Signaling pathways bridging microbial-triggered inflammation and cancer

Cellular Signalling

Volumn 25, Issue 2, 2013, Pages 403-416

  Kipanyula, Maulilio John ^a   Seke Etet, Paul Faustin ^b   Vecchio, Lorella ^c   Farahna, Mohammed ^b   Nukenine, Elias Nchiwan ^d   Nwabo Kamdje, Armel Hervé ^d,e  

^a SOKOINE UNIVERSITY OF AGRICULTURE   (Tanzania)

^b QASSIM UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF PAVIA   (Italy)

^d UNIVERSITY OF NGAOUNDERE   (Cameroon)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cancer; Carcinogenesis; Infection; Inflammation; Microbe; Signaling pathways

Indexed keywords

CYCLOOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 26; INTERLEUKIN 28; INTERLEUKIN 29; INTERLEUKIN 32; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN TYROSINE KINASE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 11; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

B CELL LYMPHOMA; BACTERIAL VIRULENCE; CANCER CELL; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; COMMENSAL; CYTOKINE RELEASE; GENE OVEREXPRESSION; HUMAN; IMMUNOBLASTIC LYMPHOMA; INFECTION SENSITIVITY; INFLAMMATION; INNATE IMMUNITY; INTESTINE FLORA; KAPOSI SARCOMA; MARGINAL ZONE LYMPHOMA; NITRATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; T CELL LEUKEMIA; WART VIRUS;

BACTERIAL INFECTIONS; CYCLOOXYGENASE 2; CYTOKINES; HUMANS; INFLAMMATION; METAGENOME; NEOPLASMS; NF-KAPPA B; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HELICOBACTER;

EID: 84869887919     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.10.014     Document Type: Review

References (179)

1. Smolinska M.J., Page T.H., Urbaniak A.M., Mutch B.E., Horwood N.J. Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1. Journal of Immunology 2011, 187:6043-6051.
2. Jarchum I., Liu M., Shi C., Equinda M., Pamer E.G. Critical role for MyD88-mediated neutrophil recruitment during Clostridium difficile colitis. Infection and Immunity 2012, 80:2989-2996.
3. Lin Y., Yu L.X., Yan H.X., Yang W., Tang L., Zhang H.L., Liu Q., Zou S.S., He Y.Q., Wang C., Wu M.C., Wang H.Y. Gut-derived lipopolysaccharide promotes T-cell-mediated hepatitis in mice through Toll-like receptor 4. Cancer Prevention Research (Philadelphia, Pa.) 2012, 5:1090-1102.
4. Duckworth C.A., Clyde D., Pritchard D.M. CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach. American Journal of Physiology. Gastrointestinal and Liver Physiology 2012, 10.1152/ajpgi.00068.
5. Rossi O., van Baarlen P., Wells J.M. Host-recognition of pathogens and commensals in the mammalian intestine. Current Topics in Microbiology and Immunology 2011, 10.1007/82_2011_191.
6. Karvellas C.J., Pink F., McPhail M., Austin M., Auzinger G., Bernal W., Sizer E., Kutsogiannis D.J., Eltringham I., Wendon J.A. Bacteremia, acute physiology and chronic health evaluation II and modified end stage liver disease are independent predictors of mortality in critically ill nontransplanted patients with acute on chronic liver failure. Critical Care Medicine 2010, 38:121-126.
7. Farooq S.M., Stadnyk A.W. Neutrophil infiltration of the colon is independent of the FPR1 yet FPR1 deficient mice show differential susceptibilities to acute versus chronic induced colitis. Digestive Diseases and Sciences 2012, 57:1802-1812.
8. Narayan C., Kumar A. Constitutive over expression of IL-1beta, IL-6, NF-kappaB, and Stat3 is a potential cause of lung tumorgenesis in urethane (ethyl carbamate) induced Balb/c mice. Journal of Carcinogenesis 2012, 11:9.
9. Saito K., Kihara K. Role of C-reactive protein in urological cancers: a useful biomarker for predicting outcomes. International Journal of Urology 2012, 10.1111/j.1442-2042.2012.03121.x.
10. Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 2001, 357:539-545.
11. Grote V.A., Kaaks R., Nieters A., Tjonneland A., Halkjaer J., Overvad K., Skjelbo Nielsen M.R., Boutron-Ruault M.C., Clavel-Chapelon F., Racine A., Teucher B., Becker S., Pischon T., Boeing H., Trichopoulou A., Cassapa C., Stratigakou V., Palli D., Krogh V., Tumino R., Vineis P., Panico S., Rodriguez L., Duell E.J., Sanchez M.J., Dorronsoro M., Navarro C., Gurrea A.B., Siersema P.D., Peeters P.H., Ye W., Sund M., Lindkvist B., Johansen D., Khaw K.T., Wareham N., Allen N.E., Travis R.C., Fedirko V., Jenab M., Michaud D.S., Chuang S.C., Romaguera D., Bueno-de-Mesquita H.B., Rohrmann S. Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort. British Journal of Cancer 2012, 106:1866-1874.
12. Wang L., Jiang Y., Zhang Y., Wang Y., Huang S., Wang Z., Tian B., Yang Y., Jiang W., Pang D. Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer. PloS one 2012, 7:e34400.
13. de Martel C., Ferlay J., Franceschi S., Vignat J., Bray F., Forman D., Plummer M. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. The Lancet Oncology 2012, 13:607-615.
14. Lopes L.V., Conceicao A.V., Oliveira J.B., Tavares A., Domingos C., Santos L.L. Cancer in Angola, resources and strategy for its control. The Pan African Medical Journal 2012, 12:13.
15. Islami F., Kamangar F. Helicobacter pylori and esophageal cancer risk: a meta-analysis. Cancer Prevention Research (Philadelphia, Pa.) 2008, 1:329-338.
