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Volumn 10, Issue 3, 2011, Pages 389-395

Vaccine effectiveness in older individuals: What has been learned from the influenza-vaccine experience

Author keywords

Cell mediated immunity; Hemagglutinin inhibition; Immunosenescence; Influenza vaccine effectiveness; Innate immunity; Older adults

Indexed keywords

ANTIBODY; HEMAGGLUTININ; INACTIVATED VACCINE; INFLUENZA VACCINE;

EID: 79955949208     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2010.09.005     Document Type: Review
Times cited : (55)

References (110)
  • 2
    • 0035915756 scopus 로고    scopus 로고
    • A simple method for the measurement of sjTREC levels in blood
    • Aspinall R., Pido J., Andrew D. A simple method for the measurement of sjTREC levels in blood. Mech. Ageing Dev. 2000, 121:59-67.
    • (2000) Mech. Ageing Dev. , vol.121 , pp. 59-67
    • Aspinall, R.1    Pido, J.2    Andrew, D.3
  • 3
  • 4
    • 0024445922 scopus 로고
    • Antibody induction by influenza vaccines in the elderly: a review of the literature
    • Beyer W.E.P., Palache A.M., Baljet M., Masurel N. Antibody induction by influenza vaccines in the elderly: a review of the literature. Vaccine 1989, 7:385-394.
    • (1989) Vaccine , vol.7 , pp. 385-394
    • Beyer, W.E.P.1    Palache, A.M.2    Baljet, M.3    Masurel, N.4
  • 7
    • 0035879705 scopus 로고    scopus 로고
    • Influenza revaccination of elderly travellers: antibody response to single influenza vaccination and revaccination at 12 weeks
    • Buxton J.A., Skowronski D.M., Ng H., et al. Influenza revaccination of elderly travellers: antibody response to single influenza vaccination and revaccination at 12 weeks. J. Infect. Dis. 2001, 184:188-191.
    • (2001) J. Infect. Dis. , vol.184 , pp. 188-191
    • Buxton, J.A.1    Skowronski, D.M.2    Ng, H.3
  • 8
    • 79955959743 scopus 로고    scopus 로고
    • A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects
    • Epub ahead of print)
    • Cate T.R., Rayford Y., Niño D., Winokur P., Brady R., Belshe R., Chen W., Atmar R.L., Couch R.B. A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects. Vaccine 2009, (Epub ahead of print).
    • (2009) Vaccine
    • Cate, T.R.1    Rayford, Y.2    Niño, D.3    Winokur, P.4    Brady, R.5    Belshe, R.6    Chen, W.7    Atmar, R.L.8    Couch, R.B.9
  • 9
    • 4344566945 scopus 로고    scopus 로고
    • Recommendation of the Advisory Committee on Immunization Practices (ACIP)
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention Recommendation of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb. Mortal. Wkly. Rep. 2004, 53(RR-06):1-40.
    • (2004) MMWR Morb. Mortal. Wkly. Rep. , vol.53 , Issue.RR 6 , pp. 1-40
  • 11
    • 67349134258 scopus 로고    scopus 로고
    • FluBlok a next generation influenza vaccine manufactured in insect cells
    • Cox M.M., Hollister J.R. FluBlok a next generation influenza vaccine manufactured in insect cells. Biologicals 2009, 37:182-189.
    • (2009) Biologicals , vol.37 , pp. 182-189
    • Cox, M.M.1    Hollister, J.R.2
  • 12
    • 33846222438 scopus 로고    scopus 로고
    • The virosomal influenza vaccine Invivac: immunogeneicity and tolerability compared to adjuvanted influenza vaccine (Fluad) in elderly subjects
    • de Bruijn I.A., Nauta J., Gerez L., Palache A.M. The virosomal influenza vaccine Invivac: immunogeneicity and tolerability compared to adjuvanted influenza vaccine (Fluad) in elderly subjects. Vaccine 2006, 24:6629-6631.
    • (2006) Vaccine , vol.24 , pp. 6629-6631
    • de Bruijn, I.A.1    Nauta, J.2    Gerez, L.3    Palache, A.M.4
  • 13
    • 70649101240 scopus 로고    scopus 로고
    • LAIV Elderly Study Trial Network. Efficacy and safety of a live attenuated influenza vaccine in adults 60 years of age and older
    • De Villiers P.J., Steele A.D., Hiemstra L.A., Rappaport R., Dunning A.J., Gruber W.C., Forrest B.D. LAIV Elderly Study Trial Network. Efficacy and safety of a live attenuated influenza vaccine in adults 60 years of age and older. Vaccine 2009, 28:228-234.
    • (2009) Vaccine , vol.28 , pp. 228-234
    • De Villiers, P.J.1    Steele, A.D.2    Hiemstra, L.A.3    Rappaport, R.4    Dunning, A.J.5    Gruber, W.C.6    Forrest, B.D.7
  • 14
    • 74849106752 scopus 로고    scopus 로고
    • Influenza vaccines provide diminished protection but are cost-saving in older adults
    • Deans G.D., Stiver H.G., McElhaney J.E. Influenza vaccines provide diminished protection but are cost-saving in older adults. J. Intern. Med. 2010, 267:220-227.
