메뉴 건너뛰기




Volumn 36, Issue 11, 2012, Pages 1428-1435

PGC-1α and exercise in the control of body weight

Author keywords

energy expenditure; exercise; PGC 1a; thermogenesis; weight control

Indexed keywords

GLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

EID: 84869080596     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2012.12     Document Type: Review
Times cited : (38)

References (99)
  • 2
    • 53849092685 scopus 로고    scopus 로고
    • Will all Americans become overweight or obese?. estimating the progression and cost of the US obesity epidemic
    • Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK. Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic. Obesity 2008; 16: 2323-2330.
    • (2008) Obesity , vol.16 , pp. 2323-2330
    • Wang, Y.1    Beydoun, M.A.2    Liang, L.3    Caballero, B.4    Kumanyika, S.K.5
  • 3
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 4
    • 34248180472 scopus 로고    scopus 로고
    • 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]
    • Lau DC, Douketis JD, Morrison KM, Hramiak IM, Sharma AM, Ur E. 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]. Cmaj 2007; 176: S1-S13.
    • (2007) Cmaj , vol.176
    • Lau, D.C.1    Douketis, J.D.2    Morrison, K.M.3    Hramiak, I.M.4    Sharma, A.M.5    Ur, E.6
  • 5
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006; 444: 847-853.
    • (2006) Nature , vol.444 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 6
    • 33746377553 scopus 로고    scopus 로고
    • Obesity-related derangements in metabolic regulation
    • Muoio DM, Newgard CB. Obesity-related derangements in metabolic regulation. Ann Rev Biochem 2006; 75: 367-401.
    • (2006) Ann Rev Biochem , vol.75 , pp. 367-401
    • Muoio, D.M.1    Newgard, C.B.2
  • 7
    • 77957275709 scopus 로고    scopus 로고
    • The therapeutics of lifestyle management on obesity
    • Dyson PA. The therapeutics of lifestyle management on obesity. Diabetes Obes Metab 2010; 12: 941-946.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 941-946
    • Dyson, P.A.1
  • 8
    • 72449152949 scopus 로고    scopus 로고
    • Effects of lifestyle changes to reduce risks of diabetes and associated cardiovascular risks: Results from large scale efficacy trials
    • Horton ES. Effects of lifestyle changes to reduce risks of diabetes and associated cardiovascular risks: results from large scale efficacy trials. Obesity 2009; 17 Suppl 3: S43-S48.
    • (2009) Obesity , vol.17 , Issue.SUPPL. 3
    • Horton, E.S.1
  • 9
    • 0030063440 scopus 로고    scopus 로고
    • Current views on obesity
    • Stunkard AJ. Current views on obesity. Am J Med 1996; 100: 230-236.
    • (1996) Am J Med , vol.100 , pp. 230-236
    • Stunkard, A.J.1
  • 10
    • 78751649862 scopus 로고    scopus 로고
    • Weight science: Evaluating the evidence for a paradigm shift
    • Bacon L, Aphramor L. Weight science: evaluating the evidence for a paradigm shift. Nutr J 2011; 10: 9.
    • (2011) Nutr J , vol.10 , pp. 9
    • Bacon, L.1    Aphramor, L.2
  • 11
    • 0034289881 scopus 로고    scopus 로고
    • Long-term efficacy of dietary treatment of obesity: A systematic review of studies published between 1931 and 1999
    • Ayyad C, Andersen T. Long-term efficacy of dietary treatment of obesity: a systematic review of studies published between 1931 and 1999. Obes Rev 2000; 1: 113-119.
    • (2000) Obes Rev , vol.1 , pp. 113-119
    • Ayyad, C.1    Andersen, T.2
  • 12
    • 78449285027 scopus 로고    scopus 로고
    • Adaptive thermogenesis in humans
    • Rosenbaum M, Leibel RL. Adaptive thermogenesis in humans. Int J Obes 2010; 34 Suppl 1: S47-S55.
    • (2010) Int J Obes , vol.34 , Issue.SUPPL. 1
    • Rosenbaum, M.1    Leibel, R.L.2
  • 13
    • 33751536127 scopus 로고    scopus 로고
    • The thrifty catch-up fat' phenotype: Its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome
    • Dulloo AG, Jacquet J, Seydoux J, Montani JP. The thrifty catch-up fat' phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome. Int J Obes 2006; 30 Suppl 4: S23-S35.
    • (2006) Int J Obes , vol.30 , Issue.SUPPL. 4
    • Dulloo, A.G.1    Jacquet, J.2    Seydoux, J.3    Montani, J.P.4
  • 15
    • 20044364157 scopus 로고    scopus 로고
    • Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: A link between catch-up growth and later metabolic syndrome
    • Cettour-Rose P, Samec S, Russell AP, Summermatter S, Mainieri D, Carrillo-Theander C et al. Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: a link between catch-up growth and later metabolic syndrome. Diabetes 2005; 54: 751-756.