16. Nagamine C.M., Rogers A.B., Fox J.G., Schauer D.B. Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice. International Journal of Cancer 2008, 122:832-838.
17. Arthur J.C., Perez-Chanona E., Muhlbauer M., Tomkovich S., Uronis J.M., Fan T.J., Campbell B.J., Abujamel T., Dogan B., Rogers A.B., Rhodes J.M., Stintzi A., Simpson K.W., Hansen J.J., Keku T.O., Fodor A.A., Jobin C. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 2012, 338(6103):120-123.
18. Ozdemir H., Ciftci E., Karbuz A., Oktay G., Aysev D., Yavuz G., Ince E. Successful treatment of multidrug-resistant Escherichia coli bacteremia with tigecycline in an acute myeloid leukemia child. The Turkish Journal of Pediatrics 2012, 54:59-60.
19. de Carvalho Parahym A.M., da Silva C.M., Leao M.P., Macario M.C., Filho G.A., de Oliveira N.T., Neves R.P. Invasive infection in an acute myeloblastic leukemia patient due to triazole-resistant Candida tropicalis. Diagnostic Microbiology and Infectious Disease 2011, 71:291-293.
20. Kurucu N., Kul S., Tosun I., Erduran E., Koksal I. Fungemia and renal fungus ball formation with Candida norvegensis in a child with acute lymphoblastic leukemia. The Turkish Journal of Pediatrics 2011, 53:448-451.
21. Marteau P., Chaput U. Bacteria as trigger for chronic gastrointestinal disorders. Digestive Diseases 2011, 29:166-171.
22. Gogia A., Bakhshi S. Plasmablastic lymphoma of oral cavity in a HIV-negative child. Pediatric Blood & Cancer 2010, 55:390-391.
23. Khan M.A., Jakate S., Komanduri S. Rare AIDS-associated plasmablastic lymphoma as the initial presentation of AIDS. Clinical Advances in Hematology and Oncology 2010, 8:55-57.
24. Compare D., Nardone G. Contribution of gut microbiota to colonic and extracolonic cancer development. Digestive Diseases 2011, 29:554-561.
25. Ohkusa T., Yoshida T., Sato N., Watanabe S., Tajiri H., Okayasu I. Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis. Journal of Medical Microbiology 2009, 58:535-545.
26. Sherman A.E., Zavros Y. Role of sonic hedgehog signaling during progression from inflammation to cancer in the stomach. World Journal of Gastrointestinal Pathophysiology 2011, 2:103-108.
27. Patwa L.G., Fan T.J., Tchaptchet S., Liu Y., Lussier Y.A., Sartor R.B., Hansen J.J. Chronic intestinal inflammation induces stress-response genes in commensal Escherichia coli. Gastroenterology 2011, 141:1842-1851.
28. Lofmark S., de Klerk N., Aro H. Neisseria gonorrhoeae infection induces altered amphiregulin processing and release. PloS one 2011, 6:e16369.
29. Li Z.H., Tang Q.B., Wang J., Zhou L., Huang W.L., Liu R.Y., Chen R.F. Hepatitis C virus core protein induces malignant transformation of biliary epithelial cells by activating nuclear factor-kappaB pathway. Journal of Gastroenterology and Hepatology 2010, 25:1315-1320.
30. Wachtler B., Citiulo F., Jablonowski N., Forster S., Dalle F., Schaller M., Wilson D., Hube B. Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PloS one 2012, 7:e36952.
31. Stadelmann B., Merino M.C., Persson L., Svard S.G. Arginine consumption by the intestinal parasite Giardia intestinalis reduces proliferation of intestinal epithelial cells. PloS one 2012, 7:e45325.
32. Chenoweth M.J., Mian M.F., Barra N.G., Alain T., Sonenberg N., Bramson J., Lichty B.D., Richards C.D., Ma A., Ashkar A.A. IL-15 can signal via IL-15Ralpha, JNK, and NF-kappaB to drive RANTES production by myeloid cells. Journal of Immunology 2012, 188:4149-4157.
33. Custovic Z., Sosa S. Focal bacterial nephritis masquerading as renal cell carcinoma: case report. Acta Clinica Croatica 2011, 50:113-114.
34. Odeh B., Bareford D. Colonic carcinoma presenting as repeated episodes of enterobacter septicaemia during induction of remission in acute myeloblastic leukaemia. BMJ 2009, 339:b4027.
35. Koulocheris P., Metzger M.C., Kesting M.R., Hohlweg-Majert B. Life-threatening complications associated with acute monocytic leukaemia after dental treatment. Australian Dental Journal 2009, 54:45-48.
36. Giulino L., Mathew S., Ballon G., Chadburn A., Barouk S., Antonicelli G., Leoncini L., Liu Y.F., Gogineni S., Tam W., Cesarman E. A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma. Blood 2011, 117:4852-4854.
37. von Hertzen L.C., Joensuu H., Haahtela T. Microbial deprivation, inflammation and cancer. Cancer and Metastasis Reviews 2011, 30:211-223.
38. Ersvaer E., Melve G.K., Bruserud O. Future perspectives: should Th17 cells be considered as a possible therapeutic target in acute myeloid leukemia patients receiving allogeneic stem cell transplantation?. Cancer Immunology, Immunotherapy 2011, 60:1669-1681.
39. Maruyama T., Kono K., Mizukami Y., Kawaguchi Y., Mimura K., Watanabe M., Izawa S., Fujii H. Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer. Cancer Science 2010, 101:1947-1954.
40. Fialova A., Partlova S., Sojka L., Hromadkova H., Brtnicky T., Fucikova J., Kocian P., Rob L., Bartunkova J., Spisek R. Dynamics of T-cell infiltration during the course of ovarian cancer: the gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells. International Journal of Cancer 2012, 10.1002/ijc.27759.
