Indigenous evolution of Plasmodium falciparum pyrimethamine resistance multiple times in Africa

Journal of Antimicrobial Chemotherapy

Volumn 63, Issue 2, 2009, Pages 252-255

  Mita, Toshihiro ^a   Tanabe, Kazuyuki ^b   Takahashi, Nobuyuki ^a   Culleton, Richard ^b,c   Ndounga, Mathieu ^d   Dzodzomenyo, Mawuli ^a,e   Akhwale, Willis S ^f   Kaneko, Akira ^g   Kobayakawa, Takatoshi ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c NAGASAKI UNIVERSITY   (Japan)

^d Centre d'Etudes sur les des Resources Vegetales   (Congo)

^e UNIVERSITY OF GHANA   (Ghana)

^f Ministry of Public Health and Sanitation   (Kenya)

^g KAROLINSKA INSTITUTE   (Sweden)

Author keywords

dhfr; Malaria; Microsatellite

Indexed keywords

BACTERIAL DNA; DIHYDROFOLATE REDUCTASE; FANSIDAR; PYRIMETHAMINE;

AFRICA; ANTIBIOTIC RESISTANCE; ARTICLE; CONGO; CONTROLLED STUDY; DNA FLANKING REGION; GENE LOCUS; GEOGRAPHIC DISTRIBUTION; GHANA; HUMAN; KENYA; MALARIA; MICROSATELLITE MARKER; MOLECULAR EVOLUTION; NONHUMAN; PLASMODIUM FALCIPARUM; SPECIES COMPARISON;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIMALARIALS; CONGO; DNA FINGERPRINTING; DNA, PROTOZOAN; DRUG RESISTANCE; GENOTYPE; GHANA; HUMANS; KENYA; MALARIA, FALCIPARUM; MICROSATELLITE REPEATS; MUTATION, MISSENSE; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; PYRIMETHAMINE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 58849122733     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkn482     Document Type: Article

References (10)

1. Plowe CV, Cortese JF, Djimde A et al. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. J Infect Dis 1997; 176: 1590-6.
2. Sirawaraporn W, Sathitkul T, Sirawaraporn R et al. Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proc Natl Acad Sci USA 1997; 94: 1124-9.
3. Wongsrichanalai C, Pickard AL, Wernsdorfer WH et al. Epidemiology of drug-resistant malaria. Lancet Infect Dis 2002; 2: 209-18.
4. Nair S, Williams JT, Brockman A et al. A selective sweep driven by pyrimethamine treatment in Southeast Asian malaria parasites. Mol Biol Evol 2003; 20: 1526-36.
5. Roper C, Pearce R, Bredenkamp B et al. Antifolate antimalarial resistance in southeast Africa: A population-based analysis. Lancet 2003; 361: 1174-81.
6. Roper C, Pearce R, Nair S et al. Intercontinental spread of pyrimethamine-resistant malaria. Science 2004; 305: 1124.
7. Maiga O, Djimde AA, Hubert V et al. A shared Asian origin of the triple-mutant dhfr allele in Plasmodium falciparum from sites across Africa. J Infect Dis 2007; 196: 165-72.
8. Certain LK, Briceno M, Kiara SM et al. Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987-2006. J Infect Dis 2008; 197 1743-51.
9. Reeder JC, Rieckmann KH, Genton B et al. Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea. Am J Trop Med Hyg 1996; 55: 209-13.
10. Mita T, Tanabe K, Takahashi N et al. Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia. Antimicrob Agents Chemother 2007; 51: 1071-7.