Reduction of transmission from malaria patients by artemisinin combination therapies: A pooled analysis of six randomized trials

Malaria Journal

Volumn 7, Issue , 2008, Pages

  Okell, Lucy C ^a   Drakeley, Chris J ^a   Ghani, Azra C ^b   Bousema, Teun ^c   Sutherland, Colin J ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ; ARTESUNATE; CHLOROQUINE; FANSIDAR; ARTEMISININ DERIVATIVE;

ARTICLE; CELL DENSITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE TRANSMISSION; ENDEMIC DISEASE; GAMBIA; GAMETOCYTE; HUMAN; KENYA; MAJOR CLINICAL STUDY; MALARIA; MICROSCOPY; MOSQUITO; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; TREATMENT FAILURE; TREATMENT OUTCOME; ANIMAL; CHILD; DRUG COMBINATION; DRUG EFFECT; MALARIA FALCIPARUM; META ANALYSIS; MULTIVARIATE ANALYSIS; PARASITEMIA; PARASITOLOGY; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; REGRESSION ANALYSIS;

ANIMALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; CULICIDAE; DRUG THERAPY, COMBINATION; GAMBIA; HUMANS; KENYA; MALARIA, FALCIPARUM; MULTIVARIATE ANALYSIS; PARASITEMIA; PLASMODIUM FALCIPARUM; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REGRESSION ANALYSIS; TREATMENT FAILURE;

EID: 48449085492     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-7-125     Document Type: Article

References (35)

