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Volumn , Issue , 2010, Pages 1-13

BACE, APP Processing, and Signal Transduction in Alzheimer's Disease

Author keywords

BACE cleavage, caspase cleavage and neuronal trophic dependence; BACE, APP processing and signal transduction in Alzheimer's disease; Key mutations proximal of app processing to A

Indexed keywords


EID: 84868580800     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470594087.ch1     Document Type: Chapter
Times cited : (3)

References (55)
  • 2
    • 27744547991 scopus 로고    scopus 로고
    • SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain
    • Madeira, A., Pommet, J.M., Prochiantz, A., and Allinquant, B. 2005 . SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain . F ASEB J 9 : 1905-1907 .
    • (2005) F ASEB J , vol.9 , pp. 1905-1907
    • Madeira, A.1    Pommet, J.M.2    Prochiantz, A.3    Allinquant, B.4
  • 3
    • 60549089207 scopus 로고    scopus 로고
    • APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    • Nikolaev, A., McLaughlin, T., O'Leary, D.D., and Tessier-Lavigne, M. 2009 . APP binds DR6 to trigger axon pruning and neuron death via distinct caspases . Nature 457 : 981-989 .
    • (2009) Nature , vol.457 , pp. 981-989
    • Nikolaev, A.1    McLaughlin, T.2    O'Leary, D.D.3    Tessier-Lavigne, M.4
  • 6
    • 33845898816 scopus 로고    scopus 로고
    • Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP
    • Saganich, M.J., Schroeder, B.E., Galvan, V., Bredesen, D.E., Koo, E.H., and Heinemann, S.F. 2006 . Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP . J Neurosci 26 : 13428-13436 .
    • (2006) J Neurosci , vol.26 , pp. 13428-13436
    • Saganich, M.J.1    Schroeder, B.E.2    Galvan, V.3    Bredesen, D.E.4    Koo, E.H.5    Heinemann, S.F.6
  • 7
    • 0031930313 scopus 로고    scopus 로고
    • Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer ' s disease
    • Yang, F., Sun, X., Beech, W., Teter, B., Wu, S., Sigel, J., Vinters, H.V., Frautschy, S.A., and Cole, G.M. 1998 . Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer ' s disease . Am J Pathol 152 : 379-389 .
    • (1998) Am J Pathol , vol.152 , pp. 379-389
    • Yang, F.1    Sun, X.2    Beech, W.3    Teter, B.4    Wu, S.5    Sigel, J.6    Vinters, H.V.7    Frautschy, S.A.8    Cole, G.M.9
  • 10
    • 0347479366 scopus 로고    scopus 로고
    • Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer ' s disease
    • Zhao, M., Su, J., Head, E., and Cotman, C.W. 2003 . Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer ' s disease . Neurobiol Dis 14 : 391-403 .
    • (2003) Neurobiol Dis , vol.14 , pp. 391-403
    • Zhao, M.1    Su, J.2    Head, E.3    Cotman, C.W.4
  • 12
    • 0028963084 scopus 로고
    • Requirement for phosphatiylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
    • Yao, R. and Cooper, G.M. 1995 . Requirement for phosphatiylinositol-3 kinase in the prevention of apoptosis by nerve growth factor . Science 267 : 2003-2006 .
    • (1995) Science , vol.267 , pp. 2003-2006
    • Yao, R.1    Cooper, G.M.2
  • 13
    • 1442295841 scopus 로고    scopus 로고
    • Apoptosis and dependence receptors: a molecular basis for cellular addiction
    • Bredesen, D.E., Mehlen, P., and Rabizadeh, S. 2004 . Apoptosis and dependence receptors: a molecular basis for cellular addiction . Physiol Rev 84 : 411-430 .
    • (2004) Physiol Rev , vol.84 , pp. 411-430
    • Bredesen, D.E.1    Mehlen, P.2    Rabizadeh, S.3
  • 16
    • 0028270620 scopus 로고
    • The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development
