Blocking of PI3K/AKT induces apoptosis by its effect on NF-κB activity in gastric carcinoma cell line SGC7901

Biomedicine and Pharmacotherapy

Volumn 64, Issue 9, 2010, Pages 600-604

  Chao, Xu ^a   Zao, Jiang ^a   Xiao Yi, Gu ^a   Li Jun, Meng ^a   Tao, Shi ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

Apoptosis; Gastric carcinoma cell line; IKK I B; NF B; PI3K Akt

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STOMACH CARCINOMA;

APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMONES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; MORPHOLINES; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 78049283700     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2010.08.008     Document Type: Article

References (27)

1. Song G., Ouyang G.L., Bao S.D. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005, 9:59-71.
2. Xu G., Zhang W.H., Betram P., Zheng X.F., McLeod H. Pharmacogenomic profiling of the PI3K/PTEN - Akt-mTOR pathway in common human tumors. Int J Oncol 2004, 24:893-900.
3. Datta S.R., Brunet A., Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev 1999, 13:2905-2927.
4. Paweletz C.P., Charboneau L., Bichsel V.E., Simone N.L., Chen T., Gillespie J.W., et al. Reverse phase protein microarrays which capture disease progression show activation of pro2 survival pathways at the cancer invasion front. Oncogene 2001, 20:1981-1989.
5. Siebenlist U., Franzoso G., Brown K. Structure, regulation and function of NF-κB. Annu Rev Cell Biol 1994, 10:405-455.
6. Chandler N.M., Canete J.J., Callery M.P. Increased expression of NF-κB subunits in human pancreatic cancer cells. J Surg Res 2004, 118:9-14.
7. Davis R.E., Brown K.D., Siebenlist U., Staudt L.M. Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 2001, 194:1861-1874.
8. Åberg M., Wickström M., Siegbahn A. Simvastatin induces apoptosis in human breast cancer cells in a NFκB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa. Thromb Res 2008, 122:191-202.
9. Yoon J.M., Lim J.J., Yoo C.G., Lee C.T., Bang Y.J., Han S.K., et al. Adenovirus -uteroglobin suppresses COX-2 expression via inhibition of NF-κB activity in lung cancer cells. Lung Cancer 2005, 48:201-209. [http://www.ncbi.nlm.nih.gov/pubmed?term=%22Shim%20YS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract].
10. Baldwin A.S. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest 2001, 107:241-246.
11. Madrid L.V., Wang C.Y., Guttridge D.C., Schottelius A.J., Baldwin A.S., Mayo M.W. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 2000, 20:1626-1638.
12. Madrid L.V., Mayo M.W., Reuther J.Y., Baldwin A.S. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 2001, 276:18934-18940.
13. Ling L., Cao Z., Goeddel D.V. NF-κB-inducing kinase activates IKKa{cyrillic} by phosphorylation of Ser-176. Proc Natl Acad Sci U S A 1998, 95:2791-2797.
14. Delhase M., Hayakawa M., Chen Y., Karin M. Positive and negative regulation of IκB kinase activity through IKKa{cyrillic} subunit phosphorylation. Science 1999, 284:309-313.
15. Kabe Y., Ando K., Hirao S., Yoshida M., Handa H. Redox regulation of NF-κB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid Redox Signal 2005, 7:395-403.
16. Karin M., Lin A. NF-κB at the crossroads of life and death. Nat Immunol 2002, 3:221-227.
17. Liang J., Slingerland J.M. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003, 2:339-345.
18. Levine D.A., Bogomolniy F., Yee C.J., Lash A., Barakat R.R., Borgen P.I., et al. Frequent mutation of PIK3CA gene in ovairan and breast cancer. Clin Cancer Res 2005, 11:2875-2878.
19. Or Y.Y., Hui A.B.Y., Tam K.Y., Huang D.P., Lo K.W. Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines. Int J Oncol 2005, 26:49-56.
20. Nyakern M., Tazzari P.L., Finelli C., Bosi C., Follo M.Y., Grafone T., et al. Frequent elevation of AKT kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients. Leukemia 2006, 20:230-238.
21. Hartmann W., Digon-sontgerath B., Koch A., Waha A., Endl E., Dani I., et al. Phosphatidylinositol 3-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN. Clin Cancer Res 2006, 12:3019-3027.
22. Thisse C., Perrinschmitt F., Stoetzel C., Thisse B. Sequence specific transactivation of the Drosophila twist gene by the dorsal gene product. Cell 1991, 65:1191-1201.
23. Tergaonkar V., Pando M., Vafa O., Wahl G., Verma I. p53 Stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell 2002, 1:493-503.
24. Shant J., Cheng K., Marasa B.S., Wang J.Y., Raufman J.P. Akt-dependent NF-κB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. Exp Cell Res 2009, 315:432-450.
25. Garcia M.G., Alaniz L.D., Russo R.I.C., Alvarez E., Hajos S.E. PI3K/Akt inhibition modulates multidrug resistance and activates NF-κB in murine lymphoma cell lines. Leukemia Res 2009, 33:288-296.
26. Yin D.L., Woodruff M., Zhang Y., Whaley S., Miao J.Y., Ferslew K., et al. Morphine promotes Jurkat cell apoptosis through pro-apoptotic FADD/P53 and anti-apoptotic PI3K/Akt/NF-κB pathways. J Neuroimmunol 2006, 174:101-107.
27. Tse A.K.W., Wan C.K., Shen X.L., Zhu G.Y., Cheung H.Y., Yang M.S., et al. 1, 25-Dihydroxyvitamin D3 induces biphasic NF-κB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IκB. Exp Cell Res 2007, 313:1722-1734.