Metal-induced apoptosis: Mechanisms

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 533, Issue 1-2, 2003, Pages 227-241

  Pulido, Marisa D ^a   Parrish, Alan R ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Apoptosis; Arsenic; Beryllium; Cadmium; Chromium; Nickel

Indexed keywords

ANTIMONY; ANTINEOPLASTIC AGENT; ARSENIC; BERYLLIUM; CADMIUM; CARCINOGEN; CHROMIUM; COBALT; LEAD; METAL; NICKEL;

APOPTOSIS; HUMAN; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0344845135     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2003.07.015     Document Type: Review

References (137)

1. Savill J. Apoptosis in resolution of inflammation. Kidney Blood Press. Res. 23:2000;173-174.
2. Ferri K.F., Kroemer G. Organelle-specific initiation of cell death pathways. Nat. Cell. Biol. 3:2001;E255-E263.
3. Chen F., Vallyathan V., Castranova V., Shi X. Cell apoptosis induced by carcinogenic metals. Mol. Cell. Biochem. 222:2001;183-188.
4. Nicholson D.W., Thornberry N.A. Caspases: killer proteases. Trends Biochem. Sci. 22:1997;299-306.
5. Cryns V., Yuan J. Proteases to die for. Genes Dev. 12:1998;1551-1570.
6. Muzio M., Stockwell B.R., Stennicke H.R., Salvesen G.S., Dixit V.M. An induced proximity model for caspase-8 activation. J. Biol. Chem. 273:1998;2926-2930.
7. Srinivasan A., Li F., Wong A., Kodandapani L., Smidt R. Jr., Krebs J.F., Fritz L.C., Wu J.C., Tomaselli K.J. Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J. Biol. Chem. 273:1998;4523-4529.
8. Earnshaw W.C., Martins L.M., Kaufmann S.H. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68:1999;383-424.
9. Cardone M.H., Salvesen G.S., Widmann C., Johnson G., Frisch S.M. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell. 90:1997;315-323.
10. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
11. Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J.L., Schroter M., Burns K., Mattmann C., Rimoldi D., French L.E., Tschopp J. Inhibition of death receptor signals by cellular FLIP. Nature. 388:1997;190-195.
12. Matsuzawa A., Ichijo H. Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1. J. Biochem. 130:2001;1-8.
13. Yoshino T., Kishi H., Nagata T., Tsukada K., Saito S., Muraguchi A. Differential involvement of p38 MAP kinase pathway and Bax translocation in the mitochondria-mediated cell death in TCR- and dexamethasone-stimulated thymocytes. Eur. J. Immunol. 31:2001;2702-2708.
14. Nebreda A.R., Gavin A.C. Perspectives: signal transduction. Cell survival demands some risk. Science. 286:1999;1309-1310.
15. Petit P.X., Susin S.A., Zamzami N., Mignotte B., Kroemer G. Mitochondria and programmed cell death: back to the future. FEBS Lett. 396:1996;7-13.
16. Li L.Y., Luo X., Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature. 412:2001;95-99.
17. van Loo G., Schotte P., van Gurp M., Demol H., Hoorelbeke B., Gevaert K., Rodriguez I., Ruiz-Carrillo A., Vandekerckhove J., Declercq W., Beyaert R., Vandenabeele P. Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ. 8:2001;1136-1142.
18. Tsujimoto Y., Shimizu S. Bcl-2 family: life-or-death switch. FEBS Lett. 466:2001;6-10.
19. 2+ ions. J. Cell Biol. 143:1998;217-224.
