Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "Wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred

Journal of Biological Chemistry

Volumn 282, Issue 2, 2007, Pages 1456-1467

  Eoff, Robert L ^a   Irimia, Adriana ^a   Egli, Martin ^a   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; MASS SPECTRAL ANALYSIS; POLYMERASE ACTIVE SITE; SULFOLOBUS SOLFATARICUS;

CATALYSIS; DNA; HYDROGEN BONDS; POLYMERIZATION; RATE CONSTANTS; SPECTRUM ANALYSIS;

ENZYME KINETICS;

6 O METHYLGUANINE; CYTOSINE; DNA POLYMERASE; PYRIMIDINE; RIBOSE; THYMIDINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE BETA; DRUG DERIVATIVE; GUANINE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CATALYSIS; ENZYME INHIBITION; GEOMETRY; HYDROGEN BOND; KINETICS; MASS SPECTROMETRY; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; STEADY STATE; STRUCTURE ANALYSIS; SULFOLOBUS SOLFATARICUS; X RAY CRYSTALLOGRAPHY; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE;

SULFOLOBUS SOLFATARICUS;

BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYTOSINE; DNA POLYMERASE BETA; GUANINE; KINETICS; MODELS, CHEMICAL; PROTEIN STRUCTURE, TERTIARY; SULFOLOBUS SOLFATARICUS;

EID: 33847713782     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609661200     Document Type: Article

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