In vitro differentiation of skin sensitizers by cell signaling pathways

Toxicology

Volumn 242, Issue 1-3, 2007, Pages 144-152

  Koeper, L M ^a   Schulz, A ^b   Ahr, H J ^a   Vohr, H W ^a  

^a BAYER PHARMA AG   (Germany)

^b Florence Nightingale Krankenhaus   (Germany)

Author keywords

ERK; Irritant compounds; JNK; p38; Reconstituted skin models; Sensitizing compounds; Skin explants

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; DODECYL SULFATE SODIUM; IRRITANT AGENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OXAZOLONE; PHOSPHOLIPASE C; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRITON X 100;

ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; EXPLANT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN CELL; TOXICITY TESTING;

ALLERGENS; ANIMALS; DINITROFLUOROBENZENE; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; IRRITANTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYMPH NODES; MEMBRANES, ARTIFICIAL; MICE; MICE, INBRED C3H; MICE, INBRED HRS; OCTOXYNOL; OXAZOLONE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN; SKIN IRRITANCY TESTS; SODIUM DODECYL SULFATE; STAT1 TRANSCRIPTION FACTOR; TISSUE CULTURE TECHNIQUES;

ANIMALIA; MURINAE;

EID: 36148995114     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.09.019     Document Type: Article

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