41. Seke Etet P.F., Palomba M., Colavito V., Grassi-Zucconi G., Bentivoglio M., Bertini G. Sleep and rhythm changes at the time of Trypanosoma brucei invasion of the brain parenchyma in the rat. Chronobiology International 2012, 29:469-481.
42. Amin D.N., Vodnala S.K., Masocha W., Sun B., Kristensson K., Rottenberg M.E. Distinct Toll-like receptor signals regulate cerebral parasite load and interferon alpha/beta and tumor necrosis factor alpha-dependent T-cell infiltration in the brains of Trypanosoma brucei-infected mice. Journal of Infectious Diseases 2012, 205:320-332.
43. Romani L., Puccetti P. Controlling pathogenic inflammation to fungi. Expert Review of Anti-Infective Therapy 2007, 5:1007-1017.
44. Huynh M.L., Fadok V.A., Henson P.M. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. The Journal of Clinical Investigation 2002, 109:41-50.
45. Gabillet J., Millet A., Pederzoli-Ribeil M., Tacnet-Delorme P., Guillevin L., Mouthon L., Frachet P., Witko-Sarsat V. Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation. Journal of Immunology 2012, 189:2574-2583.
46. Protti M.P., De M.L. Cross-talk within the tumor microenvironment mediates Th2-type inflammation in pancreatic cancer. Oncoimmunology 2012, 1:89-91.
47. Li S., Wang N., Brodt P. Metastatic cells can escape the proapoptotic effects of TNF-alpha through increased autocrine IL-6/STAT3 signaling. Cancer Research 2012, 72:865-875.
48. Sorensen L.T. Wound healing and infection in surgery: the pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: a systematic review. Annals of Surgery 2012, 255:1069-1079.
49. Maiuri M.C., Tajana G., Iuvone T., De S.D., Mele G., Ribecco M.T., Cinelli M.P., Romano M.F., Turco M.C., Carnuccio R. Nuclear factor-kappaB regulates inflammatory cell apoptosis and phagocytosis in rat carrageenin-sponge implant model. American Journal of Pathology 2004, 165:115-126.
50. Joo C.K., Seomun Y. Matrix metalloproteinase (MMP) and TGF beta 1-stimulated cell migration in skin and cornea wound healing. Cell Adhesion & Migration 2008, 2:252-253.
51. Ward S.V., Cadby G., Heyworth J.S., Fear M.W., Wallace H.J., Cole J.M., Wood F.M., Palmer L.J. Association of TGFbeta1 and clinical factors with scar outcome following melanoma excision. Archives for Dermatological Research 2012, 304:343-351.
52. Ganesh K., Das A., Dickerson R., Khanna S., Parinandi N.L., Gordillo G.M., Sen C.K., Roy S. Prostaglandin E2 induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway. Journal of Immunology 2012, 189:2563-2573.
53. Bitar M.S., Al-Mulla F. ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes. Disease Models & Mechanisms 2012, 5:375-388.
54. Lakshmi R.T., Priyanka T., Meenakshi J., Mathangi K.R., Jeyaraman V., Babu M. Low molecular weight heparin mediated regulation of nitric oxide synthase during burn wound healing. Annals of Burns and Fire Disasters 2011, 24:24-29.
55. Philip M., Rowley D.A., Schreiber H. Inflammation as a tumor promoter in cancer induction. Seminars in Cancer Biology 2004, 14:433-439.
56. Macarthur M., Hold G.L., El-Omar E.M. Inflammation and cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy. American Journal of Physiology. Gastrointestinal and Liver Physiology 2004, 286:G515-G520.
57. Tretyakova N.Y., Burney S., Pamir B., Wishnok J.S., Dedon P.C., Wogan G.N., Tannenbaum S.R. Peroxynitrite-induced DNA damage in the supF gene: correlation with the mutational spectrum. Mutation Research 2000, 447:287-303.
58. Mutamba J.T., Svilar D., Prasongtanakij S., Wang X.H., Lin Y.C., Dedon P.C., Sobol R.W., Engelward B.P. XRCC1 and base excision repair balance in response to nitric oxide. DNA Repair 2011, 10:1282-1293.
59. Shimizu T., Marusawa H., Endo Y., Chiba T. Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis. Cancer Science 2012, 10.1111/j.1349-7006.2012.02293.x.
60. Pollard J.W. Tumour-educated macrophages promote tumour progression and metastasis. Nature Reviews. Cancer 2004, 4:71-78.
61. Petrenko O., Moll U.M. Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway. Molecular Cell 2005, 17:225-236.
62. Gesser B., Rasmussen M.K., Raaby L., Rosada C., Johansen C., Kjellerup R.B., Kragballe K., Iversen L. Dimethylfumarate inhibits MIF-induced proliferation of keratinocytes by inhibiting MSK1 and RSK1 activation and by inducing nuclear p-c-Jun (S63) and p-p53 (S15) expression. Inflammation Research 2011, 60:643-653.
63. McCarron A.J., Armstrong C., Glynn G., Millar B.C., Rooney P.J., Goldsmith C.E., Xu J., Moore J.E. Antibacterial effects on acinetobacter species of commonly employed antineoplastic agents used in the treatment of haematological malignancies: an in vitro laboratory evaluation. British Journal of Biomedical Science 2012, 69:14-17.
64. Prabhash K., Medhekar A., Ghadyalpatil N., Noronha V., Biswas S., Kurkure P., Nair R., Kelkar R. Blood stream infections in cancer patients: a single center experience of isolates and sensitivity pattern. Indian Journal of Cancer 2010, 47:184-188.
