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Volumn 65, Issue 6, 2012, Pages 465-475

Evolution of Plasmodium falciparum drug resistance: Implications for the development and containment of artemisinin resistance

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEETHER; ARTEMETHER; ARTEMETHER PLUS AMODIAQUINE; ARTEMETHER PLUS BENFLUMETOL; ARTEMISIN; ARTEMISININ DERIVATIVE; ARTESUNATE; ARTESUNATE PLUS MEFLOQUINE; CHLOROQUINE; DIHYDROFOLATE REDUCTASE; PYRIMETHAMINE; PYRIMETHAMINE PLUS SULFADOXINE; SULFADOXINE; UNCLASSIFIED DRUG;

EID: 84869746661     PISSN: 13446304     EISSN: 18842836     Source Type: Journal    
DOI: 10.7883/yoken.65.465     Document Type: Review
Times cited : (94)

References (109)
  • 1
    • 84856408211 scopus 로고    scopus 로고
    • World Health Organization
    • World Health Organization (2011): World Malaria Report 2011.
    • (2011) World Malaria Report 2011.
  • 2
    • 67650397861 scopus 로고    scopus 로고
    • Spread and evolution of Plasmodium falciparum drug resistance
    • Mita, T., Tanabe, K. and Kita, K. (2009): Spread and evolution of Plasmodium falciparum drug resistance. Parasitol. Int., 58, 201-209.
    • (2009) Parasitol. Int. , vol.58 , pp. 201-209
    • Mita, T.1    Tanabe, K.2    Kita, K.3
  • 4
    • 14144253009 scopus 로고    scopus 로고
    • Mechanisms of resistance of malaria parasites to antifolates
    • Gregson, A. and Plowe, C.V. (2005): Mechanisms of resistance of malaria parasites to antifolates. Pharmacol. Rev., 57, 117-145.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 117-145
    • Gregson, A.1    Plowe, C.V.2
  • 5
    • 34548635564 scopus 로고    scopus 로고
    • Advances in understanding the genetic basis of antimalarial drug resistance
    • Ekland, E.H. and Fidock, D.A. (2007): Advances in understanding the genetic basis of antimalarial drug resistance. Curr. Opin. Microbiol., 10, 363-370.
    • (2007) Curr. Opin. Microbiol. , vol.10 , pp. 363-370
    • Ekland, E.H.1    Fidock, D.A.2
  • 6
    • 0037130254 scopus 로고    scopus 로고
    • Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
    • Wootton, J.C., Feng, X., Ferdig, M.T., et al. (2002): Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum. Nature, 418, 320-323.
    • (2002) Nature , vol.418 , pp. 320-323
    • Wootton, J.C.1    Feng, X.2    Ferdig, M.T.3
  • 7
    • 10744222802 scopus 로고    scopus 로고
    • A selective sweep driven by pyrimethamine treatment in Southeast Asian malaria parasites
    • Nair, S., Williams, J.T., Brockman, A., et al. (2003): A selective sweep driven by pyrimethamine treatment in Southeast Asian malaria parasites. Mol. Biol. Evol., 20, 1526-1536.
    • (2003) Mol. Biol. Evol. , vol.20 , pp. 1526-1536
    • Nair, S.1    Williams, J.T.2    Brockman, A.3
  • 8
    • 4143103433 scopus 로고    scopus 로고
    • Intercontinental spread of pyrimethamine-resistant malaria
    • Roper, C., Pearce, R., Nair, S., et al. (2004): Intercontinental spread of pyrimethamine-resistant malaria. Science, 305, 1124.
    • (2004) Science , vol.305 , pp. 1124
    • Roper, C.1    Pearce, R.2    Nair, S.3
  • 9
    • 33746125737 scopus 로고    scopus 로고
    • Antifolate resistance in Plasmodium falciparum: Multiple origins and identification of novel dhfr alleles
    • McCollum, A.M., Poe, A.C., Hamel, M., et al. (2006): Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles. J. Infect. Dis., 194, 189-197.
    • (2006) J. Infect. Dis. , vol.194 , pp. 189-197
    • McCollum, A.M.1    Poe, A.C.2    Hamel, M.3
  • 10
    • 33847629236 scopus 로고    scopus 로고
    • Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia
    • Mita, T., Tanabe, K., Takahashi, N., et al. (2007): Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia. Antimicrob. Agents Chemother., 51, 1071-1077.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 1071-1077
    • Mita, T.1    Tanabe, K.2    Takahashi, N.3
  • 11
    • 55849113334 scopus 로고    scopus 로고
    • Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central Africa
    • McCollum, A.M., Basco, L.K., Tahar, R., et al. (2008): Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central Africa. Antimicrob. Agents Chemother., 52, 4089-4097.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 4089-4097
    • McCollum, A.M.1    Basco, L.K.2    Tahar, R.3
  • 12
    • 58849122733 scopus 로고    scopus 로고
    • Indigenous evolution of Plasmodium falciparum pyrimethamine resistance multiple times in Africa
    • Mita, T., Tanabe, K., Takahashi, N., et al. (2009): Indigenous evolution of Plasmodium falciparum pyrimethamine resistance multiple times in Africa. J. Antimicrob. Chemother., 63, 252-255.
    • (2009) J. Antimicrob. Chemother. , vol.63 , pp. 252-255
    • Mita, T.1    Tanabe, K.2    Takahashi, N.3
  • 13
    • 81055143895 scopus 로고    scopus 로고
    • Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum Populations
    • Mita, T., Venkatesan, M., Ohashi, J., et al. (2011): Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum Populations. J. Infect. Dis., 204, 1980-1988.