20. Gross A., McDonnell J.M., Korsmeyer S.J. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13:1999;1899-1911.
21. Krammer P.H. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv. Immunol. 71:1999;163-210.
22. Heimbrook D.C., Oliff A. Therapeutic intervention and signaling. Curr. Opin. Cell Biol. 10:1998;284-288.
23. Schuler M., Green D.R. Mechanisms of p53-dependent apoptosis. Biochem. Soc. Trans. 29:2001;684-688.
24. Newton K., Strasser A. Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy. J. Exp. Med. 191:2000;195-200.
25. Shen Y., White E. p53-dependent apoptosis pathways. Adv. Cancer Res. 82:2001;55-84.
26. Polyak K., Xia Y., Zweier J.L., Kinzler K.W., Vogelstein B. A model for p53-induced apoptosis. Nature. 389:1997;300-305.
27. Ochi T., Nakajima F., Sakurai T., Kaise T., Oya-Ohta Y. Dimethylarsinic acid causes apoptosis in HL-60 cells via interaction with glutathione. Arch. Toxicol. 70:1996;815-821.
28. Chen Y.C., Lin-Shiau S.Y., Lin J.K. Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J. Cell. Physiol. 177:1998;324-333.
29. Akao Y., Nakagawa Y., Akiyama K. Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro. FEBS Lett. 455:1999;59-62.
30. Dai J., Weinberg R.S., Waxman S., Jing Y. Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. Blood. 93:1999;268-277.
31. Kito M., Akao Y., Ohishi N., Yagi K., Nozawa Y. Arsenic trioxide-induced apoptosis and its enhancement by buthionine sulfoximine in hepatocellular carcinoma cell lines. Biochem. Biophys. Res. Commun. 291:2002;861-867.
32. Nakagawa Y., Akao Y., Morikawa H., Hirata I., Katsu K., Naoe T., Ohishi N., Yagi K. Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. Life Sci. 70:2002;2253-2269.
33. 2+-dependent production of superoxide. Int. J. Cancer. 92:2001;518-526.
34. Chattopadhyay S., Bhaumik S., Purkayastha M., Basu S., Nag Chaudhuri A., Das Gupta S. Apoptosis and necrosis in developing brain cells due to arsenic toxicity and protection with antioxidants. Toxicol. Lett. 136:2002;65-76.
35. Zhu X.H., Shen Y.L., Jing Y.K.et al. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. J. Natl. Cancer Inst. 91:1999;772-778.
36. Larochette N., Decaudin D., Jacotot E., Brenner C., Marzo I., Susin S.A., Zamzami N., Xie Z., Reed J., Kroemer G. Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore. Exp. Cell Res. 249:1999;413-421.
37. Costantini P., Chernyak B.V., Petronilli V., Bernardi P. Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites. J. Biol. Chem. 271:1996;6746-6751.
38. Q. Liu, S. Hilsenbeck, Y. Gazitt, Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase 8 or caspase 9 and synergy with APO2/TRAIL, Blood 101 4078-4087.
39. Hyun Park W., Hee Cho Y., Won Jung C., Oh Park J., Kim K., Hyuck Im Y., Lee M.H., Ki Kang W., Park K. Arsenic trioxide inhibits the growth of A498 renal cell carcinoma cells via cell cycle arrest or apoptosis. Biochem. Biophys. Res. Commun. 300:2003;230-235.
40. Li J., Chen P., Sinogeeva N., Gorospe M., Wersto R.P., Chrest F.J., Barnes J., Liu Y. Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. J. Biol. Chem. 277:2002;49504-49510.
41. Huang X.J., Wiernik P.H., Klein R.S., Gallagher R.E. Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases. Med. Oncol. 16:1999;58-64.
42. Salazar A.M., Ostrosky-Wegman P., Menendez D., Miranda E., Garcia-Carranca A., Rojas E. Induction of p53 protein expression by sodium arsenite. Mutat. Res. 381:1997;259-265.
43. Waalkes M.P., Fox D.A., States J.C., Patierno S.R., McCabe M.J. Jr. Metals and disorders of cell accumulation: modulation of apoptosis and cell proliferation. Toxicol. Sci. 56:2000;255-261.