    • (2005) Diabetes , vol.54 , pp. 751-756
    • Cettour-Rose, P.1    Samec, S.2    Russell, A.P.3    Summermatter, S.4    Mainieri, D.5    Carrillo-Theander, C.6
  • 16
    • 70349634594 scopus 로고    scopus 로고
    • Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: Relevance for muscle-adipose glucose redistribution during catch-up growth
    • Summermatter S, Marcelino H, Arsenijevic D, Buchala A, Aprikian O, Assimacopoulos-Jeannet F et al. Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth. Diabetes 2009; 58: 2228-2237.
    • (2009) Diabetes , vol.58 , pp. 2228-2237
    • Summermatter, S.1    Marcelino, H.2    Arsenijevic, D.3    Buchala, A.4    Aprikian, O.5    Assimacopoulos-Jeannet, F.6
  • 17
    • 33745024819 scopus 로고    scopus 로고
    • Regulation of fat storage via suppressed thermogenesis: A thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesity
    • Dulloo AG. Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesity. Horm Res 2006; 65 (Suppl 3): 90-97.
    • (2006) Horm Res , vol.65 , Issue.SUPPL. 3 , pp. 90-97
    • Dulloo, A.G.1
  • 18
    • 0347993116 scopus 로고    scopus 로고
    • Eating, exercise, and thrifty'' genotypes: Connecting the dots toward an evolutionary understanding of modern chronic diseases
    • Chakravarthy MV, Booth FW. Eating, exercise, and thrifty'' genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases. J Appl Physiol 2004; 96: 3-10.
    • (2004) J Appl Physiol , vol.96 , pp. 3-10
    • Chakravarthy, M.V.1    Booth, F.W.2
  • 19
    • 45549108083 scopus 로고    scopus 로고
    • Reduced physical activity and risk of chronic disease: The biology behind the consequences
    • Booth FW, Laye MJ, Lees SJ, Rector RS, Thyfault JP. Reduced physical activity and risk of chronic disease: the biology behind the consequences. Eur J Appl Physiol 2008; 102: 381-390.
    • (2008) Eur J Appl Physiol , vol.102 , pp. 381-390
    • Booth, F.W.1    Laye, M.J.2    Lees, S.J.3    Rector, R.S.4    Thyfault, J.P.5
  • 20
    • 77956859042 scopus 로고    scopus 로고
    • Endurance exercise mimetics in skeletal muscle
    • Matsakas A, Narkar VA. Endurance exercise mimetics in skeletal muscle. Curr Sports Med Rep 2010; 9: 227-232.
    • (2010) Curr Sports Med Rep , vol.9 , pp. 227-232
    • Matsakas, A.1    Narkar, V.A.2
  • 22
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
    • Finck BN, Kelly DP. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 2006; 116: 615-622.
    • (2006) J Clin Invest , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 23
    • 33745221937 scopus 로고    scopus 로고
    • Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise
    • Jorgensen SB, Richter EA, Wojtaszewski JF. Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise. J Physiol 2006; 574 (Pt 1): 17-31.
    • (2006) J Physiol , vol.574 , Issue.PART. 1 , pp. 17-31
    • Jorgensen, S.B.1    Richter, E.A.2    Wojtaszewski, J.F.3
  • 24
    • 64349111923 scopus 로고    scopus 로고
    • Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle
    • Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M. Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. J Appl Physiol 2009; 106: 929-934.
    • (2009) J Appl Physiol , vol.106 , pp. 929-934
    • Gibala, M.J.1    McGee, S.L.2    Garnham, A.P.3    Howlett, K.F.4    Snow, R.J.5    Hargreaves, M.6
  • 25
    • 78649684445 scopus 로고    scopus 로고
    • Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha
    • Handschin C. Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha. J Recept Signal Transduct Res 2010; 30: 376-384.
    • (2010) J Recept Signal Transduct Res , vol.30 , pp. 376-384
    • Handschin, C.1
  • 26
    • 44949188628 scopus 로고    scopus 로고
    • Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle
    • Suwa M, Nakano H, Radak Z, Kumagai S. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle. Metabolism 2008; 57: 986-998.
    • (2008) Metabolism , vol.57 , pp. 986-998
    • Suwa, M.1    Nakano, H.2    Radak, Z.3    Kumagai, S.4
  • 27
    • 80054029513 scopus 로고    scopus 로고
    • Deacetylation of PGC-1alpha by SIRT1: Importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
    • Gurd BJ. Deacetylation of PGC-1alpha by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis. Appl Physiol Nutr Metab 2011; 36: 589-597.
