메뉴 건너뛰기




Volumn 184, Issue 6, 2010, Pages 2918-2929

Glutathione-redox balance regulates c-rel-driven IL-12 production in macrophages: Possible implications in antituberculosis immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; I KAPPA B BETA; INTERLEUKIN 12; PROTEIN P40; PROTEIN P70; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR ALPHA; GLUTATHIONE DISULFIDE; REACTIVE OXYGEN METABOLITE;

EID: 77951888771     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900439     Document Type: Article
Times cited : (48)

References (58)
  • 1
    • 27944442839 scopus 로고    scopus 로고
    • Disulfide relays and phosphorylative cascades: Partners in redox-mediated signaling pathways
    • DOI 10.1038/sj.cdd.4401754, PII 4401754
    • Filomeni, G., G. Rotilio, and M. R. Ciriolo. 2005. Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways. Cell Death Differ. 12: 1555-1563. (Pubitemid 41679161)
    • (2005) Cell Death and Differentiation , vol.12 , Issue.12 , pp. 1555-1563
    • Filomeni, G.1    Rotilio, G.2    Ciriolo, M.R.3
  • 2
    • 33750620057 scopus 로고    scopus 로고
    • Oxidative stress and redox regulation of lung inflammation in COPD
    • Rahman, I., and I. M. Adcock. 2006. Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Respir. J. 28: 219-242.
    • (2006) Eur. Respir. J. , vol.28 , pp. 219-242
    • Rahman, I.1    Adcock, I.M.2
  • 4
    • 31044455445 scopus 로고    scopus 로고
    • Redox modifications of proteinthiols: Emerging roles in cell signaling
    • Biswas, S., A. S. Chida, and I. Rahman. 2006. Redox modifications of proteinthiols: emerging roles in cell signaling. Biochem. Pharmacol. 71: 551-564.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 551-564
    • Biswas, S.1    Chida, A.S.2    Rahman, I.3
  • 7
    • 34547128886 scopus 로고    scopus 로고
    • Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB
    • Qanungo, S., D. W. Starke, H. V. Pai, J. J. Mieyal, and A. L. Nieminen. 2007. Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB. J. Biol. Chem. 282: 18427-18436.
    • (2007) J. Biol. Chem. , vol.282 , pp. 18427-18436
    • Qanungo, S.1    Starke, D.W.2    Pai, H.V.3    Mieyal, J.J.4    Nieminen, A.L.5
  • 8
    • 0026707969 scopus 로고
    • Diseases associated with HTLV-I: Virus, IL-2 receptor dysregulation and redox regulation
    • Yodoi, J., and T. Uchiyama. 1992. Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation. Immunol. Today 13: 405-411.
    • (1992) Immunol. Today , vol.13 , pp. 405-411
    • Yodoi, J.1    Uchiyama, T.2
  • 11
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • DOI 10.1016/j.cell.2004.07.002, PII S0092867404006610
    • Rakoff-Nahoum, S., J. Paglino, F. Eslami-Varzaneh, S. Edberg, and R. Medzhitov. 2004. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118: 229-241. (Pubitemid 38962578)
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 12
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 13
    • 0032539920 scopus 로고    scopus 로고
    • Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
    • Peterson, J. D., L. A. Herzenberg, K. Vasquez, and C. Waltenbaugh. 1998. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc. Natl. Acad. Sci. USA 95: 3071-3076.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3071-3076
    • Peterson, J.D.1    Herzenberg, L.A.2    Vasquez, K.3    Waltenbaugh, C.4
  • 14
    • 0036772856 scopus 로고    scopus 로고
    • IFN-γ and proinflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension
    • Murata, Y., T. Ohteki, S. Koyasu, and J. Hamuro. 2002. IFN-γ and proinflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension. Eur. J. Immunol. 32: 2866-2873.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2866-2873
    • Murata, Y.1    Ohteki, T.2    Koyasu, S.3    Hamuro, J.4
  • 15
    • 0028043326 scopus 로고
    • Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • Trinchieri, G. 1994. Interleukin 12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84: 4008-4027. (Pubitemid 24371902)
    • (1994) Blood , vol.84 , Issue.12 , pp. 4008-4027
    • Trinchieri, G.1
  • 17
    • 0031758510 scopus 로고    scopus 로고
    • Th2 biased immune response in cases with active Mycobacterium tuberculosis infection and tuberculin anergy
    • Balikó, Z., L. Szereday, and J. Szekeres-Bartho. 1998. Th2 biased immune response in cases with active Mycobacterium tuberculosis infection and tuberculin anergy. FEMS Immunol. Med. Microbiol. 22: 199-204.