65. Chiang M.C., Kuo S.C., Chen S.J., Yang S.P., Lee Y.T., Chen T.L., Fung C.P. Clinical characteristics and outcomes of bacteremia due to different genomic species of Acinetobacter baumannii complex in patients with solid tumors. Infection 2012, 40:19-26.
66. Roperto S., Di G.G., Leonardi L., Pagnini U., Manco E., Paciello O., Esposito I., Borzacchiello G., Russo V., Maiolino P., Roperto F. Bacterial isolates from the urine of cattle affected by urothelial tumors of the urinary bladder. Research in Veterinary Science 2012, 93(3):1361-1366.
67. Carvalho F.A., Aitken J.D., Vijay-Kumar M., Gewirtz A.T. Toll-like receptor-gut microbiota interactions: perturb at your own risk!. Annual Review of Physiology 2012, 74:177-198.
68. Kinross J., von Roon A.C., Penney N., Holmes E., Silk D., Nicholson J.K., Darzi A. The gut microbiota as a target for improved surgical outcome and improved patient care. Current Pharmaceutical Design 2009, 15:1537-1545.
69. Ubeda C., Taur Y., Jenq R.R., Equinda M.J., Son T., Samstein M., Viale A., Socci N.D., van den Brink M.R., Kamboj M., Pamer E.G. Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans. The Journal of Clinical Investigation 2010, 120:4332-4341.
70. Merline R., Moreth K., Beckmann J., Nastase M.V., Zeng-Brouwers J., Tralhao J.G., Lemarchand P., Pfeilschifter J., Schaefer R.M., Iozzo R.V., Schaefer L. Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Science Signaling 2011, 4:ra75.
71. Moreth K., Iozzo R.V., Schaefer L. Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation. Cell Cycle 2012, 11:2084-2091.
72. Gao Q., Zhao Y.J., Wang X.Y., Qiu S.J., Shi Y.H., Sun J., Yi Y., Shi J.Y., Shi G.M., Ding Z.B., Xiao Y.S., Zhao Z.H., Zhou J., He X.H., Fan J. CXCR6 upregulation contributes to a proinflammatory tumor microenvironment that drives metastasis and poor patient outcomes in hepatocellular carcinoma. Cancer Research 2012, 72:3546-3556.
73. Ochi A., Nguyen A.H., Bedrosian A.S., Mushlin H.M., Zarbakhsh S., Barilla R., Zambirinis C.P., Fallon N.C., Rehman A., Pylayeva-Gupta Y., Badar S., Hajdu C.H., Frey A.B., Bar-Sagi D., Miller G. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. The Journal of Experimental Medicine 2012, 1671-1687.
74. Uronis J.M., Muhlbauer M., Herfarth H.H., Rubinas T.C., Jones G.S., Jobin C. Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PloS one 2009, 4:e6026.
75. Azcarate-Peril M.A., Sikes M., Bruno-Barcena J.M. The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer?. American Journal of Physiology. Gastrointestinal and Liver Physiology 2011, 301:G401-G424.
76. Rogers A.B. Distance burning: how gut microbes promote extraintestinal cancers. Gut Microbes 2011, 2:52-57.
77. Shenoy A.K., Fisher R.C., Butterworth E.A., Pi L., Chang L.J., Appelman H.D., Chang M., Scott E.W., Huang E.H. Transition from colitis to cancer: high Wnt activity sustains the tumor-initiating potential of colon cancer stem cell precursors. Cancer Research 2012, 72(19):5091-5100.
78. Subramaniam D., Ramalingam S., Houchen C.W., Anant S. Cancer stem cells: a novel paradigm for cancer prevention and treatment. Mini Reviews in Medicinal Chemistry 2010, 10:359-371.
79. Zimmerman Z.F., Moon R.T., Chien A.J. Targeting Wnt pathways in disease. Cold Spring Harb. Perspectives in Biology 2012, 10.1101/cshperspect.a008086.
80. Seke Etet P.F., Vecchio L., Nwabo Kamdje A.H. Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: any role for Notch, Wnt and Hh signaling pathways?. Cellular Signalling 2012, 24:1433-1443.
81. Seke Etet P.F., Vecchio L., Bogne K.P., Nchiwan N.E., Krampera M., Nwabo Kamdje A.H. Normal hematopoiesis and hematologic malignancies: role of canonical Wnt signaling pathway and stromal microenvironment. Biochimica et Biophysica Acta 2012, 10.1016/j.bbcan.2012.08.002.
82. Li Y., Kundu P., Seow S.W., de Matos C.T., Aronsson L., Chin K.C., Karre K., Pettersson S., Greicius G. Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice. Carcinogenesis 2012, 33:1231-1238.
83. Naglova H., Bucova M. HMGB1 and its physiological and pathological roles. Bratislavské Lekárske Listy 2012, 113:163-171.
84. Wang Y.Z., Yan M., Tian F.F., Zhang J.M., Liu Q., Yang H., Zhou W.B., Li J. Possible involvement of Toll-like receptors in the pathogenesis of Myasthenia gravis. Inflammation 2012, 10.1007/s10753-012-9526-6.
85. Belinda L.W., Wei W.X., Hanh B.T., Lei L.X., Bow H., Ling D.J. SARM: a novel Toll-like receptor adaptor, is functionally conserved from arthropod to human. Molecular Immunology 2008, 45:1732-1742.
86. Valkov E., Stamp A., Dimaio F., Baker D., Verstak B., Roversi P., Kellie S., Sweet M.J., Mansell A., Gay N.J., Martin J.L., Kobe B. Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:14879-14884.
87. Lin S.C., Lo Y.C., Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 2010, 465:885-890.
88. Piao W., Song C., Chen H., Diaz M.A., Wahl L.M., Fitzgerald K.A., Li L., Medvedev A.E. Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling. Journal of Leukocyte Biology 2009, 86:863-875.
