-
1
-
-
0038803997
-
Chromosomal instability and human hepatocarcinogenesis
-
Nishida, N.; Nishimura, T.; Ito, T.; Komeda, T.; Fukuda, Y.; Nakao, K. Chromosomal instability and human hepatocarcinogenesis. Histol. Histopathol., 2003, 18, 897-909.
-
(2003)
Histol. Histopathol.
, vol.18
, pp. 897-909
-
-
Nishida, N.1
Nishimura, T.2
Ito, T.3
Komeda, T.4
Fukuda, Y.5
Nakao, K.6
-
2
-
-
70450270900
-
Awakening guardian angels: Drugging the p53 pathway
-
Brown, C. J.; Lain, S.; Verma, C. S.; Fersht, A. R.; Lane, D. P. Awakening guardian angels: drugging the p53 pathway. Nat. Rev. Cancer, 2009, 9, 862-873.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 862-873
-
-
Brown, C.J.1
Lain, S.2
Verma, C.S.3
Fersht, A.R.4
Lane, D.P.5
-
3
-
-
34047210411
-
TP53 mutations and hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer
-
Hussain, S. P.; Schwank, J.; Staib, F.; Wang, X. W.; Harris, C. C. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene, 2007, 26, 2166-2176.
-
(2007)
Oncogene
, vol.26
, pp. 2166-2176
-
-
Hussain, S.P.1
Schwank, J.2
Staib, F.3
Wang, X.W.4
Harris, C.C.5
-
4
-
-
0027393921
-
Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma
-
Nishida, N.; Fukuda, Y.; Kokuryu, H.; Toguchida, J.; Yandell, D. W.; Ikenega, M.; Imura, H.; Ishizaki, K. Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma. Cancer Res., 1993, 53, 368-372.
-
(1993)
Cancer Res.
, vol.53
, pp. 368-372
-
-
Nishida, N.1
Fukuda, Y.2
Kokuryu, H.3
Toguchida, J.4
Yandell, D.W.5
Ikenega, M.6
Imura, H.7
Ishizaki, K.8
-
5
-
-
0028343058
-
Geographic variation of p53 mutational profile in nonmalignant human liver
-
Aguilar, F.; Harris, C. C.; Sun, T.; Hollstein, M.; Cerutti, P. Geographic variation of p53 mutational profile in nonmalignant human liver. Science, 1994, 264, 1317-1319.
-
(1994)
Science
, vol.264
, pp. 1317-1319
-
-
Aguilar, F.1
Harris, C.C.2
Sun, T.3
Hollstein, M.4
Cerutti, P.5
-
6
-
-
0027337609
-
Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes
-
Aguilar, F.; Hussain, S. P.; Cerutti, P. Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl. Acad. Sci. USA, 1993, 90, 8586-8590.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8586-8590
-
-
Aguilar, F.1
Hussain, S.P.2
Cerutti, P.3
-
7
-
-
0034684954
-
Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from the Gambia
-
Kirk, G. D.; Camus-Randon, A. M.; Mendy, M.; Goedert, J. J.; Merle, P.; Trepo, C.; Brechot, C.; Hainaut, P.; Montesano, R. Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia. J. Natl. Cancer Inst., 2000, 92, 148-153.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 148-153
-
-
Kirk, G.D.1
Camus-Randon, A.M.2
Mendy, M.3
Goedert, J.J.4
Merle, P.5
Trepo, C.6
Brechot, C.7
Hainaut, P.8
Montesano, R.9
-
8
-
-
0027344549
-
Aflatoxin B1-induced rat hepatic hyperplastic nodules do not exhibit a site-specific mutation within the p53 gene
-
Hulla, J. E.; Chen, Z. Y.; Eaton, D. L. Aflatoxin B1-induced rat hepatic hyperplastic nodules do not exhibit a site-specific mutation within the p53 gene. Cancer Res., 1993, 53, 9-11.
-
(1993)
Cancer Res.
, vol.53
, pp. 9-11
-
-
Hulla, J.E.1
Chen, Z.Y.2
Eaton, D.L.3
-
9
-
-
0036828029
-
Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein
-
Madden, C. R.; Finegold, M. J.; Slagle, B. L. Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein. J. Virol., 2002, 76, 11770-11774.
-
(2002)
J. Virol.
, vol.76
, pp. 11770-11774
-
-
Madden, C.R.1
Finegold, M.J.2
Slagle, B.L.3
-
10
-
-
0028834376
-
Abrogation of p53-induced apoptosis by the hepatitis B virus X gene
-
Wang, X. W.; Gibson, M. K.; Vermeulen, W.; Yeh, H.; Forrester, K.; Sturzbecher, H. W.; Hoeijmakers, J. H.; Harris, C. C. Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res. 1995, 55, 6012-6016.
-
(1995)
Cancer Res.