    • (2011) J. Infect. Dis. , vol.204 , pp. 1980-1988
    • Mita, T.1    Venkatesan, M.2    Ohashi, J.3
  • 14
    • 0345652158 scopus 로고
    • Identification of the acidic compartment of Plasmodium falciparuminfected human erythrocytes as the target of the antimalarial drug chloroquine
    • Yayon, A., Cabantchik, Z.I. and Ginsburg, H. (1984): Identification of the acidic compartment of Plasmodium falciparuminfected human erythrocytes as the target of the antimalarial drug chloroquine. EMBO J., 3, 2695-2700.
    • (1984) EMBO J. , vol.3 , pp. 2695-2700
    • Yayon, A.1    Cabantchik, Z.I.2    Ginsburg, H.3
  • 15
    • 16044372680 scopus 로고    scopus 로고
    • On the molecular mechanism of chloroquine's antimalarial action
    • Sullivan, D.J., Jr., Gluzman, I.Y., Russell, D.G., et al. (1996): On the molecular mechanism of chloroquine's antimalarial action. Proc. Natl. Acad. Sci. USA, 93, 11865-11870.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11865-11870
    • Sullivan Jr., D.J.1    Gluzman, I.Y.2    Russell, D.G.3
  • 16
    • 0031818645 scopus 로고    scopus 로고
    • Access to hematin: The basis of chloroquine resistance
    • Bray, P.G., Mungthin, M., Ridley, R.G., et al. (1998): Access to hematin: the basis of chloroquine resistance. Mol. Pharmacol., 54, 170-179.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 170-179
    • Bray, P.G.1    Mungthin, M.2    Ridley, R.G.3
  • 18
    • 0014650528 scopus 로고
    • Chloroquine resistance in malaria: A deficiency of chloroquine binding
    • Fitch, C.D. (1969): Chloroquine resistance in malaria: a deficiency of chloroquine binding. Proc. Natl. Acad. Sci. USA, 64, 1181-1187.
    • (1969) Proc. Natl. Acad. Sci. USA , vol.64 , pp. 1181-1187
    • Fitch, C.D.1
  • 19
    • 0023666563 scopus 로고
    • Efflux of chloroquine from Plasmodium falciparum: Mechanism of chloroquine resistance
    • Krogstad, D.J., Gluzman, I.Y., Kyle, D.E., et al. (1987): Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science, 238, 1283-1285.
    • (1987) Science , vol.238 , pp. 1283-1285
    • Krogstad, D.J.1    Gluzman, I.Y.2    Kyle, D.E.3
  • 20
    • 0031713287 scopus 로고    scopus 로고
    • Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance
    • Saliba, K.J., Folb, P.I. and Smith, P.J. (1998): Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance. Biochem. Pharmacol., 56, 313-320.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 313-320
    • Saliba, K.J.1    Folb, P.I.2    Smith, P.J.3
  • 21
    • 0033636607 scopus 로고    scopus 로고
    • Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
    • Fidock, D.A., Nomura, T., Talley, A.K., et al. (2000): Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol. Cell, 6, 861-871.
    • (2000) Mol. Cell , vol.6 , pp. 861-871
    • Fidock, D.A.1    Nomura, T.2    Talley, A.K.3
  • 22
    • 33845711820 scopus 로고    scopus 로고
    • Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine
    • Cooper, R.A., Lane, K.D., Deng, B., et al. (2007): Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine. Mol. Microbiol., 63, 270-282.
    • (2007) Mol. Microbiol. , vol.63 , pp. 270-282
    • Cooper, R.A.1    Lane, K.D.2    Deng, B.3
  • 23
    • 70349524663 scopus 로고    scopus 로고
    • Chloroquine transport via the malaria parasite's chloroquine resistance transporter
    • Martin, R.E., Marchetti, R.V., Cowan, A.I., et al. (2009): Chloroquine transport via the malaria parasite's chloroquine resistance transporter. Science, 325, 1680-1682.
    • (2009) Science , vol.325 , pp. 1680-1682
    • Martin, R.E.1    Marchetti, R.V.2    Cowan, A.I.3
  • 24
    • 78651379485 scopus 로고    scopus 로고
    • PfCRT-mediated drug transport in malarial parasites
    • Roepe, P.D. (2011): PfCRT-mediated drug transport in malarial parasites. Biochemistry, 50, 163-171.
    • (2011) Biochemistry , vol.50 , pp. 163-171
    • Roepe, P.D.1
  • 25
    • 0042573722 scopus 로고    scopus 로고
    • Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum
    • Sanchez, C.P., Stein, W. and Lanzer, M. (2003): Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum. Biochemistry, 42, 9383-9394.
    • (2003) Biochemistry , vol.42 , pp. 9383-9394
    • Sanchez, C.P.1    Stein, W.2    Lanzer, M.3
  • 26
    • 22744436592 scopus 로고    scopus 로고
    • Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum
    • Sanchez, C.P., McLean, J.E., Rohrbach, P., et al. (2005): Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum. Biochemistry, 44, 9862-9870.
    • (2005) Biochemistry , vol.44 , pp. 9862-9870
    • Sanchez, C.P.1    McLean, J.E.2    Rohrbach, P.3
  • 27
    • 17144422120 scopus 로고    scopus 로고
    • Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance
    • Bray, P.G., Martin, R.E., Tilley, L., et al. (2005): Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance. Mol. Microbiol., 56, 323-333.
    • (2005) Mol. Microbiol. , vol.56 , pp. 323-333
    • Bray, P.G.1    Martin, R.E.2    Tilley, L.3
  • 28
    • 0001651897 scopus 로고
    • Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene
    • Bzik, D.J., Li, W.B., Horii, T., et al. (1987): Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene. Proc. Natl. Acad. Sci. USA, 84, 8360-8364.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 8360-8364
    • Bzik, D.J.1    Li, W.B.2    Horii, T.3
  • 29
    • 0028021624 scopus 로고
    • Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: Dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine
    • Brooks, D.R., Wang, P., Read, M., et al. (1994): Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur. J. Biochem., 224, 397-405.
