Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 210-222

  Shi, Zhi Hao ^a,b   Li, Nian Guang ^a   Tang, Yu Ping ^a   Wei Li, ^a   Lian Yin, ^a   Yang, Jian Ping ^a   Hao Tang, ^a   Duan, Jin Ao ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Metabolism; Quercetin; Structure activity relationship; Thrombin

Indexed keywords

2 (3,4 DIMETHOXYPHENYL) 3,5 DIHYDROXY 7 METHOXY 4H CHROMEN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 3,5,7 TRIMETHOXY 4H CHROMEN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 3,7 DIHYDROXY 5 METHOXY 4H CHROMEN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 5 HYDROXY 3,7 DIMETHOXY 4H CHROMEN 4 ONE; 3',4' O DIMETHYLQUERCETIN; 3',5 O DIMETHYLQUERCETIN; 3,5 DIHYDROXY 2 (3 HYDROXY 4 METHOXYPHENYL) 7 METHOXY 4H CHROMEN 4 ONE; 3,5 O DIMETHYLQUERCETIN; 3,7 O DIMETHYLQUERCETIN; 4' O METHYLQUERCETIN; 5 HYDROXY 2 (3 HYDROXY 4 METHOXYPHENYL) 3,7 DIMETHOXY 4H CHROMEN 4 ONE; 5 O METHYLQUERCETIN; 5,7 O DIMETHYLQUERCETIN; 7 O METHYLQUERCETIN; FIBRINOGEN; HYDROXYL GROUP; ISORHAMNETIN; METHYLQUERCETIN DERIVATIVE; QUERCETIN; QUERCETIN 3 METHYL ETHER; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; CARDIOVASCULAR DISEASE; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; MALE; MOLECULAR DOCKING; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; STRUCTURE ACTIVITY RELATION; THROMBIN TIME; THROMBOSIS;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION TESTS; CHEMISTRY TECHNIQUES, SYNTHETIC; FIBRINOGEN; MALE; METHYLATION; MOLECULAR DOCKING SIMULATION; OXYGEN; PROTEIN CONFORMATION; QUERCETIN; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 84864396922     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.044     Document Type: Article

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