Stabilizers of neuronal and mitochondrial calcium cycling as a strategy for developing a medicine for Alzheimer's disease

ACS Chemical Neuroscience

Volumn 3, Issue 11, 2012, Pages 873-883

  Fernández Morales, José Carlos ^a,b   Arranz Tagarro, Juan Alberto ^a,b,d   Calvo Gallardo, Enrique ^a,b   Maroto, Marcos ^a,b   Padín, Juan Fernando ^a,b   García, Antonio G ^a,b,c  

^a INSTITUTO TEÓFILO HERNANDO   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Alzheimer's disease; calcium and cell death; functional tetrad; L type calcium channel; mitochondrial calcium cycling; mitochondrial sodium calcium exchanger; multitarget compounds; neuronal calcium cycling; neuroprotection; neurotoxicity

Indexed keywords

1,4 DIHYDROPYRIDINE; 7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; ACETYLCHOLINESTERASE; ADENOSINE TRIPHOSPHATE; AMINO ACID DERIVATIVE; AMYLOID PRECURSOR PROTEIN; CAFFEINE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CARVEDILOL; CASEIN KINASE I; CLONAZEPAM; CYCLIN DEPENDENT KINASE 5; DILTIAZEM; E VT 101; GAMMA SECRETASE; GLYCOGEN SYNTHASE KINASE 3BETA; IONOTROPIC RECEPTOR AGONIST; MEM 1003; MEMANTINE; MITOGEN ACTIVATED PROTEIN KINASE 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; PROTEIN BCL 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; ROSCOVITINE; TACRINE; TAU PROTEIN; UNCLASSIFIED DRUG; VERATRIDINE; VOLTAGE DEPENDENT ANION CHANNEL;

ACTION POTENTIAL; ALZHEIMER DISEASE; APOPTOSIS; BRAIN DYSFUNCTION; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CATECHOLAMINE NERVE CELL; CELL ACTIVATION; CEREBROVASCULAR ACCIDENT; CHROMAFFIN CELL; COGNITIVE DEFECT; DENTATE GYRUS; DISEASE COURSE; ENDOPLASMIC RETICULUM; FIBROBLAST; HUMAN; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE DEPOLARIZATION; NERVE CELL NECROSIS; NEUROSECRETORY CELL; NEUROTOXICITY; OXIDATIVE STRESS; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN INDUCTION; REPERFUSION INJURY; REVIEW; VOLTAGE DEPENDENT CALCIUM CHANNEL;

ALZHEIMER DISEASE; APOPTOSIS; CALCINEURIN; CALCIUM; CALCIUM CHANNELS; CALPAIN; DIHYDROPYRIDINES; FREE RADICALS; HUMANS; MITOCHONDRIA; NEURONS; POLYPHENOLS; SODIUM;

ANIMALIA;

EID: 84869777952     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn3001069     Document Type: Review

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