    • (1994) Eur. J. Biochem. , vol.224 , pp. 397-405
    • Brooks, D.R.1    Wang, P.2    Read, M.3
  • 30
    • 0028291789 scopus 로고
    • Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum
    • Triglia, T. and Cowman, A.F. (1994): Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA, 91, 7149-7153.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7149-7153
    • Triglia, T.1    Cowman, A.F.2
  • 31
    • 0000854414 scopus 로고
    • Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum
    • Cowman, A.F., Morry, M.J., Biggs, B.A., et al. (1988): Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA, 85, 9109-9113.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9109-9113
    • Cowman, A.F.1    Morry, M.J.2    Biggs, B.A.3
  • 32
    • 0000841123 scopus 로고
    • Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria
    • Peterson, D.S., Walliker, D. and Wellems, T.E. (1988): Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc. Natl. Acad. Sci. USA, 85, 9114-9118.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9114-9118
    • Peterson, D.S.1    Walliker, D.2    Wellems, T.E.3
  • 33
    • 0031037364 scopus 로고    scopus 로고
    • Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase
    • Sirawaraporn, W., Sathitkul, T., Sirawaraporn, R., et al. (1997): Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proc. Natl. Acad. Sci. USA, 94, 1124-1129.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1124-1129
    • Sirawaraporn, W.1    Sathitkul, T.2    Sirawaraporn, R.3
  • 34
    • 67749098058 scopus 로고    scopus 로고
    • Stepwise acquisition of pyrimethamine resistance in the malaria parasite
    • Lozovsky, E.R., Chookajorn, T., Brown, K.M., et al. (2009): Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proc. Natl. Acad. Sci. USA, 106, 12025-12030.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 12025-12030
    • Lozovsky, E.R.1    Chookajorn, T.2    Brown, K.M.3
  • 35
    • 78649365006 scopus 로고    scopus 로고
    • Compensatory mutations restore fitness during the evolution of dihydrofolate reductase
    • Brown, K.M., Costanzo, M.S., Xu, W., et al. (2010): Compensatory mutations restore fitness during the evolution of dihydrofolate reductase. Mol. Biol. Evol., 27, 2682-2690.
    • (2010) Mol. Biol. Evol. , vol.27 , pp. 2682-2690
    • Brown, K.M.1    Costanzo, M.S.2    Xu, W.3
  • 36
    • 0031444278 scopus 로고    scopus 로고
    • Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum
    • Triglia, T., Menting, J.G., Wilson, C., et al. (1997): Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. Proc. Natl. Acad. Sci. USA, 94, 13944-13949.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13944-13949
    • Triglia, T.1    Menting, J.G.2    Wilson, C.3
  • 37
    • 33646542706 scopus 로고    scopus 로고
    • Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase
    • de Beer, T.A., Louw, A.I. and Joubert, F. (2006): Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase. Bioorg. Med. Chem., 14, 4433-4443.
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 4433-4443
    • de Beer, T.A.1    Louw, A.I.2    Joubert, F.3
  • 38
    • 77950435762 scopus 로고    scopus 로고
    • Origin and evolution of sulfadoxine resistant Plasmodium falciparum
    • Vinayak, S., Alam, M.T., Mixson-Hayden, T., et al. (2010): Origin and evolution of sulfadoxine resistant Plasmodium falciparum. PLoS Pathog., 6, e1000830.
    • (2010) PLoS Pathog. , vol.6
    • Vinayak, S.1    Alam, M.T.2    Mixson-Hayden, T.3
  • 39
    • 79851475649 scopus 로고    scopus 로고
    • Selective sweeps and genetic lineages of Plasmodium falciparum drug-resistant alleles in Ghana
    • Alam, M.T., de Souza, D.K., Vinayak, S., et al. (2011): Selective sweeps and genetic lineages of Plasmodium falciparum drug-resistant alleles in Ghana. J. Infect. Dis., 203, 220-227.
    • (2011) J. Infect. Dis. , vol.203 , pp. 220-227
    • Alam, M.T.1    de Souza, D.K.2    Vinayak, S.3
  • 40
    • 78650642051 scopus 로고    scopus 로고
    • Tracking origins and spread of sulfadoxine-resistant Plasmodium falciparum dhps alleles in Thailand
    • Alam, M.T., Vinayak, S., Congpuong, K., et al. (2011): Tracking origins and spread of sulfadoxine-resistant Plasmodium falciparum dhps alleles in Thailand. Antimicrob. Agents Chemother., 55, 155-164.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 155-164
    • Alam, M.T.1    Vinayak, S.2    Congpuong, K.3
  • 41
    • 43949094487 scopus 로고    scopus 로고
    • Increased gametocytemia after treatment: An early parasitological indicator of emerging sulfadoxine-pyrimethamine resistance in falciparum malaria
    • Barnes, K.I., Little, F., Mabuza, A., et al. (2008): Increased gametocytemia after treatment: an early parasitological indicator of emerging sulfadoxine-pyrimethamine resistance in falciparum malaria. J. Infect. Dis., 197, 1605-1613.
    • (2008) J. Infect. Dis. , vol.197 , pp. 1605-1613
    • Barnes, K.I.1    Little, F.2    Mabuza, A.3
  • 42
    • 60549110855 scopus 로고    scopus 로고
    • Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    • Stepniewska, K., Price, R.N., Sutherland, C.J., et al. (2008): Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. Malar. J., 7, 249.
