Structural basis for proficient incorporation of dTTP opposite O 6-methylguanine by human DNA polymerase ι

Journal of Biological Chemistry

Volumn 285, Issue 52, 2010, Pages 40666-40672

  Pence, Matthew G ^a   Choi, Jeong Yun ^b   Egli, Martin ^a   Guengerich, P ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Ewha Womans University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BACILLUS STEAROTHERMOPHILUS; BASE PAIRING; DNA POLYMERASE; HIGH EFFICIENCY; HIGHER EFFICIENCY; HOOGSTEEN BASE PAIRING; HOOGSTEEN HYDROGEN BONDING; HUMAN DNA POLYMERASE; S-ADENOSYLMETHIONINE; STEADY-STATE KINETICS; STRUCTURAL BASIS; SULFOLOBUS SOLFATARICUS; TRIPHOSPHATE;

ATOMS; BACTERIOLOGY; DNA; HYDROGEN; POLYMERS;

HYDROGEN BONDS;

6 O METHYLGUANINE; DNA POLYMERASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; OLIGONUCLEOTIDE; THYMIDINE TRIPHOSPHATE;

ARTICLE; BASE PAIRING; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA PROTEIN COMPLEX; DNA TEMPLATE; ENZYME ACTIVE SITE; ENZYME KINETICS; GEOBACILLUS STEAROTHERMOPHILUS; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STEADY STATE; SULFOLOBUS SOLFATARICUS;

BACTERIAL PROTEINS; BASE PAIRING; CATALYTIC DOMAIN; DEOXYCYTOSINE NUCLEOTIDES; DNA; DNA POLYMERASE BETA; DNA POLYMERASE I; DNA-DIRECTED DNA POLYMERASE; GEOBACILLUS STEAROTHERMOPHILUS; GUANINE; HUMANS; HYDROGEN BONDING; KINETICS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOLOBUS; THYMINE NUCLEOTIDES;

GEOBACILLUS STEAROTHERMOPHILUS; SULFOLOBUS SOLFATARICUS;

EID: 78650396647     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.183665     Document Type: Article

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