Mitochondrial Na+/Ca2+-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine

Journal of Pharmacology and Experimental Therapeutics

Volumn 330, Issue 3, 2009, Pages 844-854

  Nicolau, Santos M ^a,b   De Diego, Antonio M G ^a,b   Cortés, Lorena ^a,b   Egea, Javier ^a,b   González, José C ^a,b   Mosquera, Marta ^a,b   López, Manuela G ^a,b   Hernández Guijo, Jesús Miguel ^a,b   García, Antonio G ^a,b,c  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c INSTITUTO TEÓFILO HERNANDO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; CALCIUM; CYTOCHROME C; FREE RADICAL; LACTATE DEHYDROGENASE; VERATRIDINE; CALCIUM CHANNEL; CLONAZEPAM; COLORING AGENT; DRUG DERIVATIVE; REACTIVE OXYGEN METABOLITE; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CHANNEL; TETRAZOLIUM; THIAZEPINE DERIVATIVE; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CELL DEATH; CELL PROTECTION; CHROMAFFIN CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; CYTOSOL; ENZYME RELEASE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SODIUM CURRENT; ANIMAL; CATTLE; CELL CULTURE; CELL MEMBRANE POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MITOCHONDRION; PATCH CLAMP;

ANIMALS; CALCIUM CHANNELS; CALCIUM SIGNALING; CATTLE; CELL DEATH; CELLS, CULTURED; CHROMAFFIN CELLS; CLONAZEPAM; COLORING AGENTS; CYTOCHROMES C; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIALS; MITOCHONDRIA; PATCH-CLAMP TECHNIQUES; REACTIVE OXYGEN SPECIES; SODIUM CHANNELS; SODIUM-CALCIUM EXCHANGER; TETRAZOLIUM SALTS; THIAZEPINES; THIAZOLES; VERATRIDINE;

EID: 70349125076     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.154765     Document Type: Article

References (40)