    • (2008) Malar. J. , vol.7 , pp. 249
    • Stepniewska, K.1    Price, R.N.2    Sutherland, C.J.3
  • 43
    • 77949568358 scopus 로고    scopus 로고
    • Artemisinin resistance: Current status and scenarios for containment
    • Dondorp, A.M., Yeung, S., White, L., et al. (2010): Artemisinin resistance: current status and scenarios for containment. Nat. Rev. Microbiol., 8, 272-280.
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 272-280
    • Dondorp, A.M.1    Yeung, S.2    White, L.3
  • 44
    • 0017602449 scopus 로고
    • Chloroquine-resistant Plasmodium falciparum and malaria in Africa
    • Olatunde, A. (1977): Chloroquine-resistant Plasmodium falciparum and malaria in Africa. Trans. R. Soc. Trop. Med. Hyg., 71, 80-81.
    • (1977) Trans. R. Soc. Trop. Med. Hyg. , vol.71 , pp. 80-81
    • Olatunde, A.1
  • 45
    • 0018716708 scopus 로고
    • Chloroquine-resistant Plasmodium falciparum from East Africa: Cultivation and drug sensitivity of the Tanzanian I/CDC strain from an American tourist
    • Campbell, C.C., Chin, W., Collins, W.E., et al. (1979): Chloroquine-resistant Plasmodium falciparum from East Africa: cultivation and drug sensitivity of the Tanzanian I/CDC strain from an American tourist. Lancet, 2, 1151-1154.
    • (1979) Lancet , vol.2 , pp. 1151-1154
    • Campbell, C.C.1    Chin, W.2    Collins, W.E.3
  • 46
    • 0018742587 scopus 로고
    • Chloroquineresistant Plasmodium falciparum malaria in Kenya
    • Fogh, S., Jepsen, S. and Effersoe, P. (1979): Chloroquineresistant Plasmodium falciparum malaria in Kenya. Trans. R. Soc. Trop. Med. Hyg., 73, 228-229.
    • (1979) Trans. R. Soc. Trop. Med. Hyg. , vol.73 , pp. 228-229
    • Fogh, S.1    Jepsen, S.2    Effersoe, P.3
  • 47
    • 0018275967 scopus 로고
    • Relative chloroquine resistance of P. falciparum in Zambia
    • Khan, A.A. and Maguire, M.J. (1978): Relative chloroquine resistance of P. falciparum in Zambia. Br. Med. J., 1, 1669-1670.
    • (1978) Br. Med. J. , vol.1 , pp. 1669-1670
    • Khan, A.A.1    Maguire, M.J.2
  • 48
    • 0021360254 scopus 로고
    • R-III chloroquine-resistant Plasmodium falciparum malaria from northern Malawi
    • Fogh, S., Jepsen, S. and Mataya, R.H. (1984): R-III chloroquine-resistant Plasmodium falciparum malaria from northern Malawi. Trans. R. Soc. Trop. Med. Hyg., 78, 282.
    • (1984) Trans. R. Soc. Trop. Med. Hyg. , vol.78 , pp. 282
    • Fogh, S.1    Jepsen, S.2    Mataya, R.H.3
  • 49
    • 0020579374 scopus 로고
    • Failure of chloroquine prophylaxis in Plasmodium falciparum in Zaire
    • Moran, J.S. (1983): Failure of chloroquine prophylaxis in Plasmodium falciparum in Zaire. Lancet, 2, 171-172.
    • (1983) Lancet , vol.2 , pp. 171-172
    • Moran, J.S.1
  • 50
    • 0021812205 scopus 로고
    • Chloroquine-resistant Plasmodium falciparum in Cameroon
    • Sansonetti, P.J., Lebras, C., Verdier, F., et al. (1985): Chloroquine-resistant Plasmodium falciparum in Cameroon. Lancet, 1, 1154-1155.
    • (1985) Lancet , vol.1 , pp. 1154-1155
    • Sansonetti, P.J.1    Lebras, C.2    Verdier, F.3
  • 51
    • 0022846453 scopus 로고
    • Severe chloroquine-resistant falciparum malaria in Gabon with decreased sensitivity to quinine
    • Simon, F., Le Bras, J., Charmot, G., et al. (1986): Severe chloroquine-resistant falciparum malaria in Gabon with decreased sensitivity to quinine. Trans. R. Soc. Trop. Med. Hyg., 80, 996-997.
    • (1986) Trans. R. Soc. Trop. Med. Hyg. , vol.80 , pp. 996-997
    • Simon, F.1    Le Bras, J.2    Charmot, G.3
  • 52
    • 0023142823 scopus 로고
    • Decline in sensitivity of Plasmodium falciparum to chloroquine in The Gambia
    • Menon, A., Snow, R.W., Otoo, L., et al. (1987): Decline in sensitivity of Plasmodium falciparum to chloroquine in The Gambia. Lancet, 1, 1029-1030.
    • (1987) Lancet , vol.1 , pp. 1029-1030
    • Menon, A.1    Snow, R.W.2    Otoo, L.3
  • 53
    • 0024199708 scopus 로고
    • Chloroquine-resistant Plasmodium falciparum malaria from Ivory Coast
    • Charmot, G., Le Bras, J., Doury, J.C., et al. (1988): Chloroquine-resistant Plasmodium falciparum malaria from Ivory Coast. Trans. R. Soc. Trop. Med. Hyg., 82, 392-393.
    • (1988) Trans. R. Soc. Trop. Med. Hyg. , vol.82 , pp. 392-393
    • Charmot, G.1    Le Bras, J.2    Doury, J.C.3
  • 54
    • 0023988284 scopus 로고
    • A study on chloroquine resistant falciparum malaria in a rural population in Ghana
    • Huige, W.M. and Sligcher, P. (1988): A study on chloroquine resistant falciparum malaria in a rural population in Ghana. Trop. Geogr. Med., 40, 174-175.
