Translesion synthesis across 1,N6-(2-hydroxy-3- hydroxymethylpropan-1,3-diyl)-2′-deoxyadenosine (1,N6-γ- HMHP-dA) adducts by human and archebacterial DNA polymerases

Journal of Biological Chemistry

Volumn 287, Issue 46, 2012, Pages 38800-38811

  Kotapati, Srikanth ^a,c   Maddukuri, Leena ^d,e   Wickramaratne, Susith ^b,c   Seneviratne, Uthpala ^c,f   Goggin, Melissa ^a,c   Pence, Matthew G ^d   Villalta, Peter ^c   Guengerich, F Peter ^d   Marnett, Lawrence ^d   Tretyakova, Natalia ^a,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b University of Minnesota   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d VANDERBILT INGRAM CANCER CENTER   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^f Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ,2 ,3 ,4-DIEPOXYBUTANE; 1 ,3-BUTADIENE; BIFUNCTIONAL; DAMAGED SITES; DEOXYADENOSINE; DNA POLYMERASE; ERROR PRONES; FRAME-SHIFT MUTATION; GEL ANALYSIS; HPLC-ESI-MS/MS; NUCLEOBASES; PRIMER EXTENSION; SINGLE NUCLEOTIDES; SITE-SPECIFIC; TRANSLESION SYNTHESIS; WATSON-CRICK BASE PAIRING;

BUTADIENE; ENZYMES; NUCLEOTIDES;

POLYMERS;

1,N6 (2 HYDROXY 3 HYDROXYMETHYLPROPAN 1,3 DIYL) 2' DEOXYADENOSINE; BUTADIENE DIEPOXIDE; DEOXYADENOSINE DERIVATIVE; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE ETA; DNA DIRECTED DNA POLYMERASE IOTA; DNA DIRECTED DNA POLYMERASE KAPPA; DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA SEQUENCE; DNA SYNTHESIS; DNA TEMPLATE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME SPECIFICITY; FRAMESHIFT MUTATION; GEL ELECTROPHORESIS; GENE INSERTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STEADY STATE; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY;

ARCHAEA; BASE SEQUENCE; DEOXYADENOSINES; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; GENE DELETION; HUMANS; KINETICS; MASS SPECTROMETRY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84869036510     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.396788     Document Type: Article

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