Senescent B lymphopoiesis is balanced in suppressive homeostasis: Decrease in interleukin-7 and transforming growth factor-β levels in stromal cells of senescence-accelerated mice

Experimental Biology and Medicine

Volumn 229, Issue 6, 2004, Pages 494-502

  Tsuboi, Isao ^a,b   Morimoto, Kohr ^a   Hirabayashi, Yoko ^a   Li, Guang Xun ^a   Aizawa, Shin ^b   Mori, Kazuhiro J ^c   Kanno, Jun ^a   Inoue, Tohru ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

Author keywords

Aging; B lymphopoiesis; Homeosuppression; Interleukin 7; Senescence accelerated mice; Transforming growth factor

Indexed keywords

INTERLEUKIN 7; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; LYMPHOPOIESIS; MALE; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; SENESCENCE; SIGNAL TRANSDUCTION; STROMA CELL;

ANIMALIA;

EID: 2942590824     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020422900607     Document Type: Article

References (33)

1. Hodes RJ. Aging and the immune system. Immunol Rev 160:5-8, 1997.
2. Ghia P, Melchers F, Rolink AG. Age-dependent changes in B lymphocyte development in man and mouse. Exp Gerontol 35:159-165, 2000.
3. Zharhary D. Age-related changes in the capability of the bone marrow to generate B cells. J Immunol 141:1863-1869, 1988.
4. Riley RL, Kruger MG, Elia J. B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro. Clin Immunol Immunopathol 59:301-313, 1991.
5. Jonsson JI, Phillips RA. Interleukin-7 responsiveness of B220+ B cell precursors from bone marrow decreases in aging mice. Cell Immunol 147:267-278, 1993.
6. Stephan RP, Sanders VM, Witte PL. Stage-specific alterations in murine B lymphopoiesis with age. Int Immunol 8:509-518, 1996.
7. Klinman NR, Kline GH. The B-cell biology of aging. Immunol Rev 160:103-114, 1997.
8. Tang J, Nuccie BL, Ritterman I, Liesveld JL, Abboud CN, Ryan DH. TGF-beta down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors. J Immunol 159:117-125, 1997.
9. Takeda T, Hosokawa M, Takeshita S, Irino M, Higuchi K, Matsushita T, Tomita Y, Yasuhira K, Hamamoto H, Shimizu K, Ishii M, Yamamuro T. A new murine model of accelerated senescence. Mech Ageing Dev 17:183-194, 1981.
10. Izumi-Hisha H, Ito Y, Sugimoto K, Oshima H, Mori KJ. Age-related decrease in the number of hemopoietic stem cells and progenitors in senescence accelerated mice. Mech Ageing Dev 56:89-97, 1990.
11. Tsuboi I, Morimoto K, Horie T, Mori KJ. Age-related changes in various hemopoietic progenitor cells in senescence-accelerated (SAM-P) mice. Exp Hematol 19:874-877, 1991.
12. Sakuma A, Tsuboi I, Morimoto K, Horie T, Sugimoto K, Mori KJ. Age-related decreases in the reconstituting ability of hemopoietic cells and the ability of hemopoietic microenvironment to support hemopoietic reconstitution in senescence accelerated (SAM-P) mice. Mech Ageing Dev 73:127-135, 1994.
13. Saitoh T, Morimoto K, Kumagai T, Tsuboi I, Aikawa S, Horie T. Comparison of erythropoietic response to androgen in young and old senescence accelerated mice. Mech Ageing Dev 109:125-139, 1999.
14. Kumagai T, Morimoto K, Saitoh T, Tsuboi I, Aikawa S, Horie T. Age-related changes in myelopoietic response to lipopolysaccharide in senescence-accelerated (SAM) mice. Mech Ageing Dev 112:153-167, 2000.
15. Yamamoto H, Hatano M, Iitsuka Y, Mahyar NS, Yamamoto M, Tokuhisa T. Two forms of Hox11 a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes. Mol Immunol 32:1177-1182, 1995.
16. Lawrence DA, Pircher R, Jullien P. Conversion of a high molecular weight latent beta-TGF from chicken embryo fibroblasts into a low molecular weight active beta-TGF under acidic conditions. Biochem Biophys Res Commun 133:1026-10-34, 1985.
17. Updyke LW, Cocke KS, Wierda D. Age-related changes in production of interleukin-7 (IL-7) by murine long-term bone marrow cultures (LTBMC). Mech Ageing Dev 69:109-117, 1993.
18. Stephan RP, Reilly CR, Witte PL. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood 91:75-88, 1998.
19. Okada S, Yoshida T, Hong Z, Ishii G, Hatano M, Kuro OM, Nabeshima Y, Tokuhisa T. Impairment of B lymphopoiesis in precocious aging (klotho) mice. Int Immunol 12:861-871, 2000.
20. Li F, Jin F, Freitas A, Szabo P, Weksler ME. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur J Immunol 31:500-505, 2001.
21. Nemunaitis J, Tompkins CK, Andrews DF, Singer JW. Transforming growth factor beta expression in human marrow stromal cells. Eur J Haematol 46:140-145, 1991.
22. Lee G, Namen AE, Gillis S, Ellingsworth LR, Kincade PW. Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming growth factor-beta. J Immunol 142:3875-3883, 1989.
23. Kincade PW. B lymphopoiesis: global factors, local control. Proc Natl Acad Sci U S A 91:2888-2889, 1994.
24. Lehman DA, Edmiston JS. The role of TGF-beta in growth, differentiation, and maturation of B lymphocytes. Microbes Infect 1:1297-1304, 1999.
25. Stephan RP, Lill-Elghanian DA, Witte PL. Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J Immunol 158:1598-1609, 1997.
26. Sherwood EM, Xu W, King AM, Blomberg BB, Riley RL. The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins. Mech Ageing Dev 118:45-59, 2000.
27. von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181:1519-1526, 1995.
28. Dubinett SM, Huang M, Dhanani S, Wang J, Beroiza T. Down-regulation of macrophage transforming growth factor-beta messenger RNA expression by IL-7. J Immunol 151:6670-6680, 1993.
29. Gazit D, Zilberman Y, Ebner R, Kahn A. Bone loss (osteopenia) in old male mice results from diminished activity and availability of TGF-beta. J Cell Biochem 70:478-488, 1998.
30. Kline GH, Hayden TA, Klinman NR. B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation. J Immunol 162:3342-3349, 1999.
31. Miller AR, McBride WH, Dubinett SM, Dougherty GJ, Thacker JD, Shau H, Kohn DB, Moen RC, Walker MJ, Chiu R, Schuck BL, Rosenblatt JA, Huang M, Dhanani S, Rhoades K, Economou JS. Transduction of human melanoma cell lines with the human interleukin-7 gene using retroviral-mediated gene transfer: comparison of immunologic properties with interleukin-2. Blood 82:3686-3694, 1993.
32. Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood 99:3892-3904, 2002.
33. Frasca D, Nguyen D, Riley RL, Blomberg BB. Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice. J Immunol 170:719-726, 2003.