, vol.55
, pp. 6012-6016
-
-
Wang, X.W.1
Gibson, M.K.2
Vermeulen, W.3
Yeh, H.4
Forrester, K.5
Sturzbecher, H.W.6
Hoeijmakers, J.H.7
Harris, C.C.8
-
11
-
-
0033528096
-
Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer
-
Ambs, S.; Bennett, W. P.; Merriam, W. G.; Ogunfusika, M. O.; Oser, S. M.; Harrington, A. M.; Shields, P. G.; Felley-Bosco, E.; Hussain, S. P.; Harris, C. C. Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J. Natl. Cancer Inst., 1999, 91, 86-88.
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 86-88
-
-
Ambs, S.1
Bennett, W.P.2
Merriam, W.G.3
Ogunfusika, M.O.4
Oser, S.M.5
Harrington, A.M.6
Shields, P.G.7
Felley-Bosco, E.8
Hussain, S.P.9
Harris, C.C.10
-
12
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
Zhang, Y.; Xiong, Y.; Yarbrough, W. G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell, 1998, 92, 725-734.
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
13
-
-
0035950534
-
INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas
-
Tannapfel, A.; Busse, C.; Weinans, L.; Benicke, M.; Katalinic, A.; Geissler, F.; Hauss, J.; Wittekind, C. INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas. Oncogene, 2001, 20, 7104-7109.
-
(2001)
Oncogene
, vol.20
, pp. 7104-7109
-
-
Tannapfel, A.1
Busse, C.2
Weinans, L.3
Benicke, M.4
Katalinic, A.5
Geissler, F.6
Hauss, J.7
Wittekind, C.8
-
14
-
-
2542423876
-
Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas
-
Ito, T.; Nishida, N.; Fukuda, Y.; Nishimura, T.; Komeda, T.; Nakao, K. Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas. J. Gastroenterol., 2004, 39, 355-361.
-
(2004)
J. Gastroenterol.
, vol.39
, pp. 355-361
-
-
Ito, T.1
Nishida, N.2
Fukuda, Y.3
Nishimura, T.4
Komeda, T.5
Nakao, K.6
-
15
-
-
34447309035
-
P21/WAF1 is an independent survival prognostic factor for patients with hepatocellular carcinoma after resection
-
Kao J. T.; Chuah S. K.; Huang C. C.; Chen C. L.; Wang C. C.; Hung C. H.; Chen C. H.; Wang J. H.; Lu S. N.; Lee C. M.; Changchien C. S.; Hu T. H. P21/WAF1 is an independent survival prognostic factor for patients with hepatocellular carcinoma after resection. Liver Int., 2007, 27, 772-81.
-
(2007)
Liver Int.
, vol.27
, pp. 772-781
-
-
Kao, J.T.1
Chuah, S.K.2
Huang, C.C.3
Chen, C.L.4
Wang, C.C.5
Hung, C.H.6
Chen, C.H.7
Wang, J.H.8
Lu, S.N.9
Lee, C.M.10
Changchien, C.S.11
Hu, T.H.12
-
16
-
-
0037042205
-
Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein
-
Han, H. J.; Jung, E. Y.; Lee, W. J.; Jang, K. L. Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein. FEBS Lett., 2002, 518, 169-172.
-
(2002)
FEBS Lett.
, vol.518
, pp. 169-172
-
-
Han, H.J.1
Jung, E.Y.2
Lee, W.J.3
Jang, K.L.4
-
17
-
-
0032995914
-
Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: P27 independently predicts the recurrence
-
Ito, Y.; Matsuura, N.; Sakon, M.; Miyoshi, E.; Noda, K.; Takeda, T.; Umeshita, K.; Nagano, H.; Nakamori, S.; Dono, K.; Tsujimoto, M.; Nakahara, M.; Nakao, K.; Taniguchi, N.; Monden, M. Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: p27 independently predicts the recurrence. Hepatology, 1999, 30, 90-99.
-
(1999)
Hepatology
, vol.30
, pp. 90-99
-
-
Ito, Y.1
Matsuura, N.2
Sakon, M.3
Miyoshi, E.4
Noda, K.5
Takeda, T.6
Umeshita, K.7
Nagano, H.8
Nakamori, S.9
Dono, K.10
Tsujimoto, M.11
Nakahara, M.12
Nakao, K.13
Taniguchi, N.14
Monden, M.15
-
18
-
-
23844546638
-
Expression and hypermethylation of p27 kip1 in hepatocarcinogenesis
-
Lei, P. P.; Zhang, Z. J.; Shen, L. J.; Li, J. Y.; Zou, Q.; Zhang, H. X. Expression and hypermethylation of p27 kip1 in hepatocarcinogenesis. World J. Gastroenterol., 2005, 11, 4587-4591.
-
(2005)
World J. Gastroenterol.
, vol.11
, pp. 4587-4591
-
-
Lei, P.P.1
Zhang, Z.J.2
Shen, L.J.3
Li, J.Y.4
Zou, Q.5
Zhang, H.X.6
-
19
-
-
0029054399
-
Retinoblastoma-proteindependent cell-cycle inhibition by the tumour suppressor p16
-
Lukas, J.; Parry, D.; Aagaard, L.; Mann, D. J.; Bartkova, J.; Strauss, M.; Peters, G.; Bartek, J. Retinoblastoma-proteindependent cell-cycle inhibition by the tumour suppressor p16. Nature, 1995, 375, 503-506.
