Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: Application to in vivo pharmacokinetics studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 15-16, 2011, Pages 1098-1104

  Zagol Ikapitte, Irene ^a   Amarnath, Venkataraman ^a   Jadhav, Satyawan ^b   Oates, John A ^a   Boutaud, Olivier ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b Glenmark Pharmaceuticals Limited   (India)

Author keywords

1,1' Thiocarbonyldiimidazole (TCDI); 3 Methoxysalicylamine (3 MoSA); Hexylsalicylamine (HxSA); LC MS MS; Mouse tissue; Pharmacokinetics

Indexed keywords

1,1'-THIOCARBONYLDIIMIDAZOLE (TCDI); 3-METHOXYSALICYLAMINE (3-MOSA); HEXYLSALICYLAMINE (HXSA); LC-MS/MS; MOUSE TISSUE;

DRUG PRODUCTS; ELECTROSPRAY IONIZATION; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; POSITIVE IONS; TISSUE;

LIQUID CHROMATOGRAPHY;

3 METHOXYSALICYLAMINE; SALICYLAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CHEMICAL ANALYSIS; ELECTROSPRAY MASS SPECTROMETRY; MOLECULAR STABILITY; MOUSE; NONHUMAN; NONLINEAR SYSTEM; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; TISSUE LEVEL;

ADMINISTRATION, ORAL; AMINOSALICYLIC ACIDS; ANIMALS; BENZYLAMINES; BRAIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, LIQUID; INJECTIONS, INTRAPERITONEAL; LINEAR MODELS; MALE; MICE; MICE, INBRED C57BL; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 79955006761     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.03.026     Document Type: Article

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