    • (1998) FEMS Immunol. Med. Microbiol. , vol.22 , pp. 199-204
    • Balikó, Z.1    Szereday, L.2    Szekeres-Bartho, J.3
  • 19
    • 0027156811 scopus 로고
    • TNF-α response of human monocyte-derived macrophages to Mycobacterium avium, serovar 4, is of brief duration and protein kinase C dependent
    • Gan, H., G. Newman, P. L. McCarthy, and H. G. Remold. 1993. TNF-α response of human monocyte-derived macrophages to Mycobacterium avium, serovar 4, is of brief duration and protein kinase C dependent. J. Immunol. 150: 2892-2900.
    • (1993) J. Immunol. , vol.150 , pp. 2892-2900
    • Gan, H.1    Newman, G.2    McCarthy, P.L.3    Remold, H.G.4
  • 20
    • 14644443546 scopus 로고    scopus 로고
    • Interleukin-10 (IL-10) mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor
    • Rahim, S. S., N. Khan, C. S. Boddupalli, S. E. Hasnain, and S. Mukhopadhyay. 2005. Interleukin-10 (IL-10) mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor. Immunology 114: 313-321.
    • (2005) Immunology , vol.114 , pp. 313-321
    • Rahim, S.S.1    Khan, N.2    Boddupalli, C.S.3    Hasnain, S.E.4    Mukhopadhyay, S.5
  • 21
    • 32644453624 scopus 로고    scopus 로고
    • Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein
    • DOI 10.1182/blood-2005-04-1707
    • Khan, N., S. S. Rahim, C. S. Boddupalli, S. Ghousunnissa, S. Padma, N. Pathak, D. Thiagarajan, S. E. Hasnain, and S. Mukhopadhyay. 2006. Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein. Blood 107: 1513-1520. (Pubitemid 43242389)
    • (2006) Blood , vol.107 , Issue.4 , pp. 1513-1520
    • Khan, N.1    Rahim, S.S.2    Boddupalli, C.S.3    Ghousunnissa, S.4    Padma, S.5    Pathak, N.6    Thiagarajan, D.7    Hasnain, S.E.8    Mukhopadhyay, S.9
  • 22
    • 0036260609 scopus 로고    scopus 로고
    • Clinical significance of serum calcineurin in acute leukemia
    • Padma, S., and C. Subramanyam. 2002. Clinical significance of serum calcineurin in acute leukemia. Clin. Chim. Acta 321: 17-21.
    • (2002) Clin. Chim. Acta , vol.321 , pp. 17-21
    • Padma, S.1    Subramanyam, C.2
  • 24
    • 0033567049 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction
    • Mukhopadhyay, S., A. George, V. Bal, B. Ravindran, and S. Rath. 1999. Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction. J. Immunol. 163: 1786-1792. (Pubitemid 29382176)
    • (1999) Journal of Immunology , vol.163 , Issue.4 , pp. 1786-1792
    • Mukhopadhyay, S.1    George, A.2    Bal, V.3    Ravindran, B.4    Rath, S.5
  • 25
    • 2942589191 scopus 로고    scopus 로고
    • Poorer NF-κ B signaling by microfilariae in macrophages from BALB/c mice affects their ability to produce cytotoxic levels of nitric oxide to kill microfilariae
    • Mukhopadhyay, S., V. M. Srivastava, P. K. Murthy, and S. E. Hasnain. 2004. Poorer NF-κ B signaling by microfilariae in macrophages from BALB/c mice affects their ability to produce cytotoxic levels of nitric oxide to kill microfilariae. FEBS Lett. 567: 275-280.
