Endurance exercise mimetics in skeletal muscle

Current Sports Medicine Reports

Volumn 9, Issue 4, 2010, Pages 227-232

  Matsakas, Antonios ^a   Narkar, Vihang A ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIRTUIN 1;

AEROBIC CAPACITY; CARDIOVASCULAR FUNCTION; ENDURANCE; EXERCISE; HEALTH STATUS; HUMAN; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SKELETAL MUSCLE;

ANIMALS; ENERGY METABOLISM; EXERCISE; HUMANS; MUSCLE, SKELETAL; PHYSICAL ENDURANCE; SIGNAL TRANSDUCTION;

EID: 77956859042     PISSN: 1537890X     EISSN: 15378918     Source Type: Journal    
DOI: 10.1249/JSR.0b013e3181e93938     Document Type: Review

References (58)

1. Arany Z, Wagner BK, Ma Y, et al. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. Proc. Natl. Acad. Sci. U S A. 2008; 105(12): 4721-6.
2. Baar K. Involvement of PPAR gamma co-activator-1, nuclear respiratory factors 1 and 2, and PPAR alpha in the adaptive response to endurance exercise. Proc. Nutr. Soc. 2004; 63(2):269-73.
3. Barish GD, Atkins AR, Downes M, et al. PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc. Natl. Acad. Sci. U S A. 2008; 105(11):4271-6.
4. Barnes BR, Glund S, Long YC, et al. 5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics. FASEB J. 2005; 19(7):773-9.
5. Bassel-Duby R, Olson EN. Signaling pathways in skeletal muscle remodeling. Ann. Rev. Biochem. 2006; 75:19-37.
6. Bookout AL, Jeong Y, Downes M, et al. Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell. 2006; 126(4):789-99.
7. Booth FW, Laye MJ. Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery. J. Physiol. 2009; 587(Pt 23):5527-39.
8. Canto C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009; 458(7241):1056-60.
9. Chabi B, Adhihetty PJ, O'Leary MF, Menzies KJ, Hood DA. Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse. J. Appl. Physiol. 2009; 107(6):1730-5.
10. Chen Z, Heierhorst J, Mann RJ, et al. Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle. FEBS Lett. 1999; 460(2):343-8.
11. Choi CS, Befroy DE, Codella R, et al. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulinstimulated muscle glucose metabolism. Proc. Natl. Acad. Sci. U S A. 2008; 105(50):19926-31.
12. Dressel U, Allen TL, Pippal JB, et al. The peroxisome proliferatoractivated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol. Endocrinol. 2003; 17(12):2477-93.
13. Feige JN, Lagouge M, Canto C, et al. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell. Metab. 2008; 8(5):347-58.
14. Fluck M, Hoppeler H. Molecular basis of skeletal muscle plasticityYfrom gene to form and function. Rev. Physiol. Biochem. Pharmacol. 2003; 146: 159-216.
15. Fujii N, Ho RC, Manabe Y, et al. Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice. Diabetes. 2008; 57(11):2958-66.
16. Fujii N, Seifert MM, Kane EM, et al. Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle -insight from analysis of a transgenic mouse model. Diabetes. Res. Clin. Pract. 2007; 77 (suppl. 1):S92-8.
17. Gerhart-Hines Z, Rodgers JT, Bare O, et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC- 1alpha. EMBO J. 2007; 26(7):1913-23.
18. Goodyear LJ. The exercise pill: Too good to be true? N. Engl. J. Med. 2008; 359(17):1842-4.
19. Gundewar S, Calvert JW, Jha S, et al. Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ. Res. 2009; 104(3):403-11.
20. Haigis MC, Sinclair DA. Mammalian sirtuins: Biological insights and disease relevance. Ann. Rev. Pathol. 2010; 5:253-95.
21. Handschin C, Chin S, Li P, et al. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J. Biol. Chem. 2007; 282(41):30014-21.
22. Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 2006; 27(7):728-35.
23. Holloszy JO, Coyle EF. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J. Appl. Physiol. 1984; 56(4): 831-8.
24. Holst D, Luquet S, Nogueira V, et al. Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. Biochim. Biophys. Acta. 2003; 1633(1):43-50.
25. Iglesias MA, Furler SM, Cooney GJ, Kraegen EW, Ye JM. AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo. Diabetes. 2004; 53(7):1649-54.
26. Ikeda S, Kawamoto H, Kasaoka K, et al. Muscle type-specific response of PGC-1 alpha and oxidative enzymes during voluntary wheel running in mouse skeletal muscle. Acta. Physiol. (Oxf). 2006; 188(3-4):217-23.