    • (2011) Appl Physiol Nutr Metab , vol.36 , pp. 589-597
    • Gurd, B.J.1
  • 28
    • 80052193535 scopus 로고    scopus 로고
    • Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-\{gamma\} coactivator-1\{alpha\} (pgc-1\{alpha\}) deacetylation following endurance exercise
    • Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE et al. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-\{gamma\} coactivator-1\{alpha\} (pgc-1\{alpha\}) deacetylation following endurance exercise. J Biol Chem 2011; 286: 30561-30570.
    • (2011) J Biol Chem , vol.286 , pp. 30561-30570
    • Philp, A.1    Chen, A.2    Lan, D.3    Meyer, G.A.4    Murphy, A.N.5    Knapp, A.E.6
  • 29
    • 0038810035 scopus 로고    scopus 로고
    • An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
    • Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM. An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A 2003; 100: 7111-7116.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7111-7116
    • Handschin, C.1    Rhee, J.2    Lin, J.3    Tarr, P.T.4    Spiegelman, B.M.5
  • 30
    • 77954070031 scopus 로고    scopus 로고
    • Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle
    • Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N et al. Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol 2010; 588 (Pt 10): 1779-1790.
    • (2010) J Physiol , vol.588 , Issue.PART. 10 , pp. 1779-1790
    • Egan, B.1    Carson, B.P.2    Garcia-Roves, P.M.3    Chibalin, A.V.4    Sarsfield, F.M.5    Barron, N.6
  • 31
    • 34347237611 scopus 로고    scopus 로고
    • An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation
    • Miura S, Kawanaka K, Kai Y, Tamura M, Goto M, Shiuchi T et al. An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation. Endocrinology 2007; 148: 3441-3448.
    • (2007) Endocrinology , vol.148 , pp. 3441-3448
    • Miura, S.1    Kawanaka, K.2    Kai, Y.3    Tamura, M.4    Goto, M.5    Shiuchi, T.6
  • 32
    • 79251569246 scopus 로고    scopus 로고
    • Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1alpha mRNA: A role of beta-adrenergic receptor activation
    • Tadaishi M, Miura S, Kai Y, Kawasaki E, Koshinaka K, Kawanaka K et al. Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1alpha mRNA: a role of beta-adrenergic receptor activation. Am J Physiol Endocrinol Metab 2011; 300: E341-E349.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Tadaishi, M.1    Miura, S.2    Kai, Y.3    Kawasaki, E.4    Koshinaka, K.5    Kawanaka, K.6
  • 34
    • 0037102256 scopus 로고    scopus 로고
    • Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    • Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002; 418: 797-801.
    • (2002) Nature , vol.418 , pp. 797-801
    • Lin, J.1    Wu, H.2    Tarr, P.T.3    Zhang, C.Y.4    Wu, Z.5    Boss, O.6
  • 35
    • 83455223600 scopus 로고    scopus 로고
    • Remodeling of calcium handling in skeletal muscle through PGC-1\{alpha\}: Impact on force, fatigability and fiber type
    • Summermatter S, Turnheer R, Santos G, Mosca B, Baum O, Treves S et al. Remodeling of calcium handling in skeletal muscle through PGC-1\{alpha\}: impact on force, fatigability and fiber type. Am J Physiol Cell Physiol 2012; 302: C88-C99.
    • (2012) Am J Physiol Cell Physiol , vol.302
    • Summermatter, S.1    Turnheer, R.2    Santos, G.3    Mosca, B.4    Baum, O.5    Treves, S.6
  • 36
    • 36048931015 scopus 로고    scopus 로고
    • Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
    • Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ et al. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest 2007; 117: 3463-3474.
    • (2007) J Clin Invest , vol.117 , pp. 3463-3474
    • Handschin, C.1    Choi, C.S.2    Chin, S.3    Kim, S.4    Kawamori, D.5    Kurpad, A.J.6
  • 37
    • 35648937073 scopus 로고    scopus 로고
    • Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals
    • Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK et al. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem 2007; 282: 30014-30021.
    • (2007) J Biol Chem , vol.282 , pp. 30014-30021
    • Handschin, C.1    Chin, S.2    Li, P.3    Liu, F.4    Maratos-Flier, E.5    Lebrasseur, N.K.6
  • 38
    • 39749140405 scopus 로고    scopus 로고
    • HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
    • Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 2008; 451: 1008-1012.
    • (2008) Nature , vol.451 , pp. 1008-1012
    • Arany, Z.1    Foo, S.Y.2    Ma, Y.3    Ruas, J.L.4    Bommi-Reddy, A.5    Girnun, G.6
  • 39
    • 78651379305 scopus 로고    scopus 로고
    • Muscles and their myokines
    • Pedersen BK. Muscles and their myokines. J Exp Biol 2011; 214 (Pt 2): 337-346.
