Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer

Cancer Science

Volumn 101, Issue 9, 2010, Pages 1947-1954

  Maruyama, Takanori ^a   Kono, Koji ^a   Mizukami, Yoshiki ^a   Kawaguchi, Yoshihiko ^a   Mimura, Kousaku ^a   Watanabe, Mitsuaki ^a   Izawa, Shinichirou ^a   Fujii, Hideki ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; CELLULAR DISTRIBUTION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STOMACH CANCER; STOMACH MUCOSA; TH17 CELL; TH2 CELL; TUMOR ASSOCIATED LEUKOCYTE;

AGED; AGED, 80 AND OVER; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKINS; LYMPH NODES; LYMPHOCYTES; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; STOMACH NEOPLASMS; T-LYMPHOCYTES, REGULATORY; TH1-TH2 BALANCE; TH17 CELLS;

EID: 77955938173     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2010.01624.x     Document Type: Article

References (34)

1. Sakuramoto S, Sasako M, Yamaguchi T. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 2007, 357:1810-20. ACTS-GC Group
2. MacDonald JS, Smalley SR, Benedetti J. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001, 345:725-30.
3. Lee HE, Chae SW, Lee YJ. Prognostic implications of type and density of tumour-infiltrating lymphocytes in gastric cancer. Br J Cancer 2008, 99:1704-11.
4. Naito Y, Saito K, Shiiba K. CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 1998, 58:3491-4.
5. Bettelli E, Carrier Y, Gao W. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-8.
6. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol 2009, 27:485-517.
7. Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 2006, 6:329-33.
8. Ivanov II, McKenzie BS, Zhou L. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126:1121-33.
9. Yang XO, Pappu BP, Nurieva R. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 2008, 28:29-39.
10. Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008, 28:454-67.
11. Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007, 8:345-50.
12. Zhang B, Rong G, Wei H. The prevalence of Th17 cells in patients with gastric cancer. Biochem Biophys Res Commun 2008, 374:533-7.
13. Kryczek I, Wei S, Zou L. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol 2007, 178:6730-3.
14. Kryczek I, Banerjee M, Cheng P. Phenotype, distribution, generation, functional and clinical relevance of Th17 cells in the human tumor environments. Blood 2009, 114:1141-9.
15. Derhovanessian E, Adams V, Hähnel K. Pretreatment frequency of circulating IL-17(+)CD4(+) T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. Int J Cancer 2009, 125:1372-9.
16. Sakaguchi S, Ono M, Setoguchi R. Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006, 212:8-27.
17. Feuerer M, Hill JA, Mathis D, Benoist C. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009, 10:689-95.
18. Ichihara F, Kono K, Takahashi A, Kawaida H, Sugai H, Fujii H. Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patient with gastric and esophageal cancers. Clin Cancer Res 2003, 9:4404-8.
19. Wolf D, Wolf AM, Rumpold H. The expression of the regulatory T cells-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res 2005, 11:8326-31.
20. Curiel TJ, Coukos G, Zou L. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004, 10:942-9.
21. Mizukami Y, Kono K, Kawaguchi Y. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. Int J Cancer 2008, 122:2286-93.
22. Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007, 148:32-46.
23. Japanese classification of gastric carcinoma. Gastric Cancer 1998, 1:10-24. Japanese Gastric Cancer Associations, 2nd (English Edn)
24. Sfanos KS, Bruno TC, Maris CH. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin Cancer Res 2008, 14:3254-61.
25. Dhodapkar KM, Barbuto S, Matthews P. Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 2008, 112:2878-85.
26. Inozume T, Hanada K, Wang QJ, Yang JC. IL-17 secreted by tumor reactive T cells induces IL-8 release by human renal cancer cells. J Immunother 2009, 32:109-17.
27. De Marzo AM, Platz EA, Sutcliffe S. Inflammation in prostate carcinogenesis. Nat Rev Cancer 2007, 7:256-69.
28. Caruso R, Fina D, Paoluzi OA. IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa. Eur J Immunol 2008, 38:470-8.
29. Wilson NJ, Boniface K, Chan JR. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007, 8:950-7.
30. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007, 8:942-9.
31. Fina D, Sarra M, Fantini MC. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterol 2008, 134:1038-48.
32. Su X, Ye J, Hsueh EC, Zhang Y, Hoft DF, Peng G. Tumor microenvironments direct the recruitment and expansion of human Th17 cells. J Immunol 2010, 184:1630-41.
33. Mizukami Y, Kono K, Kawaguchi Y. Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer. Br J Cancer 2008, 98:148-53.
34. Wang SK, Zhu HF, He BS. CagA+ H pylori infection is associated with polarization of T helper cell immune responses in gastric carcinogenesis. World J Gastroenterol 2007, 13:2923-31.