89. Tseng P.H., Matsuzawa A., Zhang W., Mino T., Vignali D.A., Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nature Immunology 2010, 11:70-75.
90. Harhaj E.W., Dixit V.M. Regulation of NF-kappaB by deubiquitinases. Immunological Reviews 2012, 246:107-124.
91. Clark K., Peggie M., Plater L., Sorcek R.J., Young E.R., Madwed J.B., Hough J., McIver E.G., Cohen P. Novel cross-talk within the IKK family controls innate immunity. Biochemical Journal 2011, 434:93-104.
92. Matta H., Gopalakrishnan R., Graham C., Tolani B., Khanna A., Yi H., Suo Y., Chaudhary P.M. Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-kappaB pathway independent of TRAF6, TAK1 and LUBAC. PloS one 2012, 7:e36601.
93. Guma M., Hammaker D., Topolewski K., Corr M., Boyle D.L., Karin M., Firestein G.S. Pro- and anti-inflammatory functions of the p38 pathway in rheumatoid arthritis: advantages of targeting upstream kinases MKK3 or MKK6. Arthritis and Rheumatism 2012, 10.1002/art.34489.
94. Das M., Sabio G., Jiang F., Rincon M., Flavell R.A., Davis R.J. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 2009, 136:249-260.
95. Mellett M., Atzei P., Jackson R., O'Neill L.A., Moynagh P.N. Mal mediates TLR-induced activation of CREB and expression of IL-10. Journal of Immunology 2011, 186:4925-4935.
96. Polumuri S.K., Jayakar G.G., Shirey K.A., Roberts Z.J., Perkins D.J., Pitha P.M., Vogel S.N. Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists. Journal of Immunology 2012, 189:50-60.
97. Banerjee A., Gerondakis S. Coordinating TLR-activated signaling pathways in cells of the immune system. Immunology and Cell Biology 2007, 85:420-424.
98. Newton K., Dixit V.M. Signaling in innate immunity and inflammation. Cold Spring Harbor Perspectives in Biology 2012, 4.
99. Shime H., Matsumoto M., Oshiumi H., Tanaka S., Nakane A., Iwakura Y., Tahara H., Inoue N., Seya T. Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:2066-2071.
100. Kingeter L.M., Lin X. C-type lectin receptor-induced NF-kappaB activation in innate immune and inflammatory responses. Cellular & Molecular Immunology 2012, 9:105-112.
101. Matta H., Gopalakrishnan R., Punj V., Yi H., Suo Y., Chaudhary P.M. A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner. Journal of Biological Chemistry 2011, 286:21555-21564.
102. Uota S., Zahidunnabi D.M., Saitoh Y., Muto S., Itai A., Utsunomiya A., Watanabe T., Yamamoto N., Yamaoka S. An IkappaB kinase 2 inhibitor IMD-0354 suppresses the survival of adult T-cell leukemia cells. Cancer Science 2012, 103:100-106.
103. Dewan M.Z., Tomita M., Katano H., Yamamoto N., Ahmed S., Yamamoto M., Sata T., Mori N., Yamamoto N. An HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells. International Journal of Cancer 2009, 124:622-629.
104. Tang Q., Qin D., Lv Z., Zhu X., Ma X., Yan Q., Zeng Y., Guo Y., Feng N., Lu C. Herpes simplex virus type 2 triggers reactivation of Kaposi's sarcoma-associated herpesvirus from latency and collaborates with HIV-1 Tat. PloS one 2012, 7:e31652.
105. Collina F., De C.A., De R.A., De R.G., Botti G., Franco R. Chlamydia psittaci in ocular adnexa MALT lymphoma: a possible role in lymphomagenesis and a different geographical distribution. Infectious Agents and Cancer 2012, 7:8.
106. Pikarsky E., Porat R.M., Stein I., Abramovitch R., Amit S., Kasem S., Gutkovich-Pyest E., Urieli-Shoval S., Galun E., Ben-Neriah Y. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004, 431:461-466.
107. Greten F.R., Eckmann L., Greten T.F., Park J.M., Li Z.W., Egan L.J., Kagnoff M.F., Karin M. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004, 118:285-296.
108. Preciado D., Caicedo E., Jhanjee R., Silver R., Harris G., Juhn S.K., Choo D.I., Ondrey F. Pseudomonas aeruginosa lipopolysaccharide induction of keratinocyte proliferation, NF-kappa B, and cyclin D1 is inhibited by indomethacin. Journal of Immunology 2005, 174:2964-2973.
109. Karin M., Cao Y., Greten F.R., Li Z.W. NF-kappaB in cancer: from innocent bystander to major culprit. Nature Reviews. Cancer 2002, 2:301-310.
110. Luo J.L., Maeda S., Hsu L.C., Yagita H., Karin M. Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell 2004, 6:297-305.
111. Yan F., Polk D.B. Disruption of NF-kappaB signalling by ancient microbial molecules: novel therapies of the future?. Gut 2010, 59:421-426.
112. Cataisson C., Salcedo R., Hakim S., Moffitt B.A., Wright L., Yi M., Stephens R., Dai R.M., Lyakh L., Schenten D., Yuspa H.S., Trinchieri G. IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis. The Journal of Experimental Medicine 2012, 209(9):1689-1702.
113. Barbisan G., Perez L.O., Contreras A., Golijow C.D. TNF-alpha and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk. Tumour Biology 2012, 33(5):1549-1556.
114. Santos J.C., Ladeira M.S., Pedrazzoli J., Ribeiro M.L. Relationship of IL-1 and TNF-alpha polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population. Brazilian Journal of Medical and Biological Research 2012, 45:811-817.
