Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/ butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 9, 2004, Pages 2199-2218

  Marco, José L ^a   De Los Ríos, Cristóbal ^a,b   García, Antonio G ^b   Villarroya, Mercedes ^b   Carreiras, M Carmo ^c   Martins, Carla ^c   Eleutério, Ana ^c   Morreale, Antonio ^d   Orozco, M ^e   Luque, F Javier ^d  

^a Laboratorio de Radicales Libres   (Spain)

^b INSTITUTO TEÓFILO HERNANDO   (Spain)

^c RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^d UNIVERSITY OF BARCELONA   (Spain)

^e INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

Author keywords

AChE BuChE inhibitors; Ca 2+ channels; Friedl nder reaction; Molecular modelling; Neuronal nicotinic acetylcholine receptors; Tacrine analogues

Indexed keywords

5 AMINO 4 (4 CHLOROPHENYL) 6,7,8,9 TETRAHYDRO 2 METHYLBENZO[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 4 (4 CHLOROPHENYL) 7,8,9,10 TETRAHYDRO 2 METHYL 6H CYCLOHEPTA[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 4 (4 FLUOROPHENYL) 6,7,8,9 TETRAHYDRO 2 METHYLBENZO[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 4 (4 FLUOROPHENYL) 7,8,9,10 TETRAHYDRO 2 METHYL 6H CYCLOHEPTA[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 4 CYANO 2 (4 METHYLPHENYL) 1,3 OXAZOLE; 5 AMINO 4,6,7,8 TETRAHYDRO 4 (3,4 DIMETHOXYPHENYL) 2 METHYLCYCLOPENTA[B]PYRANO[3,2 E]PYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 4,6,7,8,9,10 HEXAHYDRO 4 (3,4 DIMETHOXYPHENYL) 2 METHYLCYCLOHEPTA[B]PYRANO[3,2 E]PYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 6,7,8,9 TETRAHYDRO 2 METHYL 4 (3 NITROPHENYL)BENZO[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 6,7,8,9 TETRAHYDRO 4 (3 METHOXYPHENYL) 2 METHYLBENZO[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 6,7,8,9 TETRAHYDRO 4 (3,4 DIMETHOXYPHENYL) 2 METHYL 4H PYRANO[2,3 B]QUINOLINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 6,7,8,9 TETRAHYDRO 4 (3,4 DIMETHOXYPHENYL) 2 METHYLBENZO[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 6,7,8,9,10,11 HEXAHYDRO 2 METHYL 4 PHENYLCYCLOOCTA[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 7,8,9,10 TETRAHYDRO 2 METHYL 4 (3 NITROPHENYL) 6H CYCLOHEPTA[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 7,8,9,10 TETRAHYDRO 2 METHYL 4 (4 METHYLPHENYL) 6H CYCLOHEPTA[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 7,8,9,10 TETRAHYDRO 4 (2 METHOXYPHENYL) 2 METHYL 6H CYCLOHEPTA[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 7,8,9,10 TETRAHYDRO 4 (3 METHOXYPHENYL) 2 METHYL 6H CYCLOHEPTA[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 5 AMINO 7,8,9,10 TETRAHYDRO 4 (3,4 DIMETHOXYPHENYL) 2 METHYL 6H CYCLOHEPTA[B][1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 6 AMINO 5 CYANO 2 METHYL 4 (3 NITROPHENYL) 3 PYRIDINECARBOXYLIC ACID ETHYL ESTER; 6 AMINO 5 CYANO 2 METHYL 4 (4 METHYLPHENYL) 3 PYRIDINECARBOXYLIC ACID ETHYL ESTER; 6 AMINO 5 CYANO 2 METHYL 4 PHENYL 3 PYRIDINE CARBOXYLIC ACID ISOPROPYL ESTER; 6 AMINO 5 CYANO 4 (2 METHOXYPHENYL) 2 METHYL 3 PYRIDINECARBOXYLIC ACID ETHYL ESTER; 6 AMINO 5 CYANO 4 (3 METHOXYPHENYL) 2 METHYL 3 PYRIDINECARBOXYLIC ACID ETHYL ESTER; 6 AMINO 5 CYANO 4 (3,4 DIMETHOXYPHENYL) 2 METHYL 3 PYRIDINECARBOXYLIC ACID ETHYL ESTER; 6 AMINO 5 CYANO 4 (3,4 DIMETHOXYPHENYL) 2 METHYL 4H PYRAN 3 CARBOXYLIC ACID ETHYL ESTER; 6 AMINO 5 CYANO 4 (4 FLUOROPHENYL) 2 METHYL 3 PYRIDINECARBOXYLIC ACID ETHYL ESTER; 6 AMINO 5 CYANO 4 (4 FLUOROPHENYL) 2 METHYL 4H PYRAN 3 CARBOXYLIC ACID ETHYL ESTER; CALCIUM CHANNEL L TYPE; CHOLINESTERASE INHIBITOR; HETEROCYCLIC COMPOUND; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; CATTLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; IC 50; MOLECULAR MODEL; NONHUMAN; REACTION ANALYSIS;

EID: 11144354610     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.02.017     Document Type: Article

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