    • (2010) J. Intern. Med. , vol.267 , pp. 220-227
    • Deans, G.D.1    Stiver, H.G.2    McElhaney, J.E.3
  • 15
    • 0031960363 scopus 로고    scopus 로고
    • Influenza vaccination and warfarin anticoagulation: a comparison of subcutaneous and intramuscular routes of administration in elderly men
    • Delafuente J.C., Davis J.A., Meuleman J.R., Jones R.A. Influenza vaccination and warfarin anticoagulation: a comparison of subcutaneous and intramuscular routes of administration in elderly men. Pharmacotherapy 1998, 18:631-636.
    • (1998) Pharmacotherapy , vol.18 , pp. 631-636
    • Delafuente, J.C.1    Davis, J.A.2    Meuleman, J.R.3    Jones, R.A.4
  • 17
    • 33845215290 scopus 로고    scopus 로고
    • Role of T lymphocyte replicative senescence in vaccine efficacy
    • Effros R.B. Role of T lymphocyte replicative senescence in vaccine efficacy. Vaccine 2007, 25:259-604.
    • (2007) Vaccine , vol.25 , pp. 259-604
    • Effros, R.B.1
  • 18
    • 34147222679 scopus 로고    scopus 로고
    • Telomerase induction in T cells: a cure for aging and disease?
    • Effros R.B. Telomerase induction in T cells: a cure for aging and disease?. Exp. Gerontol. 2007, 42:416-420.
    • (2007) Exp. Gerontol. , vol.42 , pp. 416-420
    • Effros, R.B.1
  • 19
    • 67650665332 scopus 로고    scopus 로고
    • Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older
    • Falsey A.R., Treanor J.J., Tornieporth N., Capellan J., Gorse G.J. Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older. J. Infect. Dis. 2009, 200:172-180.
    • (2009) J. Infect. Dis. , vol.200 , pp. 172-180
    • Falsey, A.R.1    Treanor, J.J.2    Tornieporth, N.3    Capellan, J.4    Gorse, G.J.5
  • 22
    • 48949089658 scopus 로고    scopus 로고
    • Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008
    • Centers for Disease Control and Prevention (CDC), Advisory Committee on Immunization Practice (ACIP)
    • Fiore A.E., Shay D.K., Broder K., Iskander J.K., Uyeki T.M., Mootrey G., Bresee J.S., Cox N.S., Centers for Disease Control and Prevention (CDC), Advisory Committee on Immunization Practice (ACIP) Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008. MMWR Morb. Mortal. Wkly. Rep. 2008, 57(RR-7):1-60.
    • (2008) MMWR Morb. Mortal. Wkly. Rep. , vol.57 , Issue.RR 7 , pp. 1-60
    • Fiore, A.E.1    Shay, D.K.2    Broder, K.3    Iskander, J.K.4    Uyeki, T.M.5    Mootrey, G.6    Bresee, J.S.7    Cox, N.S.8
  • 26
    • 72049128598 scopus 로고    scopus 로고
    • Safety and immunogenicity of an influenza vaccine A/H5N1 (A/Vietnam/1194/2004) when co-administered with a heat-labile enterotoxin (LT) adjuvant patch
    • Glenn G.M., Thomas D.N., Poffenberger K.L., Flyer D.C., Ellingsworth L.R., Andersen B.H., Frech S.A. Safety and immunogenicity of an influenza vaccine A/H5N1 (A/Vietnam/1194/2004) when co-administered with a heat-labile enterotoxin (LT) adjuvant patch. Vaccine 2009, 27(Suppl. 6):G60-G66.
    • (2009) Vaccine , vol.27 , Issue.SUPPL. 6
    • Glenn, G.M.1    Thomas, D.N.2    Poffenberger, K.L.3    Flyer, D.C.4    Ellingsworth, L.R.5    Andersen, B.H.6    Frech, S.A.7
  • 27
    • 32044453088 scopus 로고    scopus 로고
    • Antibody response to influenza vaccine in the elderly: a quantitative review
    • Goodwin K., Viboud C., Simonsen L. Antibody response to influenza vaccine in the elderly: a quantitative review. Vaccine 2006, 24:6808-6811.
    • (2006) Vaccine , vol.24 , pp. 6808-6811
    • Goodwin, K.1    Viboud, C.2    Simonsen, L.3
  • 28
    • 0027973478 scopus 로고
    • The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial
    • Goveart T.M., Thijs C.T., Masurel N., Sprenger M.J., Dinant G.J., Knottnerus J.A. The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial. JAMA 1994, 272:1661-1665.
    • (1994) JAMA , vol.272 , pp. 1661-1665
    • Goveart, T.M.1    Thijs, C.T.2    Masurel, N.3    Sprenger, M.J.4    Dinant, G.J.5    Knottnerus, J.A.6
  • 29
    • 16544365667 scopus 로고    scopus 로고
    • Immunization against viral respiratory disease: a review
    • Greenberg H.B., Piedra P.A. Immunization against viral respiratory disease: a review. Pediatr. Infect. Dis. J. 2004, 23(Suppl. 11):S254-S261.