115. Sakitani K., Hirata Y., Hayakawa Y., Serizawa T., Nakata W., Takahashi R., Kinoshita H., Sakamoto K., Nakagawa H., Akanuma M., Yoshida H., Maeda S., Koike K. The role of Interleukin-32 in Helicobacter pylori-induced gastric inflammation. Infection and Immunity 2012, 80(11):3795-3803.
116. Moschen A.R., Fritz T., Clouston A.D., Rebhan I., Bauhofer O., Barrie H.D., Powell E.E., Kim S.H., Dinarello C.A., Bartenschlager R., Jonsson J.R., Tilg H. Interleukin-32: a new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis. Hepatology 2011, 53:1819-1829.
117. Lee H.J., Liang Z.L., Huang S.M., Lim J.S., Yoon D.Y., Lee H.J., Kim J.M. Overexpression of IL-32 is a novel prognostic factor in patients with localized clear cell renal cell carcinoma. Oncology Letters 2012, 3:490-496.
118. Yu Y., Gong R., Mu Y., Chen Y., Zhu C., Sun Z., Chen M., Liu Y., Zhu Y., Wu J. Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. Journal of Immunology 2011, 187:4844-4860.
119. Kargi A., Yalcin A.D., Erin N., Savas B., Polat H.H., Gorczynski R.M. IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon cancer. Clinical Laboratory 2012, 58:501-505.
120. Liu X., Fang H., Chen H., Jiang X., Fang D., Wang Y., Zhu D. An artificial miRNA against HPSE suppresses melanoma invasion properties, correlating with a down-regulation of chemokines and MAPK phosphorylation. PloS one 2012, 7:e38659.
121. Chen H., Sun Y., Wu C., Magyar C.E., Li X., Cheng L., Yao J.L., Shen S., Osunkoya A.O., Liang C., Huang J. Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway. Endocrine-Related Cancer 2012, 19:321-331.
122. Shahzad M.M., Arevalo J.M., Armaiz-Pena G.N., Lu C., Stone R.L., Moreno-Smith M., Nishimura M., Lee J.W., Jennings N.B., Bottsford-Miller J., Vivas-Mejia P., Lutgendorf S.K., Lopez-Berestein G., Bar-Eli M., Cole S.W., Sood A.K. Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis. Journal of Biological Chemistry 2010, 285:35462-35470.
123. Li S., Kendall S.E., Raices R., Finlay J.B., Covarrubias M., Liu Z., Lowe G., Lin Y.H., Teh Y.H., Leigh V., Dhillon S., Flanagan S., Aboody K.S., Glackin C.A. TWIST1 associates with NF-kappaB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production. BMC Biology 2012, 10:73.
124. Buskens C.J., Van Rees B.P., Sivula A., Reitsma J.B., Haglund C., Bosma P.J., Offerhaus G.J., Van Lanschot J.J., Ristimaki A. Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus. Gastroenterology 2002, 122:1800-1807.
125. Martey C.A., Pollock S.J., Turner C.K., O'Reilly K.M., Baglole C.J., Phipps R.P., Sime P.J. Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer. American Journal of Physiology. Lung Cellular and Molecular Physiology 2004, 287:L981-L991.
126. Oyama K., Fujimura T., Ninomiya I., Miyashita T., Kinami S., Fushida S., Ohta T., Koichi M. A COX-2 inhibitor prevents the esophageal inflammation-metaplasia-adenocarcinoma sequence in rats. Carcinogenesis 2005, 26:565-570.
127. Klein R.D., Van Pelt C.S., Sabichi A.L., Dela C.J., Fischer S.M., Furstenberger G., Muller-Decker K. Transitional cell hyperplasia and carcinomas in urinary bladders of transgenic mice with keratin 5 promoter-driven cyclooxygenase-2 overexpression. Cancer Research 2005, 65:1808-1813.
128. Abdalla S.I., Sanderson I.R., Fitzgerald R.C. Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells. Carcinogenesis 2005, 26:1627-1633.
129. DuBois R.N. Leukotriene A4 signaling, inflammation, and cancer. Journal of the National Cancer Institute 2003, 95:1028-1029.
130. De Marco F., Bucaj E., Foppoli C., Fiorini A., Blarzino C., Filipi K., Giorgi A., Schinina M.E., Di D.F., Coccia R., Butterfield D.A., Perluigi M. Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues. PloS one 2012, 7:e34366.
131. Hussain S.P., Trivers G.E., Hofseth L.J., He P., Shaikh I., Mechanic L.E., Doja S., Jiang W., Subleski J., Shorts L., Haines D., Laubach V.E., Wiltrout R.H., Djurickovic D., Harris C.C. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Research 2004, 64:6849-6853.
132. Kim Y.H., Woo K.J., Lim J.H., Kim S., Lee T.J., Jung E.M., Lee J.M., Park J.W., Kwon T.K. 8-Hydroxyquinoline inhibits iNOS expression and nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and C/EBPbeta in Raw 264.7 cells. Biochemical and Biophysical Research Communications 2005, 329:591-597.
133. Yongvanit P., Pinlaor S., Bartsch H. Oxidative and nitrative DNA damage: key events in opisthorchiasis-induced carcinogenesis. Parasitology International 2012, 61:130-135.
134. Ma N., Thanan R., Kobayashi H., Hammam O., Wishahi M., El Leithy T., Hiraku Y., Amro E., Oikawa S., Ohnishi S., Murata M., Kawanishi S. Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection. Biochemical and Biophysical Research Communications 2011, 414:344-349.
135. Chaturvedi R., de S.T., Coburn L.A., Gobert A.P., Wilson K.T. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino Acids 2012, 42:627-640.
136. Kang C.I., Chung D.R., Ko K.S., Peck K.R., Song J.H. Clinical predictors of Enterobacter bacteremia among patients admitted to the ED. The American Journal of Emergency Medicine 2012, 30:165-169.