    • (1988) Trop. Geogr. Med. , vol.40 , pp. 174-175
    • Huige, W.M.1    Sligcher, P.2
  • 55
    • 0024314102 scopus 로고
    • Chloroquineresistant Plasmodium falciparum malaria in Senegal
    • Trape, J.F., Legros, F., Ndiaye, P., et al. (1989): Chloroquineresistant Plasmodium falciparum malaria in Senegal. Trans. R. Soc. Trop. Med. Hyg., 83, 761.
    • (1989) Trans. R. Soc. Trop. Med. Hyg. , vol.83 , pp. 761
    • Trape, J.F.1    Legros, F.2    Ndiaye, P.3
  • 56
    • 44449145387 scopus 로고    scopus 로고
    • Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum
    • Mehlotra, R.K., Mattera, G., Bockarie, M.J., et al. (2008): Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. Antimicrob. Agents Chemother., 52, 2212-2222.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 2212-2222
    • Mehlotra, R.K.1    Mattera, G.2    Bockarie, M.J.3
  • 57
    • 84858958997 scopus 로고    scopus 로고
    • Largescale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt
    • Takahashi, N., Tanabe, K., Tsukahara, T., et al. (2012): Largescale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt. Malar. J., 11, 92.
    • (2012) Malar. J. , vol.11 , pp. 92
    • Takahashi, N.1    Tanabe, K.2    Tsukahara, T.3
  • 58
    • 0036806981 scopus 로고    scopus 로고
    • Genetics of drug-resistant Plasmodium falciparum malaria in the Venezuelan state of Bolivar
    • Contreras, C.E., Cortese, J.F., Caraballo, A., et al. (2002): Genetics of drug-resistant Plasmodium falciparum malaria in the Venezuelan state of Bolivar. Am. J. Trop. Med. Hyg., 67, 400-405.
    • (2002) Am. J. Trop. Med. Hyg. , vol.67 , pp. 400-405
    • Contreras, C.E.1    Cortese, J.F.2    Caraballo, A.3
  • 59
    • 3242671257 scopus 로고    scopus 로고
    • Pfcrt Polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin
    • Vieira, P.P., Ferreira, M.U., Alecrim, M.G., et al. (2004): pfcrt Polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin. J. Infect. Dis., 190, 417-424.
    • (2004) J. Infect. Dis. , vol.190 , pp. 417-424
    • Vieira, P.P.1    Ferreira, M.U.2    Alecrim, M.G.3
  • 60
    • 34250866370 scopus 로고    scopus 로고
    • A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa
    • Maiga, O., Djimde, A.A., Hubert, V., et al. (2007): A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa. J. Infect. Dis., 196, 165-172.
    • (2007) J. Infect. Dis. , vol.196 , pp. 165-172
    • Maiga, O.1    Djimde, A.A.2    Hubert, V.3
  • 61
    • 34250183082 scopus 로고    scopus 로고
    • Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South America
    • McCollum, A.M., Mueller, K., Villegas, L., et al. (2007): Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South America. Antimicrob. Agents Chemother., 51, 2085-2091.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 2085-2091
    • McCollum, A.M.1    Mueller, K.2    Villegas, L.3
  • 62
    • 77950033492 scopus 로고    scopus 로고
    • Origins and spread of pfdhfr mutant alleles in Plasmodium falciparum
    • Mita, T. (2010): Origins and spread of pfdhfr mutant alleles in Plasmodium falciparum. Acta Trop., 114, 166-170.
    • (2010) Acta Trop. , vol.114 , pp. 166-170
    • Mita, T.1
  • 63
    • 46349109273 scopus 로고    scopus 로고
    • Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987-2006
    • Certain, L.K., Briceno, M., Kiara, S.M., et al. (2008): Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987-2006. J. Infect. Dis., 197, 1743-1751.
    • (2008) J. Infect. Dis. , vol.197 , pp. 1743-1751
    • Certain, L.K.1    Briceno, M.2    Kiara, S.M.3
  • 64
    • 84855165190 scopus 로고    scopus 로고
    • Identification of pyrimethamine-and chloroquine-resistant Plasmodium falciparum in Africa between 1984 and 1998: Genotyping of archive blood samples
    • Saito-Nakano, Y., Tanabe, K. and Mita, T. (2011): Identification of pyrimethamine-and chloroquine-resistant Plasmodium falciparum in Africa between 1984 and 1998: genotyping of archive blood samples. Malar. J., 10, 388.
    • (2011) Malar. J. , vol.10 , pp. 388
    • Saito-Nakano, Y.1    Tanabe, K.2    Mita, T.3
  • 65
    • 0010758549 scopus 로고
    • Chemotherapy of malaria
    • In Schnitzer, R. and Hawkings, F. (eds.), Academic Press, New York. 1963
    • Hill, J. (1963): Chemotherapy of malaria. p. 513-601. In Schnitzer, R. and Hawkings, F. (eds.), The Antimalarial Drugs, in Experimental Chemotherapy. Academic Press, New York. 1963:
    • (1963) The Antimalarial Drugs, in Experimental Chemotherapy. , pp. 513-601
    • Hill, J.1
  • 68
    • 38649109842 scopus 로고    scopus 로고
    • Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru
    • Zhou, Z., Griffing, S.M., de Oliveira, A.M., et al. (2008): Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru. Antimicrob. Agents Chemother., 52, 739-741.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 739-741
    • Zhou, Z.1    Griffing, S.M.2    de Oliveira, A.M.3
  • 69
    • 65449188363 scopus 로고    scopus 로고
    • Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria
    • Pearce, R.J., Pota, H., Evehe, M.S., et al. (2009): Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria. PLoS Med., 6, e1000055.