    • (2011) J Exp Biol , vol.214 , Issue.PART. 2 , pp. 337-346
    • Pedersen, B.K.1
  • 40
    • 79955410387 scopus 로고    scopus 로고
    • Coordinated balancing of muscle oxidative metabolism through PGC-1alpha increases metabolic flexibility and preserves insulin sensitivity
    • Summermatter S, Troxler H, Santos G, Handschin C. Coordinated balancing of muscle oxidative metabolism through PGC-1alpha increases metabolic flexibility and preserves insulin sensitivity. Biochem Biophys Res Commun 2011; 408: 180-185.
    • (2011) Biochem Biophys Res Commun , vol.408 , pp. 180-185
    • Summermatter, S.1    Troxler, H.2    Santos, G.3    Handschin, C.4
  • 41
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008; 7: 45-56.
    • (2008) Cell Metab , vol.7 , pp. 45-56
    • Koves, T.R.1    Ussher, J.R.2    Noland, R.C.3    Slentz, D.4    Mosedale, M.5    Ilkayeva, O.6
  • 42
    • 77956094483 scopus 로고    scopus 로고
    • Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity
    • Mihalik SJ, Goodpaster BH, Kelley DE, Chace DH, Vockley J, Toledo FG et al. Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity 2010; 18: 1695-1700.
    • (2010) Obesity , vol.18 , pp. 1695-1700
    • Mihalik, S.J.1    Goodpaster, B.H.2    Kelley, D.E.3    Chace, D.H.4    Vockley, J.5    Toledo, F.G.6
  • 43
    • 2342509057 scopus 로고    scopus 로고
    • Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and wholeanimal insulin resistance
    • An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI et al. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and wholeanimal insulin resistance. Nat Med 2004; 10: 268-274.
    • (2004) Nat Med , vol.10 , pp. 268-274
    • An, J.1    Muoio, D.M.2    Shiota, M.3    Fujimoto, Y.4    Cline, G.W.5    Shulman, G.I.6
  • 44
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440: 944-948.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 45
    • 25844432311 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
    • Koves TR, Li P, An J, Akimoto T, Slentz D, Ilkayeva O et al. Peroxisome proliferatoractivated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem 2005; 280: 33588-33598.
    • (2005) J Biol Chem , vol.280 , pp. 33588-33598
    • Koves, T.R.1    Li, P.2    An, J.3    Akimoto, T.4    Slentz, D.5    Ilkayeva, O.6
  • 46
    • 77958453583 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor \{gamma\} coactivator 1\{alpha\} (PGC-1\{alpha\}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway
    • Summermatter S, Baum O, Santos G, Hoppeler H, Handschin C. Peroxisome proliferator-activated receptor \{gamma\} coactivator 1\{alpha\} (PGC-1\{alpha\}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway. J Biol Chem 2010; 285: 32793-32800.
    • (2010) J Biol Chem , vol.285 , pp. 32793-32800
    • Summermatter, S.1    Baum, O.2    Santos, G.3    Hoppeler, H.4    Handschin, C.5
  • 48
    • 28544438180 scopus 로고    scopus 로고
    • PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: A mechanism for transcriptional control of muscle glucose metabolism
    • Wende AR, Huss JM, Schaeffer PJ, Giguere V, Kelly DP. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol 2005; 25: 10684-10694.
    • (2005) Mol Cell Biol , vol.25 , pp. 10684-10694
    • Wende, A.R.1    Huss, J.M.2    Schaeffer, P.J.3    Giguere, V.4    Kelly, D.P.5
  • 49
    • 58149401189 scopus 로고    scopus 로고
    • Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
    • Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ et al. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci USA 2008; 105: 19926-19931.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19926-19931
    • Choi, C.S.1    Befroy, D.E.2    Codella, R.3    Kim, S.4    Reznick, R.M.5    Hwang, Y.J.6
  • 50
    • 4043123500 scopus 로고    scopus 로고
    • Non-exercise activity thermogenesis (NEAT)
    • Levine JA. Non-exercise activity thermogenesis (NEAT). Nutr Rev 2004; 62 (7 Pt 2): S82-S97.
    • (2004) Nutr Rev , vol.62 , Issue.7 PART. 2
    • Levine, J.A.1
  • 52
    • 11144296834 scopus 로고    scopus 로고
    • Adaptive thermogenesis and uncoupling proteins: A reappraisal of their roles in fat metabolism and energy balance
    • Dulloo AG, Seydoux J, Jacquet J. Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance. Physiol Behav 2004; 83: 587-602.
    • (2004) Physiol Behav , vol.83 , pp. 587-602
    • Dulloo, A.G.1    Seydoux, J.2    Jacquet, J.3
  • 53
    • 0025047553 scopus 로고
    • Skeletal muscle metabolism is a major determinant of resting energy expenditure
    • Zurlo F, Larson K, Bogardus C, Ravussin E. Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest 1990; 86: 1423-1427.