    • (2004) Pediatr. Infect. Dis. J. , vol.23 , Issue.SUPPL. 11
    • Greenberg, H.B.1    Piedra, P.A.2
  • 31
    • 63049130261 scopus 로고    scopus 로고
    • Human CD4+ T cells recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function
    • Haines C.J., Giffon T.D., Lu L.S., Lu X., Tessier-Lavigne M., Ross D.T., Lewis D.B. Human CD4+ T cells recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. J. Exp. Med. 2009, 206:275-285.
    • (2009) J. Exp. Med. , vol.206 , pp. 275-285
    • Haines, C.J.1    Giffon, T.D.2    Lu, L.S.3    Lu, X.4    Tessier-Lavigne, M.5    Ross, D.T.6    Lewis, D.B.7
  • 32
    • 0036900831 scopus 로고    scopus 로고
    • Confounding by indication in non-experimental evaluation of vaccine effectiveness: the example of prevention of influenza complications
    • Hak E., Verheij T.J., Grobbee D.E., Nichol K.L., Hoes A.W. Confounding by indication in non-experimental evaluation of vaccine effectiveness: the example of prevention of influenza complications. J. Epidemiol. Community Health 2002, 56:951-955.
    • (2002) J. Epidemiol. Community Health , vol.56 , pp. 951-955
    • Hak, E.1    Verheij, T.J.2    Grobbee, D.E.3    Nichol, K.L.4    Hoes, A.W.5
  • 33
    • 33745587017 scopus 로고    scopus 로고
    • Benefits of influenza vaccine in US elderly-appreciating issues of confounding, bias and precision
    • Hak E., Hoes A.W., Nordin J., Nichol K.L. Benefits of influenza vaccine in US elderly-appreciating issues of confounding, bias and precision. Int. J. Epidemiol. 2006, 35:800-802.
    • (2006) Int. J. Epidemiol. , vol.35 , pp. 800-802
    • Hak, E.1    Hoes, A.W.2    Nordin, J.3    Nichol, K.L.4
  • 34
    • 58149352995 scopus 로고    scopus 로고
    • Decline of T cell-related immune functions in cancer patients and an attempt to restore them through infusion of activated autologous T cells
    • Hirokawa K., Utsuyama M., Ishikawa T., Kikuchi Y., Kitagawa M., Fujii Y., Nariuchi H., Uetake H., Sugihara K. Decline of T cell-related immune functions in cancer patients and an attempt to restore them through infusion of activated autologous T cells. Mech. Ageing Dev. 2009, 130:86-91.
    • (2009) Mech. Ageing Dev. , vol.130 , pp. 86-91
    • Hirokawa, K.1    Utsuyama, M.2    Ishikawa, T.3    Kikuchi, Y.4    Kitagawa, M.5    Fujii, Y.6    Nariuchi, H.7    Uetake, H.8    Sugihara, K.9
  • 37
    • 33744513283 scopus 로고    scopus 로고
    • Immune response to influenza vaccination in community-dwelling Chinese elderly persons
    • Hui S.L., Chu L.W., Peiris J.S., Chan K.H., Chu D., Tsui W. Immune response to influenza vaccination in community-dwelling Chinese elderly persons. Vaccine 2006, 24:5371-5380.
    • (2006) Vaccine , vol.24 , pp. 5371-5380
    • Hui, S.L.1    Chu, L.W.2    Peiris, J.S.3    Chan, K.H.4    Chu, D.5    Tsui, W.6
  • 40
    • 79955968527 scopus 로고    scopus 로고
    • Influenza, (accessed 30.04.10).
    • Influenza, 2008. (accessed 30.04.10). http://www.who.int/mediacentre/factsheets/fs211/en/.
    • (2008)
  • 41
    • 51349142314 scopus 로고    scopus 로고
    • Benefits of examining influenza vaccine associations outside of influenza season
    • Jackson L.A. Benefits of examining influenza vaccine associations outside of influenza season. Am. J. Respir. Crit. Care Med. 2008, 178:439-440.
    • (2008) Am. J. Respir. Crit. Care Med. , vol.178 , pp. 439-440
    • Jackson, L.A.1
  • 44
    • 48149110000 scopus 로고    scopus 로고
    • Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study
    • Jackson M.L., Nelson J.C., Weiss N.S., Neuzil K.M., Barlow W., Jackson L.A. Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study. Lancet 2008, 372:398-405.
    • (2008) Lancet , vol.372 , pp. 398-405
    • Jackson, M.L.1    Nelson, J.C.2    Weiss, N.S.3    Neuzil, K.M.4    Barlow, W.5    Jackson, L.A.6
  • 45
    • 33750595091 scopus 로고    scopus 로고
    • Influenza vaccination: policy versus evidence
    • Jefferson T. Influenza vaccination: policy versus evidence. BMJ 2006, 333:912-915.
