Functional and physiological characteristics of the aging skin

Aging Clinical and Experimental Research

Volumn 20, Issue 3, 2008, Pages 195-200

  Farage, Miranda A ^a   Miller, Kenneth W ^a   Eisner, Peter ^b   Maibach, Howard I ^c  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b Klinik Fur Dermatologic   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging skin; Biochemical; Neurosensory perception; Permeability; Skin pH; Skin repair; Vascularization; Vitamin D; Wound healing

Indexed keywords

ALPHA TOCOPHEROL; DEXPANTHENOL; ESTROGEN; LIPID; NICOTINAMIDE; PROGESTERONE;

AGING; CLINICAL TRIAL; COSMETIC INDUSTRY; CUTANEOUS PARAMETERS; DECUBITUS; DISEASE PREDISPOSITION; DRUG EFFICACY; ELDERLY CARE; ESTROGEN THERAPY; HUMAN; LIPID ANALYSIS; MORBIDITY; NOCICEPTION; PAIN ASSESSMENT; PH MEASUREMENT; PHOTODERMATOSIS; QUALITY OF LIFE; RISK ASSESSMENT; SHORT SURVEY; SKIN DISEASE; SKIN FUNCTION; SKIN INFECTION; SKIN PERMEABILITY; SKIN SURFACE; SKINFOLD THICKNESS; SMOKING; THERMAL INJURY; ULTRAVIOLET RADIATION; WOUND HEALING;

EID: 48449090719     PISSN: 15940667     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03324769     Document Type: Short Survey

References (40)