-
(1995)
Nature
, vol.375
, pp. 503-506
-
-
Lukas, J.1
Parry, D.2
Aagaard, L.3
Mann, D.J.4
Bartkova, J.5
Strauss, M.6
Peters, G.7
Bartek, J.8
-
20
-
-
0028292294
-
Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma
-
Nishida, N.; Fukuda, Y.; Komeda, T.; Kita, R.; Sando, T.; Furukawa, M.; Amenomori, M.; Shibagaki, I.; Nakao, K.; Ikenaga, M. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res., 1994, 54, 3107-3110.
-
(1994)
Cancer Res.
, vol.54
, pp. 3107-3110
-
-
Nishida, N.1
Fukuda, Y.2
Komeda, T.3
Kita, R.4
Sando, T.5
Furukawa, M.6
Amenomori, M.7
Shibagaki, I.8
Nakao, K.9
Ikenaga, M.10
-
21
-
-
0030801640
-
Alteration of cell cycle-related genes in hepatocarcinogenesis
-
Nishida, N.; Fukuda, Y.; Ishizaki, K.; Nakao, K. Alteration of cell cycle-related genes in hepatocarcinogenesis. Histol. Histopathol., 1997, 12, 1019-1025.
-
(1997)
Histol. Histopathol.
, vol.12
, pp. 1019-1025
-
-
Nishida, N.1
Fukuda, Y.2
Ishizaki, K.3
Nakao, K.4
-
22
-
-
17844387825
-
Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas
-
Azechi, H.; Nishida, N.; Fukuda, Y.; Nishimura, T.; Minata, M.; Katsuma, H.; Kuno, M.; Ito, T.; Komeda, T.; Kita, R.; Takahashi, R.; Nakao, K. Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. Oncology, 2001, 60, 346-354.
-
(2001)
Oncology
, vol.60
, pp. 346-354
-
-
Azechi, H.1
Nishida, N.2
Fukuda, Y.3
Nishimura, T.4
Minata, M.5
Katsuma, H.6
Kuno, M.7
Ito, T.8
Komeda, T.9
Kita, R.10
Takahashi, R.11
Nakao, K.12
-
23
-
-
0026684402
-
Accumulation of allelic loss on arms of chromosomes 13q, 16q and 17p in the advanced stages of human hepatocellular carcinoma
-
Nishida, N.; Fukuda, Y.; Kokuryu, H.; Sadamoto, T.; Isowa, G.; Honda, K.; Yamaoka, Y.; Ikenaga, M.; Imura, H.; Ishizaki, K. Accumulation of allelic loss on arms of chromosomes 13q, 16q and 17p in the advanced stages of human hepatocellular carcinoma. Int. J. Cancer, 1992, 51, 862-868.
-
(1992)
Int. J. Cancer
, vol.51
, pp. 862-868
-
-
Nishida, N.1
Fukuda, Y.2
Kokuryu, H.3
Sadamoto, T.4
Isowa, G.5
Honda, K.6
Yamaoka, Y.7
Ikenaga, M.8
Imura, H.9
Ishizaki, K.10
-
24
-
-
0028023861
-
Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma
-
Zhang, X.; Xu, H. J.; Murakami, Y.; Sachse, R.; Yashima, K.; Hirohashi, S.; Hu, S. X.; Benedict, W. F.; Sekiya, T. Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma. Cancer Res., 1994, 54, 4177-4182.
-
(1994)
Cancer Res.
, vol.54
, pp. 4177-4182
-
-
Zhang, X.1
Xu, H.J.2
Murakami, Y.3
Sachse, R.4
Yashima, K.5
Hirohashi, S.6
Hu, S.X.7
Benedict, W.F.8
Sekiya, T.9
-
25
-
-
18444369018
-
Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma
-
Roncalli, M.; Bianchi, P.; Bruni, B.; Laghi, L.; Destro, A.; Di Gioia, S.; Gennari, L.; Tommasini, M.; Malesci, A.; Coggi, G. Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. Hepatology, 2002, 36, 427-432.
-
(2002)
Hepatology
, vol.36
, pp. 427-432
-
-
Roncalli, M.1
Bianchi, P.2
Bruni, B.3
Laghi, L.4
Destro, A.5
Di Gioia, S.6
Gennari, L.7
Tommasini, M.8
Malesci, A.9
Coggi, G.10
-
26
-
-
0029665012
-
Infrequent alterations of the p16INK4A gene in liver cancer
-
Kita, R.; Nishida, N.; Fukuda, Y.; Azechi, H.; Matsuoka, Y.; Komeda, T.; Sando, T.; Nakao, K.; Ishizaki, K. Infrequent alterations of the p16INK4A gene in liver cancer. Int. J. Cancer, 1996, 67, 176-180.
-
(1996)
Int. J. Cancer
, vol.67
, pp. 176-180
-
-
Kita, R.1
Nishida, N.2
Fukuda, Y.3
Azechi, H.4
Matsuoka, Y.5
Komeda, T.6
Sando, T.7
Nakao, K.8
Ishizaki, K.9
-
27
-
-
0032924622
-
p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
-
Matsuda, Y.; Ichida, T.; Matsuzawa, J.; Sugimura, K.; Asakura, H. p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology, 1999, 116, 394-400.
