POSITIVE IONS; TISSUE;

EXTRACTION;

3 DEAZANEPLANOCIN A; ANTINEOPLASTIC AGENT; BENZENEBORONIC ACID; TUBERCIDIN;

ACCURACY; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG FECES LEVEL; DRUG TISSUE LEVEL; DRUG URINE LEVEL; EPIGENETICS; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIMIT OF QUANTITATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ADENOSINE; ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, LIQUID; DIGESTIVE SYSTEM; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LEAST-SQUARES ANALYSIS; LUNG; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; TUBERCIDIN;

RATTUS;

EID: 78751704011     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.12.009     Document Type: Article

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