137. Conde-Estevez D., Grau S., Albanell J., Terradas R., Salvado M., Knobel H. Clinical characteristics and outcomes of patients with vancomycin-susceptible Enterococcus faecalis and Enterococcus faecium bacteraemia in cancer patients. European Journal of Clinical Microbiology and Infectious Diseases 2011, 30:103-108.
138. Wang X., Yang Y., Moore D.R., Nimmo S.L., Lightfoot S.A., Huycke M.M. 4-hydroxy-2-nonenal mediates genotoxicity and bystander effects caused by Enterococcus faecalis-infected macrophages. Gastroenterology 2012, 142:543-551.
139. Ma Q., Cavallin L.E., Yan B., Zhu S., Duran E.M., Wang H., Hale L.P., Dong C., Cesarman E., Mesri E.A., Goldschmidt-Clermont P.J. Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:8683-8688.
140. Ke Q., Costa M. Hypoxia-inducible factor-1 (HIF-1). Molecular Pharmacology 2006, 70:1469-1480.
141. Hara T., Mimura K., Abe T., Shioi G., Seiki M., Sakamoto T. Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock. Journal of Biological Chemistry 2011, 286:32542-32551.
142. Staples K.J., Sotoodehnejadnematalahi F., Pearson H., Frankenberger M., Francescut L., Ziegler-Heitbrock L., Burke B. Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1alpha mRNA. Immunobiology 2011, 216:832-839.
143. Mimouna S., Goncalves D., Barnich N., Darfeuille-Michaud A., Hofman P., Vouret-Craviari V. Crohn disease-associated Escherichia coli promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses. Gut Microbes 2011, 2:335-346.
144. Jo S., Juhasz A., Zhang K., Ruel C., Loera S., Wilczynski S.P., Yen Y., Liu X., Ellenhorn J., Lim D., Paz B., Somlo G., Vora N., Shibata S. Human papillomavirus infection as a prognostic factor in oropharyngeal squamous cell carcinomas treated in a prospective phase II clinical trial. Anticancer Research 2009, 29:1467-1474.
145. Li G., He L., Zhang E., Shi J., Zhang Q., Le A.D., Zhou K., Tang X. Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1alpha and VEGF expression in non-small cell lung cancer cells. Cancer Letters 2011, 311:160-170.
146. Bodily J.M., Mehta K.P., Laimins L.A. Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. Cancer Research 2011, 71:1187-1195.
147. Nasimuzzaman M., Waris G., Mikolon D., Stupack D.G., Siddiqui A. Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. Journal of Virology 2007, 81:10249-10257.
148. Kim S.H., Koo B.S., Kang S., Park K., Kim H., Lee K.R., Lee M.J., Kim J.M., Choi E.C., Cho N.H. HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation. International Journal of Cancer 2007, 120:1418-1425.
149. Wilson G.K., Brimacombe C.L., Rowe I.A., Reynolds G.M., Fletcher N.F., Stamataki Z., Bhogal R.H., Simoes M.L., Ashcroft M., Afford S.C., Mitry R.R., Dhawan A., Mee C.J., Hubscher S.G., Balfe P., McKeating J.A. A dual role for hypoxia inducible factor-1alpha in the hepatitis C virus lifecycle and hepatoma migration. Journal of Hepatology 2012, 56:803-809.
150. Veeranna R.P., Haque M., Davis D.A., Yang M., Yarchoan R. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. Journal of Virology 2012, 86:1097-1108.
151. Oh S.H., Woo J.K., Jin Q., Kang H.J., Jeong J.W., Kim K.W., Hong W.K., Lee H.Y. Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha. International Journal of Cancer 2008, 122:5-14.
152. Cho I.R., Koh S.S., Min H.J., Park E.H., Ratakorn S., Jhun B.H., Jeong S.H., Yoo Y.H., Youn H.D., Johnston R.N., Chung Y.H. Down-regulation of HIF-1alpha by oncolytic reovirus infection independently of VHL and p53. Cancer Gene Therapy 2010, 17:365-372.
153. Choi S.H., Shin H.W., Park J.Y., Yoo J.Y., Kim do Y., Ro W.S., Yun C.O., Han K.H. Effects of the knockdown of hypoxia inducible factor-1alpha expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines. The Korean Journal of Hepatology 2010, 16:280-287.
154. Wang J., Ma Y., Jiang H., Zhu H., Liu L., Sun B., Pan S., Krissansen G.W., Sun X. Overexpression of von Hippel-Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice. Journal of Hepatology 2011, 55:359-368.
155. Wang T., Cai G., Qiu Y., Fei N., Zhang M., Pang X., Jia W., Cai S., Zhao L. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME Journal 2012, 6:320-329.
156. Yoshino Y., Kitazawa T., Ikeda M., Tatsuno K., Yanagimoto S., Okugawa S., Ota Y., Yotsuyanagi H. Clinical features of Bacteroides bacteremia and their association with colorectal carcinoma. Infection 2012, 40:63-67.
157. Ortega M., Marco F., Soriano A., Almela M., Martinez J.A., Lopez J., Pitart C., Mensa J. Epidemiology and prognostic determinants of bacteraemic biliary tract infection. Journal of Antimicrobial Chemotherapy 2012, 67:1508-1513.
158. Kato M., Kaise M., Obata T., Yonezawa J., Toyoizumi H., Yoshimura N., Yoshida Y., Kawamura M., Tajiri H. Bacteremia and endotoxemia after endoscopic submucosal dissection for gastric neoplasia: pilot study. Gastric Cancer 2012, 15:15-20.
159. Gehmert S., Gehmert S., Bai X., Klein S., Ortmann O., Prantl L. Limitation of in vivo models investigating angiogenesis in breast cancer. Clinical Hemorheology and Microcirculation 2011, 49:519-526.
