Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry

Volumn 14, Issue 19, 2000, Pages 1729-1735

  Tamvakopoulos, C S ^a   Colwell, L F ^a   Barakat, K ^a   Fenyk Melody, J ^a   Griffin, P R ^a   Nargund, R ^a   Palucki, B ^a   Sebhat, I ^a   Shen, X ^a   Stearns, R A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; LIQUID CHROMATOGRAPHY;

ANALYTES; BRAIN HOMOGENATES; DRUG CONCENTRATION; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; PLASMA DRUG CONCENTRATION; SIMPLE++; SINGLE COMPOUND; SPECIFIC CLASS;

MASS SPECTROMETRY;

DRUG;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG DOSAGE FORM; DRUG ISOLATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NONHUMAN; PHARMACOKINETICS; RAT; RAT STRAIN; STANDARD; TANDEM MASS SPECTROMETRY;

EID: 0033794877     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0231(20001015)14:19<1729::AID-RCM85>3.0.CO;2-5     Document Type: Article

References (11)