    • (2009) PLoS Med. , vol.6
    • Pearce, R.J.1    Pota, H.2    Evehe, M.S.3
  • 70
    • 80052937334 scopus 로고    scopus 로고
    • Artemisinin: Discovery from the Chinese herbal garden
    • Miller, L.H. and Su, X. (2011): Artemisinin: discovery from the Chinese herbal garden. Cell, 146, 855-858.
    • (2011) Cell , vol.146 , pp. 855-858
    • Miller, L.H.1    Su, X.2
  • 71
    • 0018612308 scopus 로고
    • Antimalaria studies on Qinghaosu
    • Group, Q.A.C.R. (1979): Antimalaria studies on Qinghaosu. Chin. Med. J. (Engl)., 92, 811-816.
    • (1979) Chin. Med. J. (Engl). , vol.92 , pp. 811-816
    • Group, Q.A.C.R.1
  • 72
    • 42349104331 scopus 로고    scopus 로고
    • Qinghaosu (artemisinin): The price of success
    • White, N.J. (2008): Qinghaosu (artemisinin): the price of success. Science, 320, 330-334.
    • (2008) Science , vol.320 , pp. 330-334
    • White, N.J.1
  • 73
    • 1642461372 scopus 로고    scopus 로고
    • Activities of artesunate and primaquine against asexualand sexual-stage parasites in falciparum malaria
    • Pukrittayakamee, S., Chotivanich, K., Chantra, A., et al. (2004): Activities of artesunate and primaquine against asexualand sexual-stage parasites in falciparum malaria. Antimicrob. Agents Chemother., 48, 1329-1334.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 1329-1334
    • Pukrittayakamee, S.1    Chotivanich, K.2    Chantra, A.3
  • 74
    • 48449085492 scopus 로고    scopus 로고
    • Reduction of transmission from malaria patients by artemisinin combination therapies: A pooled analysis of six randomized trials
    • Okell, L.C., Drakeley, C.J., Ghani A.C., et al. (2008): Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. Malar. J., 7, 125.
    • (2008) Malar. J. , vol.7 , pp. 125
    • Okell, L.C.1    Drakeley, C.J.2    Ghani, A.C.3
  • 75
    • 0030858470 scopus 로고    scopus 로고
    • Assessment of the pharmacodynamic properties of antimalarial drugs in vivo
    • White, N.J. (1997): Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob. Agents Chemother., 41, 1413-1422.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1413-1422
    • White, N.J.1
  • 76
    • 72349090161 scopus 로고    scopus 로고
    • Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    • White, N.J., Pongtavornpinyo, W., Maude, R.J., et al. (2009): Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance. Malar. J., 8, 253.
    • (2009) Malar. J. , vol.8 , pp. 253
    • White, N.J.1    Pongtavornpinyo, W.2    Maude, R.J.3
  • 77
    • 0032429282 scopus 로고    scopus 로고
    • Artesunate versus artemether for the treatment of recrudescent multidrugresistant falciparum malaria
    • Price, R., van Vugt, M., Nosten, F., et al. (1998): Artesunate versus artemether for the treatment of recrudescent multidrugresistant falciparum malaria. Am. J. Trop. Med. Hyg., 59, 883-888.
    • (1998) Am. J. Trop. Med. Hyg. , vol.59 , pp. 883-888
    • Price, R.1    van Vugt, M.2    Nosten, F.3
  • 78
    • 0030271322 scopus 로고    scopus 로고
    • Strategies for the prevention of antimalarial drug resistance: Rationale for combination chemotherapy for malaria
    • White, N.J. and Olliaro, P.L. (1996): Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malaria. Parasitol. Today, 12, 399-401.
    • (1996) Parasitol. Today , vol.12 , pp. 399-401
    • White, N.J.1    Olliaro, P.L.2
  • 79
    • 2142659388 scopus 로고    scopus 로고
    • Antimalarial drug resistance
    • White, N.J. (2004): Antimalarial drug resistance. J. Clin. Invest., 113, 1084-1092.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1084-1092
    • White, N.J.1
  • 80
    • 79251599335 scopus 로고    scopus 로고
    • Plasmodium sensitivity to artemisinins: Magic bullets hit elusive targets
    • Ding, X.C., Beck, H.P. and Raso, G. (2011): Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets. Trends Parasitol., 27, 73-81.
    • (2011) Trends Parasitol. , vol.27 , pp. 73-81
    • Ding, X.C.1    Beck, H.P.2    Raso, G.3
  • 81
    • 0032415433 scopus 로고    scopus 로고
    • Two patients with falciparum malaria and poor in vivo responses to artesunate
    • Luxemburger, C., Brockman, A., Silamut, K., et al. (1998): Two patients with falciparum malaria and poor in vivo responses to artesunate. Trans. R. Soc. Trop. Med. Hyg., 92, 668-669.
    • (1998) Trans. R. Soc. Trop. Med. Hyg. , vol.92 , pp. 668-669
    • Luxemburger, C.1    Brockman, A.2    Silamut, K.3
  • 82
    • 0033624609 scopus 로고    scopus 로고
    • Probable resistance to parenteral artemether in Plasmodium falciparum: Case reports from Mumbai (Bombay), India
    • Gogtay, N.J., Kadam, V.S., Karnad, D.R., et al. (2000): Probable resistance to parenteral artemether in Plasmodium falciparum: case reports from Mumbai (Bombay), India. Ann. Trop. Med. Parasitol., 94, 519-520.