    • (2006) BMJ , vol.333 , pp. 912-915
    • Jefferson, T.1
  • 46
    • 25844467829 scopus 로고    scopus 로고
    • Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review
    • Jefferson T., Rivetti D., Rivetti A., Rudin M., Di Pietrantonj C., Demicheli V. Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet 2005, 366:1165-1174.
    • (2005) Lancet , vol.366 , pp. 1165-1174
    • Jefferson, T.1    Rivetti, D.2    Rivetti, A.3    Rudin, M.4    Di Pietrantonj, C.5    Demicheli, V.6
  • 49
    • 54249154153 scopus 로고    scopus 로고
    • Safety and immunogenicity of an inactivated influenza A/H5N1 vaccine given with or without aluminium hydroxide to healthy adults: results of a phase I-II randomized clinical trial
    • Keitel W.A., Campbell J.D., Treanor J.J., Walter E.B., Patel S.M., He F., Noah D.L., Hill H. Safety and immunogenicity of an inactivated influenza A/H5N1 vaccine given with or without aluminium hydroxide to healthy adults: results of a phase I-II randomized clinical trial. J. Infect. Dis. 2008, 198:1309-1316.
    • (2008) J. Infect. Dis. , vol.198 , pp. 1309-1316
    • Keitel, W.A.1    Campbell, J.D.2    Treanor, J.J.3    Walter, E.B.4    Patel, S.M.5    He, F.6    Noah, D.L.7    Hill, H.8
  • 50
    • 33847705342 scopus 로고    scopus 로고
    • Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly
    • Keylock K.T., Lowder T., Leifheit K.A., et al. Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly. J. Appl. Physiol. 2007, 102:1090-1098.
    • (2007) J. Appl. Physiol. , vol.102 , pp. 1090-1098
    • Keylock, K.T.1    Lowder, T.2    Leifheit, K.A.3
  • 52
    • 44449158272 scopus 로고    scopus 로고
    • Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication
    • Lang A., Brien J.D., Messaoudi I., Nikolich-Zugich J. Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication. J. Immunol. 2008, 180:4848-4857.
    • (2008) J. Immunol. , vol.180 , pp. 4848-4857
    • Lang, A.1    Brien, J.D.2    Messaoudi, I.3    Nikolich-Zugich, J.4
  • 53
    • 76249117986 scopus 로고    scopus 로고
    • Inflation and long-term maintenance of CD8 T cells responding to a latent herpes virus depend upon establishment of latency and presence of viral antigens
    • Lang A., Brien J.D., Nikolich-Zugich J. Inflation and long-term maintenance of CD8 T cells responding to a latent herpes virus depend upon establishment of latency and presence of viral antigens. J. Immunol. 2009, 183:8077-8087.
    • (2009) J. Immunol. , vol.183 , pp. 8077-8087
    • Lang, A.1    Brien, J.D.2    Nikolich-Zugich, J.3
  • 54
    • 58149194782 scopus 로고    scopus 로고
    • Seasonal influenza vaccine delivered by intradermal microinjection: A randomised controlled safety and immunogenicity trial in adults
    • Leroux-Roels I., Vets E., Freese R., Seiberling M., Weber F., Salamand C., Leroux-Roels G. Seasonal influenza vaccine delivered by intradermal microinjection: A randomised controlled safety and immunogenicity trial in adults. Vaccine 2008, 26:6614-6619.
    • (2008) Vaccine , vol.26 , pp. 6614-6619
    • Leroux-Roels, I.1    Vets, E.2    Freese, R.3    Seiberling, M.4    Weber, F.5    Salamand, C.6    Leroux-Roels, G.7
  • 55
    • 71249164116 scopus 로고    scopus 로고
    • Priming with AS03 A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterogeneous booster vaccination: an open non-randomised extension of a double-blind randomised primary study
    • Leroux-Roels I.RF., Forgus S., Maes C., De Boever F., Dramé M., Gillard P., van der Most R., Van Mechelen M., Hanon E., Leroux-Roels G. Priming with AS03 A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterogeneous booster vaccination: an open non-randomised extension of a double-blind randomised primary study. Vaccine 2010, 28:849-857.
    • (2010) Vaccine , vol.28 , pp. 849-857
    • Leroux-Roels, I.R.F.1    Forgus, S.2    Maes, C.3    De Boever, F.4    Dramé, M.5    Gillard, P.6    van der Most, R.7    Van Mechelen, M.8    Hanon, E.9    Leroux-Roels, G.10
  • 56
    • 33846124632 scopus 로고    scopus 로고
    • Evolving strategies for the prevention of influenza infection: potential for multistrain targeting
    • Livingston B.D., Higgins D., Van Nest G. Evolving strategies for the prevention of influenza infection: potential for multistrain targeting. BioDrugs 2006, 20:335-340.
    • (2006) BioDrugs , vol.20 , pp. 335-340
    • Livingston, B.D.1    Higgins, D.2    Van Nest, G.3
  • 57
    • 33745461186 scopus 로고    scopus 로고
    • Influenza vaccination health impact and cost effectiveness among adults aged 50-64 and 65 and older
    • Maciosek M.V., Solberg L.I., Coffield A.B., Edwards N.M., Goodman M.J. Influenza vaccination health impact and cost effectiveness among adults aged 50-64 and 65 and older. Am. J. Prev. Med. 2006, 31:72-79.
