Sensitive quantitation of reboxetine enantiomers in rat plasma and brain, using an optimised reverse phase chiral LC-MS/MS method

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 1, 2009, Pages 133-139

  Turnpenny, Paul ^a   Fraier, Daniela ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Electrospray ionisation; Enantiomers; R,R reboxetine; Racemate; S,S reboxetine

Indexed keywords

ACETIC ACID; AMMONIUM CARBONATE; BORIC ACID; FORMIC ACID; REBOXETINE; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHIRAL CHROMATOGRAPHY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; ENANTIOMER; FLOW RATE; HOMOGENATE; LIQUID LIQUID EXTRACTION; NONHUMAN; PH; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BRAIN CHEMISTRY; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FREEZING; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; MORPHOLINES; QUALITY CONTROL; RATS; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

EID: 58249136291     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.10.033     Document Type: Article

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