44. Jiang X.H., Wong B.C., Yuen S.T., Jiang S.H., Cho C.H., Lai K.C., Lin M.C., Kung H.F., Lam S.K., Chun-Yu Wong B. Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of p53 and activation of caspase-3. Int. J. Cancer. 91:2001;173-179.
45. Huang C., Ma W.Y., Li J., Dong Z. Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway. Cancer Res. 59:1999;3053-3058.
46. Ludwig S., Hoffmeyer A., Goebeler M., Kilian K., Hafner H., Neufeld B., Han J., Rapp U.R. The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. J. Biol. Chem. 273:1998;1917-1922.
47. Cavigelli M., Li W.W., Lin A., Su B., Yoshioka K., Karin M. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J. 15:1996;6269-6279.
48. Chen N.Y., Ma W.Y., Huang C., Ding M., Dong Z. Activation of PKC is required for arsenite-induced signal transduction. J. Environ. Pathol. Toxicol. Oncol. 19:2000;297-305.
49. Huang C., Bode A.M., Chen N.Y., Ma W.Y., Li J., Nomura M., Dong Z. Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate. Anticancer Res. 21:2001;261-267.
50. Huang C., Ma W.Y., Li J., Goranson A., Dong Z. Requirement of Erk, but not JNK, for arsenite-induced cell transformation. J. Biol. Chem. 274:1999;14595-14601.
51. Meriin A.B., Yaglom J.A., Gabai V.L., Zon L., Ganiatsas S., Mosser D.D., Zon L., Sherman M.Y. Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol. Cell. Biol. 19:1999;2547-2555.
52. Dong Z. The molecular mechanisms of arsenic-induced cell transformation and apoptosis. Environ. Health Perspect. 110:2002;757-759.
53. Namgung U., Xia Z. Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicol. Appl. Pharmacol. 174:2001;130-138.
54. el Azzouzi B., Tsangaris G.T., Pellegrini O., Manuel Y., Benveniste J., Thomas Y. Cadmium induces apoptosis in a human T cell line. Toxicology. 88:1994;127-139.
55. Dong S., Shen H.M., Ong C.N. Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes. Mol. Cell. Biochem. 222:2001;11-20.
56. de la Fuente H., Portales-Perez D., Baranda L., Diaz-Barriga F., Saavedra-Alanis V., Layseca E., Gonzalez-Amaro R. Effect of arsenic, cadmium and lead on the induction of apoptosis of normal human mononuclear cells. Clin. Exp. Immunol. 129:2002;69-77.
57. Gennari A., Cortese E., Boveri M., Casado J., Prieto P. Sensitive endpoints for evaluating cadmium-induced acute toxicity in LLC-PK1 cells. Toxicology. 183:2003;211-220.
58. Choi M.K., Kim B.H., Chung Y.Y., Han M.S. Cadmium-induced apoptosis in h9c2, a7r5, and c6-glial cell. Bull. Environ. Contam. Toxicol. 69:2002;335-341.
59. Habeebu S.S., Liu J., Klaassen C.D. Cadmium-induced apoptosis in mouse liver. Toxicol. Appl. Pharmacol. 149:1998;203-209.
60. Watjen W., Cox M., Biagioli M., Beyersmann D. Cadmium-induced apoptosis in C6 glioma cells: mediation by caspase 9-activation. Biometals. 15:2002;15-25.
61. Shimoda R., Nagamine T., Takagi H., Mori M., Waalkes M.P. Induction of apoptosis in cells by cadmium: quantitative negative correlation between basal or induced metallothionein concentration and apoptotic rate. Toxicol. Sci. 64:2001;208-215.
62. McAleer M.F., Tuan R.S. Metallothionein protects against severe oxidative stress-induced apoptosis of human trophoblastic cells. In Vitro Mol. Toxicol. 14:2001;219-231.
63. Beyersmann D., Hechtenberg S. Cadmium, gene regulation, and cellular signalling in mammalian cells. Toxicol. Appl. Pharmacol. 144:1997;247-261.
