Impact of PGC-1α on the topology and rate of superoxide production by the mitochondrial electron transport chain

Free Radical Biology and Medicine

Volumn 51, Issue 12, 2011, Pages 2243-2248

  Austin, Shane ^a   Klimcakova, Eva ^a   St Pierre, Julie ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Free radicals; Mitochondria; PGC 1; Respiration; ROS; Topology

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL TISSUE; ARTICLE; BREATHING RATE; COMPLEX FORMATION; CONTROLLED STUDY; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; MOUSE; MUSCLE MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RESPIRATORY CHAIN;

ANIMALS; ELECTRON TRANSPORT; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; SUPEROXIDES; TRANS-ACTIVATORS;

MUS MUSCULUS;

EID: 81855178288     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.08.036     Document Type: Article

References (31)

1. P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright, and B.M. Spiegelman A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell 92 1998 829 839 (Pubitemid 28155321)
2. J. Lin, P. Puigserver, J. Donovan, P. Tarr, and B.M. Spiegelman Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1β), a novel PGC-1-related transcription coactivator associated with host cell factor J. Biol. Chem. 277 2002 1645 1648 (Pubitemid 34968733)
3. U. Andersson, and R.C. Scarpulla Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells Mol. Cell. Biol. 21 2001 3738 3749 (Pubitemid 32466987)
4. Z. Wu, P. Puigserver, U. Andersson, C. Zhang, G. Adelmant, V. Mootha, A. Troy, S. Cinti, B. Lowell, R.C. Scarpulla, and B.M. Spiegelman Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 Cell 98 1999 115 124 (Pubitemid 29331201)
5. J. St-Pierre, J. Lin, S. Krauss, P.T. Tarr, R. Yang, C.B. Newgard, and B.M. Spiegelman Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1α and PGC-1β) in muscle cells J. Biol. Chem. 278 2003 26597 26603 (Pubitemid 36876804)
6. V.K. Mootha, C. Handschin, D. Arlow, X. Xie, J. St Pierre, S. Sihag, W. Yang, D. Altshuler, P. Puigserver, N. Patterson, P.J. Willy, I.G. Schulman, R.A. Heyman, E.S. Lander, and B.M. Spiegelman Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle Proc. Natl. Acad. Sci. USA 101 2004 6570 6575 (Pubitemid 38586015)
7. S.N. Schreiber, R. Emter, M.B. Hock, D. Knutti, J. Cardenas, M. Podvinec, E.J. Oakeley, and A. Kralli The estrogen-related receptor alpha (ERRα) functions in PPARgamma coactivator 1alpha (PGC-1α)-induced mitochondrial biogenesis Proc. Natl. Acad. Sci. USA 101 2004 6472 6477 (Pubitemid 38585998)
8. S.K. Powers, E.E. Talbert, and P.J. Adhihetty Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle J. Physiol. 589 2011 2129 2138
9. I. Valle, A. Alvarez-Barrientos, E. Arza, S. Lamas, and M. Monsalve PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells Cardiovasc. Res. 66 2005 562 573 (Pubitemid 40725768)
10. J. St-Pierre, S. Drori, M. Uldry, J.M. Silvaggi, J. Rhee, S. Jager, C. Handschin, K. Zheng, J. Lin, W. Yang, D.K. Simon, R. Bachoo, and B.M. Spiegelman Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators Cell 127 2006 397 408 (Pubitemid 44572377)
11. T. Wenz, S.G. Rossi, R.L. Rotundo, B.M. Spiegelman, and C.T. Moraes Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging Proc. Natl. Acad. Sci. USA 106 2009 20405 20410
12. M.D. Brand The sites and topology of mitochondrial superoxide production Exp. Gerontol. 45 2010 466 472
13. 2 emission during long-chain fatty acid oxidation J. Biol. Chem. 285 2010 5748 5758
14. J. St-Pierre, J.A. Buckingham, S.J. Roebuck, and M.D. Brand Topology of superoxide production from different sites in the mitochondrial electron transport chain J. Biol. Chem. 277 2002 44784 44790 (Pubitemid 36159072)