-
(1999)
Gastroenterology
, vol.116
, pp. 394-400
-
-
Matsuda, Y.1
Ichida, T.2
Matsuzawa, J.3
Sugimura, K.4
Asakura, H.5
-
28
-
-
34250342495
-
Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: Evidence for two distinct pathways of human hepatocarcinogenesis
-
Nishida, N.; Nishimura, T.; Nagasaka, T.; Ikai, I.; Goel, A.; Boland, C. R. Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res., 2007, 67, 4586-4594.
-
(2007)
Cancer Res.
, vol.67
, pp. 4586-4594
-
-
Nishida, N.1
Nishimura, T.2
Nagasaka, T.3
Ikai, I.4
Goel, A.5
Boland, C.R.6
-
29
-
-
21644473614
-
p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma
-
Li, X.; Hui, A. M.; Sun, L.; Hasegawa, K.; Torzilli, G.; Minagawa, M.; Takayama, T.; Makuuchi, M. p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma. Clin. Cancer Res., 2004, 10, 7484-7489.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 7484-7489
-
-
Li, X.1
Hui, A.M.2
Sun, L.3
Hasegawa, K.4
Torzilli, G.5
Minagawa, M.6
Takayama, T.7
Makuuchi, M.8
-
30
-
-
0029664368
-
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
-
Rubinfeld, B.; Albert, I.; Porfiri, E.; Fiol, C.; Munemitsu, S.; Polakis, P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science, 1996, 272, 1023-1026.
-
(1996)
Science
, vol.272
, pp. 1023-1026
-
-
Rubinfeld, B.1
Albert, I.2
Porfiri, E.3
Fiol, C.4
Munemitsu, S.5
Polakis, P.6
-
31
-
-
9344271549
-
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein
-
Matsumine, A.; Ogai, A.; Senda, T.; Okumura, N.; Satoh, K.; Baeg, G. H.; Kawahara, T.; Kobayashi, S.; Okada, M.; Toyoshima, K.; Akiyama, T. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science, 1996, 272, 1020-1023.
-
(1996)
Science
, vol.272
, pp. 1020-1023
-
-
Matsumine, A.1
Ogai, A.2
Senda, T.3
Okumura, N.4
Satoh, K.5
Baeg, G.H.6
Kawahara, T.7
Kobayashi, S.8
Okada, M.9
Toyoshima, K.10
Akiyama, T.11
-
32
-
-
0034625641
-
Signaling specificity by Frizzled receptors in Drosophila
-
Boutros, M.; Mihaly, J.; Bouwmeester, T.; Mlodzik, M. Signaling specificity by Frizzled receptors in Drosophila. Science, 2000, 288, 1825-1828.
-
(2000)
Science
, vol.288
, pp. 1825-1828
-
-
Boutros, M.1
Mihaly, J.2
Bouwmeester, T.3
Mlodzik, M.4
-
33
-
-
0025899162
-
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
-
Nishisho, I.; Nakamura, Y.; Miyoshi, Y.; Miki, Y.; Ando, H.; Horii, A.; Koyama, K.; Utsunomiya, J.; Baba, S.; Hedge, P. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science, 1991, 253, 665-669.
-
(1991)
Science
, vol.253
, pp. 665-669
-
-
Nishisho, I.1
Nakamura, Y.2
Miyoshi, Y.3
Miki, Y.4
Ando, H.5
Horii, A.6
Koyama, K.7
Utsunomiya, J.8
Baba, S.9
Hedge, P.10
-
34
-
-
24944500115
-
Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous
-
Renkonen, E. T.; Nieminen, P.; Abdel-Rahman, W. M.; Moisio, A. L.; Jarvela, I.; Arte, S.; Jarvinen, H. J.; Peltomaki, P. Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous. J. Clin. Oncol., 2005, 23, 5651-5659.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5651-5659
-
-
Renkonen, E.T.1
Nieminen, P.2
Abdel-Rahman, W.M.3
Moisio, A.L.4
Jarvela, I.5
Arte, S.6
Jarvinen, H.J.7
Peltomaki, P.8
-
35
-
-
0032568370
-
Ecadherin germline mutations in familial gastric cancer
-
Guilford, P.; Hopkins, J.; Harraway, J.; McLeod, M.; McLeod, N.; Harawira, P.; Taite, H.; Scoular, R.; Miller, A.; Reeve, A. E. Ecadherin germline mutations in familial gastric cancer. Nature, 1998, 392, 402-405.
-
(1998)
Nature
, vol.392
, pp. 402-405
-
-
Guilford, P.1
Hopkins, J.2
Harraway, J.3
McLeod, M.4
McLeod, N.5
Harawira, P.6
Taite, H.7
Scoular, R.8
Miller, A.9
Reeve, A.E.10
-
36
-
-
0030949463
-
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
-
Morin, P. J.; Sparks, A. B.; Korinek, V.; Barker, N.; Clevers, H.; Vogelstein, B.; Kinzler, K. W. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science, 1997, 275, 1787-1790.