64. Iryo Y., Matsuoka M., Wispriyono B., Sugiura T., Igisu H. Involvement of the extracellular signal-regulated protein kinase (ERK) pathway in the induction of apoptosis by cadmium chloride in CCRF-CEM cells. Biochem. Pharmacol. 60:2000;1875-1882.
65. Chuang S.M., Wang I.C., Yang J.L. Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis. 21:2000;1423-1432.
66. Galan A., Garcia-Bermejo M.L., Troyano A., Vilaboa N.E., de Blas E., Kazanietz M.G., Aller P. Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells. J. Biol. Chem. 275:2000;11418-11424.
67. Biagioli M., Watjen W., Beyersmann D., Zoncu R., Cappellini C., Ragghianti M., Cremisi F., Bucci S. Cadmium-induced apoptosis in murine fibroblasts is suppressed by Bcl-2. Arch. Toxicol. 75:2001;313-320.
68. Kim M.S., Kim B.J., Woo H.N., Kim K.W., Kim K.B., Kim I.K., Jung Y.K. Cadmium induces caspase-mediated cell death: suppression by Bcl-2. Toxicology. 145:2000;27-37.
69. 2+ effects on isolated rat liver mitochondria. J. Bioenerg. Biomembr. 33:2001;303-318.
70. Zazueta C., Sanchez C., Garcia N., Correa F. Possible involvement of the adenine nucleotide translocase in the activation of the permeability transition pore induced by cadmium. Int. J. Biochem. Cell Biol. 32:2000;1093-1101.
71. Pourahmad J., Mihajlovic A., O'Brien P.J. Hepatocyte lysis induced by environmental metal toxins may involve apoptotic death signals initiated by mitochondrial injury. Adv. Exp. Med. Biol. 500:2001;249-252.
72. 2+-calpain and caspase-mitochondria-dependent pathways. J. Biol. Chem. 275:2000;39702-39709.
73. Szuster-Ciesielska A., Stachura A., Slotwinska M., Kaminska T., Sniezko R., Paduch R., Abramczyk D., Filar J., Kandefer-Szerszen M. The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology. 145:2000;159-171.
74. Thevenod F., Friedmann J.M., Katsen A.D., Hauser I.A. Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. J. Biol. Chem. 275:2000;1887-1896.
75. Hart B.A., Lee C.H., Shukla G.S., Shukla A., Osier M., Eneman J.D., Chiu J.F. Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress. Toxicology. 133:1999;43-58.
76. Stohs S.J., Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 18:1995;321-336.
77. Hassoun E.A., Stohs S.J. Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A.1 cell cultures. Toxicology. 112:1996;219-226.
78. Koizumi T., Shirakura H., Kumagai H., Tatsumoto H., Suzuki K.T. Mechanism of cadmium-induced cytotoxicity in rat hepatocytes: cadmium-induced active oxygen-related permeability changes of the plasma membrane. Toxicology. 114:1996;125-134.
79. Tsuzuki K., Sugiyama M., Haramaki N. DNA single-strand breaks and cytotoxicity induced by chromate(VI), cadmium(II), and mercury(II) in hydrogen peroxide-resistant cell lines. Environ. Health Perspect. 102:1994;341-342.
80. Lag M., Westly S., Lerstad T., Bjornsrud C., Refsnes M., Schwarze P.E. Cadmium-induced apoptosis of primary epithelial lung cells: involvement of Bax and p53, but not of oxidative stress. Cell Biol. Toxicol. 18:2002;29-42.
81. Blankenship L.J., Manning F.C., Orenstein J.M., Patierno S.R. Apoptosis is the mode of cell death caused by carcinogenic chromium. Toxicol. Appl. Pharmacol. 126:1994;75-83.
82. Singh J., Carlisle D.L., Pritchard D.E., Patierno S.R. Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis. Oncol. Rep. 5:1998;1307-1318.