    • (1990) J Clin Invest , vol.86 , pp. 1423-1427
    • Zurlo, F.1    Larson, K.2    Bogardus, C.3    Ravussin, E.4
  • 54
    • 0038036024 scopus 로고    scopus 로고
    • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells
    • St-Pierre J, Lin J, Krauss S, Tarr PT, Yang R, Newgard CB et al. Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem 2003; 278: 26597-26603.
    • (2003) J Biol Chem , vol.278 , pp. 26597-26603
    • St-Pierre, J.1    Lin, J.2    Krauss, S.3    Tarr, P.T.4    Yang, R.5    Newgard, C.B.6
  • 55
    • 60549087508 scopus 로고    scopus 로고
    • PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
    • O'Hagan KA, Cocchiglia S, Zhdanov AV, Tambuwala MM, Cummins EP, Monfared M et al. PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells. Proc Natl Acad Sci U S A 2009; 106: 2188-2193.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2188-2193
    • O'Hagan, K.A.1    Cocchiglia, S.2    Zhdanov, A.V.3    Tambuwala, M.M.4    Cummins, E.P.5    Monfared, M.6
  • 56
    • 81855178288 scopus 로고    scopus 로고
    • Impact of PGC-1alpha on the topology and rate of superoxide production by the mitochondrial electron transport chain
    • Austin S, Klimcakova E, St-Pierre J. Impact of PGC-1alpha on the topology and rate of superoxide production by the mitochondrial electron transport chain. Free Radic Biol Med 2011; 51: 2243-2248.
    • (2011) Free Radic Biol Med , vol.51 , pp. 2243-2248
    • Austin, S.1    Klimcakova, E.2    St-Pierre, J.3
  • 57
    • 45149108625 scopus 로고    scopus 로고
    • Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
    • Calvo JA, Daniels TG, Wang X, Paul A, Lin J, Spiegelman BM et al. Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol 2008; 104: 1304-1312.
    • (2008) J Appl Physiol , vol.104 , pp. 1304-1312
    • Calvo, J.A.1    Daniels, T.G.2    Wang, X.3    Paul, A.4    Lin, J.5    Spiegelman, B.M.6
  • 58
    • 0032549811 scopus 로고    scopus 로고
    • A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A coldinducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92: 829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 59
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277-359.
    • (2004) Physiol Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 60
    • 0037253404 scopus 로고    scopus 로고
    • The novel' uncoupling' proteins UCP2 and UCP3: What do they really do? Pros and cons for suggested functions
    • Nedergaard J, Cannon B. The novel' uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions. Exp Physiol 2003; 88: 65-84.
    • (2003) Exp Physiol , vol.88 , pp. 65-84
    • Nedergaard, J.1    Cannon, B.2
  • 61
    • 23644434842 scopus 로고    scopus 로고
    • Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells
    • MacLellan JD, Gerrits MF, Gowing A, Smith PJ, Wheeler MB, Harper ME. Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes 2005; 54: 2343-2350.
    • (2005) Diabetes , vol.54 , pp. 2343-2350
    • MacLellan, J.D.1    Gerrits, M.F.2    Gowing, A.3    Smith, P.J.4    Wheeler, M.B.5    Harper, M.E.6
  • 62
    • 0032742372 scopus 로고    scopus 로고
    • UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged
    • Cadenas S, Buckingham JA, Samec S, Seydoux J, Din N, Dulloo AG et al. UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged. FEBS Lett 1999; 462: 257-260.
    • (1999) FEBS Lett , vol.462 , pp. 257-260
    • Cadenas, S.1    Buckingham, J.A.2    Samec, S.3    Seydoux, J.4    Din, N.5    Dulloo, A.G.6
  • 63
    • 79960562547 scopus 로고    scopus 로고
    • Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice
    • Nabben M, Shabalina IG, Moonen-Kornips E, van Beurden D, Cannon B, Schrauwen P et al. Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice. Biochimica et biophysica acta 2011; 1807: 1095-1105.
    • (2011) Biochimica et Biophysica Acta , vol.1807 , pp. 1095-1105
    • Nabben, M.1    Shabalina, I.G.2    Moonen-Kornips, E.3    Van Beurden, D.4    Cannon, B.5    Schrauwen, P.6
  • 64
    • 8844255472 scopus 로고    scopus 로고
    • The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation
    • Solinas G, Summermatter S, Mainieri D, Gubler M, Pirola L, Wymann MP et al. The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation. FEBS Lett 2004; 577: 539-544.