    • Barrett, G.L. and Bartlett, P.F. 1994 . The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development . Proc Natl Acad Sci U S A 91 : 6501-6505 .
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6501-6505
    • Barrett, G.L.1    Bartlett, P.F.2
  • 17
    • 0030017892 scopus 로고    scopus 로고
    • The low-affinity nerve growth factor receptor p75NGFR mediates death of PC12 cells after nerve growth factor withdrawal
    • Barrett, G.L. and Georgiou, A. 1996 . The low-affinity nerve growth factor receptor p75NGFR mediates death of PC12 cells after nerve growth factor withdrawal . J Neurosci Res 45 : 117-128 .
    • (1996) J Neurosci Res , vol.45 , pp. 117-128
    • Barrett, G.L.1    Georgiou, A.2
  • 19
    • 0030610707 scopus 로고    scopus 로고
    • P75NTR and apoptosis: Trk-dependent and Trk-independent effects
    • Bredesen, D.E. and Rabizadeh, S. 1997 . p75NTR and apoptosis: Trk-dependent and Trk-independent effects . Trends Neurosci 20 : 287-290 .
    • (1997) Trends Neurosci , vol.20 , pp. 287-290
    • Bredesen, D.E.1    Rabizadeh, S.2
  • 20
    • 0035853158 scopus 로고    scopus 로고
    • The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation
    • Forcet, C., Ye, X., Granger, L., Corset, V., Shin, H., Bredesen, D.E., and Mehlen, P. 2001 . The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation . Proc Natl Acad Sci U S A 98 : 3416-3421 .
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3416-3421
    • Forcet, C.1    Ye, X.2    Granger, L.3    Corset, V.4    Shin, H.5    Bredesen, D.E.6    Mehlen, P.7
  • 21
    • 0035355209 scopus 로고    scopus 로고
    • Netrin-1 acts as a survival factor via its receptors UNC5H and DCC
    • Llambi, F., Causeret, F., Bloch-Gallego, E., and Mehlen, P. 2001 . Netrin-1 acts as a survival factor via its receptors UNC5H and DCC . EMBO J 20 : 2715-2722 .
    • (2001) EMBO J , vol.20 , pp. 2715-2722
    • Llambi, F.1    Causeret, F.2    Bloch-Gallego, E.3    Mehlen, P.4
  • 22
    • 0032558787 scopus 로고    scopus 로고
    • The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis
    • Mehlen, P., Rabizadeh, S., Snipas, S.J., Assa-Munt, N., Salvesen, G.S., and Bredesen, D.E. 1998 . The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis . Nature 395 : 801-804 .
    • (1998) Nature , vol.395 , pp. 801-804
    • Mehlen, P.1    Rabizadeh, S.2    Snipas, S.J.3    Assa-Munt, N.4    Salvesen, G.S.5    Bredesen, D.E.6
  • 23
    • 0028670573 scopus 로고
    • Is p75NGFR involved in developmental neural cell death?
    • Rabizadeh, S. and Bredesen, D.E. 1994 . Is p75NGFR involved in developmental neural cell death? . Dev Neurosci 16 : 207-211 .
    • (1994) Dev Neurosci , vol.16 , pp. 207-211
    • Rabizadeh, S.1    Bredesen, D.E.2
  • 24
    • 0035851912 scopus 로고    scopus 로고
    • Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins
    • Stupack, D.G., Puente, X.S., Boutsaboualoy, S., Storgard, C.M., and Cheresh, D.A. 2001 . Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins . J Cell Biol 155 : 459-470 .
    • (2001) J Cell Biol , vol.155 , pp. 459-470
    • Stupack, D.G.1    Puente, X.S.2    Boutsaboualoy, S.3    Storgard, C.M.4    Cheresh, D.A.5
  • 27
    • 0000620478 scopus 로고    scopus 로고
    • Keeping neurons alive: the molecular control of apoptosis (part I)
    • Bredesen, D.E. 1996 . Keeping neurons alive: the molecular control of apoptosis (part I) . Neuroscientist 2 : 181-190 .
    • (1996) Neuroscientist , vol.2 , pp. 181-190
    • Bredesen, D.E.1
  • 28
