In vitro bypass of the major malondialdehyde-and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, τ, and Rev1

Biochemistry

Volumn 49, Issue 38, 2010, Pages 8415-8424

  Maddukuri, Leena ^a   Eoff, Robert L ^a   Choi, Jeong Yun ^a,c   Rizzo, Carmelo J ^a,b   Guengerich, F Peter ^a   Marnett, Lawrence J ^a,b  

^a A B Hancock Jr Memorial Laboratory for Cancer Research   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Ewha Womans University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; ESCHERICHIA COLI; GENES; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; OXIDATION; POLYMERS;

COMBINED ACTIONS; COMPLEX PRODUCTS; DNA ADDUCTS; DNA POLYMERASE; ERYTHRO; FRAME-SHIFT MUTATION; IN-VITRO; IN-VIVO; LIPID PEROXIDATION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALONDIALDEHYDE; MAMMALIAN CELLS; PEROXIDATION; SINGLE NUCLEOTIDES; STEADY-STATE KINETICS;

DNA;

3 (2' DEOXY BETA DEXTRO ERYTHROPENTOFURANOSYL)PYRIMIDO [1,2 A]PURIN 10(3H) ONE; ACROLEIN; DNA POLYMERASE; DNA POLYMERASE IOTA; DNA POLYMERASE KAPPA; DNA POLYMERASE REV1; MALONALDEHYDE; UNCLASSIFIED DRUG; DNA; DNA ADDUCT; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ETA; DNA HYDROPEROXIDE; MUTAGENIC AGENT; PEROXIDE; POLK PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA SEQUENCE; DNA TEMPLATE; ESCHERICHIA COLI; FRAMESHIFT MUTATION; GENE INSERTION; IN VITRO STUDY; KINETICS; LIPID PEROXIDATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; STEADY STATE; CHEMISTRY; DNA DAMAGE; DNA REPLICATION; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE;

ESCHERICHIA COLI; MAMMALIA;

BASE SEQUENCE; DNA; DNA ADDUCTS; DNA DAMAGE; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; HUMANS; IN VITRO TECHNIQUES; KINETICS; MALONDIALDEHYDE; MUTAGENS; PEROXIDES;

EID: 77957080930     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1009024     Document Type: Article

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