    • (2006) Am. J. Prev. Med. , vol.31 , pp. 72-79
    • Maciosek, M.V.1    Solberg, L.I.2    Coffield, A.B.3    Edwards, N.M.4    Goodman, M.J.5
  • 58
    • 0017359388 scopus 로고
    • Influenza subunit vaccine: antibody responses to one and two doses of vaccine and length of response, with particular reference to the elderly
    • MacKenzie J.S. Influenza subunit vaccine: antibody responses to one and two doses of vaccine and length of response, with particular reference to the elderly. Br. Med. J. 1977, 1:200-202.
    • (1977) Br. Med. J. , vol.1 , pp. 200-202
    • MacKenzie, J.S.1
  • 59
    • 22544459957 scopus 로고    scopus 로고
    • The unmet need in the elderly: designing new influenza vaccines for older adults
    • McElhaney J.E. The unmet need in the elderly: designing new influenza vaccines for older adults. Vaccine 2005, 23(Suppl. 1):S10-S25.
    • (2005) Vaccine , vol.23 , Issue.SUPPL. 1
    • McElhaney, J.E.1
  • 60
    • 0027436082 scopus 로고
    • Antibody response to whole-virus and split-virus influenza vaccines in successful ageing
    • McElhaney J.E., Meneilly G.S., Lechelt K.E., Beattie B.L., Bleackley R.C. Antibody response to whole-virus and split-virus influenza vaccines in successful ageing. Vaccine 1993, 11:1055-1060.
    • (1993) Vaccine , vol.11 , pp. 1055-1060
    • McElhaney, J.E.1    Meneilly, G.S.2    Lechelt, K.E.3    Beattie, B.L.4    Bleackley, R.C.5
  • 61
    • 84978372465 scopus 로고    scopus 로고
    • Healthy lifestyle behaviours among older US adults with and without disabilities. Behavioral risk factor surveillance system, 2003
    • Available at
    • McGuire L.C., Strine T.W., Okoro C.A., Ahluwalia I.B., Ford E.S. Healthy lifestyle behaviours among older US adults with and without disabilities. Behavioral risk factor surveillance system, 2003. Prev. Chronic Dis. [Online Serial] 2007, 4:1-11. Available at: http://www.cdc.gov/pcd/issues/2007/jan/06 0029.htm.
    • (2007) Prev. Chronic Dis. [Online Serial] , vol.4 , pp. 1-11
    • McGuire, L.C.1    Strine, T.W.2    Okoro, C.A.3    Ahluwalia, I.B.4    Ford, E.S.5
  • 62
    • 79951832329 scopus 로고    scopus 로고
    • Promoting life course vaccination
    • in press.
    • Michel, J.P., Lang, P.O., 2011. Promoting life course vaccination. Rejuvenation Res., in press.
    • (2011) Rejuvenation Res.
    • Michel, J.P.1    Lang, P.O.2
  • 63
    • 77949824961 scopus 로고    scopus 로고
    • Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study
    • Miller E., Hoschler K., Hardelid P., Stanford E., Andrews N., Zambon M. Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study. Lancet 2010, 375:1100-1108.
    • (2010) Lancet , vol.375 , pp. 1100-1108
    • Miller, E.1    Hoschler, K.2    Hardelid, P.3    Stanford, E.4    Andrews, N.5    Zambon, M.6
  • 64
    • 0032889660 scopus 로고    scopus 로고
    • Safety and immunogenicity of an inactivated subunit influenza virus vaccine combined with MF59 adjuvant emulsion in elderly subjects, immunized for three consecutive influenza seasons
    • Minutello M., Senatore F., Cecchinelli G., et al. Safety and immunogenicity of an inactivated subunit influenza virus vaccine combined with MF59 adjuvant emulsion in elderly subjects, immunized for three consecutive influenza seasons. Vaccine 1999, 17:99-104.
    • (1999) Vaccine , vol.17 , pp. 99-104
    • Minutello, M.1    Senatore, F.2    Cecchinelli, G.3
  • 65
    • 84919729525 scopus 로고    scopus 로고
    • Interleukine-7 and immunorejuvenation
    • Springer Science+Business Media BV, T. Fulop, C. Franceschi, K. Hirokawa, G. Pawelec (Eds.)
    • Mitchell W.A., Aspinall R. Interleukine-7 and immunorejuvenation. Handbook of Immunosenescence: Basic Understanding and Clinical Applications 2009, 1516-1546. Springer Science+Business Media BV. T. Fulop, C. Franceschi, K. Hirokawa, G. Pawelec (Eds.).
    • (2009) Handbook of Immunosenescence: Basic Understanding and Clinical Applications , pp. 1516-1546
    • Mitchell, W.A.1    Aspinall, R.2
  • 68
    • 0035879596 scopus 로고    scopus 로고
    • Influenza vaccine effectiveness among elderly nursing home residents: a cohort study
    • Monto A.S., Hornbuckle K., Ohmit S.E. Influenza vaccine effectiveness among elderly nursing home residents: a cohort study. Am. J. Epidemiol. 2001, 154:155-160.