    • (2004) FEBS Lett , vol.577 , pp. 539-544
    • Solinas, G.1    Summermatter, S.2    Mainieri, D.3    Gubler, M.4    Pirola, L.5    Wymann, M.P.6
  • 65
    • 29344473323 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid oxidation
    • Solinas G, Summermatter S, Mainieri D, Gubler M, Montani JP, Seydoux J et al. Corticotropin-releasing hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid oxidation. Endocrinology 2006; 147: 31-38.
    • (2006) Endocrinology , vol.147 , pp. 31-38
    • Solinas, G.1    Summermatter, S.2    Mainieri, D.3    Gubler, M.4    Montani, J.P.5    Seydoux, J.6
  • 66
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 2003; 100: 8466-8471.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3    Cusi, K.4    Berria, R.5    Kashyap, S.6
  • 67
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34: 267-273.
    • (2003) Nat Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3    Subramanian, A.4    Sihag, S.5    Lehar, J.6
  • 68
    • 26244453391 scopus 로고    scopus 로고
    • Transcriptional profiling in mouse skeletal muscle following a single bout of voluntary running: Evidence of increased cell proliferation
    • Choi S, Liu X, Li P, Akimoto T, Lee SY, Zhang M et al. Transcriptional profiling in mouse skeletal muscle following a single bout of voluntary running: evidence of increased cell proliferation. J Appl Physiol 2005; 99: 2406-2415.
    • (2005) J Appl Physiol , vol.99 , pp. 2406-2415
    • Choi, S.1    Liu, X.2    Li, P.3    Akimoto, T.4    Lee, S.Y.5    Zhang, M.6
  • 69
    • 34147109662 scopus 로고    scopus 로고
    • PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
    • Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM. PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Gene Dev 2007; 21: 770-783.
    • (2007) Gene Dev , vol.21 , pp. 770-783
    • Handschin, C.1    Kobayashi, Y.M.2    Chin, S.3    Seale, P.4    Campbell, K.P.5    Spiegelman, B.M.6
  • 70
    • 79953649622 scopus 로고    scopus 로고
    • PGC-1alpha promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice
    • Geng T, Li P, Yin X, Yan Z. PGC-1alpha promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice. Am J Pathol 2011; 178: 1738-1748.
    • (2011) Am J Pathol , vol.178 , pp. 1738-1748
    • Geng, T.1    Li, P.2    Yin, X.3    Yan, Z.4
  • 72
    • 33746644497 scopus 로고    scopus 로고
    • Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle
    • Steinberg GR, Watt MJ, McGee SL, Chan S, Hargreaves M, Febbraio MA et al. Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle. Appl Physiol Nutr Metab 2006; 31: 302-312.
    • (2006) Appl Physiol Nutr Metab , vol.31 , pp. 302-312
    • Steinberg, G.R.1    Watt, M.J.2    McGee, S.L.3    Chan, S.4    Hargreaves, M.5    Febbraio, M.A.6
  • 73
    • 0036064261 scopus 로고    scopus 로고
    • Glycogendependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMPactivated protein kinase and glycogen synthase activities in rat skeletal muscle
    • Wojtaszewski JF, Jorgensen SB, Hellsten Y, Hardie DG, Richter EA. Glycogendependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMPactivated protein kinase and glycogen synthase activities in rat skeletal muscle. Diabetes 2002; 51: 284-292.
    • (2002) Diabetes , vol.51 , pp. 284-292
    • Wojtaszewski, J.F.1    Jorgensen, S.B.2    Hellsten, Y.3    Hardie, D.G.4    Richter, E.A.5
  • 74
    • 61449106744 scopus 로고    scopus 로고
    • AMPK and the biochemistry of exercise: Implications for human health and disease
    • Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J 2009; 418: 261-275.
    • (2009) Biochem J , vol.418 , pp. 261-275
    • Richter, E.A.1    Ruderman, N.B.2
  • 75
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    • St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006; 127: 397-408.
    • (2006) Cell , vol.127 , pp. 397-408
    • St-Pierre, J.1    Drori, S.2    Uldry, M.3    Silvaggi, J.M.4    Rhee, J.5    Jager, S.6
  • 76
    • 80053163909 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) \{beta\}1\{beta\}2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
    • O'Neill HM, Maarbjerg SJ, Crane JD, Jeppesen J, Jorgensen SB, Schertzer JD et al. AMP-activated protein kinase (AMPK) \{beta\}1\{beta\}2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci USA 2011; 108: 16092-16097.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16092-16097
    • O'Neill, H.M.1    Maarbjerg, S.J.2    Crane, J.D.3    Jeppesen, J.4    Jorgensen, S.B.5    Schertzer, J.D.6
  • 77
    • 67650348685 scopus 로고    scopus 로고
    • Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase
    • Chambers MA, Moylan JS, Smith JD, Goodyear LJ, Reid MB. Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase. J Physiol 2009; 587 (Pt 13): 3363-3373.