    • (2004) FEBS Lett. , vol.567 , pp. 275-280
    • Mukhopadhyay, S.1    Srivastava, V.M.2    Murthy, P.K.3    Hasnain, S.E.4
  • 26
    • 34548851693 scopus 로고    scopus 로고
    • Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method
    • Rahman, I., A. Kode, and S. K. Biswas. 2006. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat. Protoc. 1: 3159-3165.
    • (2006) Nat. Protoc. , vol.1 , pp. 3159-3165
    • Rahman, I.1    Kode, A.2    Biswas, S.K.3
  • 27
    • 4644269598 scopus 로고    scopus 로고
    • Regions of high antigenicity within the hypothetical PPE major polymorphic tandem repeat open-reading frame, Rv2608, show a differential humoral response and a low T cell response in various categories of patients with tuberculosis
    • Chakhaiyar, P., Y. Nagalakshmi, B. Aruna, K. J. Murthy, V. M. Katoch, and S. E. Hasnain. 2004. Regions of high antigenicity within the hypothetical PPE major polymorphic tandem repeat open-reading frame, Rv2608, show a differential humoral response and a low T cell response in various categories of patients with tuberculosis. J. Infect. Dis. 190: 1237-1244.
    • (2004) J. Infect. Dis. , vol.190 , pp. 1237-1244
    • Chakhaiyar, P.1    Nagalakshmi, Y.2    Aruna, B.3    Murthy, K.J.4    Katoch, V.M.5    Hasnain, S.E.6
  • 28
    • 0024432603 scopus 로고
    • Regulation of cellular glutathione
    • Deneke, S. M., and B. L. Fanburg. 1989. Regulation of cellular glutathione. Am. J. Physiol. 257: L163-L173.
    • (1989) Am. J. Physiol. , vol.257
    • Deneke, S.M.1    Fanburg, B.L.2
  • 30
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3: 133-146.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 31
    • 0025852479 scopus 로고
    • Modulation of transcription factor NF-κ B binding activity by oxidation-reduction in vitro
    • Toledano, M. B., and W. J. Leonard. 1991. Modulation of transcription factor NF-κ B binding activity by oxidation-reduction in vitro. Proc. Natl. Acad. Sci. USA 88: 4328-4332.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4328-4332
    • Toledano, M.B.1    Leonard, W.J.2
  • 33
    • 0031897632 scopus 로고    scopus 로고
    • NF-κ B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κ B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225-260.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 34
    • 0034256090 scopus 로고    scopus 로고
    • Calmodulin: A prototypical calcium sensor
    • Chin, D., and A. R. Means. 2000. Calmodulin: a prototypical calcium sensor. Trends Cell Biol. 10: 322-328.
    • (2000) Trends Cell Biol. , vol.10 , pp. 322-328
    • Chin, D.1    Means, A.R.2
  • 36
    • 0027319121 scopus 로고
    • Calmodulin inhibitor trifluoperazine in combination with doxorubicin induces the selection of tumour cells with the multidrug resistant phenotype
    • Kamath, N., D. Grabowski, J. Ford, and R. Ganapathi. 1993. Calmodulin inhibitor trifluoperazine in combination with doxorubicin induces the selection of tumour cells with the multidrug resistant phenotype. Br. J. Cancer 67: 1203-1208. (Pubitemid 23172853)
    • (1993) British Journal of Cancer , vol.67 , Issue.6 , pp. 1203-1208
    • Kamath, N.1    Grabowski, D.2    Ford, J.3    Ganapathi, R.4
  • 38
    • 0031126702 scopus 로고    scopus 로고
    • Rel/NF-κ B and I κ B proteins: An overview
    • May, M. J., and S. Ghosh. 1997. Rel/NF-κ B and I κ B proteins: an overview. Semin. Cancer Biol. 8: 63-73.
    • (1997) Semin. Cancer Biol. , vol.8 , pp. 63-73
    • May, M.J.1    Ghosh, S.2
  • 39
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • Karin, M., and Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18: 621-663.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 40
    • 33750448661 scopus 로고    scopus 로고
    • Transcriptional regulation via the NF-κB signaling module
    • DOI 10.1038/sj.onc.1209933, PII 1209933
    • Hoffmann, A., G. Natoli, and G. Ghosh. 2006. Transcriptional regulation via the NF-κB signaling module. Oncogene 25: 6706-6716. (Pubitemid 44657847)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6706-6716
    • Hoffmann, A.1    Natoli, G.2    Ghosh, G.3
  • 42
    • 0347955360 scopus 로고    scopus 로고
    • Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA
    • Ryo, A., F. Suizu, Y. Yoshida, K. Perrem, Y. C. Liou, G. Wulf, R. Rottapel, S. Yamaoka, and K. P. Lu. 2003. Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol. Cell 12: 1413-1426.
