The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation

FEBS Letters

Volumn 577, Issue 3, 2004, Pages 539-544

  Solinas, Giovanni ^a   Summermatter, Serge ^a   Mainieri, Davide ^a   Gubler, Marcel ^b   Pirola, Luciano ^c   Wymann, Matthias P ^a   Rusconi, Sandro ^a   Montani, Jean Pierre ^a   Seydoux, Josiane ^d   Dulloo, Abdul G ^a  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

^b Dept of Vasc and Metab Diseases ^*  (Switzerland)

^c INSERM   (France)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

AMPK, AMP activated protein kinase; EDL, extensor digitorum longus; IRS1, insulin receptor substrate 1; MO2, respiration (oxygen consumption) rate; ObRb, long form of the leptin receptor; PI3K, phosphatidylinositol 3 kinase; PY, phosphotyrosine

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CARNITINE PALMITOYLTRANSFERASE INHIBITOR; CITRIC ACID; ETOMOXIR; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; LIPID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; WORTMANNIN;

ANIMAL TISSUE; ARTICLE; BREATHING RATE; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ASSAY; GLUCOSE METABOLISM; LIPID METABOLISM; LIPID OXIDATION; LIPID STORAGE; LIPOGENESIS; MALE; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; THERMOGENESIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENYLATE KINASE; ANIMALS; GLUCOSE; LEPTIN; LIPID METABOLISM; MALE; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION; SUBSTRATE CYCLING; THERMOGENESIS;

EID: 8844255472     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.10.066     Document Type: Article

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