83. Wang S., Leonard S.S., Ye J., Ding M., Shi X. The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. Am. J. Physiol. Cell Physiol. 279:2000;C868-C875.
84. Carlisle D.L., Pritchard D.E., Singh J., Patierno S.R. Chromium(VI) induces p53-dependent apoptosis in diploid human lung and mouse dermal fibroblasts. Mol. Carcinogen. 28:2000;111-118.
85. Shi X., Chiu A., Chen C.T., Halliwell B., Castranova V., Vallyathan V. Reduction of chromium(VI) and its relationship to carcinogenesis. J. Toxicol. Environ. Health B Crit. Rev. 2:1999;87-104.
86. Blankenship L.J., Carlisle D.L., Wise J.P., Orenstein J.M., Dye L.E. III, Patierno S.R. Induction of apoptotic cell death by particulate lead chromate: differential effects of Vitamins C and E on genotoxicity and survival. Toxicol. Appl. Pharmacol. 146:1997;270-280.
87. Ashcroft M., Kubbutat M.H., Vousden K.H. Regulation of p53 function and stability by phosphorylation. Mol. Cell. Biol. 19:1999;1751-1758.
88. Ye J., Wang S., Leonard S.S., Sun Y., Butterworth L., Antonini J., Ding M., Rojanasakul Y., Vallyathan V., Castranova V., Shi X. Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis. J. Biol. Chem. 274:1999;34974-34980.
89. Pritchard D.E., Singh J., Carlisle D.L., Patierno S.R. Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. Carcinogenesis. 21:2000;2027-2033.
90. Ryberg D., Alexander J. Mechanisms of chromium toxicity in mitochondria. Chem. Biol. Interact. 75:1990;141-151.
91. D'Agostini F., Izzotti A., Bennicelli C., Camoirano A., Tampa E., De Flora S. Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI). Carcinogenesis. 23:2002;587-593.
92. Chuang S.M., Yang J.L. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. Mol. Cell. Biochem. 222:2001;85-95.
93. Shiao Y.H., Lee S.H., Kasprzak K.S. Cell cycle arrest, apoptosis and p53 expression in nickel(II) acetate-treated Chinese hamster ovary cells. Carcinogenesis. 19:1998;1203-1207.
94. Kim K., Lee S.H., Seo Y.R., Perkins S.N., Kasprzak K.S. Nickel(II)-induced apoptosis in murine T cell hybridoma cells is associated with increased fas ligand expression. Toxicol. Appl. Pharmacol. 185:2002;41-47.
95. Dally H., Hartwig A. Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells. Carcinogenesis. 18:1997;1021-1026.
96. Athar M., Hasan S.K., Srivastava R.C. Evidence for the involvement of hydroxyl radicals in nickel mediated enhancement of lipid peroxidation: implications for nickel carcinogenesis. Biochem. Biophys. Res. Commun. 147:1987;1276-1281.
97. Goebeler M., Roth J., Brocker E.B., Sorg C., Schulze-Osthoff K. Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt. J. Immunol. 155:1995;2459-2467.
98. Chen F., Shi X. Intracellular signal transduction of cells in response to carcinogenic metals. Crit. Rev. Oncol. Hematol. 42:2002;105-121.
99. Sunderman F.W. Jr., Hopfer S.M., Lin S.M., Plowman M.C., Stojanovic T., Wong S.H., Zaharia O., Ziebka L. Toxicity to alveolar macrophages in rats following parenteral injection of nickel chloride. Toxicol. Appl. Pharmacol. 100:1989;107-118.
100. Li L., Jiao L., Lau B.H. Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes. Cancer Biother. 8:1993;263-272.
101. Salnikow K., Gao M., Voitkun V., Huang X., Costa M. Altered oxidative stress responses in nickel-resistant mammalian cells. Cancer Res. 54:1994;6407-6412.
