Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987-2006

Journal of Infectious Diseases

Volumn 197, Issue 12, 2008, Pages 1743-1751

  Certain, Laura K ^a   Briceño, Marnie ^a   Kiara, Steven M ^b   Nzila, Alexis M ^b   Watkins, William M ^c   Sibley, Carol Hopkins ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; FANSIDAR; PYRIMETHAMINE;

AFRICA; ALLELE; ARTICLE; ASIA; DHFR GENE; GENE; GENE FREQUENCY; HAPLOTYPE; HUMAN; KENYA; MICROSATELLITE MARKER; MUTANT; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; ANTIMALARIALS; DRUG RESISTANCE; GENE FREQUENCY; HAPLOTYPES; HUMANS; KENYA; MALARIA, FALCIPARUM; MICROSATELLITE REPEATS; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; TIME FACTORS;

EID: 46349109273     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/588198     Document Type: Article

References (31)

1. Wongsrichanalai C, Pickard AL, Wernsdorfer WH, Meshnick SR. Epidemiology of drug-resistant malaria. Lancet Infect Dis 2002; 2:209-18.
2. Gregson A, Plowe CV. Mechanisms of resistance of malaria parasites to antifolates. Pharmacol Rev 2005; 57:117-45.
3. Kublin JG, Dzinjalamala FK, Kamwendo DD, et al. Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. J Infect Dis 2002; 185:380-8.
4. Sibley CH, Hyde JE, Sims PF, et al. Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? Trends Parasitol 2001; 17:582-8.
5. White NJ, Nosten F, Looareesuwan S, et al. Averting a malaria disaster. Lancet 1999; 353:1965-7.
6. Paget-McNicol S, Saul A. Mutation rates in the dihydrofolate reductase gene of Plasmodium falciparum. Parasitology 2001; 122:497-505.
7. Plowe CV, Kublin JG, Doumbo OK. P. falciparum dihydrofolate reductase and dihydropteroate synthase mutations: epidemiology and role in clinical resistance to antifolates. Drug Resist Updat 1998; 1:389-96.
8. Doumbo OK, Kayentao K, Djimde A, et al. Rapid selection of Plasmodium falciparum dihydrofolate reductase mutants by pyrimethamine prophylaxis. J Infect Dis 2000; 182:993-6.
9. Roper C, Pearce R, Bredenkamp B, et al. Antifolate antimalarial resistance in southeast Africa: a population-based analysis. Lancet 2003; 361:1174-81.
10. Nair S, Williams JT, Brockman A, et al. A selective sweep driven by pyrimethamine treatment in Southeast Asian malaria parasites. Mol Biol Evol 2003; 20:1526-36.
11. Roper C, Pearce R, Nair S, Sharp B, Nosten F, Anderson T. Intercontinental spread of pyrimethamine-resistant malaria. Science 2004; 305:1124.
12. Maiga O, Djimde AA, Hubert V, et al. A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa. J Infect Dis 2007; 196:165-72.
13. Noranate N, Durand R, Tall A, et al. Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use. PLoS ONE 2007; 2:e139.
14. McCollum AM, Poe AC, Hamel M, et al. Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles. J Infect Dis 2006; 194:189-97.
15. Ndiaye D, Daily JP, Sarr O, et al. Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal. Acta Trop 2006; 99:106-11.
16. Certain LK, Sibley CH. Plasmodium falciparum: a novel method for analyzing haplotypes in mixed infections. Exp Parasitol 2007; 115:233-41.
17. Mberu EK, Mosobo MK, Nzila AM, Kokwaro GO, Sibley CH, Watkins WM. The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya. Am J Trop Med Hyg 2000; 62:396-401.
18. Williams T. KEMRI CGMRC Kilifi, Kenya. INDEPTH Network. 2006. Available at: http://www.indepth-network.org/dss_site_profiles/ KILIFI%20PROFILE%202006.pdf. Accessed 6 May 2008.
19. Kyes S, Harding R, Black G, et al. Limited spatial clustering of individual Plasmodium falciparum alleles in field isolates from coastal Kenya. Am J Trop Med Hyg 1997; 57:205-15.
20. Mbogo CN, Snow RW, Khamala CP, et al. Relationships between Plasmodium falciparum transmission by vector populations and the incidence of severe disease at nine sites on the Kenyan coast. Am J Trop Med Hyg 1995; 52:201-6.
21. Watkins WM, Mosobo M. Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: selective pressure for resistance is a function of long elimination half-life. Trans R Soc Trop Med Hyg 1993; 87:75-8.
22. Nzila-Mounda A, Mberu EK, Sibley CH, Plowe CV, Winstanley PA, Watkins WM. Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain. Antimicrob Agents Chemother 1998; 42:164-9.
23. Amukoye E, Winstanley PA, Watkins WM, et al. Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria. Antimicrob Agents Chemother 1997; 41:2261-4.
24. Duraisingh MT, Curtis J, Warhurst DC. Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol 1998; 89:1-8.
25. Bandelt HJ, Forster P, Rohl A. Median-joining networks for inferring intraspecific phylogenies. Mol Biol Evol 1999; 16:37-48.
26. Spencer HC, Masaba SC, Kiaraho D. Sensitivity of Plasmodium falciparum isolates to chloroquine in Kisumu and Malindi, Kenya. Am J Trop Med Hyg 1982; 31:902-6.
27. Hagos B, Khan B, Ofulla AV, Kariuki D, Martin SK. Response of falciparum malaria to chloroquine and three second line antimalarial drugs in a Kenyan coastal school age population. East Afr Med J 1993; 70:620-3.
28. Anderson TJ, Su XZ, Roddam A, Day KP. Complex mutations in a high proportion of microsatellite loci from the protozoan parasite Plasmodium falciparum. Mol Ecol 2000; 9:1599-608.
29. Keen J, Farcas GA, Zhong K, Dunne MW, Kain KC. Real-time PCR assay for the rapid detection and analysis of PfCRT haplotypes of chloroquine-resistant Plasmodium falciparum isolates from India. J Clin Microbiol 2007; 45: 2889-93.
30. Anderson TJ, Haubold B, Williams JT, et al. Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol Biol Evol 2000; 17:1467-82.
31. Sandefur CI, Wooden JM, Quaye IK, Sirawaraporn W, Sibley CH. Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro. Mol Biochem Parasitol 2007; 154:1-5.