    • (2003) Mol. Cell , vol.12 , pp. 1413-1426
    • Ryo, A.1    Suizu, F.2    Yoshida, Y.3    Perrem, K.4    Liou, Y.C.5    Wulf, G.6    Rottapel, R.7    Yamaoka, S.8    Lu, K.P.9
  • 43
    • 47649118596 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis heat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages
    • Khan, N., K. Alam, S. C. Mande, V. L. Valluri, S. E. Hasnain, and S. Mukhopadhyay. 2008. Mycobacterium tuberculosis heat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages. Cell. Microbiol. 10: 1711-1722.
    • (2008) Cell. Microbiol. , vol.10 , pp. 1711-1722
    • Khan, N.1    Alam, K.2    Mande, S.C.3    Valluri, V.L.4    Hasnain, S.E.5    Mukhopadhyay, S.6
  • 44
    • 17044395507 scopus 로고    scopus 로고
    • L-γ-Glutamyl-L-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- And anti-inflammatory cytokines: A signaling transcriptional scenario for redox(y) immunologic sensor(s)?
    • Haddad, J. J., and H. L. Harb. 2005. L-γ-Glutamyl-L-cysteinyl- glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)? Mol. Immunol. 42: 987-1014.
    • (2005) Mol. Immunol. , vol.42 , pp. 987-1014
    • Haddad, J.J.1    Harb, H.L.2
  • 45
    • 14044277556 scopus 로고    scopus 로고
    • Redox regulation of NF-κB activation: Distinct redox regulation between the cytoplasm and the nucleus
    • Kabe, Y., K. Ando, S. Hirao, M. Yoshida, and H. Handa. 2005. Redox regulation of NF-κB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid. Redox Signal. 7: 395-403.
    • (2005) Antioxid. Redox Signal. , vol.7 , pp. 395-403
    • Kabe, Y.1    Ando, K.2    Hirao, S.3    Yoshida, M.4    Handa, H.5
  • 46
    • 0038784487 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: Role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production
    • Utsugi, M., K. Dobashi, T. Ishizuka, K. Endou, J. Hamuro, Y. Murata, T. Nakazawa, and M. Mori. 2003. c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production. J. Immunol. 171: 628-635.
    • (2003) J. Immunol. , vol.171 , pp. 628-635
    • Utsugi, M.1    Dobashi, K.2    Ishizuka, T.3    Endou, K.4    Hamuro, J.5    Murata, Y.6    Nakazawa, T.7    Mori, M.8
  • 47
    • 33846543956 scopus 로고    scopus 로고
    • High concentration of antioxidants N-acetylcysteine and mitoquinone-Q induces intercellular adhesion molecule 1 and oxidative stress by increasing intracellular glutathione
    • Mukherjee, T. K., A. K. Mishra, S. Mukhopadhyay, and J. R. Hoidal. 2007. High concentration of antioxidants N-acetylcysteine and mitoquinone-Q induces intercellular adhesion molecule 1 and oxidative stress by increasing intracellular glutathione. J. Immunol. 178: 1835-1844.
    • (2007) J. Immunol. , vol.178 , pp. 1835-1844
    • Mukherjee, T.K.1    Mishra, A.K.2    Mukhopadhyay, S.3    Hoidal, J.R.4
  • 48
    • 38949159129 scopus 로고    scopus 로고
    • Effect of chronic Nacetyl cysteine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum
    • Harvey, B. H., C. Joubert, J. L. du Preez, and M. Berk. 2008. Effect of chronic Nacetyl cysteine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum. Neurochem. Res. 33: 508-517.