    • (2001) Am. J. Epidemiol. , vol.154 , pp. 155-160
    • Monto, A.S.1    Hornbuckle, K.2    Ohmit, S.E.3
  • 72
    • 67349102276 scopus 로고    scopus 로고
    • New strategies are needed to improve the accuracy of influenza vaccine effectiveness estimates among senior
    • Nelson J.C., Jackson M.L., Weiss N.S., Jackson L.A. New strategies are needed to improve the accuracy of influenza vaccine effectiveness estimates among senior. J. Clin. Epidemiol. 2009, 62:687-694.
    • (2009) J. Clin. Epidemiol. , vol.62 , pp. 687-694
    • Nelson, J.C.1    Jackson, M.L.2    Weiss, N.S.3    Jackson, L.A.4
  • 73
    • 70349962885 scopus 로고    scopus 로고
    • Challenges in evaluating influenza vaccine effectiveness and the mortality benefits controversy
    • Nichol K.L. Challenges in evaluating influenza vaccine effectiveness and the mortality benefits controversy. Vaccine 2009, 27:6305-6311.
    • (2009) Vaccine , vol.27 , pp. 6305-6311
    • Nichol, K.L.1
  • 74
    • 0032517071 scopus 로고    scopus 로고
    • Benefits of influenza vaccination for low-, intermediate-, and high-risk senior citizens
    • Nichol K.L., Wuorenma J., von Sternberg T. Benefits of influenza vaccination for low-, intermediate-, and high-risk senior citizens. Arch. Intern. Med. 1998, 158:1769-1776.
    • (1998) Arch. Intern. Med. , vol.158 , pp. 1769-1776
    • Nichol, K.L.1    Wuorenma, J.2    von Sternberg, T.3
  • 76
    • 79955964677 scopus 로고    scopus 로고
    • Note for Guidance on Harmonization of Requirements for Influenza Vaccines, March 12. CPMP/BWP/214/96 (circular 96-0666): 1-22.) (accessed 30.04.10).
    • Note for Guidance on Harmonization of Requirements for Influenza Vaccines, 1997, March 12. CPMP/BWP/214/96 (circular 96-0666): 1-22.) (accessed 30.04.10). http://www.emea.europa.eu/pdfs/human/bwp/021496en.pdf.
    • (1997)
  • 78
    • 0021981430 scopus 로고
    • Efficacy of influenza vaccine in nursing homes. Reduction in illness and complications during an influenza A (H3N2) epidemic
    • Patriarca P.A., Weber J.A., Parker R.A., Hall W.M., Kendal A.P., Bregman D.J., Schonberger L.B. Efficacy of influenza vaccine in nursing homes. Reduction in illness and complications during an influenza A (H3N2) epidemic. JAMA 1985, 253:1136-1139.
    • (1985) JAMA , vol.253 , pp. 1136-1139
    • Patriarca, P.A.1    Weber, J.A.2    Parker, R.A.3    Hall, W.M.4    Kendal, A.P.5    Bregman, D.J.6    Schonberger, L.B.7
  • 80
    • 0035077630 scopus 로고    scopus 로고
    • Immunogenicity and safety of three commercial influenza vaccines in institutionalized elderly
    • Pegliasco F., Mensi C., Serpilli W., Speccher L., Masella P., Belloni A. Immunogenicity and safety of three commercial influenza vaccines in institutionalized elderly. Aging (Milano) 2001, 13:38-43.
    • (2001) Aging (Milano) , vol.13 , pp. 38-43
    • Pegliasco, F.1    Mensi, C.2    Serpilli, W.3    Speccher, L.4    Masella, P.5    Belloni, A.6
  • 81
    • 0023924090 scopus 로고
    • Antibody response of an elderly population to a supplemental dose of influenza B vaccine
    • Peters N.L., Meiklejohn G., Jahnigen D.W. Antibody response of an elderly population to a supplemental dose of influenza B vaccine. J. Am. Geriatr. Soc. 1988, 36:593-599.
    • (1988) J. Am. Geriatr. Soc. , vol.36 , pp. 593-599
    • Peters, N.L.1    Meiklejohn, G.2    Jahnigen, D.W.3
  • 82
    • 67349216217 scopus 로고    scopus 로고
    • Trends affecting the future of vaccine development and delivery: the role of demographics, regulatory science, the anti-vaccine movement, and vaccinomics
    • Poland G.A., Jacobson R.M., Ovsyannikova I.G. Trends affecting the future of vaccine development and delivery: the role of demographics, regulatory science, the anti-vaccine movement, and vaccinomics. Vaccine 2009, 27:3240-3244.
    • (2009) Vaccine , vol.27 , pp. 3240-3244
    • Poland, G.A.1    Jacobson, R.M.2    Ovsyannikova, I.G.3
  • 83
    • 0028806065 scopus 로고
    • In previously immunized elderly adults inactivated influenza A (H1N1) virus vaccines induce poor antibody responses that are not enhanced by liposome adjuvant
    • Powers D.C., Hanscome P.J., Pietrobon P.J.F. In previously immunized elderly adults inactivated influenza A (H1N1) virus vaccines induce poor antibody responses that are not enhanced by liposome adjuvant. Vaccine 1995, 13:1330-1335.
