Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4

Journal of Biological Chemistry

Volumn 281, Issue 4, 2006, Pages 2358-2372

  Zang, Hong ^a   Irimia, Adriana ^a   Choi, Jeong Yun ^a   Angel, Karen C ^a   Loukachevitch, Lioudmila V ^a   Egli, Martin ^a   Guengerich, F Peter ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b 638 Robinson Research Bldg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOMEDICAL ENGINEERING; CATALYST ACTIVITY; CRYSTAL STRUCTURE; ENZYMES;

DNA POLYMERASES; INCORPORATION EFFICIENCY; OLIGONUCLEOTIDE; WATSON-CRICK GEOMETRY;

DNA;

2',3' DIDEOXYCYTIDINE 5' TRIPHOSPHATE; 7,8 DIHYDRO 8 OXODEOXYGUANOSINE; CALCIUM ION; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE; DEOXYGUANOSINE TRIPHOSPHATE; DNA POLYMERASE; DNA POLYMERASE4; OLIGONUCLEOTIDE; PRIMER DNA; UNCLASSIFIED DRUG; 2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE; 8 OXO 7 HYDRODEOXYGUANOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYCYTIDINE PHOSPHATE; DNA; DNA DIRECTED DNA POLYMERASE; DRUG DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL BOND; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME STRUCTURE; GENE INSERTION; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STEADY STATE; SULFOLOBUS SOLFATARICUS; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; ESCHERICHIA COLI; FRAMESHIFT MUTATION; KINETICS; LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN BINDING; TIME; X RAY DIFFRACTION;

SULFOLOBUS SOLFATARICUS;

BASE SEQUENCE; CHROMATOGRAPHY, LIQUID; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANOSINE; DNA; DNA PRIMERS; DNA-DIRECTED DNA POLYMERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FRAMESHIFT MUTATION; KINETICS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; SULFOLOBUS SOLFATARICUS; TIME FACTORS; X-RAY DIFFRACTION;

EID: 33644866040     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510889200     Document Type: Article

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