15. S. Miwa, J. St-Pierre, L. Partridge, and M.D. Brand Superoxide and hydrogen peroxide production by Drosophila mitochondria Free Radic. Biol. Med. 35 2003 938 948 (Pubitemid 37211448)
16. F.L. Muller, Y. Liu, and H. Van Remmen Complex III releases superoxide to both sides of the inner mitochondrial membrane J. Biol. Chem. 279 2004 49064 49073 (Pubitemid 39625788)
17. S. Miwa, and M.D. Brand The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria Biochim. Biophys. Acta 1709 2005 214 219 (Pubitemid 41254214)
18. J. Lin, H. Wu, P.T. Tarr, C.Y. Zhang, Z. Wu, O. Boss, L.F. Michael, P. Puigserver, E. Isotani, E.N. Olson, B.B. Lowell, R. Bassel-Duby, and B.M. Spiegelman Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres Nature 418 2002 797 801
19. A.J. Lambert, H.M. Boysen, J.A. Buckingham, T. Yang, A. Podlutsky, S.N. Austad, T.H. Kunz, R. Buffenstein, and M.D. Brand Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms Aging Cell 6 2007 607 618 (Pubitemid 47400043)
20. Hoeks, J., Arany, Z., Phielix, E., Moonen-Kornips, E., Hesselink, M.K., Schrauwen, P. Enhanced lipid- but not carbohydrate-supported mitochondrial respiration in skeletal muscle of PGC-1alpha overexpressing mice. J. Cell. Physiol. (in press).
21. C. Handschin, and B.M. Spiegelman Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism Endocr. Rev. 27 2006 728 735 (Pubitemid 44936056)
22. C. Zechner, L. Lai, J.F. Zechner, T. Geng, Z. Yan, J.W. Rumsey, D. Collia, Z. Chen, D.F. Wozniak, T.C. Leone, and D.P. Kelly Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity Cell Metab. 12 2010 633 642
23. J. Lin, P.H. Wu, P.T. Tarr, K.S. Lindenberg, J. St-Pierre, C.Y. Zhang, V.K. Mootha, S. Jager, C.R. Vianna, R.M. Reznick, L. Cui, M. Manieri, M.X. Donovan, Z. Wu, M.P. Cooper, M.C. Fan, L.M. Rohas, A.M. Zavacki, S. Cinti, G.I. Shulman, B.B. Lowell, D. Krainc, and B.M. Spiegelman Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice Cell 119 2004 121 135 (Pubitemid 39349325)
24. L. Cui, H. Jeong, F. Borovecki, C.N. Parkhurst, N. Tanese, and D. Krainc Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration Cell 127 2006 59 69 (Pubitemid 44466642)
25. P. Weydt, V.V. Pineda, A.E. Torrence, R.T. Libby, T.F. Satterfield, E.R. Lazarowski, M.L. Gilbert, G.J. Morton, T.K. Bammler, A.D. Strand, L. Cui, R.P. Beyer, C.N. Easley, A.C. Smith, D. Krainc, S. Luquet, I.R. Sweet, M.W. Schwartz, and A.R. La Spada Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration Cell Metab. 4 2006 349 362 (Pubitemid 44645069)
26. C. Handschin, Y.M. Kobayashi, S. Chin, P. Seale, K.P. Campbell, and B.M. Spiegelman PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy Genes Dev. 21 2007 770 783 (Pubitemid 46572357)
27. B.N. Finck, and D.P. Kelly PGC-1 coactivators: inducible regulators of energy metabolism in health and disease J. Clin. Invest. 116 2006 615 622 (Pubitemid 43326866)
28. J.J. Lehman, P.M. Barger, A. Kovacs, J.E. Saffitz, D.M. Medeiros, and D.P. Kelly Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis J. Clin. Invest. 106 2000 847 856
29. L.K. Russell, C.M. Mansfield, J.J. Lehman, A. Kovacs, M. Courtois, J.E. Saffitz, D.M. Medeiros, M.L. Valencik, J.A. McDonald, and D.P. Kelly Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner Circ. Res. 94 2004 525 533 (Pubitemid 38326288)
30. Z. Arany, M. Novikov, S. Chin, Y. Ma, A. Rosenzweig, and B.M. Spiegelman Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha Proc. Natl. Acad. Sci. USA 103 2006 10086 10091 (Pubitemid 43993627)
31. A. Sanz, J. Gomez, P. Caro, and G. Barja Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage J. Bioenerg. Biomembr. 38 2006 327 333 (Pubitemid 44952976)