A capillary gas chromatography-selected ion monitoring mass spectrometry method for the analysis of atractylenolide I in rat plasma and tissues, and application in a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 863, Issue 2, 2008, Pages 215-222

  Wang, Changhe ^a   Wang, Sicen ^a   Chen, Qinhua ^a   He, Langchong ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Atractylenolide I; GC MS; Pharmacokinetics; Protein binding; Tissue distribution

Indexed keywords

BOVINE SERUM ALBUMIN; PHARMACOKINETIC STUDY;

MASS SPECTROMETRY; PARAMETER ESTIMATION; PLASMA (HUMAN); PROTEINS; TISSUE;

GAS CHROMATOGRAPHY;

ATRACTYLENOLIDE; ATRACTYLODES MACROCEPHALA EXTRACT; BOVINE SERUM ALBUMIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; CALIBRATION; CAPILLARY GAS CHROMATOGRAPHY; CEREBELLUM; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; HEART; HUMAN; ION MONITORING; KIDNEY; LIQUID LIQUID EXTRACTION; LIVER; LUNG; MALE; MASS SPECTROMETRY; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; SPLEEN;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; ATRACTYLODES; CALIBRATION; CEREBRUM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; KIDNEY; LACTONES; LIVER; LUNG; MALE; MYOCARDIUM; PLANT ROOTS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SESQUITERPENES; SPLEEN; TISSUE DISTRIBUTION;

BOVINAE; RATTUS;

EID: 39749185891     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.01.004     Document Type: Article

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