    • 0030702084 scopus 로고    scopus 로고
    • Caspases: intracellular signaling by proteolysis
    • Salvesen, G.S. and Dixit, V.M. 1997 . Caspases: intracellular signaling by proteolysis . Cell 91 : 443-446 .
    • (1997) Cell , vol.91 , pp. 443-446
    • Salvesen, G.S.1    Dixit, V.M.2
  • 30
    • 0345602771 scopus 로고    scopus 로고
    • Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes
    • Lu, D.C., Shaked, G.M., Masliah, E., Bredesen, D.E., and Koo, E.H. 2003 . Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes . Ann Neurol 54 : 781-789 .
    • (2003) Ann Neurol , vol.54 , pp. 781-789
    • Lu, D.C.1    Shaked, G.M.2    Masliah, E.3    Bredesen, D.E.4    Koo, E.H.5
  • 31
    • 0142179222 scopus 로고    scopus 로고
    • Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity
    • Lu, D.C., Soriano, S., Bredesen, D.E., and Koo, E.H. 2003 . Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity . J Neurochem 87 : 733-741 .
    • (2003) J Neurochem , vol.87 , pp. 733-741
    • Lu, D.C.1    Soriano, S.2    Bredesen, D.E.3    Koo, E.H.4
  • 32
    • 1842519391 scopus 로고    scopus 로고
    • Alzheimer ' s amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide
    • Butterfield, D.A. and Bush, A.I. 2004 . Alzheimer ' s amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide . Neurobiol Aging 25 : 563-568 .
    • (2004) Neurobiol Aging , vol.25 , pp. 563-568
    • Butterfield, D.A.1    Bush, A.I.2
  • 33
    • 33845661843 scopus 로고    scopus 로고
    • A β induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)
    • Shaked, G.M., Kummer, M.P., Lu, D.C., Galvan, V., Bredesen, D.E., and Koo, E.H. 2006 . A β induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624) . FASEB J 20 : 1254-1256 .
    • (2006) FASEB J , vol.20 , pp. 1254-1256
    • Shaked, G.M.1    Kummer, M.P.2    Lu, D.C.3    Galvan, V.4    Bredesen, D.E.5    Koo, E.H.6
  • 34
    • 34248181511 scopus 로고    scopus 로고
    • Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer ' s disease mouse model
    • Roberson, E.D., Scearce-Levie, K., Palop, J.J., Yan, F., Cheng, I.H., Wu, T., Gerstein, H., Yu, G.Q., and Mucke, L. 2007 . Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer ' s disease mouse model . Science 316 : 750-754 .
    • (2007) Science , vol.316 , pp. 750-754
    • Roberson, E.D.1    Scearce-Levie, K.2    Palop, J.J.3    Yan, F.4    Cheng, I.H.5    Wu, T.6    Gerstein, H.7    Yu, G.Q.8    Mucke, L.9
  • 35
    • 38449120482 scopus 로고    scopus 로고
    • Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664
    • Nguyen, T.V., Galvan, V., Huang, W., Banwait, S., Tang, H., Zhang, J., and Bredesen, D.E. 2008 . Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664 . J Neurochem 104 : 1065-1080 .
    • (2008) J Neurochem , vol.104 , pp. 1065-1080
    • Nguyen, T.V.1    Galvan, V.2    Huang, W.3    Banwait, S.4    Tang, H.5    Zhang, J.6    Bredesen, D.E.7
  • 36
    • 0030030005 scopus 로고    scopus 로고
    • Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I
    • Beher, D., Hesse, L., Masters, C.L., and Multhaup, G. 1996 . Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I . J Biol Chem 271 : 1613-1620 .
    • (1996) J Biol Chem , vol.271 , pp. 1613-1620
    • Beher, D.1    Hesse, L.2    Masters, C.L.3    Multhaup, G.4
  • 37
    • 1842364870 scopus 로고    scopus 로고
    • Interaction between Alzheimer ' s disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans
    • Caceres, J. and Brandan, E. 1997 . Interaction between Alzheimer ' s disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans . J Cell Biochem 65 : 145-158 .