-
(1997)
Science
, vol.275
, pp. 1787-1790
-
-
Morin, P.J.1
Sparks, A.B.2
Korinek, V.3
Barker, N.4
Clevers, H.5
Vogelstein, B.6
Kinzler, K.W.7
-
37
-
-
0032813907
-
Beta-catenin expression pattern in stage I and II ovarian carcinomas: Relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome
-
Gamallo, C.; Palacios, J.; Moreno, G.; Calvo de Mora, J.; Suarez, A.; Armas, A. beta-catenin expression pattern in stage I and II ovarian carcinomas: relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome. Am. J. Pathol., 1999, 155, 527-536.
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 527-536
-
-
Gamallo, C.1
Palacios, J.2
Moreno, G.3
de Calvo Mora, J.4
Suarez, A.5
Armas, A.6
-
38
-
-
0037130449
-
Mutational spectrum of betacatenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
-
Taniguchi, K.; Roberts, L. R.; Aderca, I. N.; Dong, X.; Qian, C.; Murphy, L. M.; Nagorney, D. M.; Burgart, L. J.; Roche, P. C.; Smith, D. I.; Ross, J. A.; Liu, W. Mutational spectrum of betacatenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene, 2002, 21, 4863-4871.
-
(2002)
Oncogene
, vol.21
, pp. 4863-4871
-
-
Taniguchi, K.1
Roberts, L.R.2
Aderca, I.N.3
Dong, X.4
Qian, C.5
Murphy, L.M.6
Nagorney, D.M.7
Burgart, L.J.8
Roche, P.C.9
Smith, D.I.10
Ross, J.A.11
Liu, W.12
-
39
-
-
33846846541
-
Differential effects of inactivated Axin1 and activated betacatenin mutations in human hepatocellular carcinomas
-
Zucman-Rossi, J.; Benhamouche, S.; Godard, C.; Boyault, S.; Grimber, G.; Balabaud, C.; Cunha, A. S.; Bioulac-Sage, P.; Perret, C. Differential effects of inactivated Axin1 and activated betacatenin mutations in human hepatocellular carcinomas. Oncogene, 2007, 26, 774-780.
-
(2007)
Oncogene
, vol.26
, pp. 774-780
-
-
Zucman-Rossi, J.1
Benhamouche, S.2
Godard, C.3
Boyault, S.4
Grimber, G.5
Balabaud, C.6
Cunha, A.S.7
Bioulac-Sage, P.8
Perret, C.9
-
40
-
-
33748921022
-
Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: A case report
-
Katoh, H.; Shibata, T.; Kokubu, A.; Ojima, H.; Kosuge, T.; Kanai, Y.; Hirohashi, S. Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report. Genes Chromosomes Cancer, 2006, 45, 1050-1057.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 1050-1057
-
-
Katoh, H.1
Shibata, T.2
Kokubu, A.3
Ojima, H.4
Kosuge, T.5
Kanai, Y.6
Hirohashi, S.7
-
41
-
-
0030020705
-
Ligand activation of overexpressed epidermal growth factor receptor results in colony dissociation and disturbed E-cadherin function in HSC-1 human cutaneous squamous carcinoma cells
-
Fujii, K.; Furukawa, F.; Matsuyoshi, N. Ligand activation of overexpressed epidermal growth factor receptor results in colony dissociation and disturbed E-cadherin function in HSC-1 human cutaneous squamous carcinoma cells. Exp. Cell Res., 1996, 223, 50-62.
-
(1996)
Exp. Cell Res.
, vol.223
, pp. 50-62
-
-
Fujii, K.1
Furukawa, F.2
Matsuyoshi, N.3
-
42
-
-
0031951561
-
Immunoexpression of E-cadherin and beta-catenin correlates to survival of patients with hepatocellular carcinomas
-
Garcia, S.; Martini, F.; De Micco, C.; Andrac, L.; Hardwigsen, J.; Sappa, P.; Lavaut, M. N.; Le Treut, Y. P.; Charpin, C. Immunoexpression of E-cadherin and beta-catenin correlates to survival of patients with hepatocellular carcinomas. Int. J. Oncol., 1998, 12, 443-447.
-
(1998)
Int. J. Oncol.
, vol.12
, pp. 443-447
-
-
Garcia, S.1
Martini, F.2
de Micco, C.3
Andrac, L.4
Hardwigsen, J.5
Sappa, P.6
Lavaut, M.N.7
Le Treut, Y.P.8
Charpin, C.9
-
43
-
-
57249103576
-
Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: Methylation of the E-cadherin promoter
-
Lim, S. O.; Gu, J. M.; Kim, M. S.; Kim, H. S.; Park, Y. N.; Park, C. K.; Cho, J. W.; Park, Y. M.; Jung, G. Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology, 2008, 135, 2128-2140.
