Mitochondrial Ca2+ overload underlies Aβ oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs

PLoS ONE

Volumn 3, Issue 7, 2008, Pages

  Sanz Blasco, Sara ^a   Valero, Ruth A ^a   Rodríguez Crespo, Ignacio ^b   Villalobos, Carlos ^a   Núñez, Lucía ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AEQUORIN; AMYLOID BETA PROTEIN[1-42]; CALCIUM ION; CYTOCHROME C; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; OLIGOMER; SALICYLIC ACID; SULINDAC SULFIDE; AMYLOID BETA PROTEIN; CALCIUM; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOLUMINESCENCE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; COGNITIVE DEFECT; CONTROLLED STUDY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; ENZYME RELEASE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; CELL MEMBRANE POTENTIAL; CEREBELLUM; CHEMISTRY; METABOLISM; MITOCHONDRION; NERVE CELL; WISTAR RAT;

AMYLOID BETA-PROTEIN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CALCIUM; CEREBELLUM; CYTOCHROMES C; MEMBRANE POTENTIALS; MITOCHONDRIA; MODELS, BIOLOGICAL; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 50549096439     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002718     Document Type: Article

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