    • (2000) Ann. Trop. Med. Parasitol. , vol.94 , pp. 519-520
    • Gogtay, N.J.1    Kadam, V.S.2    Karnad, D.R.3
  • 83
    • 0034898043 scopus 로고    scopus 로고
    • Apparent drug failure following artesunate treatment of Plasmodium falciparum malaria in Freetown, Sierra Leone: Four case reports
    • Sahr, F., Willoughby, V.R., Gbakima, A.A., et al. (2001): Apparent drug failure following artesunate treatment of Plasmodium falciparum malaria in Freetown, Sierra Leone: four case reports. Ann. Trop. Med. Parasitol., 95, 445-449.
    • (2001) Ann. Trop. Med. Parasitol. , vol.95 , pp. 445-449
    • Sahr, F.1    Willoughby, V.R.2    Gbakima, A.A.3
  • 84
    • 23644435759 scopus 로고    scopus 로고
    • Artemisinin resistance: How can we find it?
    • Noedl, H. (2005): Artemisinin resistance: how can we find it? Trends Parasitol., 21, 404-405.
    • (2005) Trends Parasitol. , vol.21 , pp. 404-405
    • Noedl, H.1
  • 85
    • 0027509620 scopus 로고
    • Qinghaosu
    • Hien, T.T. and White, N.J. (1993): Qinghaosu. Lancet, 341, 603-608.
    • (1993) Lancet , vol.341 , pp. 603-608
    • Hien, T.T.1    White, N.J.2
  • 86
    • 0035897913 scopus 로고    scopus 로고
    • Fake artesunate in southeast Asia
    • Newton, P., Proux, S., Green, M., et al. (2001): Fake artesunate in southeast Asia. Lancet, 357, 1948-1950.
    • (2001) Lancet , vol.357 , pp. 1948-1950
    • Newton, P.1    Proux, S.2    Green, M.3
  • 87
    • 57749099137 scopus 로고    scopus 로고
    • Evidence of artemisinin-resistant malaria in western Cambodia
    • Noedl, H., Se, Y., Schaecher, K., et al. (2008): Evidence of artemisinin-resistant malaria in western Cambodia. N. Engl. J. Med., 359, 2619-2620.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 2619-2620
    • Noedl, H.1    Se, Y.2    Schaecher, K.3
  • 88
    • 58649122842 scopus 로고    scopus 로고
    • Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia
    • Rogers, W.O., Sem, R., Tero, T., et al. (2009): Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Malar. J., 8, 10.
    • (2009) Malar. J. , vol.8 , pp. 10
    • Rogers, W.O.1    Sem, R.2    Tero, T.3
  • 89
    • 84858449712 scopus 로고    scopus 로고
    • Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment
    • Carrara, V.I., Zwang, J., Ashley, E.A., et al. (2009): Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment. PLoS One, 4, e4551.
    • (2009) PLoS One , vol.4
    • Carrara, V.I.1    Zwang, J.2    Ashley, E.A.3
  • 90
    • 0142124894 scopus 로고    scopus 로고
    • Changes in susceptibility of Plasmodium falciparum to artesunate in vitro in Yunnan Province, China
    • Yang, H., Liu, D., Yang, Y., et al. (2003): Changes in susceptibility of Plasmodium falciparum to artesunate in vitro in Yunnan Province, China. Trans. R. Soc. Trop. Med. Hyg., 97, 226-228.
    • (2003) Trans. R. Soc. Trop. Med. Hyg. , vol.97 , pp. 226-228
    • Yang, H.1    Liu, D.2    Yang, Y.3
  • 91
    • 84861461519 scopus 로고    scopus 로고
    • Emergence of artemisinin-resistant malaria on the western border of Thailand: A longitudinal study
    • Phyo, A.P., Nkhoma, S., Stepniewska, K., et al. (2012): Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet, 379, 1960-1966.
    • (2012) Lancet , vol.379 , pp. 1960-1966
    • Phyo, A.P.1    Nkhoma, S.2    Stepniewska, K.3
  • 92
    • 78651077288 scopus 로고    scopus 로고
    • Intrahost modeling of artemisinin resistance in Plasmodium falciparum
    • Saralamba, S., Pan-Ngum, W., Maude, R.J., et al. (2011): Intrahost modeling of artemisinin resistance in Plasmodium falciparum. Proc. Natl. Acad. Sci. USA, 108, 397-402.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 397-402
    • Saralamba, S.1    Pan-Ngum, W.2    Maude, R.J.3
  • 93
    • 84859506329 scopus 로고    scopus 로고
    • A major genome region underlying artemisinin resistance in malaria
    • Cheeseman, I.H., Miller, B.A., Nair, S., et al. (2012): A major genome region underlying artemisinin resistance in malaria. Science, 336, 79-82.
    • (2012) Science , vol.336 , pp. 79-82
    • Cheeseman, I.H.1    Miller, B.A.2    Nair, S.3
  • 94
    • 84857650801 scopus 로고    scopus 로고
    • Malaria in the Greater Mekong subregion: Heterogeneity and complexity
    • Cui, L., Yan, G., Sattabongkot, J., et al. (2011): Malaria in the Greater Mekong subregion: heterogeneity and complexity. Acta Trop., 121, 227-239.
    • (2011) Acta Trop. , vol.121 , pp. 227-239
    • Cui, L.1    Yan, G.2    Sattabongkot, J.3
  • 95
    • 0022826831 scopus 로고
    • Epidemiology of the emergence and spread of drug-resistant falciparum malaria in South-East Asia and Australasia
    • Verdrager, J. (1986): Epidemiology of the emergence and spread of drug-resistant falciparum malaria in South-East Asia and Australasia. J. Trop. Med. Hyg., 89, 277-289.