    • (1997) J Cell Biochem , vol.65 , pp. 145-158
    • Caceres, J.1    Brandan, E.2
  • 39
    • 0031967942 scopus 로고    scopus 로고
    • A new paradigm for neurotoxicity by FAD mutants of betaAPP: a signaling abnormality
    • Nishimoto, I. 1998 . A new paradigm for neurotoxicity by FAD mutants of betaAPP: a signaling abnormality . Neurobiol Aging 19 : S33-S38 .
    • (1998) Neurobiol Aging , vol.19
    • Nishimoto, I.1
  • 40
    • 65249105453 scopus 로고    scopus 로고
    • Selective vulnerability in Alzheimer ' s disease: amyloid precursor protein and p75(NTR) interaction
    • Fombonne, J., Rabizadeh, S., Banwait, S., Mehlen, P., and Bredesen, D.E. 2009 . Selective vulnerability in Alzheimer ' s disease: amyloid precursor protein and p75(NTR) interaction . Ann Neurol 65 : 294-303 .
    • (2009) Ann Neurol , vol.65 , pp. 294-303
    • Fombonne, J.1    Rabizadeh, S.2    Banwait, S.3    Mehlen, P.4    Bredesen, D.E.5
  • 41
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer ' s disease in the APP gene at the N-terminus of beta-amyloid
    • Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., and Lannfelt, L. 1992 . A pathogenic mutation for probable Alzheimer ' s disease in the APP gene at the N-terminus of beta-amyloid . Nat Genet 1 : 345-347 .
    • (1992) Nat Genet , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3    Houlden, H.4    Lilius, L.5    Winblad, B.6    Lannfelt, L.7
  • 45
    • 0034982951 scopus 로고    scopus 로고
    • Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy
    • Grabowski, T.J., Cho, H.S., Vonsattel, J.P., Rebeck, G.W., and Greenberg, S.M. 2001 . Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy . Ann Neurol 49 : 697-705 .
    • (2001) Ann Neurol , vol.49 , pp. 697-705
    • Grabowski, T.J.1    Cho, H.S.2    Vonsattel, J.P.3    Rebeck, G.W.4    Greenberg, S.M.5
  • 49
    • 0033616590 scopus 로고    scopus 로고
    • Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 -< . Met betaAPP-770 mutation responsible for probable early-onset Alzheimer ' s disease
    • Ancolio, K., Dumanchin, C., Barelli, H., Warter, J.M., Brice, A., Campion, D., Frebourg, T., and Checler, F. 1999 . Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 -<. Met betaAPP-770 mutation responsible for probable early-onset Alzheimer ' s disease . Proc Natl Acad Sci U S A 96 : 4119-4124 .
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4119-4124
    • Ancolio, K.1    Dumanchin, C.2    Barelli, H.3    Warter, J.M.4    Brice, A.5    Campion, D.6    Frebourg, T.7    Checler, F.8
  • 51
    • 0025950987 scopus 로고
    • A mutation in the amyloid precursor protein associated with hereditary Alzheimer ' s disease
    • Murrell, J., Farlow, M., Ghetti, B., and Benson, M.D. 1991 . A mutation in the amyloid precursor protein associated with hereditary Alzheimer ' s disease . Science 254 : 97-99 .
    • (1991) Science , vol.254 , pp. 97-99
    • Murrell, J.1    Farlow, M.2    Ghetti, B.3    Benson, M.D.4
  • 54
    • 0033966705 scopus 로고    scopus 로고
    • Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis
    • Kwok, J.B., Li, Q.X., Hallupp, M., Whyte, S., Ames, D., Beyreuther, K., Masters, C.L., and Schofield, P.R. 2000 . Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis . Ann Neurol 47 : 249-253 .
    • (2000) Ann Neurol , vol.47 , pp. 249-253
    • Kwok, J.B.1    Li, Q.X.2    Hallupp, M.3    Whyte, S.4    Ames, D.5    Beyreuther, K.6    Masters, C.L.7    Schofield, P.R.8


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