    • (1995) Vaccine , vol.13 , pp. 1330-1335
    • Powers, D.C.1    Hanscome, P.J.2    Pietrobon, P.J.F.3
  • 84
    • 20444462373 scopus 로고    scopus 로고
    • The efficacy and effectiveness of influenza vaccination among Thai elderly persons living in the community
    • Praditsuwan R., Assantachai P., Wasi C., Puthavatana P., Kositanont U. The efficacy and effectiveness of influenza vaccination among Thai elderly persons living in the community. J. Med. Assoc. Thai. 2005, 88:256-264.
    • (2005) J. Med. Assoc. Thai. , vol.88 , pp. 256-264
    • Praditsuwan, R.1    Assantachai, P.2    Wasi, C.3    Puthavatana, P.4    Kositanont, U.5
  • 86
    • 75249101993 scopus 로고    scopus 로고
    • Immunogenicity and safety in adults of one dose of influenza A H1N1v 2009 vaccine formulated with and without AS03A-adjuvant: preliminary report of an observer-blind, randomised-trial
    • Roman F., Vaman T., Gerlach B., Markendorf A., Gillard P., Devaster J.M. Immunogenicity and safety in adults of one dose of influenza A H1N1v 2009 vaccine formulated with and without AS03A-adjuvant: preliminary report of an observer-blind, randomised-trial. Vaccine 2010, 28:1740-1745.
    • (2010) Vaccine , vol.28 , pp. 1740-1745
    • Roman, F.1    Vaman, T.2    Gerlach, B.3    Markendorf, A.4    Gillard, P.5    Devaster, J.M.6
  • 88
    • 4043130309 scopus 로고    scopus 로고
    • Open, randomized study to compare the immunogenicity and reactogenicity of an influenza split vaccine with an MF59-adjuvanted subunit vaccine and a virosome-based subunit vaccine in elderly
    • Ruf B.R., Colberg K., Frick M., Preusche A. Open, randomized study to compare the immunogenicity and reactogenicity of an influenza split vaccine with an MF59-adjuvanted subunit vaccine and a virosome-based subunit vaccine in elderly. Infection 2004, 32:191-198.
    • (2004) Infection , vol.32 , pp. 191-198
    • Ruf, B.R.1    Colberg, K.2    Frick, M.3    Preusche, A.4
  • 90
    • 52149124652 scopus 로고    scopus 로고
    • Greenberg HB Influence of prior influenza vaccination on antibody and B-cell responses
    • Sasaki S., He X.S., Holmes T.H., Dekker C.L., Kemble G.W., Arvin A.M. Greenberg HB Influence of prior influenza vaccination on antibody and B-cell responses. PLoS One 2008, 3:e2975.
    • (2008) PLoS One , vol.3
    • Sasaki, S.1    He, X.S.2    Holmes, T.H.3    Dekker, C.L.4    Kemble, G.W.5    Arvin, A.M.6
  • 91
    • 79955944425 scopus 로고    scopus 로고
    • Seasonal Human Influenza and Vaccination,(accessed 30.04.10).
    • Seasonal Human Influenza and Vaccination, 2010.) (accessed 30.04.10). http://www.ecdc.europa.eu/en/press/Press%2520Releases/071012_PR_SI_Prof_Fact_Sheet.pdf.
    • (2010)
  • 92
    • 61349097791 scopus 로고    scopus 로고
    • B-cell responses to vaccination at the extremes of age
    • Siegrist C.A., Aspinall R. B-cell responses to vaccination at the extremes of age. Nat. Rev. Immunol. 2009, 9:185-193.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 185-193
    • Siegrist, C.A.1    Aspinall, R.2
  • 93
    • 34548847744 scopus 로고    scopus 로고
    • Mortality benefits of influenza vaccination in elderly people: an ongoing controversy
    • Simonsen L., Taylor R.J., Viboud C., Miller M.A., Jackson L.A. Mortality benefits of influenza vaccination in elderly people: an ongoing controversy. Lancet Infect. Dis. 2007, 7:658-666.
    • (2007) Lancet Infect. Dis. , vol.7 , pp. 658-666
    • Simonsen, L.1    Taylor, R.J.2    Viboud, C.3    Miller, M.A.4    Jackson, L.A.5
  • 94
    • 70349976420 scopus 로고    scopus 로고
    • Influenza vaccination and mortality benefits: new insights, new opportunity
    • Simonsen L., Viboud C., Taylor R.J., Miller M.A., Jackson L.A. Influenza vaccination and mortality benefits: new insights, new opportunity. Vaccine 2009, 27:6300-6304.
    • (2009) Vaccine , vol.27 , pp. 6300-6304
    • Simonsen, L.1    Viboud, C.2    Taylor, R.J.3    Miller, M.A.4    Jackson, L.A.5
  • 95
    • 40049108737 scopus 로고    scopus 로고
    • Rapid decline of influenza vaccine-induced antibody in the elderly: is it real, or is it relevant?
