Quantitation of SU11248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction

Journal of Chromatography A

Volumn 1024, Issue 1-2, 2004, Pages 87-94

  Baratte S ^a   Sarati, S ^a   Frigerio, E ^a   James, C A ^a   Ye, C ^b   Zhang, Q ^b  

^a PFIZER INC   (United States)

^b SUGEN INC   (United States)

Author keywords

Enzyme inhibitors; SU11248

Indexed keywords

AMMONIUM COMPOUNDS; LIQUID CHROMATOGRAPHY; PH EFFECTS;

ANTICANCER DRUGS; ROBOTIC LIQUID HANDLERS;

TISSUE;

PROTEIN TYROSINE KINASE INHIBITOR; SUNITINIB; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; INDOLE DERIVATIVE; PROTEIN TYROSINE KINASE; PYRROLE DERIVATIVE;

ANALYTIC METHOD; ANIMAL TISSUE; BRAIN; CALIBRATION; CONFERENCE PAPER; CONTROLLED STUDY; EVALUATION; KIDNEY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; LIVER; MONKEY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STANDARDIZATION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS; ANIMAL; ARTICLE; DRUG ANTAGONISM; HAPLORHINI; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STANDARD; TISSUE DISTRIBUTION; VALIDATION STUDY;

ANIMALIA;

ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, LIQUID; ENZYME INHIBITORS; HAPLORHINI; INDOLES; MASS SPECTROMETRY; PROTEIN-TYROSINE KINASES; PYRROLES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

EID: 0347480511     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2003.10.085     Document Type: Conference Paper

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