    • (2009) J Physiol , vol.587 , Issue.PART. 13 , pp. 3363-3373
    • Chambers, M.A.1    Moylan, J.S.2    Smith, J.D.3    Goodyear, L.J.4    Reid, M.B.5
  • 78
    • 57349159453 scopus 로고    scopus 로고
    • The alpha-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro
    • Lefort N, St-Amand E, Morasse S, Cote CH, Marette A. The alpha-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro. Am J Physiol Endocrinol Metab 2008; 295: E1447-E1454.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Lefort, N.1    St-Amand, E.2    Morasse, S.3    Cote, C.H.4    Marette, A.5
  • 79
    • 78649815489 scopus 로고    scopus 로고
    • Downstream mechanisms of nitric oxidemediated skeletal muscle glucose uptake during contraction
    • Merry TL, Lynch GS, McConell GK. Downstream mechanisms of nitric oxidemediated skeletal muscle glucose uptake during contraction. Am J Physiol Regul Integr Comp Physiol 2010; 299: R1656-R1665.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299
    • Merry, T.L.1    Lynch, G.S.2    McConell, G.K.3
  • 80
    • 77954551887 scopus 로고    scopus 로고
    • 2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle
    • Zhang SJ, Sandstrom M, Ahlsen M, Ivarsson N, Zhu H, Ma J et al. 2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle. Exp Physiol 2010; 95: 892-898.
    • (2010) Exp Physiol , vol.95 , pp. 892-898
    • Zhang, S.J.1    Sandstrom, M.2    Ahlsen, M.3    Ivarsson, N.4    Zhu, H.5    Ma, J.6
  • 81
    • 50349095537 scopus 로고    scopus 로고
    • Hormone-sensitive lipase is necessary for normal mobilization of lipids during submaximal exercise
    • Fernandez C, Hansson O, Nevsten P, Holm C, Klint C. Hormone-sensitive lipase is necessary for normal mobilization of lipids during submaximal exercise. Am J Physiol Endocrinol Metab 2008; 295: E179-E186.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Fernandez, C.1    Hansson, O.2    Nevsten, P.3    Holm, C.4    Klint, C.5
  • 82
    • 33845590561 scopus 로고    scopus 로고
    • Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine
    • Prats C, Donsmark M, Qvortrup K, Londos C, Sztalryd C, Holm C et al. Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine. J Lipid Res 2006; 47: 2392-2399.
    • (2006) J Lipid Res , vol.47 , pp. 2392-2399
    • Prats, C.1    Donsmark, M.2    Qvortrup, K.3    Londos, C.4    Sztalryd, C.5    Holm, C.6
  • 83
    • 0026053940 scopus 로고
    • Muscle glycogen synthesis before and after exercise
    • Ivy JL. Muscle glycogen synthesis before and after exercise. Sports Med 1991; 11: 6-19.
    • (1991) Sports Med , vol.11 , pp. 6-19
    • Ivy, J.L.1
  • 84
    • 34547460212 scopus 로고    scopus 로고
    • Physical activity in the treatment of obesity: Beyond body weight reduction
    • Janiszewski PM, Ross R. Physical activity in the treatment of obesity: beyond body weight reduction. Appl Physiol Nutr Metab 2007; 32: 512-522.
    • (2007) Appl Physiol Nutr Metab , vol.32 , pp. 512-522
    • Janiszewski, P.M.1    Ross, R.2
  • 85
    • 20144387673 scopus 로고    scopus 로고
    • Functional role of AMP-activated protein kinase in the heart during exercise
    • Musi N, Hirshman MF, Arad M, Xing Y, Fujii N, Pomerleau J et al. Functional role of AMP-activated protein kinase in the heart during exercise. FEBS Lett 2005; 579: 2045-2050.
    • (2005) FEBS Lett , vol.579 , pp. 2045-2050
    • Musi, N.1    Hirshman, M.F.2    Arad, M.3    Xing, Y.4    Fujii, N.5    Pomerleau, J.6
  • 86
    • 0033803048 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    • Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 2000; 106: 847-856.
    • (2000) J Clin Invest , vol.106 , pp. 847-856
    • Lehman, J.J.1    Barger, P.M.2    Kovacs, A.3    Saffitz, J.E.4    Medeiros, D.M.5    Kelly, D.P.6
  • 87
    • 79960071622 scopus 로고    scopus 로고
    • Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age
    • Qi Z, He J, Su Y, He Q, Liu J, Yu L et al. Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age. PLoS One 2011; 6: e21140.