160. Santolaya M.E., Farfan M.J., De L.M., Cocina V.M., Santelices F., Alvarez A.M., Aviles C.L., Becker A., O'Ryan M., Roman P., Salgado C., Silva P., Topelberg S., Tordecilla J., Varas M., Villarroel M., Viviani T., Zubieta M., Torres J.P. Diagnosis of bacteremia in febrile neutropenic episodes in children with cancer: microbiologic and molecular approach. Pediatric Infectious Disease Journal 2011, 30:957-961.
161. Huang C.C., Wu C.J., Wang L.R., Lee H.C., Chang C.M., Lee N.Y., Chen T.Y., Ko W.C. Antimicrobial susceptibility of bacteremic isolates from cancer patients with or without neutropenia at a medical center in southern Taiwan. Journal of Microbiology, Immunology and Infection 2011, 44:376-381.
162. Trecarichi E.M., Tumbarello M., Caira M., Candoni A., Cattaneo C., Pastore D., Fanci R., Nosari A., Vianelli N., Busca A., Spadea A., Pagano L. Multidrug resistant Pseudomonas aeruginosa bloodstream infection in adult patients with hematologic malignancies. Haematologica 2011, 96:e1-e3.
163. Katsibardi K., Papadakis V., Charisiadou A., Pangalis A., Polychronopoulou S. Blood stream infections throught the entire course of acute lymphoblastic leukemia treatment. Neoplasma 2011, 58:326-330.
164. Jeddi R., Ghedira H., Ben A.R., Turki A., Kacem K., Ben A.Y., Ben L.R., Aissaoui L., Ben A.H., Bel H.Z., Meddeb B. Risk factors of septic shock in patients with hematologic malignancies and Pseudomonas infections. Hematology 2011, 16:160-165.
165. Horino T., Chiba A., Kawano S., Kato T., Sato F., Maruyama Y., Nakazawa Y., Yoshikawa K., Yoshida M., Hori S. Clinical characteristics and risk factors for mortality in patients with bacteremia caused by Pseudomonas aeruginosa. Internal Medicine 2012, 51:59-64.
166. Soroceanu L., Matlaf L., Bezrookove V., Harkins L., Martinez R., Greene M., Soteropoulos P., Cobbs C.S. Human cytomegalovirus US28 found in glioblastoma promotes an invasive and angiogenic phenotype. Cancer Research 2011, 71:6643-6653.
167. Sfanos K.S., Sauvageot J., Fedor H.L., Dick J.D., De Marzo A.M., Isaacs W.B. A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms. Prostate 2008, 68:306-320.
168. Nishida N., Goel A. Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review. Current Genomics 2011, 12:130-137.
169. Lay C.J., Zhuang H.J., Ho Y.H., Tsai Y.S., Wang L.S., Tsai C.C. Different clinical characteristics between polymicrobial and monomicrobial Aeromonas bacteremia-a study of 216 cases. Internal Medicine 2010, 49:2415-2421.
170. Tsai M.S., Kuo C.Y., Wang M.C., Wu H.C., Chien C.C., Liu J.W. Clinical features and risk factors for mortality in Aeromonas bacteremic adults with hematologic malignancies. Journal of Microbiology, Immunology and Infection 2006, 39:150-154.
171. Papadakis V., Poniros N., Katsibardi K., Charissiadou A.E., Anastasopoulos J., Polychronopoulou S. Fulminant Aeromonas hydrophila infection during acute lymphoblastic leukemia treatment. Journal of Microbiology, Immunology and Infection 2012, 45:154-157.
172. Sutcliffe S., Platz E.A. Inflammation and prostate cancer: a focus on infections. Current Urology Reports 2008, 9:243-249.
173. Fassi F.L., Mak T.N., Laube B., Brinkmann V., Ogilvie L.A., Mollenkopf H., Lein M., Schmidt T., Meyer T.F., Bruggemann H. Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells. International Journal of Medical Microbiology 2011, 301:69-78.
174. Sulzyc-Bielicka V., Kolodziejczyk L., Jaczewska S., Bielicki D., Kladny J., Safranow K. Prevalence of Cryptosporidium sp. in patients with colorectal cancer. Polski Przeglad Chirurgiczny 2012, 84:348-351.
175. Benamrouz S., Conseil V., Creusy C., Calderon E., Dei-Cas E., Certad G. Parasites and malignancies, a review, with emphasis on digestive cancer induced by Cryptosporidium parvum (Alveolata: Apicomplexa). Parasite 2012, 19:101-115.
176. Chene A., Donati D., Guerreiro-Cacais A.O., Levitsky V., Chen Q., Falk K.I., Orem J., Kironde F., Wahlgren M., Bejarano M.T. A molecular link between malaria and Epstein-Barr virus reactivation. PLoS Pathogens 2007, 3:e80.
177. Chene A., Donati D., Orem J., Mbidde E.R., Kironde F., Wahlgren M., Bejarano M.T. Endemic Burkitt's lymphoma as a polymicrobial disease: new insights on the interaction between Plasmodium falciparum and Epstein-Barr virus. Seminars in Cancer Biology 2009, 19:411-420.
178. Tragiannidis A., Fegeler W., Rellensmann G., Debus V., Muller V., Hoernig-Franz I., Siam K., Pana Z.D., Jurgens H., Groll A.H. Candidaemia in a European Paediatric University Hospital: a 10-year observational study. Clinical Microbiology and Infection 2012, 18:E27-E30.
179. Chitasombat M.N., Kofteridis D.P., Jiang Y., Tarrand J., Lewis R.E., Kontoyiannis D.P. Rare opportunistic (non-Candida, non-Cryptococcus) yeast bloodstream infections in patients with cancer. Journal of Infection 2012, 64:68-75.