-
(2008)
Gastroenterology
, vol.135
, pp. 2128-2140
-
-
Lim, S.O.1
Gu, J.M.2
Kim, M.S.3
Kim, H.S.4
Park, Y.N.5
Park, C.K.6
Cho, J.W.7
Park, Y.M.8
Jung, G.9
-
44
-
-
0033765496
-
Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma
-
Kondo, Y.; Kanai, Y.; Sakamoto, M.; Mizokami, M.; Ueda, R.; Hirohashi, S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology, 2000, 32, 970-979.
-
(2000)
Hepatology
, vol.32
, pp. 970-979
-
-
Kondo, Y.1
Kanai, Y.2
Sakamoto, M.3
Mizokami, M.4
Ueda, R.5
Hirohashi, S.6
-
45
-
-
34247190634
-
Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein
-
Park, I. Y.; Sohn, B. H.; Yu, E.; Suh, D. J.; Chung, Y. H.; Lee, J. H.; Surzycki, S. J.; Lee, Y. I. Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology, 2007, 132, 1476-1494.
-
(2007)
Gastroenterology
, vol.132
, pp. 1476-1494
-
-
Park, I.Y.1
Sohn, B.H.2
Yu, E.3
Suh, D.J.4
Chung, Y.H.5
Lee, J.H.6
Surzycki, S.J.7
Lee, Y.I.8
-
46
-
-
34250854122
-
Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway
-
Jung, J. K.; Arora, P.; Pagano, J. S.; Jang, K. L. Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway. Cancer Res., 2007, 67, 5771-5778.
-
(2007)
Cancer Res.
, vol.67
, pp. 5771-5778
-
-
Jung, J.K.1
Arora, P.2
Pagano, J.S.3
Jang, K.L.4
-
47
-
-
39249084744
-
Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b
-
Arora, P.; Kim, E. O.; Jung, J. K.; Jang, K. L. Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b. Cancer Lett., 2008, 261, 244-252.
-
(2008)
Cancer Lett.
, vol.261
, pp. 244-252
-
-
Arora, P.1
Kim, E.O.2
Jung, J.K.3
Jang, K.L.4
-
48
-
-
40949161396
-
Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
-
Nishida, N.; Nagasaka, T.; Nishimura, T.; Ikai, I.; Boland, C. R.; Goel, A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology, 2008, 47, 908-918.
-
(2008)
Hepatology
, vol.47
, pp. 908-918
-
-
Nishida, N.1
Nagasaka, T.2
Nishimura, T.3
Ikai, I.4
Boland, C.R.5
Goel, A.6
-
49
-
-
77953066813
-
Impact of hepatitis virus and aging on DNA methylation in human hepatocarcinogenesis
-
Nishida, N. Impact of hepatitis virus and aging on DNA methylation in human hepatocarcinogenesis. Histol. Histopathol., 2010, 25, 647-654.
-
(2010)
Histol. Histopathol.
, vol.25
, pp. 647-654
-
-
Nishida, N.1
-
50
-
-
0032893755
-
Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients
-
Wong, I. H.; Lo, Y. M.; Zhang, J.; Liew, C. T.; Ng, M. H.; Wong, N.; Lai, P. B.; Lau, W. Y.; Hjelm, N. M.; Johnson, P. J. Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. Cancer Res., 1999, 59, 71-73.
-
(1999)
Cancer Res.
, vol.59
, pp. 71-73
-
-
Wong, I.H.1
Lo, Y.M.2
Zhang, J.3
Liew, C.T.4
Ng, M.H.5
Wong, N.6
Lai, P.B.7
Lau, W.Y.8
Hjelm, N.M.9
Johnson, P.J.10
-
51
-
-
33646091508
-
Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients
-
Wang, J.; Qin, Y.; Li, B.; Sun, Z.; Yang, B. Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients. Clin. Biochem., 2006, 39, 344-348.
-
(2006)
Clin. Biochem.
, vol.39
, pp. 344-348
-
-
Wang, J.1
Qin, Y.2
Li, B.3
Sun, Z.4
Yang, B.5
-
52
-
-
34247895661
-
Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA
-
Zhang, Y. J.; Wu, H. C.; Shen, J.; Ahsan, H.; Tsai, W. Y.; Yang, H. I.; Wang, L. Y.; Chen, S. Y.; Chen, C. J.; Santella, R. M. Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clin. Cancer Res., 2007, 13, 2378-2384.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 2378-2384
-
-
Zhang, Y.J.1
Wu, H.C.2
Shen, J.3
Ahsan, H.4
Tsai, W.Y.5
Yang, H.I.6
Wang, L.Y.7
Chen, S.Y.8
Chen, C.J.9
Santella, R.M.10
-
53
-
-
53049086329
-
Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
-
Chiang, D. Y.; Villanueva, A.; Hoshida, Y.; Peix, J.; Newell, P.; Minguez, B.; LeBlanc, A. C.; Donovan, D. J.; Thung, S. N.; Sole, M.; Tovar, V.; Alsinet, C.; Ramos, A. H.; Barretina, J.; Roayaie, S.; Schwartz, M.; Waxman, S.; Bruix, J.; Mazzaferro, V.; Ligon, A. H.; Najfeld, V.; Friedman, S. L.; Sellers, W. R.; Meyerson, M.; Llovet, J. M. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res., 2008, 68, 6779-6788.
