Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 4, 2005, Pages 1167-1175

  León, Rafael ^a,b   Marco Contelles, José ^a   García, Antonio G ^b   Villarroya, Mercedes ^b  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b INSTITUTO TEÓFILO HERNANDO   (Spain)

Author keywords

AChE; Inhibitors; Neuroprotection; Tacrine analogues

Indexed keywords

CHOLINESTERASE INHIBITOR; ETHYL 4 (1 ACETYL 1H PYRROL 2 YL) 5 AMINO 6,7,8,9 TETRAHYDRO 2 METHYL 4H PYRAN[2,3 B]QUINOLINE 3 CARBOXYLATE; ETHYL 5 AMINO 4,6,7,8 TETRAHYDRO 2 METHYL 4 (3 PYRIDYL)CYCLOPENTA[B] PYRAN[3,2 E]PYRIDINE 3 CARBOXYLATE; ETHYL 5 AMINO 4,6,7,8 TETRAHYDRO 2 METHYL 4 (4 PYRIDYL)CYCLOPENTA[B] PYRAN[3,2 E]PYRIDINE 3 CARBOXYLATE; ETHYL 5 AMINO 4,6,7,8,9,10 HEXAHYDRO 2 METHYL 4 (2 THIENYL)CYCLOHEPTA[B] PYRAN[3,2 E]PYRIDINE 3 CARBOXYLATE; ETHYL 5 AMINO 4,6,7,8,9,10 HEXAHYDRO 2 METHYL 4 (3 PYRIDYL)CYCLOHEPTA[B] PYRAN[3,2 E]PYRIDINE 3 CARBOXYLATE; ETHYL 5 AMINO 4,6,7,8,9,10 HEXAHYDRO 2 METHYL 4 (4 PYRIDYL)CYCLOHEPTA[B] PYRAN[3,2 E]PYRIDINE 3 CARBOXYLATE; ETHYL 5 AMINO 6,7,8,9 TETRAHYDRO 2 METHYL 4 (2 THIENYL) 4H PYRAN[2,3 B]QUINOLINE 3 CARBOXYLATE; ETHYL 5 AMINO 6,7,8,9 TETRAHYDRO 2 METHYL 4 (3 PYRIDYL) 4H PYRAN[2,3 B]QUINOLINE 3 CARBOXYLATE; ETHYL 5 AMINO 6,7,8,9 TETRAHYDRO 2 METHYL 4 (4 PYRIDYL) 4H PYRAN[2,3 B]QUINOLINE 3 CARBOXYLATE; ETHYL 5 AMINO 6,7,8,9 TETRAHYDRO 2 METHYL 4 (4 PYRIDYL)BENZO[B][1,8] NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 5 AMINO 7,8 DIHYDRO 2 METHYL 4 (4 PYRIDYL) 6H CYCLOPENTA[B][1,8] NAPHTHYRIDINE 3 CARBOXYLATE; ETHYL 5 AMINO 7,8,9,10 TETRAHYDRO 2 METHYL 4 (4 PYRIDYL) 6H CYCLOHEPTA[B][1,8]NAPHTHYRIDINE 3 CARBOXYLATE; NEUROPROTECTIVE AGENT; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NEUROPROTECTION; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; CATTLE; CHOLINESTERASE INHIBITORS; CHROMAFFIN CELLS; NEUROPROTECTIVE AGENTS; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 12944262130     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.11.020     Document Type: Article

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