Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms

Chemico-Biological Interactions

Volumn 135, Issue 136, 2001, Pages 325-341

  Recio, Leslie ^a   Steen, Ann Marie ^a   Pluta, Linda J ^a   Meyer, Kathy G ^a   Saranko, Christopher J ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

1,3 Butadiene; Diepoxybutane; Epoxybutene; Hprt; Laci; Mutagenicity; Mutational spectrum

Indexed keywords

1,2 EPOXY 3,4 BUTANEIDOL; 1,2 EPOXYBUTENE; 1,3 BUTADIENE; BUTADIENE DIEPOXIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; BONE MARROW; CARCINOGENESIS; CHROMOSOME ABERRATION; CONFERENCE PAPER; CONTROLLED STUDY; EXPOSURE; FEMALE; GENE DELETION; INHALATION; LUNG; LYMPHOBLAST; MALE; MOUSE; MUTAGENESIS; MUTATION RATE; NONHUMAN; POINT MUTATION; SPLEEN; TRANSGENIC MOUSE;

AIR POLLUTANTS; ANIMALS; BACTERIAL PROTEINS; BUTADIENES; CELL LINE; EPOXY COMPOUNDS; ESCHERICHIA COLI PROTEINS; FEMALE; HUMANS; MALE; MICE; MICE, TRANSGENIC; MUTAGENICITY TESTS; MUTAGENS; RATS; REPRESSOR PROTEINS; SPLEEN;

MUS MUSCULUS; RODENTIA;

EID: 0035369995     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00220-4     Document Type: Article

References (40)

1. The industrial production and use of 1,3-butadiene
2. Butadiene, market & economics/product focus
3. Occupational exposure to 1,3-butadiene; final rule
4. 1,3-Butadiene
5. A follow-up study of synthetic rubber workers
6. Leukemia and cumulative exposure to butadiene, styrene and benzene among workers in the synthetic rubber industry
7. Toxicology and epidemiology of 1,3-butadiene
8. Comparison of the disposition of butadiene epoxides in Sprague-Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation
9. Mutagenicity of butadiene and its epoxide metabolites. I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts
10. Clastogenicity of diepoxybutane in bone marrow cells and male germ cells of mice
11. In vitro and in vivo mutagenicity of the butadiene metabolites butadiene diolepoxide, butadiene monoepoxide and diepoxybutane
12. Molecular dosimetry of N-7 guanine adduct formation in mice and rats exposed to 1,3-butadiene
13. Assessment of 1,3-butadiene mutagenicity in the bone marrow of B6C3F1 laci transgenic mice (Big Blue©): A review of mutational spectrum and laci mutant frequency after a 5-day 625 ppm 1,3-butadiene exposure
14. The in vivo mutagenicity and mutational spectrum at the laci transgene recovered from the spleens of B6C3F1 laci transgenic mice following a 4-week inhalation exposure to 1,3-butadiene
15. Comparison of the mutagenic potency of 1,3-butadiene at the hprt locus of T-lymphocytes following inhalation exposure of female B6C3F1 mice and F344 rats
16. Comparison of induction of hprt mutations by 1,3-butadiene and/or its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in lymphocytes from spleen of adult male mice and rats in vivo
17. New approaches to understanding p53 gene tumor mutation spectra
18. Molecular epidemiology and carcinogenesis: Endogenous and exogenous carcinogens
19. Characterization of hprt mutations following 1,2-epoxy-3-butene exposure of human TK6 cells
20. Analysis of hprt mutations occurring in human TK6 lymphoblastoid cells following exposure to 1,2,3,4-diepoxybutane
21. The molecular analysis of laci mutants from transgenic fibroblasts exposed to the butadiene metabolite, 1,2-epoxybutene
22. The butadiene metabolite, 1,2,3,4-diepoxybutane, induces micronuclei but is only weakly mutagenic at laci in the Big Blue Rat2 laci transgenic cell line
23. 1,3-butadiene: Cancer, mutations, and adducts. Part II: Roles of two metabolites of 1,3-butadiene in mediating its in vivo genotoxicity
24. Lung-specific mutagenicity and mutational spectrum in B6C3F1 laci transgenic mice following inhalation exposure to 1,2-epoxybutene
25. Molecular analysis of laci mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene
26. Spontaneous and X-ray-induced deletion mutations in a LacZ plasmid-based transgenic mouse model
27. Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: Frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes
28. Allelotype analysis of 2′,3′-dideoxycytidine and 1,3-butadiene-induced lymphomas in B6C3F1 mice
29. Hydroquinone, a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells
30. 1,3-butadiene: Cancer, mutations, and adducts. Part I: Carcinogenicity of 1,2,3,4-dipepoxybutane
31. 1,3-butadiene: Cancer, mutations, and adducts. Part IV: Molecular dosimetry of 1,3-butadiene
32. Butadiene diolepoxide- and diepoxybutane-derived DNA adducts at N7-guanine: A high occurrence of diolepoxide-derived adducts in mouse lung after 1,3-butadiene exposure
33. Human DNA adducts of 1,3-butadiene, an important environmental carcinogen
34. Mutagenic potential of guanine N(2) adducts of butadiene mono- and diolepoxide
35. Mutagenic potential of adenine N(6) adducts of monoepoxide and diolepoxide derivatives of butadiene
36. Butadiene-induced intrastrand DNA cross-links: A possible role in deletion mutagenesis
37. Inactivations of p16INK4a-alpha, p16INK4a-beta and p15INK4b genes in 2′,3′-dideoxycytidine-and 1,3-butadiene-induced murine lymphomas
38. Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years