27. Jager S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. U S A. 2007; 104(29):12017-22.
28. Jones AM, Carter H. The effect of endurance training on parameters of aerobic fitness. Sports Med. 2000; 29(6):373-86.
29. Kleiner S, Nguyen-Tran V, Bare O, et al. PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function. J. Biol. Chem. 2009; 284(28):18624-33.
30. Kramer DK, Al-Khalili L, Guigas B, et al. Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle. J. Biol. Chem. 2007; 282(27):19313-20.
31. Kramer DK, Al-Khalili L, Perrini S, et al. Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes. 2005; 54(4):1157-63.
32. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006; 127(6):1109-22.
33. Lin J, Wu H, Tarr PT, et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 2002; 418(6899): 797-801.
34. Luquet S, Lopez-Soriano J, Holst D, et al. Peroxisome proliferatoractivated receptor delta controls muscle development and oxidative capability. FASEB J. 2003; 17(15):2299-301.
35. Mahlapuu M, Johansson C, Lindgren K, et al. Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 2004; 286(2):E194-200.
36. Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: The second decade. Cell. 1995; 83(6):835-9.
37. Merrill GF, Kurth EJ, Hardie DG, Winder WW. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am. J. Physiol. 1997; 273(6 Pt 1):E1107-12.
38. Milne JC, Lambert PD, Schenk S, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007; 450(7170):712-6.
39. Narkar VA, Downes M, Yu RT, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008; 134(3):405-15.
40. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: Focus on muscle-derived interleukin-6. Physiol. Rev. 2008; 88(4):1379-406.
41. Puigserver P,WuZ, Park CW, et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998; 92(6):829-39.
42. Reilly SM, Lee CH. PPAR delta as a therapeutic target in metabolic disease. FEBS Lett. 2008; 582(1):26-31.
43. Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: Implications for human health and disease. Biochem. J. 2009; 418(2): 261-75.
44. Russell RR 3rd, Li J, Coven DL, et al. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest. 2004; 114(4):495-503.
45. Schuler M, Ali F, Chambon C, et al. PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab. 2006; 4(5):407-14.
46. Shaw RJ, Lamia KA, Vasquez D, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005; 310(5754):1642-6.
47. Sheng L, Ye P, Liu YX, Han CG, Zhang ZY. Peroxisome proliferatoractivated receptor beta/delta activation improves angiotensin II-induced cardiac hypertrophy in vitro. Clin Exp Hypertens. 2008; 30(2):109-19.
48. Smith AG, Muscat GE. Orphan nuclear receptors: Therapeutic opportunities in skeletal muscle. Am. J. Physiol. Cell. Physiol. 2006; 291(2): C203-17.
49. Stapleton D, Mitchelhill KI, Gao G, et al. Mammalian AMP-activated protein kinase subfamily. J. Biol. Chem. 1996; 271(2):611-4.
50. Suwa M, Nakano H, Kumagai S. Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. J. Appl. Physiol. 2003; 95(3):960-8.
51. Suwa M, Nakano H, Radak Z, Kumagai S. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle. Metabolism. 2008; 57(7):986-98.
52. Takekoshi K, Fukuhara M, Quin Z, et al. Long-term exercise stimulates adenosine monophosphate-activated protein kinase activity and subunit expression in rat visceral adipose tissue and liver. Metabolism. 2006; 55(8):1122-8.
53. Tanaka T, Yamamoto J, Iwasaki S, et al. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc. Natl. Acad. Sci. U S A. 2003; 100(26):15924-9.
54. Wang YX, Lee CH, Tiep S, et al. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell. 2003; 113(2):159-70.
55. Wang YX, Zhang CL, Yu RT, et al. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS. Biol. 2004; 2(10):e294.
56. Winder WW, Holmes BF, Rubink DS, et al. Activation of AMPactivated protein kinase increases mitochondrial enzymes in skeletal muscle. J. Appl. Physiol. 2000; 88(6):2219-26.
57. Winder WW, Taylor EB, Thomson DM. Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise. Med. Sci. Sports Exerc. 2006; 38(11):1945-9.
58. Yang J, Holman GD. Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes. J. Biol. Chem. 2005; 280(6):4070-8.