-
(2008)
Cancer Res.
, vol.68
, pp. 6779-6788
-
-
Chiang, D.Y.1
Villanueva, A.2
Hoshida, Y.3
Peix, J.4
Newell, P.5
Minguez, B.6
Le Blanc, A.C.7
Donovan, D.J.8
Thung, S.N.9
Sole, M.10
Tovar, V.11
Alsinet, C.12
Ramos, A.H.13
Barretina, J.14
Roayaie, S.15
Schwartz, M.16
Waxman, S.17
Bruix, J.18
Mazzaferro, V.19
Ligon, A.H.20
Najfeld, V.21
Friedman, S.L.22
Sellers, W.R.23
Meyerson, M.24
Llovet, J.M.25
more..
-
54
-
-
33749479908
-
Downregulation of miR-122 in the rodent and human hepatocellular carcinomas
-
Kutay, H.; Bai, S.; Datta, J.; Motiwala, T.; Pogribny, I.; Frankel, W.; Jacob, S. T.; Ghoshal, K. Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J. Cell Biochem., 2006, 99, 671-678.
-
(2006)
J. Cell Biochem.
, vol.99
, pp. 671-678
-
-
Kutay, H.1
Bai, S.2
Datta, J.3
Motiwala, T.4
Pogribny, I.5
Frankel, W.6
Jacob, S.T.7
Ghoshal, K.8
-
55
-
-
34447117003
-
Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
-
Gramantieri, L.; Ferracin, M.; Fornari, F.; Veronese, A.; Sabbioni, S.; Liu, C. G.; Calin, G. A.; Giovannini, C.; Ferrazzi, E.; Grazi, G. L.; Croce, C. M.; Bolondi, L.; Negrini, M. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res., 2007, 67, 6092-6099.
-
(2007)
Cancer Res.
, vol.67
, pp. 6092-6099
-
-
Gramantieri, L.1
Ferracin, M.2
Fornari, F.3
Veronese, A.4
Sabbioni, S.5
Liu, C.G.6
Calin, G.A.7
Giovannini, C.8
Ferrazzi, E.9
Grazi, G.L.10
Croce, C.M.11
Bolondi, L.12
Negrini, M.13
-
56
-
-
52949127316
-
MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
-
Fornari, F.; Gramantieri, L.; Ferracin, M.; Veronese, A.; Sabbioni, S.; Calin, G. A.; Grazi, G. L.; Giovannini, C.; Croce, C. M.; Bolondi, L.; Negrini, M. MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene, 2008, 27, 5651-5661.
-
(2008)
Oncogene
, vol.27
, pp. 5651-5661
-
-
Fornari, F.1
Gramantieri, L.2
Ferracin, M.3
Veronese, A.4
Sabbioni, S.5
Calin, G.A.6
Grazi, G.L.7
Giovannini, C.8
Croce, C.M.9
Bolondi, L.10
Negrini, M.11
-
57
-
-
34547524771
-
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
-
Meng, F.; Henson, R.; Wehbe-Janek, H.; Ghoshal, K.; Jacob, S. T.; Patel, T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology, 2007, 133, 647-658.
-
(2007)
Gastroenterology
, vol.133
, pp. 647-658
-
-
Meng, F.1
Henson, R.2
Wehbe-Janek, H.3
Ghoshal, K.4
Jacob, S.T.5
Patel, T.6
-
58
-
-
70349871321
-
MicroRNA expression, survival, and response to interferon in liver cancer
-
Ji, J.; Shi, J.; Budhu, A.; Yu, Z.; Forgues, M.; Roessler, S.; Ambs, S.; Chen, Y.; Meltzer, P. S.; Croce, C. M.; Qin, L. X.; Man, K.; Lo, C. M.; Lee, J.; Ng, I. O.; Fan, J.; Tang, Z. Y.; Sun, H. C.; Wang, X. W. MicroRNA expression, survival, and response to interferon in liver cancer. N. Engl. J. Med., 2009, 361, 1437-1447.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1437-1447
-
-
Ji, J.1
Shi, J.2
Budhu, A.3
Yu, Z.4
Forgues, M.5
Roessler, S.6
Ambs, S.7
Chen, Y.8
Meltzer, P.S.9
Croce, C.M.10
Qin, L.X.11
Man, K.12
Lo, C.M.13
Lee, J.14
Ng, I.O.15
Fan, J.16
Tang, Z.Y.17
Sun, H.C.18
Wang, X.W.19
-
59
-
-
34447327216
-
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
-
Naugler, W. E.; Sakurai, T.; Kim, S.; Maeda, S.; Kim, K.; Elsharkawy, A. M.; Karin, M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science, 2007, 317, 121-124.