102. Lynn S., Yew F.H., Chen K.S., Jan K.Y. Reactive oxygen species are involved in nickel inhibition of DNA repair. Environ. Mol. Mutagen. 29:1997;208-216.
103. Lee S.H., Kim D.K., Seo Y.R., Woo K.M., Kim C.S., Cho M.H. Nickel(II)-induced apoptosis and G2/M enrichment. Exp. Mol. Med. 30:1998;171-176.
104. Lee S.H., Choi J.G., Cho M.H. Apoptosis, bcl2 expression, and cell cycle analyses in nickel(II)-treated normal rat kidney cells. J. Korean Med. Sci. 16:2001;165-168.
105. Sawyer R.T., Fadok V.A., Kittle L.A., Maier L.A., Newman L.S. Beryllium-stimulated apoptosis in macrophage cell lines. Toxicology. 149:2000;129-142.
106. Joseph P., Muchnok T., Ong T. Gene expression profile in BALB/c-3T3 cells transformed with beryllium sulfate. Mol. Carcinogen. 32:2001;28-35.
107. Kittle L.A., Sawyer R.T., Fadok V.A., Maier L.A., Newman L.S. Beryllium induces apoptosis in human lung macrophages. Sarcoidosis Vasc. Diffuse Lung Dis. 19:2002;101-113.
108. Lavastre V., Roberge C.J., Pelletier M., Gauthier M., Girard D. Toxaphene, but not beryllium, induces human neutrophil chemotaxis and apoptosis via reactive oxygen species (ROS): involvement of caspases and ROS in the degradation of cytoskeletal proteins. Clin. Immunol. 104:2002;40-48.
109. Fox D.A., He L., Poblenz A.T., Medrano C.J., Blocker Y.S., Srivastava D. Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis. Toxicol. Lett. 102-103:1998;359-361.
110. Shabani A., Rabbani A. Lead nitrate induced apoptosis in alveolar macrophages from rat lung. Toxicology. 149:2000;109-114.
111. Columbano A., Ledda-Columbano G.M., Coni P.P., Faa G., Liguori C., Santa Cruz G., Pani P. Occurrence of cell death (apoptosis) during the involution of liver hyperplasia. Lab. Invest. 52:1985;670-675.
112. Cheng Y.J., Yang B.C., Hsieh W.C., Huang B.M., Liu M.Y. Enhancement of TNF-alpha expression does not trigger apoptosis upon exposure of glial cells to lead and lipopolysaccharide. Toxicology. 178:2002;183-191.
113. He L., Poblenz A.T., Medrano C.J., Fox D.A. Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. J. Biol. Chem. 275:2000;12175-12184.
114. He L., Perkins G.A., Poblenz A.T., Harris J.B., Hung M., Ellisman M.H., Fox D.A. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc. Natl. Acad. Sci. U.S.A. 100:2000;1022-1027.
115. Sharifi A.M., Baniasadi S., Jorjani M., Rahimi F., Bakhshayesh M. Investigation of acute lead poisoning on apoptosis in rat hippocampus in vivo. Neurosci. Lett. 329:2002;45-48.
116. Huang H., Shu S.C., Shih J.H., Kuo C.J., Chiu I.D. Antimony trichloride induces DNA damage and apoptosis in mammalian cells. Toxicology. 129:1998;113-123.
117. Tirmenstein M.A., Plews P.I., Walker C.V., Woolery M.D., Wey H.E., Toraason M.A. Antimony-induced oxidative stress and toxicity in cultured cardiac myocytes. Toxicol. Appl. Pharmacol. 130:1995;41-47.
118. Lecureur V., Lagadic-Gossmann D., Fardel O. Potassium antimonyl tartrate induces reactive oxygen species-related apoptosis in human myeloid leukemic HL60 cells. Int. J. Oncol. 20:2002;1071-1076.
119. Zou W., Yan M., Xu W., Huo H., Sun L., Zheng Z., Liu X. Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. J. Neurosci. Res. 64:2001;646-653.