    • (1986) J. Trop. Med. Hyg. , vol.89 , pp. 277-289
    • Verdrager, J.1
  • 96
    • 68049123592 scopus 로고    scopus 로고
    • Artemisinin resistance in Plasmodium falciparum malaria
    • Dondorp, A.M., Nosten, F., Yi, P., et al. (2009): Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med., 361, 455-467.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 455-467
    • Dondorp, A.M.1    Nosten, F.2    Yi, P.3
  • 97
    • 19344377211 scopus 로고    scopus 로고
    • Drug resistance models for malaria
    • Mackinnon, M.J. (2005): Drug resistance models for malaria. Acta Trop., 94, 207-217.
    • (2005) Acta Trop. , vol.94 , pp. 207-217
    • Mackinnon, M.J.1
  • 98
    • 4744343699 scopus 로고    scopus 로고
    • The origins of antimalarial drug resistance
    • Hastings, I.M. (2004): The origins of antimalarial drug resistance. Trends Parasitol., 20, 512-518.
    • (2004) Trends Parasitol. , vol.20 , pp. 512-518
    • Hastings, I.M.1
  • 99
    • 0033795404 scopus 로고    scopus 로고
    • Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum
    • Anderson, T.J., Haubold, B., Williams, J.T., et al. (2000): Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol. Biol. Evol., 17, 1467-1482.
    • (2000) Mol. Biol. Evol. , vol.17 , pp. 1467-1482
    • Anderson, T.J.1    Haubold, B.2    Williams, J.T.3
  • 100
    • 66249140986 scopus 로고    scopus 로고
    • Genetic diversity and population structure of Plasmodium falciparum in the Philippines
    • Iwagami, M., Rivera, P.T., Villacorte, E.A., et al. (2009): Genetic diversity and population structure of Plasmodium falciparum in the Philippines. Malar. J., 8, 96.
    • (2009) Malar. J. , vol.8 , pp. 96
    • Iwagami, M.1    Rivera, P.T.2    Villacorte, E.A.3
  • 101
    • 0001726921 scopus 로고
    • The theoretical variance within and among subdivisions of a population that is in a steady state
    • Wright, S. (1952): The theoretical variance within and among subdivisions of a population that is in a steady state. Genetics, 37, 312-321.
    • (1952) Genetics , vol.37 , pp. 312-321
    • Wright, S.1
  • 102
    • 0002261251 scopus 로고    scopus 로고
    • The Metapopulation Approach, Its History, Conceptual Domain and Application to Conservation
    • In Hanski, I.A. and Gilpin, M.E. (eds.), Academic Press, San Diego
    • Hanski, I.A. and Simberloff, D. (1997): The Metapopulation Approach, Its History, Conceptual Domain and Application to Conservation. p. 5-26. In Hanski, I.A. and Gilpin, M.E. (eds.), Metapopulation Biology: Ecology, Genetics, and Evolution. Academic Press, San Diego.
    • (1997) Metapopulation Biology: Ecology, Genetics, and Evolution. , pp. 5-26
    • Hanski, I.A.1    Simberloff, D.2
  • 103
    • 0037298841 scopus 로고    scopus 로고
    • Metapopulation concepts applied to falciparum malaria and their impacts on the emergence and spread of chloroquine resistance
    • Ariey, F., Duchemin, J.B. and Robert, V. (2003): Metapopulation concepts applied to falciparum malaria and their impacts on the emergence and spread of chloroquine resistance. Infect. Genet. Evol., 2, 185-192.
    • (2003) Infect. Genet. Evol. , vol.2 , pp. 185-192
    • Ariey, F.1    Duchemin, J.B.2    Robert, V.3
  • 104
    • 0030829371 scopus 로고    scopus 로고
    • Variations in frequencies of drug resistance in Plasmodium falciparum
    • Rathod, P.K., McErlean, T. and Lee, P.C. (1997): Variations in frequencies of drug resistance in Plasmodium falciparum. Proc. Natl. Acad. Sci. USA, 94, 9389-9393.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9389-9393
    • Rathod, P.K.1    McErlean, T.2    Lee, P.C.3
  • 105
    • 79953878868 scopus 로고    scopus 로고
    • Malaria drug resistance is associated with defective DNA mismatch repair
    • Castellini, M.A., Buguliskis, J.S., Casta, L.J., et al. (2011): Malaria drug resistance is associated with defective DNA mismatch repair. Mol. Biochem. Parasitol., 177, 143-147.
    • (2011) Mol. Biochem. Parasitol. , vol.177 , pp. 143-147
    • Castellini, M.A.1    Buguliskis, J.S.2    Casta, L.J.3
  • 107
    • 13944271928 scopus 로고    scopus 로고
    • How do patients use antimalarial drugs? A review of the evidence
    • Yeung, S. and White, N.J. (2005): How do patients use antimalarial drugs? A review of the evidence. Trop. Med. Int. Health, 10, 121-138.
    • (2005) Trop. Med. Int. Health , vol.10 , pp. 121-138
    • Yeung, S.1    White, N.J.2
  • 108
    • 37749020557 scopus 로고    scopus 로고
    • An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites
    • Dittrich, S., Mitchell, S.L., Blagborough, A.M., et al. (2008): An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites. Mol. Microbiol., 67, 609-618.
    • (2008) Mol. Microbiol. , vol.67 , pp. 609-618
    • Dittrich, S.1    Mitchell, S.L.2    Blagborough, A.M.3
  • 109
    • 55449133690 scopus 로고    scopus 로고
    • Adaptive copy number evolution in malaria parasites
    • Nair, S., Miller, B., Barends, M., et al. (2008): Adaptive copy number evolution in malaria parasites. PLoS Genet., 4, e1000243.
    • (2008) PLoS Genet. , vol.4
    • Nair, S.1    Miller, B.2    Barends, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.