-
(2007)
Science
, vol.317
, pp. 121-124
-
-
Naugler, W.E.1
Sakurai, T.2
Kim, S.3
Maeda, S.4
Kim, K.5
Elsharkawy, A.M.6
Karin, M.7
-
60
-
-
70349849505
-
Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: An analysis based on gender differences
-
Nakagawa, H.; Maeda, S.; Yoshida, H.; Tateishi, R.; Masuzaki, R.; Ohki, T.; Hayakawa, Y.; Kinoshita, H.; Yamakado, M.; Kato, N.; Shiina, S.; Omata, M. Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences. Int. J. Cancer, 2009, 125, 2264-2269.
-
(2009)
Int. J. Cancer
, vol.125
, pp. 2264-2269
-
-
Nakagawa, H.1
Maeda, S.2
Yoshida, H.3
Tateishi, R.4
Masuzaki, R.5
Ohki, T.6
Hayakawa, Y.7
Kinoshita, H.8
Yamakado, M.9
Kato, N.10
Shiina, S.11
Omata, M.12
-
61
-
-
66449136951
-
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
-
Kota, J.; Chivukula, R. R.; O'Donnell, K. A.; Wentzel, E. A.; Montgomery, C. L.; Hwang, H-W.; Chang, T-C.; Vivekanandan, P.; Torbenson, M.; Clark, K. R.; Mendell, J. R.; Mendell, J. T. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell, 2009, 137, 1005-1017.
-
(2009)
Cell
, vol.137
, pp. 1005-1017
-
-
Kota, J.1
Chivukula, R.R.2
O'Donnell, K.A.3
Wentzel, E.A.4
Montgomery, C.L.5
Hwang, H.-W.6
Chang, T.-C.7
Vivekanandan, P.8
Torbenson, M.9
Clark, K.R.10
Mendell, J.R.11
Mendell, J.T.12
-
62
-
-
40949087185
-
Identification of metastasis-related microRNAs in hepatocellular carcinoma
-
Budhu, A.; Jia, H. L.; Forgues, M.; Liu, C. G.; Goldstein, D.; Lam, A.; Zanetti, K. A.; Ye, Q. H.; Qin, L. X.; Croce, C. M.; Tang, Z. Y.; Wang, X. W. Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology, 2008, 47, 897-907.
-
(2008)
Hepatology
, vol.47
, pp. 897-907
-
-
Budhu, A.1
Jia, H.L.2
Forgues, M.3
Liu, C.G.4
Goldstein, D.5
Lam, A.6
Zanetti, K.A.7
Ye, Q.H.8
Qin, L.X.9
Croce, C.M.10
Tang, Z.Y.11
Wang, X.W.12
-
63
-
-
42249089850
-
MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma
-
Varnholt, H.; Drebber, U.; Schulze, F.; Wedemeyer, I.; Schirmacher, P.; Dienes, H. P.; Odenthal, M. MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology, 2008, 47, 1223-1232.
-
(2008)
Hepatology
, vol.47
, pp. 1223-1232
-
-
Varnholt, H.1
Drebber, U.2
Schulze, F.3
Wedemeyer, I.4
Schirmacher, P.5
Dienes, H.P.6
Odenthal, M.7
-
64
-
-
65449154685
-
Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
-
Ura, S.; Honda, M.; Yamashita, T.; Ueda, T.; Takatori, H.; Nishino, R.; Sunakozaka, H.; Sakai, Y.; Horimoto, K.; Kaneko, S. Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology, 2009, 49, 1098-1112.
-
(2009)
Hepatology
, vol.49
, pp. 1098-1112
-
-
Ura, S.1
Honda, M.2
Yamashita, T.3
Ueda, T.4
Takatori, H.5
Nishino, R.6
Sunakozaka, H.7
Sakai, Y.8
Horimoto, K.9
Kaneko, S.10
-
65
-
-
77950602604
-
Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma
-
Xiong, Y.; Fang, J. H.; Yun, J. P.; Yang, J.; Zhang, Y.; Jia, W. H.; Zhuang, S. M. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology, 2010, 51, 836-845.
-
(2010)
Hepatology
, vol.51
, pp. 836-845
-
-
Xiong, Y.1
Fang, J.H.2
Yun, J.P.3
Yang, J.4
Zhang, Y.5
Jia, W.H.6
Zhuang, S.M.7
-
66
-
-
77950622025
-
MicroRNA-30d promotes tumor invasion and metastasis by targeting Galphai2 in hepatocellular carcinoma
-
Yao, J.; Liang, L.; Huang, S.; Ding, J.; Tan, N.; Zhao, Y.; Yan, M.; Ge, C.; Zhang, Z.; Chen, T.; Wan, D.; Yao, M.; Li, J.; Gu, J.; He, X. MicroRNA-30d promotes tumor invasion and metastasis by targeting Galphai2 in hepatocellular carcinoma. Hepatology, 2010, 51, 846-856.
-
(2010)
Hepatology
, vol.51
, pp. 846-856
-
-
Yao, J.1
Liang, L.2
Huang, S.3
Ding, J.4
Tan, N.5
Zhao, Y.6
Yan, M.7
Ge, C.8
Zhang, Z.9
Chen, T.10
Wan, D.11
Yao, M.12
Li, J.13
Gu, J.14
He, X.15
|