1. Cano-Abad MF, López MG, Hernández-Guijo JM, Zapater P, Gandía L, Sánchez-García P, and García AG (1998) Effects of the neuroprotectant lubeluzole on the cytotoxic actions of veratridine, barium, ouabain and 6-hydroxydopamine in chromaffin cells. Br J Pharmacol 124:1187-1196.
2. Cano-Abad MF, Villarroya M, García AG, Gabilan NH, and López MG (2001) Calcium entry through L-type calcium channels causes mitochondrial disruption and chromaffin cell death. J Biol Chem 276:39695-39704. (Pubitemid 37391374)
3. 2+ exchange. Trends Pharmacol Sci 14:408-413.
4. Duchen MR (2000) Mitochondria and calcium: from cell signalling to cell death. J Physiol 529:57-68.
5. Egea J, Rosa AO, Cuadrado A, García AG, and López MG (2007) Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress. J Neurochem 102:1842-1852. (Pubitemid 47329263)
6. 2+ oscillations are spontaneously generated by ventral spinal neurons during development in vitro. Cell Calcium 41:317-329.
7. Gallo V, Kingsbury A, Balázs R, and Jørgensen OS (1987) The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci 7:2203-2213. (Pubitemid 17114929)
8. Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman DS, Tabrizi SJ, Wood NW, et al. (2009) PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell 33:627-638.
9. García AG, García-De-Diego AM, Gandía L, Borges R, and García-Sancho J (2006) Calcium signaling and exocytosis in adrenal chromaffin cells. Physiol Rev 86: 1093-1131. (Pubitemid 44523705)
10. Ha HC, Woster PM, Yager JD, and Casero RA Jr (1997) The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc Natl Acad Sci U S A 94:11557-11562. (Pubitemid 27451037)
11. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cellfree membrane patches. Pflugers Arch 391:85-100. (Pubitemid 11012976)
12. 2+ oscillations. Cell Calcium 40:53-61.
13. Jordán J, Galindo MF, Calvo S, González-García C, and Ceña V (2000) Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production. Br J Pharmacol 130:1496-1504.
14. Jouaville LS, Pinton P, Bastianutto C, Rutter GA, and Rizzuto R (1999) Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc Natl Acad Sci U S A 96:13807-13812.
15. Kilpatrick DL, Slepetis RJ, Corcoran JJ, and Kirshner N (1982) Calcium uptake and catecholamine secretion by cultured bovine adrenal medulla cells. J Neurochem 38:427-435.
16. Kluck RM, Bossy-Wetzel E, Green DR, and Newmeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136. (Pubitemid 27097313)
17. Koh JY and Cotman CW (1992) Programmed cell death: its possible contribution to neurotoxicity mediated by calcium channel antagonists. Brain Res 587:233-240.
18. Koh JY and Choi DW (1987) Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods 20:83-90.
19. 2+ determine nerve growth factor dependence of sympathetic ganglion cells. Proc Natl Acad Sci U S A 86:6421-6425.
20. Korn SJ and Horn R (1989) Influence of sodium-calcium exchange on calcium current rundown and the duration of calcium-dependent chloride currents in pituitary cells, studied with whole cell and perforated patch recording. J Gen Physiol 94:789-812.
21. Livett BG (1984) Adrenal medullary chromaffin cells in vitro. Physiol Rev 64:1103-1161. (Pubitemid 15218055)
22. Lopez MG, Artalejo AR, Garcia AG, Neher E, and Garcia-Sancho J (1995) Veratridine- induced oscillations of cytosolic calcium and membrane potential in bovine chromaffin cells. J Physiol 482:15-27.
23. 2+ oscillations induced by veratridine. Eur J Pharmacol 270:331-339.
24. 2+) oscillations. Brain Res 714:209-214.
25. Martikainen P, Kyprianou N, Tucker RW, and Isaacs JT (1991) Programmed death of nonproliferating androgen-independent prostatic cancer cells. Cancer Res 51: 4693-4700.
26. Mattson MP (2007) Calcium and neurodegeneration. Aging Cell 6:337-350.
27. 2+ transients that modulate secretion. Nat Cell Biol 2:57-61.
28. Moro MA, López MG, Gandía L, Michelena P, and García AG (1990) Separation and culture of living adrenaline- and noradrenaline- containing cells from bovine adrenal medullae. Anal Biochem 185:243-248.
29. Narita M, Shimizu S, Ito T, Chittenden T, Lutz RJ, Matsuda H, and Tsujimoto Y (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A 95:14681-14686. (Pubitemid 29003690)
30. Nicholls DG (1985) A role for the mitochondrion in the protection of cells against calcium overload? Prog Brain Res 63:97-106.
31. Novalbos J, Abad-Santos F, Zapater P, Cano-Abad MF, Moradiellos J, Sánchez- García P, and García AG (1999) Effects of dotarizine and flunarizine on chromaffin cell viability and cytosolic Ca2+. Eur J Pharmacol 366:309-317. (Pubitemid 29080796)
32. Orozco C, García-de-Diego AM, Arias E, Hernández-Guijo JM, García AG, Villarroya M, and López MG (2006) Depolarization preconditioning produces cytoprotection against veratridine-induced chromaffin cell death. Eur J Pharmacol 553:28-38. (Pubitemid 44779585)
33. Ota M, Narahashi T, and Keeler RF (1973) Effects of veratrum alkaloids on membrane potential and conductance of squid and crayfish giant axons. J Pharmacol Exp Ther 184:143-154.
34. 2+-mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine. Mol Pharmacol 36:525-531.
35. Schanne FA, Kane AB, Young EE, and Farber JL (1979) Calcium dependence of toxic cell death: a final common pathway. Science 206:700-702.
36. Sedlak TW and Snyder SH (2006) Messenger molecules and cell death: therapeutic implications. JAMA 295:81-89. (Pubitemid 43042693)
37. Smiley ST, Reers M, Mottola-Hartshorn C, Lin M, Chen A, Smith TW, Steele GD Jr, and Chen LB (1991) Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci U S A 88:3671-3675.
38. 2+ transport. Eur J Pharmacol 289:73-80.
39. 2+ antagonist drugs. J Biol Chem 257:6000-6002.
40. 2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons. J Neurosci 15: 1318-1328.