Low molecular weight heparin mediated regulation of nitric oxide synthase during burn wound healing

Annals of Burns and Fire Disasters

Volumn 24, Issue 1, 2011, Pages 24-29

  Lakshmi, R T S ^a   Priyanka, T ^a   Meenakshi, J ^a   Mathangi, K R ^b   Jeyaraman, V ^c   Babu, M ^a  

^a CENTRAL LEATHER RESEARCH INSTITUTE   (India)

^b MEDICAL RESEARCH FOUNDATION   (India)

^c Kilpauk Medical College   (India)

Author keywords

Burns; Heparin; Inflammation; Nitric oxide

Indexed keywords

EID: 79957662448     PISSN: 11211539     EISSN: 15929566     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Wallace JL: Nitric oxide as a regulator of inflammatory processes. Mem Inst Oswaldo Cruz, Rio de Janeiro, 100: 5-9, 2005.
2. Wallis JP: Nitric oxide and blood: A review. Transfusion Medicine, 15: 1-11, 2005.
3. Filippou D, Papadopoulos VP, Triga A et al.: Nitric oxide, antioxidant capacity, nitric oxide synthase and xanthine oxidase plasma levels in a cohort of burn patients. Burns, 33: 1001-1007, 2007.
4. Shin SG, Kang JK, Lee KR et al.: Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression in RAW 264.7 macrophages by sesquiterpene lactones. J Toxicol Environ Health Part A, 68: 2119-2131, 2005.
5. Takeuchi K, Yokota A, Tanaka A et al.: Factors involved in up-regulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs. Dig Dis Sci, 51: 1250-1259, 2006.
6. Vallance P: Nitric oxide: Therapeutic opportunities. Fund & Clin Pharmacol, 17: 1-10, 2003.
7. Traber DL, Hawkins HK, Enkhbaatar P et al.: The role of the bronchial circulation in the acute lung injury resulting from burn and smoke inhalation. Pulm Pharmacol Ther, 20: 163-166, 2007.
8. Coleman JW: Nitric oxide: A regulator of mast cell activation and mast cell-mediated inflammation. Clin Exp Immunol, 129: 4-10, 2002.
9. Beltrán AE, Concepción F, Manzanares D et al.: Heparin and low molecular weight heparin decrease nitric oxide production by human polymorphonuclear cells. Arch Med Res, 30: 116-119, 1999.
10. Rawlingson A: Nitric oxide, inflammation and acute burn injury. Burns, 29: 631-610, 2003.
11. Oliveira GV, Shimoda K, Enkhbaatar P et al.: Skin nitric oxide and its metabolites are increased in nonburned skin after thermal injuries. Shock, 22: 278-282, 2004.
12. Ravikumar T, Shanmugasundaram N, Mathangi Ramakrishnan VK, Babu M: Low molecular weight heparin-induced pharmacological modulation of burn wound healing. Ann Burns and Fire Disasters, 19: 123-129, 2006.
13. Mookerjee RP, Dalton RN, Davies NA et al.: Inflammation is an important determinant of levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in acute liver failure. Liver Transpl, 22: 13, 400-405, 2007.
14. Isenberg JS, Ridnour LA, Espey MG et al.: Nitric oxide in wound-healing. Microsurgery, 25: 442-451, 2005.
15. Robinson EK, Seaworth CM, Suliburk JW et al.: Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia. Shock, 25: 507-514, 2006.
16. Su CF, Yang FL, Chen HI: Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats. Clin Exp Pharmacol Physiol, 34: 339-316, 2007.
17. Oremus M, Hanson M, Whitlock R et al.: The uses of heparin to treat burn injury. Evid Rep Technol Assess, 148: 1-58, 2006.
18. Young E: The anti-inflammatory effects of heparin and related compounds. Thromb Res, 122: 743-752, 2008.
19. Troshev K, Dimitrov R: Application of heparin in the local treatment of burns. Acta Chir Plast, 43: 143-144, 2001.
20. Paulsen SM, Wurster SH, Nanney LB: Expression of inducible nitric oxide synthase in human burn wounds. Wound Repair and Regeneration, 6: 142-148, 1998.
21. Mousa SA, Johansen K: Pharmacodynamic effects of low molecular weight heparin in obese subjects following subcutaneous administration of 75 IU/kg on plasma tissue factor pathway inhibitor and nitric oxide. Int Angiol, 24: 40-42, 2005.
22. Enkhbaatar P, Traber DL: Pathophysiology of acute lung injury in combined burn and smoke inhalation injury. Clinical Science, 107: 137-143, 2004.
23. Schlaich MP, Schmitt D, Ott C et al.: Basal nitric oxide synthase activity is a major determinant of glomerular haemodynamics in humans. J Hypertens, 26: 110-116, 2008.
24. Fareed D, Iqbal O, Tobu M et al.: Blood levels of nitric oxide, C-reactive protein, and tumor necrosis factor-α are upregulated in patients with malignancy-associated hypercoagulable state: Pathophysiologic implications. Clinical and Applied Thrombosis/Hemo-stasis, 10: 357-364, 2004.
25. Panaro MA Brandonisio O, Acquafredda A et al.: Evidences for iNOS expression and nitric oxide production in the human macrophages. Curr Drug Targets Immune Endocr Metabol Disord, 3: 210-211, 2003.