    • (2011) PLoS One , vol.6
    • Qi, Z.1    He, J.2    Su, Y.3    He, Q.4    Liu, J.5    Yu, L.6
  • 88
    • 37849052672 scopus 로고    scopus 로고
    • Systemic and mitochondrial adaptive responses to moderate exercise in rodents
    • Boveris A, Navarro A. Systemic and mitochondrial adaptive responses to moderate exercise in rodents. Free Radic Biol Med 2008; 44: 224-229.
    • (2008) Free Radic Biol Med , vol.44 , pp. 224-229
    • Boveris, A.1    Navarro, A.2
  • 89
    • 80054044902 scopus 로고    scopus 로고
    • Skeletal muscle and beyond: The role of exercise as a mediator of systemic mitochondrial biogenesis
    • Little JP, Safdar A, Benton CR, Wright DC. Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis. Appl Physiol Nutr Metab 2011; 36: 598-607.
    • (2011) Appl Physiol Nutr Metab , vol.36 , pp. 598-607
    • Little, J.P.1    Safdar, A.2    Benton, C.R.3    Wright, D.C.4
  • 90
    • 77954909425 scopus 로고    scopus 로고
    • PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity
    • Lira VA, Benton CR, Yan Z, Bonen A. PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab 2010; 299: E145-E161.
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Lira, V.A.1    Benton, C.R.2    Yan, Z.3    Bonen, A.4
  • 91
    • 0042232026 scopus 로고    scopus 로고
    • Overexpression of peroxisome proliferatoractivated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles
    • Miura S, Kai Y, Ono M, Ezaki O. Overexpression of peroxisome proliferatoractivated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles. J Biol Chem 2003; 278: 31385-31390.
    • (2003) J Biol Chem , vol.278 , pp. 31385-31390
    • Miura, S.1    Kai, Y.2    Ono, M.3    Ezaki, O.4
  • 92
    • 34347272966 scopus 로고    scopus 로고
    • Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP
    • Miura S, Tomitsuka E, Kamei Y, Yamazaki T, Kai Y, Tamura M et al. Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP. Am J Pathol 2006; 169: 1129-1139.
    • (2006) Am J Pathol , vol.169 , pp. 1129-1139
    • Miura, S.1    Tomitsuka, E.2    Kamei, Y.3    Yamazaki, T.4    Kai, Y.5    Tamura, M.6
  • 93
    • 68649109608 scopus 로고    scopus 로고
    • The biology of PGC-1alpha and its therapeutic potential
    • Handschin C. The biology of PGC-1alpha and its therapeutic potential. Trends Pharmacol Sci 2009; 30: 322-329.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 322-329
    • Handschin, C.1
  • 94
    • 11144349089 scopus 로고    scopus 로고
    • Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity
    • McCarty MF. Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity. Med Hypotheses 2005; 64: 399-407.
    • (2005) Med Hypotheses , vol.64 , pp. 399-407
    • McCarty, M.F.1
  • 95
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): Transcriptional coactivator and metabolic regulator
    • Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 2003; 24: 78-90.
    • (2003) Endocr Rev , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 96
    • 12144286554 scopus 로고    scopus 로고
    • Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stagedependent manner
    • Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE et al. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stagedependent manner. Circ Res 2004; 94: 525-533.
    • (2004) Circ Res , vol.94 , pp. 525-533
    • Russell, L.K.1    Mansfield, C.M.2    Lehman, J.J.3    Kovacs, A.4    Courtois, M.5    Saffitz, J.E.6
  • 97
    • 80054705598 scopus 로고    scopus 로고
    • Physical inactivity as the culprit of metabolic inflexibility: Evidences from bed-rest studies
    • Bergouignan A, Rudwill F, Simon C, Blanc S. Physical inactivity as the culprit of metabolic inflexibility: evidences from bed-rest studies. J Appl Physiol 2011; 111: 1201-1210.
    • (2011) J Appl Physiol , vol.111 , pp. 1201-1210
    • Bergouignan, A.1    Rudwill, F.2    Simon, C.3    Blanc, S.4
  • 98
    • 78651276763 scopus 로고    scopus 로고
    • The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: Human and rodent perspectives
    • Garland Jr T, Schutz H, Chappell MA, Keeney BK, Meek TH, Copes LE et al. The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives. J Exp Biol 2011; 214 (Pt 2): 206-229.
    • (2011) J Exp Biol , vol.214 , Issue.PART. 2 , pp. 206-229
    • Garland Jr., T.1    Schutz, H.2    Chappell, M.A.3    Keeney, B.K.4    Meek, T.H.5    Copes, L.E.6
  • 99
    • 35748941921 scopus 로고    scopus 로고
    • Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    • Hamilton MT, Hamilton DG, Zderic TW. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 2007; 56: 2655-2667.
    • (2007) Diabetes , vol.56 , pp. 2655-2667
    • Hamilton, M.T.1    Hamilton, D.G.2    Zderic, T.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.