    • Skowronski D.M., Tweed S.A., De Serres G. Rapid decline of influenza vaccine-induced antibody in the elderly: is it real, or is it relevant?. J. Infect. Dis. 2008, 197:490-502.
    • (2008) J. Infect. Dis. , vol.197 , pp. 490-502
    • Skowronski, D.M.1    Tweed, S.A.2    De Serres, G.3
  • 96
    • 33746724834 scopus 로고    scopus 로고
    • Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP)
    • Smith N.M., Bresee J.S., Shay D.K., Uyeki T.M., Cox N.J., Strikas R.A. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb. Mortal. Wkly. Rep. 2006, 55(RR-10):1-42.
    • (2006) MMWR Morb. Mortal. Wkly. Rep. , vol.55 , Issue.RR 10 , pp. 1-42
    • Smith, N.M.1    Bresee, J.S.2    Shay, D.K.3    Uyeki, T.M.4    Cox, N.J.5    Strikas, R.A.6
  • 97
    • 34447319921 scopus 로고    scopus 로고
    • No immune risk profile among individuals who reach 100 years of age findings from the Swedish NONA immune longitudinal study
    • Strindhall J., Nilsson B.O., lofgren S., Ernerudh, Pawelec G., Johansson B., Wikby A. No immune risk profile among individuals who reach 100 years of age findings from the Swedish NONA immune longitudinal study. Exp. Gerontol. 2007, 42:753-761.
    • (2007) Exp. Gerontol. , vol.42 , pp. 753-761
    • Strindhall, J.1    Nilsson, B.O.2    lofgren, S.3    Ernerudh4    Pawelec, G.5    Johansson, B.6    Wikby, A.7
  • 100
    • 0242317690 scopus 로고    scopus 로고
    • Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence
    • Trzonkowski P., Mysliwska J., Szmit E., et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence. Vaccine 2003, 21:3826-3836.
    • (2003) Vaccine , vol.21 , pp. 3826-3836
    • Trzonkowski, P.1    Mysliwska, J.2    Szmit, E.3
  • 101
    • 20344379893 scopus 로고    scopus 로고
    • CD28 extinction in human T-cells: altered functions and the program of T-cell senescence
    • Vallejo A.N. CD28 extinction in human T-cells: altered functions and the program of T-cell senescence. Immunol. Rev. 2005, 205:158-169.
    • (2005) Immunol. Rev. , vol.205 , pp. 158-169
    • Vallejo, A.N.1
  • 102
    • 0029987267 scopus 로고    scopus 로고
    • Immunogenicity of an inactivated split influenza vaccine in institutionalized elderly patients
    • Van Hoecke C., Prikazsky V., Uto I., Menschikowski C. Immunogenicity of an inactivated split influenza vaccine in institutionalized elderly patients. Gerontology 1996, 42:190-198.
    • (1996) Gerontology , vol.42 , pp. 190-198
    • Van Hoecke, C.1    Prikazsky, V.2    Uto, I.3    Menschikowski, C.4
  • 103
    • 67649660551 scopus 로고    scopus 로고
    • Redefining chronic viral infection
    • Virgin H.W., Wherry E.J., Ahmed R. Redefining chronic viral infection. Cell 2009, 138:30-50.
    • (2009) Cell , vol.138 , pp. 30-50
    • Virgin, H.W.1    Wherry, E.J.2    Ahmed, R.3
  • 105
    • 0037086692 scopus 로고    scopus 로고
    • A meta-analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community
    • Vu T., Farish S., Jenkins M., Kelly H. A meta-analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community. Vaccine 2002, 20:1831-1836.
    • (2002) Vaccine , vol.20 , pp. 1831-1836
    • Vu, T.1    Farish, S.2    Jenkins, M.3    Kelly, H.4
  • 107
    • 50649111879 scopus 로고    scopus 로고
    • The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age
    • Wikby A., Månsson I.A., Johansson B., Strindhall J., Nilsson S.E. The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age. Biogerontology 2008, 9:299-308.
    • (2008) Biogerontology , vol.9 , pp. 299-308
    • Wikby, A.1    Månsson, I.A.2    Johansson, B.3    Strindhall, J.4    Nilsson, S.E.5
  • 108
    • 27744604756 scopus 로고    scopus 로고
    • Influenza vaccines
    • World Health Organization
    • World Health Organization Influenza vaccines. Wkly. Epidemiol. Rec. 2005, 80:279-287.
    • (2005) Wkly. Epidemiol. Rec. , vol.80 , pp. 279-287
  • 109
    • 27944446111 scopus 로고    scopus 로고
    • Predictors of influenza immunization in persons over age 65
    • Xakellis G.C. Predictors of influenza immunization in persons over age 65. J. Am. Board Fam. Pract. 2005, 18:426-433.
    • (2005) J. Am. Board Fam. Pract. , vol.18 , pp. 426-433
    • Xakellis, G.C.1


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