    • (2008) Neurochem. Res. , vol.33 , pp. 508-517
    • Harvey, B.H.1    Joubert, C.2    Du Preez, J.L.3    Berk, M.4
  • 50
    • 0026472927 scopus 로고
    • Failure of N-acetylcysteine to reduce low-density lipoprotein oxidizability in healthy subjects
    • Kleinveld, H. A., P. N. Demacker, and A. F. Stalenhoef. 1992. Failure of N-acetylcysteine to reduce low-density lipoprotein oxidizability in healthy subjects. Eur. J. Clin. Pharmacol. 43: 639-642.
    • (1992) Eur. J. Clin. Pharmacol. , vol.43 , pp. 639-642
    • Kleinveld, H.A.1    Demacker, P.N.2    Stalenhoef, A.F.3
  • 51
    • 42649123028 scopus 로고    scopus 로고
    • Prooxidant and cytotoxic action of N-acetylcysteine and glutathione in combinations with vitamin B12b
    • Solov'eva, M. E., V. V. Solov'ev, A. A. Faskhutdinova, A. A. Kudryavtsev, and V. S. Akatov. 2007. Prooxidant and cytotoxic action of N-acetylcysteine and glutathione in combinations with vitamin B12b. Dokl. Biol. Sci. 1: 40-49.
    • (2007) Dokl. Biol. Sci. , vol.1 , pp. 40-49
    • Solov'eva, M.E.1    Solov'ev, V.V.2    Faskhutdinova, A.A.3    Kudryavtsev, A.A.4    Akatov, V.S.5
  • 52
  • 53
    • 27944481354 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine on lipopolysaccharide-induced intra-uterine fetal death and intra-uterine growth retardation in mice
    • Xu, D. X., Y. H. Chen, H. Wang, L. Zhao, J. P. Wang, and W. Wei. 2005. Effect of N-acetylcysteine on lipopolysaccharide-induced intra-uterine fetal death and intra-uterine growth retardation in mice. Toxicol. Sci. 88: 525-533.
    • (2005) Toxicol. Sci. , vol.88 , pp. 525-533
    • Xu, D.X.1    Chen, Y.H.2    Wang, H.3    Zhao, L.4    Wang, J.P.5    Wei, W.6
  • 54
    • 0347758406 scopus 로고    scopus 로고
    • Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide- stimulated RAW 264.7 cells
    • Song, M., J. A. Kellum, H. Kaldas, and M. P. Fink. 2004. Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells. J. Pharmacol. Exp. Ther. 308: 307-316.
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 307-316
    • Song, M.1    Kellum, J.A.2    Kaldas, H.3    Fink, M.P.4
  • 55
    • 0033561579 scopus 로고    scopus 로고
    • Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages
    • Wadsworth, T. L., and D. R. Koop. 1999. Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. Biochem. Pharmacol. 57: 941-949.
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 941-949
    • Wadsworth, T.L.1    Koop, D.R.2
  • 56
    • 33644819208 scopus 로고    scopus 로고
    • N-Acetyl- L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-κB activation in alveolar macrophages by different mechanisms
    • Li, Y. Q., Z. X. Zhang, Y. J. Xu, W. Ni, S. X. Chen, Z. Yang, and D. Ma. 2006. N-Acetyl- L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-κB activation in alveolar macrophages by different mechanisms. Acta Pharmacol. Sin. 27: 339-346.
    • (2006) Acta Pharmacol. Sin. , vol.27 , pp. 339-346
    • Li, Y.Q.1    Zhang, Z.X.2    Xu, Y.J.3    Ni, W.4    Chen, S.X.5    Yang, Z.6    Ma, D.7
  • 58
    • 0033557730 scopus 로고    scopus 로고
    • IFN-α 2B enhances Th1 cytokine responses in bladder cancer patients receiving Mycobacterium bovis bacillus Calmette-Guérin immunotherapy
    • Luo, Y., X. Chen, T. M. Downs, W. C. DeWolf, and M. A. O'Donnell. 1999. IFN-α 2B enhances Th1 cytokine responses in bladder cancer patients receiving Mycobacterium bovis bacillus Calmette-Guérin immunotherapy. J. Immunol. 162: 2399-2405.
    • (1999) J. Immunol. , vol.162 , pp. 2399-2405
    • Luo, Y.1    Chen, X.2    Downs, T.M.3    DeWolf, W.C.4    O'Donnell, M.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.