1. Public health impact of drug resistant Plasmodium falciparum malaria. A Bjorkman A Bhattarai, Acta Trop 2005 94 163 169 15893289
2. WHO Global Malaria Programme (GMP): treatment policies. http://www.who.int/malaria/treatmentpolicies.html
3. Antimalarial drug resistance. NJ White, J Clin Invest 2004 113 1084 1092 15085184
4. The infectivity of gametocytes of Plasmodium falciparum from patients treated with artemisinin. PQ Chen GQ Li XB Guo KR He YX Fu LC Fu YZ Song, Chinese Med J 1994 107 709 711 7805466
5. Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum. N Kumar H Zheng, Parasitol Res 1990 76 214 218 10.1007/BF00930817 2179946
6. Artesunate combinations for treatment of malaria: meta-analysis. M Adjuik A Babiker P Garner P Olliaro W Taylor N White, Lancet 2004 363 9 17 10.1016/S0140-6736(03)15162-8 14723987
7. Plasmodium falciparum gametocytes: The effect of chloroquine on their development. ME Smalley, Trans R Soc Trop Med Hyg 1977 71 526 529 10.1016/0035-9203(77)90149-3 343314
8. Antimalarial drugs and the mosquito transmission of Plasmodium. GA Butcher, Int J Parasitol 1997 27 975 987 10.1016/S0020-7519(97)00079-9 9363480
9. Effect of Artemether-Lumefantrine Policy and Improved Vector Control on Malaria Burden in KwaZulu-Natal, South Africa. KI Barnes DN Durrheim F Little A Jackson U Mehta E Allen SS Dlamini J Tsoka B Bredenkamp DJ Mthembu NJ White BL Sharp, PLoS Med 2005 2 e330 16187798 10.1371/journal.pmed.0020330
10. Effects of artemisinin derivatives on malaria transmissibility. RN Price F Nosten C Luxemburger FO ter Kuile L Paiphun T Chongsuphajaisiddhi NJ White, Lancet 1996 347 1654 1658 10.1016/S0140-6736(96)91488-9 8642959
11. Insecticide-treated bed nets for the prevention of Plasmodium falciparum malaria in Cambodia: a cluster-randomised trial. T Sochantha S Hewitt C Nguon L Okell N Alexander S Yeung H Vannara M Rowland D Socheat, Trop Med Int Health 2006 11 1166 1177 10.1111/j.1365-3156.2006.01673.x 16903880
12. Malaria control in Vietnam: the Binh Thuan experience. N Van Nam PJ de Vries L Van Toi N Nagelkerke, Trop Med Int Health 2005 10 357 365 10.1111/j.1365-3156.2005.01387.x 15807800
13. Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes. RL Hallett CJ Sutherland N Alexander R Ord M Jawara CJ Drakeley M Pinder G Walraven GA Targett A Alloueche, Antimicrob Agents Chemother 2004 48 3940 3943 15388456 10.1128/AAC.48.10.3940- 3943.2004
14. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. F Nosten M van Vugt R Price C Luxemburger KL Thway A Brockman R McGready F ter Kuile S Looareesuwan NJ White, Lancet 2000 356 297 302 10.1016/S0140-6736(00)02505-8 11071185
15. Efficacy and safety of the six-dose regimen of artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in adolescents and adults: A pooled analysis of individual patient data from randomized clinical trials. EA Mueller M van Vugt W Kirch K Andriano P Hunt PI de Palacios, Acta Trop 2006 100 41 53 10.1016/j.actatropica.2006.09.007 17045558
16. Experimental infections of Anopheles gambiae with Plasmodium falciparum of naturally infected gametocyte carriers in Cameroon: factors influencing the infectivity to mosquitoes. T Tchuinkam B Mulder K Dechering H Stoffels JP Verhave M Cot P Carnevale JH Meuwissen V Robert, Trop Med Parasitol 1993 44 271 276 8134766
17. Plasmodium sex determination and transmission to mosquitoes. RE Paul PT Brey V Robert, Trends Parasitol 2002 18 32 38 10.1016/S1471-4922(01)02122-5 11850012
18. The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion. C Drakeley C Sutherland JT Bousema RW Sauerwein GA Targett, Trends Parasitol 2006 22 424 430 10.1016/j.pt.2006.07.001 16846756
19. Moderate Effect of Artemisinin-Based combination therapy on transmission of Plasmodium falciparum. JT Bousema P Schneider LC Gouagna CJ Drakeley A Tostmann R Houben JI Githure R Ord CJ Sutherland SA Omar RW Sauerwein, J Infect Dis 2006 193 1151 1159 10.1086/503051 16544256
20. Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes. CJ Drakeley M Jawara GA Targett G Walraven U Obisike R Coleman M Pinder CJ Sutherland, Trop Med Int Health 2004 9 53 61 10.1046/j.1365-3156.2003.01169.x 14728607
21. Reduction of malaria transmission to anopheles mosquitoes with a six-dose regimen of co-artemether. CJ Sutherland R Ord S Dunyo M Jawara CJ Drakeley N Alexander R Coleman M Pinder G Walraven GA Targett, PLoS Med 2005 2 e92 15839740 10.1371/journal.pmed.0020092
22. Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae. G Targett C Drakeley M Jawara L von Seidlein R Coleman J Deen M Pinder T Doherty C Sutherland G Walraven P Milligan, J Infect Dis 2001 183 1254 1259 10.1086/319689 11262208
23. Risk of malaria attacks in Gambian children is greater away from malaria vector breeding sites. SE Clarke C Bogh RC Brown GE Walraven CJ Thomas SW Lindsay, Trans R Soc Trop Med Hyg 2002 96 499 506 10.1016/S0035-9203(02)90419-0 12474476
24. Chloroquine/Sulphadoxine-Pyrimethamine for Gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparum. RL Hallett S Dunyo R Ord M Jawara M Pinder A Randall A Alloueche G Walraven GA Targett N Alexander CJ Sutherland, PLoS Clin Trials 2006 1 e15 16871318 10.1371/journal.pctr.0010015
25. Quantification of Plasmodium falciparum gametocytes in differential stages of development by quantitative nucleic acid sequence-based amplification. P Schneider G Schoone H Schallig D Verhage D Telgt W Eling R Sauerwein, Mol Biochem Parasitol 2004 137 35 41 10.1016/j.molbiopara.2004.03.018 15279949
26. Generalized linear modelling for parasitologists. K Wilson BT Grenfell, Parasitol Today 1997 13 33 38 10.1016/S0169-4758(96)40009-6 15275165
27. Plasmodium falciparum gametocytes: their longevity and infectivity. ME Smalley RE Sinden, Parasitology 1977 74 1 8 320542
28. Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania. A Martensson J Stromberg C Sisowath MI Msellem JP Gil SM Montgomery P Olliaro AS Ali A Bjorkman, Clin Infect Dis 2005 41 1079 1086 10.1086/444460 16163624
29. Gametocytemia and infectivity to mosquitoes of patients with uncomplicated Plasmodium falciparum malaria attacks treated with chloroquine or sulfadoxine plus pyrimethamine. V Robert HP Awono-Ambene JY Le Hesran JF Trape, Am J Trop Med Hyg 2000 62 210 216 10813475
30. Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasites. R Ord N Alexander S Dunyo R Hallett M Jawara G Targett CJ Drakeley CJ Sutherland, J Infect Dis 2007 196 1613 1619 10.1086/522154 18008244
31. Submicroscopic Plasmodium falciparum gametocyte carriage is common in an area of low and seasonal transmission in Tanzania. SA Shekalaghe JT Bousema KK Kunei P Lushino A Masokoto LR Wolters S Mwakalinga FW Mosha RW Sauerwein CJ Drakeley, Trop Med Int Health 2007 12 547 553 17445146
32. Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children. A Sowunmi AA Adedeji GO Gbotosho BA Fateye TC Happi, Mem Inst Oswaldo Cruz 2006 101 887 893 10.1590/S0074-02762006000800011 17293984
33. Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum. S Dunyo P Milligan T Edwards C Sutherland G Targett M Pinder, PLoS Clin Trials 2006 1 e20 17013431 10.1371/journal.pctr.0010020
34. Specific and nonspecific responses to Plasmodium falciparum blood-stage parasites and observations on the gametocytemia in schoolchildren living in a malaria-endemic area of Mozambique. B Hogh R Thompson C Hetzel SL Fleck NA Kruse I Jones M Dgedge J Barreto RE Sinden, Am J Trop Med Hyg 1995 52 50 59 7856825
35. Age-structured gametocyte allocation links immunity to epidemiology in malaria parasites. RE Paul S Bonnet C Boudin T Tchuinkam V Robert, Malar J 2007 6 123 17850648 10.1186/1475-2875-6-123