1. Arias E. United States life tables, 2002. National vital statistics reports; Vol. 53, No. 6. Hyattsville, Maryland: National Center for Health Statistics 2004.
2. Kligman AM, Koblenzer C. Demographics and psychological implications for the aging population. Dermatol Clin 1997; 15: 549-53.
3. Life expectancy will be 100. [document on the Internet]. 2006 Feb 22. [cited 2006 Feb 24]. Available from: http//www.news24com/News24/ Technology/News/0,9294,2-13-1443_1885709,00.html.
4. Brincat MP, Baron YM, Galea R. Estrogens and the skin. Climacteric 2005; 8: 110-23.
5. Guinot C, Malvy DJ, Ambroisine L, et al. Relative contribution of intrinsic vs extrinsic factors to skin aging as determined by a validated skin age score. Arch Dermatol 2002; 138: 1454-60.
6. Fenske NA, Lober CW. Structural and functional changes of normal aging skin. J Am Acad Dermatol 1986; 15: 571-85.
7. Klaassen CD. Casarett and Doull's toxicology: the basic science of poisons, 5th ed. New York: McGraw-Hill, 1996: 529-46.
8. Monteiro-Riviere NA. Introduction to histological aspects of dermatotoxicology. Microsc Res Tech 1997; 37: 171.
9. Menon G, Ghadially R. Morphology of lipid alterations in the epidermis: a review. Microsc Res Tech 1997; 37: 180-92.
10. Grove GL. Physiologic changes in older skin. Clin Geriatr Med 1989; 5: 115-25.
11. McCallion R, Li Wan Po A. Dry and photo-aged skin: manifestations and management. J Clin Pharm Ther 1993; 18: 15-32.
12. Jackson SM, Williams ML, Feingold KR, Elias PM. Pathobiology of the stratum corneum. West J Med 1993; 158: 279-85.
13. Fiers SA. Breaking the cycle: the etiology of incontinence dermatitis and evaluating and using skin care products. Ostomy Wound Manage 1996: 42: 32-40.
14. Waller JM, Maibach HI. Age and skin structure and function, a quantitative approach (I): blood flow, pH, thickness, and ultrasound echogenicity. Skin Res Technol 2005; 11: 221-35.
15. Lautenbacher S, Lunz M, Strate P, Nielsen E, Arendt-Nielsen L. Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain. Pain 2005; 115: 410-8.
16. Harvell JD, Maibach HI. Percutaneous absorption and inflammation in aged skin: a review. J Am Acad Dermatol 1994; 194: 1015-21.
17. Martini F. Fundamentals of Anatomy and Physiology. San Francisco: Benjamin-Cummings, 2004.
18. Roskos KV, Guy RH, Maibach HI. Percutaneous absorption in the aged. Dermatol Clin 1986; 4: 455-65.
19. Ghadially R. Aging and the epidermal permeability barrier: implications for contact dermatitis. Am J Contact Dermat 1998; 9: 162-9.
20. Martini FH, Bartholomew EF. Essentials of Anatomy and Physiology, 3rd edition. San Francisco: Pearson Benjamin Cummings, 2002.
21. Elsner P, Wilhelm D, Maibach HI. Sodium lauryl sulfate-induced irritant contact dermatitis in vulvar and forearm skin of premenopausal and postmenopausal women. J Am Acad Dermatol 1990; 23: 648-52.
22. Suter-Widmer J, Eisner P. Age and irritation. In: Agner T, Maibach H, eds. The irritant contact dermatitis syndrome. Boca Raton, Florida: CRC Press, 1996: 257-65.
23. Changes in Allergic Reactivity. Aging and the Immune System. Merck Manual of Geriatrics. [Online] [cited 2006 August 23] http://www.merck.com/mrkshared/mmg/sec16/ch131/ch131e.jsp.
24. Robinson MK. Population differences in skin structure and physiology and the susceptibility to irritant and allergic contact dermatitis: implications for skin safety testing and risk assessment. Contact Dermatitis 1999; 41: 65-79.
25. Montagna W. Advances in biology of the skin. In: Aging, Vol. VI. Oxford: Pergamon Press, 1965: 1-16.
26. Muggleton-Harris AL, Reisert PS, Burghoff RL. In vitro characterization of response to stimulus (wounding) with regard to ageing in human skin fibroblasts. Mech Ageing Dev 1982; 19: 37-43.
27. Grove GL, Kligman AM. Age-associated changes in human epidermal cell renewal. J Gerontol 1983; 38: 137-42.
28. Barland CO, Zettersten E, Brown BS, Ye J, Elias PM, Ghadially R. Imiquimod-induced interleukin-1 alpha stimulation improves barrier homeostatis in aged murin epidermis. J Invest Dermatol 2004; 122: 330-6.
29. Hall GK, Phillips TJ. Skin and hormone therapy. Clin Obstet Gynecol 2004; 47: 437-49.
30. Farage MA, Miller KW, Elsner P, Maibach I. Structural characteristics of the aging skin: a review. Cutan Ocul Toxicol 2007; 26: 343-57.
31. Wolff EF, Narayan D, Taylor HS. Long-term effects of hormone therapy on skin rigidity and wrinkles. Fertil Steril 2005; 84: 285-8.
32. Draelos ZD, Ertel K, Berge C. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis 2005; 76: 135-41.
33. Schneider TE, Barland C, Alex AM, et al. Measuring stem cell frequency in epidermis: A quantitative in vivo functional assay for long-term repopulating cells. Proc Natl Acad Sci USA 2003; 100: 11412-7.
34. Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 1995; 95: 2281-90.
35. Wilhelm KP, Maibach H. Influence of aging on the barrier function of human skin evaluated by in vivo transepidermal water loss measurements. In Leveque JL, Agache PG, eds. Aging Skin: Properties and Functional Changes. New York: Marcel Dekker, Inc, 1993: 239-49.
36. Buckley C, Rustin MH. Management of irritable skin disorders in the elderly. Br J Hosp Med 1990: 44: 24-32.
37. Phillips T, Kanj L. Clinical manifestations of skin aging. In: Squier C, Hill MW, eds. The effect of aging in oral mucosa and skin. Boca Raton, Florida: CRC Press, 1994: 25-40.
38. Saint-Leger D, Agache PG. Variations in skin surface lipids during life. In Leveque JL, Agache PG, eds. Aging Skin: Properties and Functional Changes. New York: Marcel Dekker, Inc, 1993: 251-62.
39. Ryan J. Direct observation of capillary modifications in the aged. In Leveque JL, Agache PG, eds. Aging Skin: Properties and Functional Changes. New York: Marcel Dekker, Inc, 1993: 87-104.
40. Farage M, Maibach H. Lifetime changes in the vulva and vagina. Arch Gynecol Obstet 2006; 273: 195-202.