120. Tomaro M.L., Frydman J., Frydman R.B. Heme oxygenase induction by CoCl2, Co-protoporphyrin IX, phenylhydrazine, and diamide: evidence for oxidative stress involvement. Arch. Biochem. Biophys. 286:1991;610-617.
121. Araya J., Maruyama M., Inoue A., Fujita T., Kawahara J., Sassa K., Hayashi R., Kawagishi Y., Yamashita N., Sugiyama E., Kobayashi M. Inhibition of proteasome activity is involved in cobalt-induced apoptosis of human alveolar macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 283:2002;L849-L858.
122. Zou W., Zeng J., Zhuo M., Xu W., Sun L., Wang J., Liu X. Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. J. Neurosci. Res. 67:2002;837-843.
123. Hamadeh H.K., Vargas M., Lee E., Menzel D.B. Arsenic disrupts cellular levels of p53 and mdm2: a potential mechanism of carcinogenesis. Biochem. Biophys. Res. Commun. 263:1999;446-449.
124. Bustamante J., Tovar-B A., Montero G., Boveris A. Early redox changes during rat thymocyte apoptosis. Arch. Biochem. Biophys. 337:1997;121-128.
125. Lu M., Levin J., Sulpice E., Sequeira-Le Grand A., Alemany M., Caen J.P., Han Z.C. Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines. Exp. Hematol. 27:1999;845-852.
126. Cai X., Shen Y.L., Zhu Q., Jia P.M., Yu Y., Zhou L., Huang Y., Zhang J.W., Xiong S.M., Chen S.J., Wang Z.Y., Chen Z., Chen G.Q. Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia. 14:2000;262-270.
127. Kitamura K., Minami Y., Yamamoto K., Akao Y., Kiyoi H., Saito H., Naoe T. Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis. Leukemia. 14:2000;1743-1750.
128. Shen Z.Y., Tan L.J., Cai W.J., Shen J., Chen C., Tang X.M., Zheng M.H. Arsenic trioxide induces apoptosis of oesophageal carcinoma in vitro. Int. J. Mol. Med. 4:1999;33-37.
129. Siu K.P., Chan J.Y., Fung K.P. Effect of arsenic trioxide on human hepatocellular carcinoma HepG2 cells: inhibition of proliferation and induction of apoptosis. Life Sci. 71:2002;275-285.
130. Du Y.H., Ho P.C. Arsenic compounds induce cytotoxicity and apoptosis in cisplatin-sensitive and -resistant gynecological cancer cell lines. Cancer Chemother. Pharmacol. 47:2001;481-490.
131. Zheng J., Deng Y.P., Lin C., Fu M., Xiao P.G., Wu M. Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression. Int. J. Cancer. 82:1999;286-292.
132. Hossain K., Akhand A.A., Kato M., Du J., Takeda K., Wu J., Takeuchi K., Liu W., Suzuki H., Nakashima I. Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. J. Immunol. 165:2000;4290-4297.
133. Bode A., Dong Z. Apoptosis induction by arsenic: mechanisms of action and possible clinical applications for treating therapy-resistant cancers. Drug Resist. Updat. 3:2000;21-29.
134. Alpert D., Schwenger P., Han J., Vilcek J. Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activation. J. Biol. Chem. 274:1999;22176-22183.
135. Achanzar W.E., Achanzar K.B., Lewis J.G., Webber M.M., Waalkes M.P. Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis. Toxicol. Appl. Pharmacol. 164:2000;291-300.
136. Chrestensen C.A., Starke D.W., Mieyal J.J. Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis. J. Biol. Chem. 275:2000;26556-26565.
137. Stinson L.J., Darmon A.J., Dagnino L., D'Souza S.J. Delayed apoptosis post-cadmium injury in renal proximal tubule epithelial cells. Am. J. Nephrol. 23:2003;27-37.